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| 1 | Effects of Banxia Xiexin Decoction (半夏泻心汤) on Cisplatin-Induced Apoptosis of Human A549 Lung Cancer Cells显示文摘Objective: To examinie the synergistic effects of Banxia Xiexin Decoction(半夏泻心汤,Known as Banhasasim-tang in Korean) extract(BXDE) on cisplatin-induced cytotoxicity in the A549 human lung cancer cell lines. Methods: A549 cells were treated with varying concentrations(50–200 μg/m L) of cisplatin and BXDE alone or in combination for 96 h. We used 1-(4,5-dimethylthiazol-2-yl)-3,5-diphenylformazan assay and flow cytometry to analyze cell viability and apoptosis, respectively. Results: The exposure of cells to cisplatin and BXDE alone or in combination decreased cell viability dose-and time-dependently(P<0.05), which was found to be mediated by the apoptotic pathway as confirmed by the increase in the annexin V+/propidium iodide-stained cell population and a ladder pattern of discontinuous DNA fragments. Furthermore, the apoptosis was inhibited by the pan-caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp(OMe) fluoromethylketone(z-VAD-FMK). Conclusions: BXDE significantly potentiated apoptotic effects of cisplatin in A549 cells. Moreover, apoptosis induced by BXDE might be the pivotal mechanism mediating its chemopreventative action against cancer. | Ha-Rim Kim Guem-San Lee Mi-Seong Kim Do-Gon Ryu Hong-Seob So Hyoung-Chul Moon Young-Rae Lee Sei-Hoon Yang Kang-Beom Kwon | 2018 | Chinese Journal of Integrative Medicine2018，24，6： | 9 |
| 2 | Knockdown of β-catenin controls both apoptotic and autophagic cell death through LKB1/AMPK signaling in head and neck squamous cell carcinoma cell lines显示文摘 | Hyo Won Chang Yoon Se Lee Hae Yun Nam MyoungWol Han Hyo Jung Kim So Young Moon HyesungJeon Jung Je Park Thomas E. Carey Sung Eun Chang Seong Who Kim Sang Yoon Kim | 2012 | Cellular Signalling2012，，： | 2 |
| 3 | Cisplatin ototoxicity involves cytokines and STAT6 signaling network显示文摘我们此处调查了在支持 inflammatory cytokines 和 cisplatin ototoxicity 的生产表明串联的 STAT 的角色。cisplatin 注射引起的一个重要听觉缺陷在 Balb/c 被观察(野类型, WT ) 并且 STAT4 −/−, 然而并非在 STAT6 −/− 老鼠。而且,蛋白质的表示层次和支持 inflammatory cytokines 的 mRNA,包括 TNF-α, IL-1β,并且 IL-6,显著地在 WT 和 STAT4 −/−, 然而并非 STAT6 −/− 老鼠的浆液和蜗被增加。Organotypic 文化表明 stereocilia 捆的形状和在从 STAT6 −/− 鼠标的 Corti 的机关的感觉毛细胞层的数组在有 cisplatin 的处理以后是未经触动的,而那些高度在处理以后从 WT 和 STAT4 −/− 鼠标被弄歪并且弄乱。Cisplatin 在 HEI-OC1 听觉的房间导致了 STAT6 的 phosphorylation,并且由显著地保护的 STAT6 特定的 siRNA 的 STAT6 击倒从导致 cisplatin 的房间死亡的 HEI-OC1 听觉的房间和禁止的支持 inflammatory cytokine 生产。我们进一步证明 cisplatin 导致的 IL-4 和 IL-13 与 IL-4 受体 alpha 和 IL-13Rα 由绑定调制了 STAT6 的 phosphorylation; 1。这些调查结果建议发信号的 STAT6 在调停 cisplatin 的支持 inflammatory cytokine 生产和 ototoxicity 起一个枢轴的作用。 | Hyung-Jin Kim Gi-Su Oh Jeong-Han Lee Ah-Ra Lyu Hye-Min Ji Sang-Heon Lee Jeho Song Sung-Joo Park Yong-Ouk You Jeong-Dug Sul Channy Park Sang-Young Chung Sung-Kyun Moon David J Lim Hong-Seob So Raekil Park | 2011 | Cell Research2011，21，6： | 2 |
| 4 | Histological improvement following administration of autologous bone marrow‐derived mesenchymal stem cells for alcoholic cirrhosis: a pilot study显示文摘 | Yoon Ok Jang Young Ju Kim Soon Koo Baik Moon Young Kim Young Woo Eom Mee Yon Cho Hong Jun Park So Yeon Park Bo Ra Kim Jae Woo Kim Hyun Soo Kim Sang Ok Kwon Eun Hee Choi Yong Man Kim | 2014 | Liver Int2014，，1： | 2 |
| 5 | Tissue engineered regeneration of completely transected spinal cord using human mesenchymal stem cells显示文摘 | Kkot Nim Kang Da Yeon Kim So Mi Yoon Ju Young Lee Bit Na Lee Jin Seon Kwon Hyo Won Seo Il Woo Lee Ha Cheol Shin Young Man Kim Hyun Soo Kim Jae Ho Kim Byoung Hyun Min Hai Bang Lee Moon Suk Kim | 2012 | Biomaterials2012，，19： | 1 |
| 6 | Angiopoietin -2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3 ' - kinase/Akt signal transduction pathway 显示文摘 | Kim I Kim JH Moon SO | 2000 | Oncogene2000，19，39： | 1 |
| 7 | Angiopoietin-1 induces endothelial cell Sprouting through the activation of focal adhesion kinase and plasmin secretion显示文摘 | Kim I Kim HG Moon SO | 2000 | Cite Res2000，86，9： | 1 |
| 8 | Structural equation model for pre- dicting technology commercialization success index (TCSI) 显示文摘 | Sohn So Young Moon Tae Hee | 2003 | Technological Forecasting and Social Chang e2003，70，9： | 1 |
| 9 | Predictive value of maximum standardized uptake value (SUVmax) on 18F-FDG PET/CT in patients with locally advanced or metastatic pancreatic cancer 显示文摘 | Moon SY Joo KR So YR | 2013 | Clin Nucl Med2013，38，10： | 1 |
| 10 | Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes显示文摘 | Lee S Kim W Moon SO | | 0，，： | 1 |
| 11 | COMP-angiopoietin-1 ameliorates renal fibrosis in a unilateral ureteral obstruction model显示文摘 | Moon SO Lee SY | 2006 | J Am Soc Nephrol2006，17，9： | 1 |
| 12 | Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM- 1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells 显示文摘 | Kim I Moon SO Kim SH | 2001 | J Cell Biochem2001，276，1： | 1 |
| 13 | Predictive value of maximumstandardized uptake value (SUVmax) on 18F-FDG PET/CT inpatients with locally advanced or metastatic pancreatic cancer显示文摘 | Moon SY Joo KR So YR | 2013 | Clin Nucl Med2013，38，10： | 1 |
| 14 | Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from Pseudomonas syringae 显示文摘 | Munos JW Moon S J Mansoorabadi SO | 2008 | Biochemistry2008，47，33： | 1 |
| 15 | Sasim attenuates LPS-in- duced TNF-alpha production through the induction of HO-1 in THP-1 differentiated macrophage-like cells显示文摘 | Kim Y So HS Moon BS | 2008 | J Ethno- pharmacol2008，119，1： | 1 |
| 16 | Photo-production of hydrogen over the CdS-TiO2 nano-composite particulate films treated with TiCl4显示文摘 | So Won-Wook Kim Kwang-Je Moon Sang-Jin | 2004 | International Journal of Hydrogen Energy2004，29，3： | 1 |
| 17 | Multidetector row CT of various hepatic artery complications after living donor liver transplantation显示文摘 | So Yeon Kim Kyoung Won Kim Min Ju Kim Yong Moon Shin Moon-Gyu Lee Sung Gyu Lee | 2007 | Abdominal Imaging2007，，5： | 1 |
| 18 | Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway显示文摘 | Kim I Kim JH Moon SO | 2000 | Oncogene2000，19，39： | 1 |
| 19 | Sasim attenuates LPS- induced TNF-alpha production through the induction of HO-1 in THP-1 differentiated macrophage-like cells显示文摘 | Kim Y So HS Moon BS | 2008 | Ethnopharmacol2008，119，1： | 1 |
| 20 | Angiopoietin-1 reduces VEGF stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1,VCAM-1, and E-selection expression 显示文摘 | Kim I Moon SO Park SK | 2001 | Circ Res2001，89，6： | 1 |
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