|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Carbohydrate recognition on MUC1-expressing targets enhances cytotoxicity of a T cell subpopulation显示文摘 | Mulder MC Zennadi R | 1997 | Scand J Immunol1997，46，： | 1 |
| 2 | Ten - year follow - up on Dutch orthopaedic blood management ( DATA III survey) 显示文摘 | Struijk - Mulder MC Horstmann WG Verheyen CC | 2014 | Arch Orthop Trauma Surg2014，134，： | 1 |
| 3 | Vascular effects of sphingolipids 显示文摘 | Michel MC Mulders AC Jongsma M | 2007 | Acta Paediatr Suppl2007，96，455： | 1 |
| 4 | Freedom fi'om paroxysmal atrial fibrillation after successful pulmonary vein isolation with pulmonary vein ablation catheter-phased radiofrequency energy: 2-year follow-up and predictors of failm 显示文摘 | Mulder AA Wijffels MC Wever EF | 2012 | Europace2012，14，： | 1 |
| 5 | High revision rate after treatment of femoral neck fractures with an optionally(un)cemented stem显示文摘 | Coosen JH Mulder MC Bongers KJ | | 0，，06： | 1 |
| 6 | Consumption of gluten with gluten-degrading enzyme by celiac patients: A pilot-study显示文摘AIM:To assesses the safety and efficacy of Aspergillus niger prolyl endoprotease(AN-PEP)to mitigate the im-munogenic effects of gluten in celiac patients.METHODS:Patients with initial diagnosis of celiac disease as confirmed by positive serology with subtotal or total villous atrophy on duodenal biopsies who adhere to a strict gluten-free diet(GFD)resulting in normalised antibodies and mucosal healing classified as Marsh 0 orⅠwere included.In a randomised double-blind placebo-controlled pilot study,patients consumed toast(approximately 7 g/d gluten)with AN-PEP for 2 wk(safety phase).After a 2-wk washout period with adherence of the usual GFD,14 patients were randomised to gluten intake with either AN-PEP or placebo for 2 wk(efficacy phase).Measurements at baseline included complaints,quality-of-life,serum antibodies,immunophenotyping of T-cells and duodenal mucosa immunohistology.Furthermore,serum and quality of life questionnaires were collected during and after the safety,washout and efficacy phase.Duodenal biopsies were collected after the safety phase and after the efficacy phase.A change in histological evaluation according to the modified Marsh classification was the primary endpoint.RESULTS:In total,16 adults were enrolled in the study.No serious adverse events occurred during the trial and no patients withdrew during the trial.The mean score for the gastrointestinal subcategory of the celiac disease quality(CDQ)was relatively high throughout the study,indicating that AN-PEP was well tolerated.In the efficacy phase,the CDQ scores of patients consuming gluten with placebo or gluten with AN-PEP did not significantly deteriorate and moreover no differences between the groups were observed.During the efficacy phase,neither the placebo nor the AN-PEP group developed significant antibody titers.The IgA-EM concentrations remained negative in both groups.Two patients were excluded from entering the efficacy phase as their mucosa showed an increase oftwo Marsh steps after the safety phase,yet with undetectable serum antibodies,while 14 patients were considered histologically stable on gluten with AN-PEP.Also after the efficacy phase,no significant deterioration was observed regarding immunohistological and flow cytometric evaluation in the group consuming placebo compared to the group receiving AN-PEP.Furthermore,IgA-tTG deposit staining increased after 2 wk of gluten compared to baseline in four out of seven patients on placebo.In the seven patients receiving AN-PEP,one patient showed increased and one showed decreased IgA-tTG deposits.CONCLUSION:AN-PEP appears to be well tolerated.However,the primary endpoint was not met due to lack of clinical deterioration upon placebo,impeding an effect of AN-PEP. | Greetje J Tack Jolanda MW van de Water Maaike J Bruins Engelina MC Kooy-Winkelaar Jeroen van Bergen Petra Bonnet Anita CE Vreugdenhil Ilma Korponay-Szabo Luppo Edens B Mary E von Blomberg Marco WJ Schreurs Chris J Mulder Frits Koning | 2013 | World Journal of Gastroenterology2013，19，35： | 1 |
| 7 | Biodiversity and ecosystem functioning:reconciling the results of experimental and observational studies显示文摘 | Hector A Joshi J Scherer-Lorenzen M Schmid B Spehn EM Wacker L Weilenmann M Bazeley-White E Beierkuhnlein C Caldeira MC Dimitrakopoulos PG Finn JA Huss-Danell K Jumpponen A Leadley PW Loreau M Mulder CPH Nesshoover C Palmborg C Read D J Siamantziouras ASD | | 0，，： | 1 |
| 8 | Plant diversity and productivity experiments in European grasslands显示文摘 | Hector A Schmid B Beierkuhnlein C Caldeira MC Diemer M Dimitrakopoulos PG Finn JA Freitas H Giller PS Good J Harris R H(o)gberg P Huss-DanelI K Joshi J Jumpponen A Korner C Leadley PW Loreau M Minns A Mulder CPH O'Donovan G Otway S J Pereira JS Prinz A Re | | 0，，5442： | 1 |
| 9 | Application, eco-physiology and biodiversity of anaerobic ammonium-oxidizing bacteria 显示文摘 | Kartal B van Niftrik L Sliekers O Schmid MC Schmidt I van de Pas- Schoonen K Cirpus I van der Star W van Loosdrecht M Abma W Kuenen JG Mulder J-W Jetten MSM den Camp HO Strous M van de Vossenberg J | 2004 | Rev Environ Sci Biotech2004，3，3： | 1 |
| 10 | Death and venous thromboembolism after lower extremity, amputation 显示文摘 | Struijk- Mulder MC Van Wijhe W Sze YK | 2010 | J Thromb Haemost2010，8，12： | 1 |
| 11 | Arrhythmia de- tection after atrial fibrillation ablation: value of incremen- tal monitoring time显示文摘 | Mulder AA Wijffels MC Wever EF | 2012 | Pacing Clin Electrophysiol2012，35，2： | 1 |
| 12 | Vascular effects of sphingolipids 显示文摘 | Michel MC Mulders AC Jongsma M | 2007 | Acta Paediatr Suppl2007，96，455： | 1 |
| 13 | Comparison of complication rates and postoperative astiogmatism between nylon and mersilene sutures for corneal transplants in patients with fuchs endothelial dystrophy显示文摘 | Bartels MC van Rooij J Geerards AJ Mulder PG Remeijer L | 2006 | Cornea2006，25，5： | 1 |
| 14 | Freedom from paroxysmal atrial fibrillation after successful pulmonary vein isolation with pulmonary vein ablation catheter-phased radiofrequency energy: 2-year follow-up and predictors of failure 显示文摘 | Mulder AA Wijffels MC Wever EF | 2012 | Europace2012，14，： | 1 |
| 15 | Full-scale application of the SHARON process for treatment of rejection water of digested sludge dewatefing显示文摘 | Mulder JW van Loosdrecht MC Hellinga C van Kempen R | 2001 | Water Sci Technol2001，43，11： | 1 |
| 16 | Comparing consensus guidelines on thromboprophylaxis in orthopedic surgery 显示文摘 | Struijk - Mulder MC Ettema HB Verheyen CC | 2010 | J Thromb Haemost2010，8，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员