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| 1 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 2 | Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?显示文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course. | Sophia Fu Albert Stanek Cathy M Mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael E Zenilman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 3 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 4 | SLAM receptors and SAP influence lymphocyte interactions, development and function 显示文摘 | Schwartzberg PL Mueller KL Qi H | 2009 | Nat Rev Immunol2009，9，1： | 1 |
| 5 | Expression profile of the putative catalytic subunit of the telomerase gene显示文摘 | RAMAKRISHNAN S EPPENBERGER U MUELLER H | 1998 | Cancer Res1998，58，4： | 1 |
| 6 | Inflammation and long-term mortality after ono-ST elevation acute coronary syndrome treated with a very early invasive strategy in 1042 consecutive patients显示文摘 | Mueller C Buettner H J Hodgson J M | 2002 | Circula-tion2002，105，： | 1 |
| 7 | influence of the application time on the penetration of different dental adhesives and a fissure sealant into artifical subsurface lesions in bovine enamel显示文摘 | Meyer-lueckel H Paris S Mueller J | | 0，，01： | 1 |
| 8 | Industrial Research and Development, Intangible Capital Stocks, and Firm Profit Rates 显示文摘 | Grabowski H G D C Mueller | 1978 | The Bell Journal of Economics1978，9，2： | 1 |
| 9 | Tricuspid valve involvement in combined mitrial and aortic valve surgery显示文摘 | Mueller X M Tevaearai H T Stumpe F | 2001 | J Cardiovasc Surg2001，42，4： | 1 |
| 10 | Effects of ultra-marathon on circulating DNA and mRNA ex- pression of pro-and anti-apoptotic genes in mono-nuclear cells 显示文摘 | Atamaniuk J Stuhlmeier K M Vidotto C Tschan H Dossenbach-Glaninger A Mueller M | 2008 | Eur J Appl Physiol2008，104，4： | 1 |
| 11 | Treatment of metastatic carcinoid tumours using multimodality therapy of octreotide acetate, intra - arterial chemotherapy and hepatic arterial chemoembolization显示文摘 | Diaco D S Hajarizadeh H Mueller C R | 1995 | Am J Surg1995，169，： | 1 |
| 12 | Evaluation of various fire retardants for use in wood flour-polyethylene composites 显示文摘 | Stark N M White R H Mueller S A | 2010 | Polymer Degradation and Stability2010，95，9： | 1 |
| 13 | Progression of sealed initial bovine enamel lesions under demineralizing conditions in vitro 显示文摘 | Paris S Meyer-Lueckel H Mueller J | 2006 | Caries Res2006，40，2： | 1 |
| 14 | Clonal expansion of CD8+ effec-tor T cells in childhood tuberculosis显示文摘 | Jacobsen M Detjen A K Mueller H Gutschmidt A Le-itner S Wahn U | 2007 | J Immunol2007，179，： | 1 |
| 15 | Following single antibody binding to purple membranes in real time显示文摘 | KIENBERGER F MUELLER H PASTUSHENKO V | 2004 | EMBO reports2004，5，6： | 1 |
| 16 | Factors affecting the genotoxie potency ranking of natural anthraquinones in mammalian cell culture systems显示文摘 | Mueller SO Lutz WK Stopper H | 1998 | Murat Res1998，414，13： | 1 |
| 17 | Women do have an improved long-term outcome after non-ST-elevation acute coronary syndromes treated very early and predominantly with percutaneous coronary intervention:a prospective study in 1,450 consecutive patients显示文摘 | MUELLER C NEUMANN FJ ROSKAMM H | 2002 | J Am Coll Cardiol2002，40，2： | 1 |
| 18 | A simple improved velocity estimation for low-speed regions based on position measurement only显示文摘 | SuY X Zheng C H Mueller P C | 2006 | IEEE Transactions on Control Systems Technology2006，14，5： | 1 |
| 19 | Rho kinase,a promising drug target for neurological disorders显示文摘 | Mueller BK Mack H Teusch N | 2005 | Nat Rev Drug Discov2005，4，： | 1 |
| 20 | Accu- mulation of several heavy metals and lanthanides in mushrooms (Agaricales) from the Chicago region 显示文摘 | Aruguete D M Aldstadt J H Mueller G M | 1998 | The Science of The Total Environment1998，224，13： | 1 |
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