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| 1 | Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux显示文摘AIM: To study the effect of combined omeprazole (Ome) and domperidone (Dom) therapy on asthma symptoms and pulmonary function in asthmatics with gastroesoph- ageal reflux. METHODS: We selected 198 asthmatics with gastroesophageal reflux diagnosed by 24-h esophageal pH monitoring to receive Ome 20 mg twice daily and Dom 10 mg three times daily or placebo for 16 wk (1:1 double-blind randomization). Spirometry was done at baseline and af- ter 16 wk of treatment. The primary outcome measures were: mean daily daytime and nighttime asthma symp- tom scores. Mean daily reflux symptom scores, albuterol use as rescue medication (number of puffs), daytime and nighttime peak expiratory flow rate (PEFR), postbroncho- dilator forced expiratory volume in 1 second (FEV1) and postbronchodilator forced vital capacity (FVC) were secondary outcome measures. RESULTS: Comparison of mean change from baseline between antireflux therapy and placebo groups revealed significant reduction in daytime asthma symptom score (17.4% vs 8.9%), nighttime asthma symptom score (19.6% vs 5.4%), reflux symptom score (8.7% vs 1.6%) and rescue medication use (23.2% vs 3.1%) after antire- flux therapy compared to mean change in placebo group (P < 0.001). There was significant improvement in morn- ing PEFR (7.9% vs 0.2%), evening PEFR (9.8% vs 0.5%), FEV1 (11.1% vs 3.78%) and FVC (9.3% vs 1.52%) in the antireflux therapy group compared to placebo on compar-ing the mean change from baseline after 16 wk (P < 0.01). | Bhavneesh Sharma Manisha Sharma Mradul Kumar Daga Gopal Krishan Sachdev Elliott Bondi | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Intravenous administration of ulinastatin (human urinary trypsin inhibitor) in severe sepsis: a multicenter randomized controlled study显示文摘 | Dilip R. Karnad Rakesh Bhadade Pradeep K. Verma Nivedita D. Moulick Mradul K. Daga Neelima D. Chafekar Shivakumar Iyer | 2014 | Intensive Care Medicine2014，，6： | 2 |
| 3 | Critical care practice in India:Results of the intensive care unit need assessment survey(ININ2018)显示文摘BACKGROUND A diverse country like India may have variable intensive care units(ICUs)practices at state and city levels.AIM To gain insight into clinical services and processes of care in ICUs in India,this would help plan for potential educational and quality improvement interventions.METHODS The Indian ICU needs assessment research group of diverse-skilled individuals was formed.A pan-India survey'Indian National ICU Needs'assessment(ININ 2018-I)was designed on google forms and deployed from July 23rd-August 25th,2018.The survey was sent to select distribution lists of ICU providers from all 29 states and 7 union territories(UTs).In addition to emails and phone calls,social medial applications-WhatsApp™,Facebook™and LinkedIn™were used to remind and motivate providers.By completing and submitting the survey,providers gave their consent for research purposes.This study was deemed eligible for category-2 Institutional Review Board exempt status.RESULTS There were total 134 adult/adult-pediatrics ICU responses from 24(83%out of 29)states,and two(28%out of 7)UTs in 61 cities.They had median(IQR)16(10-25)beds and most,were mixed medical-surgical,111(83%),with 108(81%)being adult-only ICUs.Representative responders were young,median(IQR),38(32-44)years age and majority,n=108(81%)were males.The consultants were,n=101(75%).A total of 77(57%)reported to have 24 h in-house intensivist.A total of 68(51%)ICUs reported to have either 2:1 or 2≥:1 patient:nurse ratio.More than 80%of the ICUs were open,and mixed type.Protocols followed regularly by the ICUs included sepsis care,ventilator-associated pneumonia(83%each);nutrition(82%),deep vein thrombosis prophylaxis(87%),stress ulcer prophylaxis(88%)and glycemic control(92%).Digital infrastructure was found to be poor,with only 46%of the ICUs reporting high-speed internet availability.CONCLUSION In this large,national,semi-structured,need-assessment survey,the need for improved manpower including;in-house intensivists,and decreasing patient-tonurse ratios was evident.Sepsis was the most common diagnosis and quality and research initiatives to decrease sepsis mortality and ICU length of stay could be prioritized.Additionally,subsequent surveys can focus on digital infrastructure for standardized care and efficient resource utilization and enhancing compliance with existing protocols. | Rahul Kashyap Kirtivardhan Vashistha Chetan Saini Taru Dutt Dileep Raman Vikas Bansal Harpreet Singh Geeta Bhandari Nagarajan Ramakrishnan Harshit Seth Divya Sharma Premkumar Seshadri Mradul Kumar Daga Mohan Gurjar Yash Javeri Salim Surani Joseph Varon 无 | 2020 | World Journal of Critical Care Medicine2020，9，2： | 1 |
| 4 | Multi-detector computed tomography imaging of large airway pathology:A pictorial review显示文摘The tracheobronchial tree is a musculo-cartilagenous framework which acts as a conduit to aerate the lungs and consequently the entire body. A large spectrum of pathological conditions can involve the trachea and bronchial airways. These may be congenital anomalies, infections, post-intubation airway injuries, foreign body aspiration or neoplasms involving the airway. Appropriate management of airway disease requires an early and accurate diagnosis. In this pictorial essay review, we will comprehensively describe the various airway pathologies and their imaging findings by multi-detector computed tomography. | Tejeshwar Singh Jugpal Anju Garg Gulshan Rai Sethi Mradul Kumar Daga Jyoti Kumar | 2015 | World Journal of Radiology2015，7，12： | 1 |
| 5 | In vitro wound-healing effects of biosynthesized copper nanoparticles显示文摘Copper,the magical element,has been reported for centuries due to its significant role in the treatment of skin ailments.Copper is an essential element to our body and is known to possess antimicrobial,anti-inflammatory and angiogenetic properties.Hence,it makes it useful in wound healing[1].In the present study we evaluated biosynthesized copper nanoparticles(BCuNps)for their wound-healing potential[2]. | Mradul Tiwari Prateek Jain Raghu Chandrashekhar Hariharpura Nayanabhirama Udupa Josyula Venkata Rao | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 0 |
| 6 | Gamma/hadron segregation for a ground based imaging atmospheric Cherenkov telescope using machine learning methods: Random Forest leads显示文摘A detailed case study of γ-hadron segregation for a ground based atmospheric Cherenkov telescope is presented. We have evaluated and compared various supervised machine learning methods such as the Random Forest method, Artificial Neural Network, Linear Discriminant method, Naive Bayes Classifiers, Support Vector Machines as well as the conventional dynamic supercut method by simulating triggering events with the Monte Carlo method and applied the results to a Cherenkov telescope. It is demonstrated that the Random Forest method is the most sensitive machine learning method for γ-hadron segregation. | Mradul Sharma Jitadeepa Nayak Maharaj Krishna Koul Smarajit Bose Abhas Mitra | 2014 | Research in Astronomy and Astrophysics2014，14，11： | 0 |
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