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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Comparison of three commercially available peptide-based immunoglobulin G (IgG) and IgA assays to microimmunofluorescence assay for detection of Chlamydia trachomatis antibodies显示文摘 | Munk C Persson K | 2002 | J Clin Microbiol2002，40，2： | 1 |
| 3 | Regulation of weibel- patade body exocytosis显示文摘 | Lowenstein CJ Morreli CN Yamakuchi M | 2005 | Semin Vasc Med2005，15，8： | 1 |
| 4 | Comparison of the tumor markers tumor M2-PK,CEA,CYFRA 21-1,NSE and SCC in the diagnosis of lung cancer显示文摘 | Schneider J Velcovsky HG Morr H | | 0，，6： | 1 |
| 5 | Current status of soy protein functionality in food systems 显示文摘 | Morr C V | 1990 | Journal of the American Oil Chemists Society1990，67，： | 1 |
| 6 | Enhanced imagery using spectral-estimation-based techniques显示文摘 | T G Morre B W Zuerndorfer | 1997 | Lincoln Laboratory Journal1997，10，2： | 1 |
| 7 | Cellular and molecular basis of pulmollary arterial hypertension tension 显示文摘 | Morre N Adnot S Archer S | 2009 | J Am Coll Cardiol2009，54，： | 1 |
| 8 | Hidden order in the cuprates显示文摘 | Chakravarty S Laughlin R B Morr D K | 2001 | Phys Rev B2001，63，94： | 1 |
| 9 | Surface oxidase and oxi- dative stress propagation in aging显示文摘 | Morre DM Lenaz G Morre DJ | 2000 | Exp Biol2000，203，10： | 1 |
| 10 | Acquired homotypic and heterotypic immunity against oculogenital Chlamydia trachomatis serovars following female genital tract infection in mice显示文摘 | Lyons J M Morre SA Airo-Brown lP | 2005 | BMC Infect Dis2005，5，： | 1 |
| 11 | Triuret:a novel product of peroxynitrite-mediated oxidation of urate显示文摘 | Robinson K M Morre J T Beckman J S | 2004 | Arch Biochem Biophys2004，423，1： | 1 |
| 12 | Whey protein concentrates and iso- lates : processing and functional properties 显示文摘 | Morr C V Ha E Y W | 1993 | Critical Re- views in Food Science and Nutrition1993，33，： | 1 |
| 13 | CD14 and TLR4 gene polymorphisms in adult periodontitis 显示文摘 | LAINE M L MORRE S A MURILLO L S | 2005 | Dent Res2005，84，11： | 1 |
| 14 | An antidiabetic thiazolidinedion is a high affinity ligand for peroxisome proliferator-activated receptor γ显示文摘 | Lehmann JM Morre LB Smith-Oliver TA | 1995 | J Biol Chem1995，270，12： | 1 |
| 15 | Expression of IL-7 receptor α is necessary but not sufficient for the formation of memory CD8 T cells during viral infection 显示文摘 | Hand TW Morre M Kaech SM | 2007 | Proc Natl Acad Sci USA2007，104，11： | 1 |
| 16 | Chlamydia trachomatis serovar E isolates from patients with different clinical manifestations have similar courses of infection in a murine model:host factors as major determinants of C trachomatis mediated pathogenesis显示文摘 | Lyons JM Ito JI Jr Morre S A | 2004 | J Clin Pathol2004，57，6： | 1 |
| 17 | Maturation of mismatch negativity in school age children显示文摘 | Shafer VL Morr ML Kreuzer JA | 2000 | Ear Hear2000，21，： | 1 |
| 18 | Red imported ftre ant control with diazinon and chlorpyrifos drenches显示文摘 | Morr L B M | 1977 | J Georgia Entomol Soc1977，12，： | 1 |
| 19 | The effects of postradiation treatment with tamoxifen on local control and cosmetic outcome in conservatively treated breast cancer显示文摘 | Morr J Erban JK | 1997 | Cancer1997，80，： | 1 |
| 20 | GGDEF and EAL domains inversely regulate cyclic di- GMP levels and transition from sessility to motili- ty显示文摘 | SIMM R MORR M KADER A | 2004 | Mol Microbiol2004，53，4： | 1 |
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