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| 1 | Rifaximin,but not growth factor 1,reduces brain edema in cirrhotic rats显示文摘AIM:To compare rifaximin and insulin-like growth factor(IGF)-1 treatment of hyperammonemia and brain edema in cirrhotic rats with portal occlusion.METHODS:Rats with CCl4-induced cirrhosis with ascites plus portal vein occlusion and controls were randomized into six groups:Cirrhosis;Cirrhosis + IGF-1;Cirrhosis + rifaximin;Controls;Controls + IGF-1;and Controls + rifaximin.An oral glutamine-challenge test was performed,and plasma and cerebral ammonia,glucose,bilirubin,transaminases,endotoxemia,brain water content and ileocecal cultures were measured and liver histology was assessed.RESULTS:Rifaximin treatment significantly reduced bacterial overgrowth and endotoxemia compared with cirrhosis groups,and improved some liver function parameters(bilirubin,alanine aminotransferase and aspartate aminotransferase).These effects were associated with a significant reduction in cerebral water content.Blood and cerebral ammonia levels,and area-underthe-curve values for oral glutamine-challenge tests were similar in rifaximin-treated cirrhotic rats and control group animals.By contrast,IGF-1 administration failed to improve most alterations observed in cirrhosis.CONCLUSION:By reducing gut bacterial overgrowth,only rifaximin was capable of normalizing plasma and brain ammonia and thereby abolishing low-grade brain edema,alterations associated with hepatic encephalopathy. | Gemmaòdena Mireia Miquel Anna Serafín Amparo Galan Rosa Morillas Ramon Planas Ramon Bartolí | 2012 | World Journal of Gastroenterology2012，18，17： | 6 |
| 2 | 在与心肌的梗塞介绍的就医的病人的心率的预示的意义显示文摘 AIM: To investigate the prognostic significance of resting heart rate in patients with acute coronary syndrome (ACS), independent of other known factors. METHODS: Patients 40 years of age or older who had been admitted with acute coronary syndrome (ACS) to one of the 94 hospitals participating in the Prevalence of Peripheral Arterial Disease in Patients with Acute Coronary Syndrome (PAMISCA) study were included. Patients were divided into two groups based on their resting heart rate (HR ≥ or < 70 bpm). Complications were recording during a follow-up period of 1 year. RESULTS: There were 1054 ACS patients analyzed (43.5% with ST segment elevation and 56.5% without elevation). Mean age was 66.6 ± 11.7 years, 70.6% were male and 29.4% of subjects were female. During follow-up, more patients in the HR ≥ 70 bpm group were hospitalized for heart failure and they also had a higher mortality rate. In the multivariate analysis, a heart rate of ≥ 70 bpm was independently related to overall mortality during the follow-up period (hazard ratio 2.5; 95% confidence interval, 1.26-4.97, P = 0.009). CONCLUSION: A resting heart rate ≥ 70 bpm in patients who survive an ACS is an indicator of a high risk of suffering cardiovascular events during follow-up. | Lorenzo Fácila Pedro Morillas Juan Quiles Federico Soria Alberto Cordero Pilar Mazón Manuel Anguita Cándido Martín-Luengo Jose Ramón Gonzalez-Juanatey Vicente Bertomeu | 2012 | World Journal of Cardiology2012，4，1： | 3 |
| 3 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 4 | Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5显示文摘Since late 2022, the share of infections caused by the SARS-CoV2 lineage XBB.1.5 has gradually increased in the United States,resulting in XBB.1.5 becoming the dominating SARS-CoV-2lineage in the United States and a similar trend is likely to soontake place also in European countries. However, information onthe virological properties of XBB.1.5 is scarce. Here, weconducted an initial virological assessment of the SARS-CoV-2XBB.1.5 lineage. | Markus Hoffmann Prerna Arora Inga Nehlmeier Amy Kempf Anne Cossmann Sebastian R.Schulz Gema Morillas Ramos Luis A.Manthey Hans-Martin Jäck Georg M.N.Behrens Stefan Pöhlmann | 2023 | Cellular & Molecular Immunology2023，20，4： | 2 |
| 5 | Impact of Periampullary Duodenal Diverticula at Endoscopic Retrograde Cholangiopancreatography: A Proposed Classification of Periampullary Duodenal Diverticula显示文摘 | Jaume Boix Vicente Lorenzo-Zú?iga Fidel A?a?os Eugeni Domènech Rosa M. Morillas Miguel A. Gassull | 2006 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2006，，4： | 2 |
| 6 | Genetic causes of bronchie- ectasis : primary ciliary dyskinesia 显示文摘 | Morillas I-IN Zariwala M Knowles MR | 2007 | Respiration2007，74，3： | 1 |
| 7 | A rev iew:inflammatory process in Alzheimer’s disease, role of cytokines显示文摘 | RUBIO - PEREZ JM MORILLAS - RUIZ JM | 2012 | ScientificWorldjoumal2012，2012，75： | 1 |
| 8 | A classification of acute leukaemia for the 1990s显示文摘 | D. Catovsky E. Matutes V. Buccheri V. Shetty J. Hanslip N. Yoshida R. Morilla | 1991 | Annals of Hematology1991，，1： | 1 |
| 9 | High prevalence of Pneumo- cystis jiroveci colonization among young HIV-infected patients 显示文摘 | Guti6rrez S Morilla R Le6n JA | 2010 | J Adolesc Health2010，48，1： | 1 |
| 10 | Input Output coefficients importance: A fuzzy logic approach显示文摘 | Morillas A Robles L | 2011 | International Journal of Uncertainty Fuzziness and Knowledge-Based Systems2011，19，6： | 1 |
| 11 | Long-term Clinical Course of Decompensated Alcoholic Cirrhosis: A Prospective Study of 165 Patients显示文摘 | Marco Antonio Alvarez Isabel Cirera Ricard Solà Ana Bargalló Rosa Maria Morillas Ramon Planas | 2011 | Journal of Clinical Gastroenterology2011，，10： | 1 |
| 12 | Muscle metastasis of low-grade endometrial arcinoma seven years after diagnosis:a case report显示文摘 | Oaknin A Barretina MP Morilla 1 | 2010 | Eur J Gynecol Oncol2010，31，1： | 1 |
| 13 | A comparative study of the disc diffusion method with the broth microdilution and Etest methods for voriconazole susceptibility testing of Aspergillus spp显示文摘 | Serrano MC Ramirez M Morilla D | 2004 | J Antimicrob Chemother2004，53，： | 1 |
| 14 | Etanidazole in pH-sensitive liposomes:design,charaterization and in vitro/in vivo anti-trypanosoma cruzi activity显示文摘 | MORILLA M J MONTANARI J FRANK F | 2005 | J ControlLED Rele2005，103，3： | 1 |
| 15 | Definition of acute bi-phe- notypic leukemia显示文摘 | Matutes E Morilla R Farahat N | 1997 | Hematology1997，82，1： | 1 |
| 16 | Pneumocystis jirovecii colonization in patients treated with infliximab 显示文摘 | Wissmann G Morilla R Mart i n-Garrido I | 2011 | Eur J Clinlnvest2011，41，3： | 1 |
| 17 | Genetic causes of bronchiectasis: primary ciliary dyski- nesia显示文摘 | MORILLAS H N ZARIWALA M KNOWLES M R | 2007 | Respiration2007，74，： | 1 |
| 18 | Patho- logical ankle brachial index is equivalent of advanced age in a- cute coronary syndromes显示文摘 | Cordero A Morillas P Bertomeu-Gonzalez V | 2011 | Eur J Clin Invest2011，41，12： | 1 |
| 19 | All chemical YBa2Cu3O7 superconducting multilayers: Critical role of CeO2 cap layer flatness显示文摘 | M. Coll J. Gàzquez R. Huhne B. Holzapfel Y. Morilla J. García-López A. Pomar F. Sandiumenge T. Puig X. Obradors | 2009 | Journal of Materials Research2009，，4： | 1 |
| 20 | Genetic causes of bronchi ectasis:primaty ciliary dyskinesia 显示文摘 | Morillas HNZariwala M Knowles MR | 2007 | Respiration2007，74，3： | 1 |
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