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| 1 | Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis显示文摘AIM: To determine the gene expression profile data for the whole liver during development of dimethylni-trosamine (DMN)-induced hepatic fibrosis.METHODS: Marker genes were identified for different types of hepatic cells, including hepatic stellate cells (HSCs), Kupffer cells (including other inflammatory cells), and hepatocytes, using independent temporal DNA microarray data obtained from isolated hepatic cells. RESULTS: The cell-type analysis of gene expression gave several key results and led to formation of three hypotheses: (1) changes in the expression of HSC-specific marker genes during fibrosis were similar to gene expression data in in vitro cultured HSCs, suggesting a major role of the self-activating characteristics of HSCs in formation of fibrosis; (2) expression of mast cell-specific marker genes reached a peak during liver fibrosis, suggesting a possible role of mast cells in formation of fibrosis; and (3) abnormal expression of hepatocyte-specific marker genes was found across several metabolic pathways during fibrosis, including sulfur-containing amino acid metabolism, fatty acid metabolism, and drug metabolism, suggesting a mechanistic relationship between these abnormalities and symptoms of liver fibrosis. CONCLUSION: Analysis of marker genes for specific hepatic cell types can identify the key aspects of fibro-genesis. Sequential activation of inflammatory cells and the self-supporting properties of HSCs play an important role in development of fibrosis. | Yoshiyuki Takahara Mitsuo Takahashi Hiroki Wagatsuma Fumihiko Yokoya Qing-Wei Zhang Mutsuyo Yamaguchi Hiroyuki Aburatani Norifumi Kawada | 2006 | World Journal of Gastroenterology2006，12，40： | 5 |
| 2 | A highly attenuated rabies virus HEP-Flury strain reverts to virulent by single amino acid substitution to arginine at position 333 in glycoprotein 显示文摘 | Mutsuyo T Ken-ichi I B Yoko S C | 2006 | Virus Res2006，10，16： | 1 |
| 3 | Rescue of Rabies Virus from Cloned cDNA and Identification of the Pathogenicity-Related Gene:Glycoprotein Gene Is Associated with Virulence for Adult Mice显示文摘 | Naoto Ito Mutsuyo Takayama Kentaro Yamada Makoto Sugiyama And Nobuyuki Minamoto | 2001 | Journal of Virology2001，75，19： | 1 |
| 4 | Videomicroscopic and histopathological investigation of intense pulsed light therapy for solar lentigines显示文摘 | Akira Kawada Mutsuyo Asai Hiroko Kameyama Yoshiko Sangen Yoshinori Aragane Tadashi Tezuka Kouji Iwakiri | 2002 | Journal of Dermatological Science2002，，2： | 1 |
| 5 | Improved recovery of rabies virus from cloned cDNA using a vaccinia virus-free reverse genetics system 显示文摘 | ITO N MUTSUYO T I KENTARO Y | 2003 | Microbiol Immunol2003，47，： | 1 |
| 6 | Improved recovery of rabies virus from cloned cDNA显示文摘 | Ito N Mutsuyo T I Kentaro Y | 2004 | Virology2004，330，： | 1 |
| 7 | Improved recovery of rabies virus from cloned cDNA using a vaccinia virus-free reverse genetics system 显示文摘 | Ito N Mutsuyo T I Kentaro Y | 2003 | Microbiology and Immunology2003，47，： | 1 |
| 8 | Improved recovery of rabies virus from cloned cDNA using a vaceinia virus free reverse genetics system显示文摘 | ho N Mutsuyo T I Kentaro Y | 2003 | Microbiol Immunol2003，47，： | 1 |
| 9 | A highly attenuated rabies virus HEP-Flury strain reverts to virulent by single amino acid substitution to arginine at position 333 in glycoprotein显示文摘 | Mutsuyo Takayama-Ito Ken-ichi Inoue Yoko Shoji Satoshi Inoue Toshio Iijima Takeo Sakai Ichiro Kurane Kinjiro Morimoto | 2006 | Virus Research2006，，2： | 1 |
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