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| 1 | Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats显示文摘瞄准:在老鼠在导致 caerulein 的胰腺炎和联系肝损伤上处于导致胰腺炎的肝的损坏和象 melatonin,抗坏血酸和 N 乙酰半胱氨酸那样的抗氧化剂代理人的效果调查氧化损害的角色。方法:38 只女 Wistar 老鼠被使用。尖锐胰腺炎(AP ) 被 caerulein 的二 i.p 注射在 2-h 间隔导致(在 100 microg/kg b.wt 的全部的剂量) 。另外的二个组收到了另外的 melatonin (20 mg/kg b.wt ) 或包含 L (+) 维生素酸(14.3 mg/kb.wt.) 和 N 乙酰半胱氨酸(181 mg/kg b.wt ) 的抗氧化剂混合物立即在 caerulein 的每注射前的 i.p。老鼠被斩首杀头 12 h 在 caerulein 的最后注射以后牺牲。胰腺、肝的氧化压力标记被变化在在织物抗氧化剂酶层次,过氧化氢酶(猫) 和谷胱甘肽过氧化物酶(GPx ) 作为 malondialdehyde (MDA ) 和变化测量的类脂化合物过氧化物的数量评估。组织病理学说的检查用获得系统被执行。结果:肝的房间退化,细胞内部的空泡形成,脉管的拥挤,正弦曲线膨胀和炎性浸润的度显示出在 caerulein 和 caerulein + melatonin 之间的有效差量(P = 0.001 ) ,并且 careulein 和 caerulein + L (+) 维生素酸 +N 乙酰半胱氨酸组(P = 0.002 ) 。ciner 房间退化,胰腺的浮肿,细胞内部的空泡形成和炎性浸润的度显示出在 caerulein 和 caerulein + melatonin 之间的有效差量(P = 0.004 ) ,并且 careulein 和 caerulein + L (+) 维生素酸 +N 乙酰半胱氨酸组(P = 0.002 ) 。 导致Caerulein 胰腺并且肝损坏伴有织物 MDA 层次的重要增加( P = 0.01 , P = 0.003 ,分别地)而在猫的重要减少( P = 0.002 , P = 0.003 ,分别地)并且 GPx 活动( P = 0.002 , P = 0.03 ,分别地)。Melatonin 和 L (+) 维生素 acid+N 乙酰半胱氨酸管理显著地减少了在胰的 MDA 层次(P=0.03, P=0.002,分别地) 并且肝(P = 0.007, P = 0.01,分别地) 。这些代理人的管理增加了胰腺、肝的猫和 GPx 活动。Melatonin 显著地增加了胰腺、肝的猫(P = 0.002, P = 0.001,分别地) 并且 GPx 活动(P = 0.002, P = 0.001 ) 。另外, L (+) 维生素酸 +N 乙酰半胱氨酸显著地增加了胰腺的 GPx (P = 0.002 ) 并且肝的猫和 GPx 活动(P = 0.001, P = 0.007,分别地).CONCLUSION:氧化损害不仅在 AP 的致病而且处于导致胰腺炎的肝的损坏起一个重要作用。抗氧化剂代理人象 melatonin 和抗坏血酸 +N 乙酰半胱氨酸那样,能够限制经由恢复织物抗氧化剂酶活动在 AP 期间生产的胰腺、肝的损坏。 | Mukaddes E■refoglu Mehmet Gül Burhan Ate■ Kadir Batoglu Mukadder Ay■e Selimoglu | 2006 | World Journal of Gastroenterology2006，12，2： | 29 |
| 2 | Role of stem cells in repair of liver injury:Experimental and clinical benefit of transferred stem cells on liver failure显示文摘Although the liver has a high regenerative capacity,as a result of massive hepatocyte death,liver failure occurs. In addition to liver failure,for acute,chronic and hereditary diseases of the liver,cell transplantation therapies can stimulate regeneration or at least ensure sufficient function until liver transplantation can be performed. The lack of donor organs and the risks of rejection have prompted extensive experimental and clinical research in the field of cellular transplantation. Transplantation of cell lineages involved in liver regeneration,including mature hepatocytes,fetal hepatocytes,fetal liver progenitor cells,fetal stem cells,hepatic progenitor cells,hepatic stem cells,mesenchymal stem cells,hematopoietic stem cells,and peripheral blood and umbilical cord blood stem cells,have been found to be beneficial in the treatment of liver failure.In this article,the results of experimental and clinical cell transplantation trials for liver failure are reviewed,with an emphasis on regeneration. | Mukaddes Esrefoglu | 2013 | World Journal of Gastroenterology2013，19，40： | 14 |
| 3 | Examining the whole bowel, double balloon enteroscopy: Indications, diagnostic yield and complications显示文摘Double balloon enteroscopy(DBE) is an advanced type of endoscopic procedure which brings the advantage of reaching the whole small bowel using anterograde or the retrograde route. This procedure is both diagnostic and interventional for a variety of small intestinal diseases, such as vascular lesions, tumors, polyps and involvement of inflammatory bowel diseases.Main indication is the diagnosis and treatment of mid-gastrointestinal bleeding according to the recent published data all over the world. The complication rates seem to be higher than conventional procedures but growing experience is lowering them and improving the procedure to be safe and well tolerated. This review is about the technique, indications, diagnostic importance and complications of DBE according to the literature growing since 2001. | Fatih Saygili Saba Mukaddes Saygili Erkin Oztas | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 9 |
| 4 | Experimental and clinical evidence of antioxidant therapy in acute pancreatitis显示文摘Oxidative stress has been shown to play an important role in the pathogenesis of acute pancreatitis (AP). Antioxidants, alone or in combination with conventional therapy, should improve oxidative-stress-induced organ damage and therefore accelerate the rate of recovery. In recent years, substantial amounts of data about the efficiency of antioxidants against oxidative damage have been obtained from experiments with rodents. Some of these antioxidants have been found beneficial in the treatment of AP in humans; however, at present there is insufficient clinical data to support the benefits of antioxidants, alone or in combination with conven-tional therapy, in the management of AP in humans. Conflicting results obtained from experimental animals and humans may represent distinct pathophysiological mechanisms mediating tissue injury in different species. Further detailed studies should be done to clarify the exact mechanisms of tissue injury in human AP. Herein I tried to review the existing experimental and clinical studies on AP in order to determine the efficiency of antioxidants. The use of antioxidant enriched nutrition is a potential direction of clinical research in AP given the lack of clues about the efficiency and safety of antioxidant usage in patients with AP. | Mukaddes Esrefoglu | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 5 | Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats显示文摘AIM: To investigate the role of oxidative injury and the effect of exogenous melatonin administration on liver damage induced by bile duct ligation (BDL), and second,to evaluate the role of nitric oxide (NO), a free oxygen radical, in oxidative injury.METHODS: Thirty-two Sprague-Dawley rats were assigned to four groups: sham operation (SO), BDL, BDL+melatonin,and BDL+vehicle. Cholestasis was achieved by double ligature of the common bile duct. Melatonin was injected intraperitoneally 500 μg/(kg.d) for 8 d. Hepatic oxidative stress markers were evaluated by changes in the amount of lipid peroxides, measured as malondialdehyde (MDA),and reduced GSH. Total nitrite (NOx) concentrations were determined in hepatic homogenates. Histopathological examination was performed using a histological scoring system.RESULTS: The histopathological changes including portal inflammation, necrosis, apoptosis, focal inflammation and fibrosis were severe in the BDL and BDL+vehicle groups. There were numerous large areas of coagulation necrosis. Histological Activity Index scores of these groups were significantly higher than that of the SO group. Treatment with melatonin reduced these alterations significantly. The degree of necro-infiammation and fibrosis showed significant difference between the BDL and BDL+melatonin groups. BDL was accompanied by a significant increase in MDA and NOx, and a significant decrease in GSH levels. Mean±SE values of MDA, GSH and NOx levels of SO group were 147.47±6.69, 0.88±0.33 μmol/g and 180.70±6.58 nm/g, respectively. The values of BDL group were 200.14±21.30, 0.65±0.02 μmol/g, and 400.46±48.89 nm/g, respectively, whereas the values of BDL+melatonin group were 115.93±6.8, 0.74±0.02 μmol/g,and 290.38±32.32 nm/g, respectively. Melatonin treatment was associated with a significant recovery of MDA, GSH and NOx levels.CONCLUSION: We have concluded that oxidative stress is associated with the pathogenesis of cholestatic liver damage and NO contributes to oxidative damage. Melatonin,even at low dose, is an efficient agent in reducing negative parameters of cholestasis. | Mukaddes Esrefoglu Mehmet Gül Memet Hanifi Emre Alaattin Polat Mukadder Ayse Selimoglu | 2005 | World Journal of Gastroenterology2005，11，13： | 6 |
| 6 | Effectiveness of Saccharomyces boulardii in a rat model of colitis显示文摘AIM:To investigate the effects of Saccharomyces boulardii(S.boulardii) in an experimental rat model of trinitrobenzene sulfonic acid(TNBS)-induced colitis.METHODS:Thirty-two Wistar albino female rats were categorized into five groups.On the first day of the study,50 mg TNBS was administered via a rectal catheter in order to induce colitis in all rats,except those in the control group.For 14 d,the rats were fed a standard diet,without the administration of any additional supplements to either the control or TNBS groups,in addition to 1 mg/kg per day S.boulardii to the S.boulardii group,1 mg/kg per day methyl prednisolone(MP) to the MP group.The animals in the S.boulardii + MP group were coadministered these doses of S.boulardii and MP.During the study,weight loss,stool consistency,and the presence of obvious blood in the stool were evaluated,and the disease activity index(DAI) for colitis was recorded.The intestines were examined and colitis was macro-and microscopically scored.The serum and tissue levels of tumor necrosis factor-α(TNF-α) and nitric oxide(NO) were determined,and fungemia was evaluated in the blood samples.RESULTS:The mean DAI scores for the MP and S.boulardii + MP groups was significantly lower than the TNBS group(3.69 ± 0.61 vs 4.46 ± 0.34,P = 0.018 and 3.77 ± 0.73 vs 4.46 ± 0.34,P = 0.025,respectively).While no significant differences between the TNBS and the S.boulardii or MP groups could be determined in terms of serum NO levels,the level of serum NO in the S.boulardii + MP group was significantly higher than in the TNBS and S.boulardii groups(8.12 ± 4.25 μmol/L vs 3.18 ± 1.19 μmol/L,P = 0.013;8.12 ± 4.25 μmol/L vs 3.47 ± 1.66 μmol/L,P = 0.012,respectively).The tissue NO levels in the S.boulardii,MP and S.boulardii + MP groups were significantly lower than the TNBS group(16.62 ± 2.27 μmol/L vs 29.72 ± 6.10 μmol/L,P = 0.002;14.66 ± 5.18 μmol/Lvs 29.72 ± 6.10 μmol/L,P = 0.003;11.95 ± 2.34 μmol/Lvs 29.72 ± 6.10 μmol/L,P = 0.002,respectively).The tissue NO levels in the S.boulardii,MP and S.boulardii + MP groups were similar.The mean serum and tissue TNF-α levels were determined to be 12.97 ± 18.90 pg/mL and 21.75 ± 15.04 pg/mL in the control group,18.25 ± 15.44 pg/mL and 25.27 ± 11.95 pg/mL in the TNBS group,20.59 ± 16.15 pg/mL and 24.39 ± 13.06 pg/mL in the S.boulardii group,9.05 ± 5.13 pg/mL and 24.46 ± 10.85 pg/mL in the MP group,and 13.95 ± 10.17 pg/mL and 24.26 ± 10.37 pg/mL in the S.boulardii + MP group.Significant differences in terms of the levels of serum and tissue TNF-α and the macroscopic and microscopic scores were not found between the groups.S.boulardii fungemia was not observed in any of the rats.However,Candida fungemia was detected in one rat(14%) in the TNBS group,two rats(28%) in the S.boulardii group,three rats(50%) in the MP group,and three rats(42%) in S.boulardii + MP group.CONCLUSION:S.boulardii does not demonstrate considerable effects on the DAI,pathological scores,or cytokine levels but does decrease the tissue NO levels. | Mujde Soyturk Saba Mukaddes Saygili Huseyin Baskin Ozgul Sagol Osman Yilmaz Fatih Saygili Hale Akpinar | 2012 | World Journal of Gastroenterology2012，18，44： | 6 |
| 7 | Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats显示文摘AIM:To investigate the effects of long term pretreatment with low-,medium-and high-dose aspirin(acetylsalicylic acid,ASA) on a model of acute pancreatitis(AP) induced in rats.METHODS:Forty male Wistar rats were used.Three experimental groups,each consisting of eight animals,received low-(5 mg/kg per day),medium-(150 mg/kg per day) and high-dose(350 mg/kg per day) ASA in supplemented pellet chow for 100 d.Eight animals,serving as the AP-control group,and another eight,serving as reference value(RV) group,were fed with standard pellet chow for the same period.After pretreatment,AP was induced in the experimental animals by intraperitoneal administration of cerulein(2 × 50 μg/kg),while the RV group received saline in the same way.Twelve hours after the second injection,the animals were sacrificed.Pancreatic tissue and plasma samples were collected.One part of the collected pancreatic tissues was used for histopathological evaluation,and the remaining portion was homogenized.Cytokine levels [tumor necrosis factor,interleukin(IL)1β,IL-6],hemogram parameters,biochemical parameters(amylase and lipase),nuclear factor-κB,aspirin triggered lipoxins and parameters related to the antioxidant system(malondialdehyde,nitric oxide,hemeoxygenase-1,catalase and superoxide dismutase) were measured.RESULTS:Cerulein administration induced mild pancreatitis,characterized by interstitial edema(total histopathological score of 5.88 ± 0.44vs 0.25 ± 0.16,P < 0.001).Subsequent pancreatic tissue damage resulted in an increase in amylase(2829.71 ± 772.48 vs 984.57 ± 49.22 U/L,P = 0.001) and lipase(110.14 ± 75.84 U/L vs 4.71 ± 0.78 U/L,P < 0.001) in plasma,and leucocytes(6.89 ± 0.48 vs 4.36 ± 0.23,P = 0.001) in peripheral blood.Cytokines,IL-1β(18.81 ± 2.55 pg/μg vs 6.65 ± 0.24 pg/μg,P = 0.002) and IL-6(14.62 ± 1.98 pg/μg vs 9.09 ± 1.36 pg/μg,P = 0.04) in pancreatic tissue also increased.Aspirin pretreatment reduced the increase in the aforementioned parameters to a certain degree and partially improved the histopathological alterations caused by cerulein.No evidence of side effects related to chronic ASA administration(e.g.,inflammation or bleeding) was observed in the gastrointestinal tract in macroscopic and histopathological examination.CONCLUSION:Long term ASA pretreatment could prevent and/or ameliorate certain hematological,serological and histological alterations caused by ceruleininduced AP. | Ibrahim Akyazi Evren Eraslan Ahmet Gülubuk Elif Ergül Ekiz Zeynep L rakli Damla Haktanir Deniz Aktaran Bala Mete zkurt Erdal Matur Mukaddes zcan | 2013 | World Journal of Gastroenterology2013，19，19： | 5 |
| 8 | Cefpodoxime Proxetil-Related Hemolysis and Acute Interstitial Nephritis显示文摘 | Hakki Yilmaz Mukadder Ayse Bilgic Nuket Bavbek Ali Akcay | 2013 | Current Drug Safety2013，，2： | 1 |
| 9 | Two cases with pachydermoperiostosis and discussion of tamoxifen citrate treatment for arthralgia显示文摘 | Ay?enur Okten Ilke Mungan Mukaddes Kalyoncu Zerrin Orbak | 2007 | Clinical Rheumatology2007，，1： | 1 |
| 10 | Psychiatric disorders in individuals with high-functioning autism and Asperger's disorder:similarities and differences显示文摘 | Mukaddes NM Hergüner S Tanidir C | | 0，，08： | 1 |
| 11 | Influence of diabetic education on patient metabolic control 显示文摘 | Mukadder M Emel B | 2009 | Applied Nursing Research2009，22，3： | 1 |
| 12 | Relationship between seminal plasma interleukin-6 and tumor necrosis factor α levels with semen parameters in fertile and infertile men显示文摘 | Izzet Ko?ak ?igdem Yenisey Mehmet Dündar Pinar Okyay Mukadder Serter | 2002 | Urological Research2002，，4： | 1 |
| 13 | The significance of IgA class of antineutrophil cytoplasmic antibodies (ANCA) in childhood Henoch–Sch?nlein purpura显示文摘 | Fatih Ozaltin Aysin Bakkaloglu Seza Ozen Rezan Topaloglu Umut Kavak Mukaddes Kalyoncu Nesrin Besbas | 2004 | Clinical Rheumatology2004，，5： | 1 |
| 14 | Vitamin E protects against oxidative damage caused by formaldehyde in the liver and plasma of rats 显示文摘 | Mukaddes Gulec Ahmet Gurel Ferah Armutcu | 2006 | Molecular and Cellular Biochemistry2006，290，： | 1 |
| 15 | Adiponectiu as a biomarker of systemic inflammatory response in smoker patients with stable and exacerbation phases of chronic obstructive pulmo- nary disease 显示文摘 | Sevin Kirdar Mukadder Setter Emel Ceylan | 2009 | Scandinavian Journal of Clinical and Laboratory Investigation2009，69，2： | 1 |
| 16 | Dermatological signs in Wilson' s disease 显示文摘 | Muammer S Teoman E Mukadder A | 2009 | Pediatrics International2009，51，3： | 1 |
| 17 | Antioxidant enzyme activities and oxidative stress in affective disorders 显示文摘 | Ozcan E Mukaddes G Elif O | 2004 | Int Clin Psychopharmacol2004，19，2： | 1 |
| 18 | Two cases with pachydermoperiostosis and discussion of tamoxifen cit- rate treatment for arthralgia显示文摘 | Okten Aysenur Mungan Ilke Kalyoncu Mukaddes | 2007 | Clinical Rheumatology2007，26，1： | 1 |
| 19 | Antioxidant enzyme activities and oxidative stress in affective disorders显示文摘 | Ozcan E Mukaddes G Elif O | 2004 | Int Clin Psychopharmacol2004，19，2： | 1 |
| 20 | A multicenter study of patients with adult-onset Still′s disease compared with systemic juvenile idiopat-hic arthritis显示文摘 | Salih P Nuran T Mukaddes K | 2006 | J Rheumatol2006，25，12： | 1 |
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