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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | An evaluation of methods for breaking seed dormancy in kudzu (Pueraria lobata)显示文摘 | Susko D J Mueller J P Spears J F | 2001 | Can J Bot2001，79，： | 2 |
| 3 | Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial显示文摘 | Philipp Schuetz Alexander Kutz Eva Grolimund Sebastian Haubitz Désirée Demann Alaadin V?geli Fabienne Hitz Mirjam Christ-Crain Robert Thomann Claudine Falconnier Claus Hoess Christoph Henzen Robert J. Marlowe Werner Zimmerli Beat Mueller | 2014 | International Journal of Cardiology2014，，3： | 2 |
| 4 | Analysis of the novel TPH2 gene in bipolar disorder and suicidality 显示文摘 | De Luca V Mueller D J Tharmalingam S | 2004 | Mol Psychiary2004，9，10： | 1 |
| 5 | Voltage sags in industrial systems显示文摘 | MCGRANAGHAN M F MUELLER D R SAMOTYJ M J | 1993 | IEEE Trans Industry Applications1993，29，2： | 1 |
| 6 | Combining bioinformatics and phylogenetics to identify large sets of single-copy orthologous genes (COSⅡ) for comparative, evolutionary and systematic studies: a test case in the euasterid plant clade显示文摘 | Wu F N Mueller L A Crouzillat D Petiard V Tanksley S D | 2006 | Genetics2006，174，： | 1 |
| 7 | Suppression of virus accumulation in transgenic plants exhibiting silencing of nuclear gene 显示文摘 | English J J Mueller E Baulcombe D C | 1996 | Plant Cell1996，8，： | 1 |
| 8 | Voltage saganalysis case studies显示文摘 | Lamorce J Mueller D Vinett P | 1994 | IEEE Trans on IndustryApplications1994，30，4： | 1 |
| 9 | Anti-angiogenic treatment of endometriosis : biochemical aspects 显示文摘 | Taylor R N Mueller M D | 2004 | Gynecol Obstet Invest2004，57，1： | 1 |
| 10 | Apple cuhivar re- sponse to 1- methylcyclopropene 显示文摘 | Mueller R S Murr D P DeEu J R | 2001 | Hortscience2001，36，3： | 1 |
| 11 | Clinical and histopathological features of patients with systemic sclerosis un- dergoing endomyocardial biopsy 显示文摘 | MUELLER KA MUELLER II EPPLER D | 2015 | PLoS One2015，10，01： | 1 |
| 12 | Industrial Research and Development, Intangible Capital Stocks, and Firm Profit Rates 显示文摘 | Grabowski H G D C Mueller | 1978 | The Bell Journal of Economics1978，9，2： | 1 |
| 13 | Patents, research and development, and the measurement of inventive activity 显示文摘 | Mueller D C | 1966 | Journal of In- dustry Economics1966，15，1： | 1 |
| 14 | Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease 显示文摘 | Haubenberger D Reinthaler E Mueller J C | 2011 | Neurobiol Aging2011，32，2： | 1 |
| 15 | Consumer perceptions in East- em European food markets 显示文摘 | Baron P J Mueller R D | 1995 | British Food Journal1995，，2： | 1 |
| 16 | Usefulness of soluble concentrations of interleukin family member ST2 as predictor of mortality in patients with acutely decompensated heart failure relative to left ventricular ejection fraction 显示文摘 | Manzano-Fernrndez S Mueller T Pascual-Figal D et at | 2011 | Am J Cardiol2011，107，： | 1 |
| 17 | A Life Cycle Theory of the Firm 显示文摘 | Mueller D C | 1972 | The Journal of Industrial Economics1972，，3： | 1 |
| 18 | New for the milennium : 4PL 显示文摘 | Bade D J Mueller J K | 1999 | Transportation & Distribution1999，40，2： | 1 |
| 19 | Differential sensitization of afferent neuronal pathway during postoperative ileus in the mouse jejunum显示文摘 | Mueller MH Glatzle J Kampitoglou D | 2008 | Ann surg2008，247，5： | 1 |
| 20 | Effect of SiO2 on densification and microstructure development in Nd:YAG transparent ceramics 显示文摘 | STEVENSON A J LI Xin MART1NEZ M A ANDERSON J M SUCHY D L KUPP E R DICKEY1 Z C MUELLER K T MESSING G L | 2011 | J Am Ceram Soc2011，94，： | 1 |
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