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| 1 | The prognostic value of preoperative serum levels of CEA,CA19-9 and CA72-4 in patients with colorectal cancer显示文摘INTRODUCTIONCarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3].Carbohydrate antigen 19-9(CA19-9), obtained with a monoclonal antibody produced by immunizing a monoclonal antibody produced by immunizing a mouse with a colonic cancer cell line in 1979[4],is a ligand for E-selectin that plays an important role in the addhesion of cancer cells to endothelial cells [5,6]. | Chao Xu Zheng~1 Wen Hua Zhan~1 Ji Zong Zhao~2 Dong Zheng~3 Dong Ping Wang~1 Yu Long He~1 Zhang Qing Zheng~1 ~1Department of General Surgery,~2Laboratory of Surgery,~3Department of Medicine,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,Guangzhou 510080,Guangdong Province,ChinaDr.Chao Xu Zheng now working as a surgeon and lecturer in the Department of General Surgery,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,who is a Ph.D.student,having 7 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 25 |
| 2 | 脊髓灰质炎疫苗:世界卫生组织立场文件-2016年3月显示文摘1前言依据为各成员国提供卫生政策方面指导意见这一职责,世界卫生组织(WHO)就预防具有全球公共卫生影响的疾病的相关疫苗及联合疫苗,发布一系列定期更新的立场文件。这些文件着重关注疫苗在大规模免疫规划项目中的使用。 | WHO | 2016 | 中国疫苗和免疫2016，22，6： | 25 |
| 3 | Deficit of mitochondria-derived ATP during oxidative stress impairs mouse MII oocyte spindles显示文摘尽管在母亲的老化和不孕的氧化应力的角色被建议了,内在的机制充分没被理解。现在的学习被设计在氧化应力下面在中期 II (MII ) 卵母细胞决定在 mitochondrial 功能和锭子稳定性之间的关系。MII 老鼠卵母细胞当面与 H2O2 被对待或渗透转变毛孔(PTP ) 的缺席块 ers cyclosporin A (CsA ) 。另外,抗氧化剂 N-acetylcysteine (NAC ) , F0/F1 synthase 禁止者 oligomycin A,线粒体 uncoupler 羰基氰化物 4-trifluoro-methoxyphenylhydrazone (FCCP ) 或加 2.5 公里 Ca2+(Th+2.5 公里 Ca2+) 的 thapsigargin 在机械学的研究被使用。卵母细胞锭子和染色体的词法分析被执行并且 mitochondrial 膜潜力(DeltaPsim ) ,细胞质的免费的钙集中([Ca2+] c ) 并且在卵母细胞以内的细胞质的 ATP 内容也是 assayed。在一时间 -- 并且 H2O2 剂量依赖者举止,锭子在卵母细胞以后被发现的 meiotic 的混乱与 H2O2 被对待,它被预告的处理与 NAC 阻止。H2O2 的管理导致了 DeltaPsim 的驱散,的增加[Ca2+] 在细胞质的 ATP 的 c 和减少铺平。到 H2O2 处理的卵母细胞的这些有害回答能被孵化前与 CsA 堵住。类似于驱散的 H2O2,两 oligomycin A 和 FCCP DeltaPsim,减少的细胞质的 ATP 内容和拆卸的 MII 卵母细胞锭子,当时高[Ca2+] c 独自没在锭子形态学上有效果。在结论,在导出线粒体的 ATP 的减少可以在氧化应力期间引起老鼠 MII 卵母细胞锭子的拆卸,大概由于 mitochondrial PTP 的开始。 | Xiao Zhang~(1,2,*) Xue Qing Wu~(1,3,*) Shuang Lu~(4,5,6) Ying Lu Guo~1 Xu Ma~(4,5,6) ~1Peking University First Hospital,Institute of Urology of Peking University,Beijing 100034,China ~2Reproductive and Genetic Center of Peking University First Hospital,Beijing 100034,China ~3Department of Obstetrics and Gynecology,Shanxi Medical University Second Hospital,Taiyuan 030000,China ~4Reproductive and Genetic Center of National Research Institute for Family Planning,Beijing 100038,China ~5Department of Genetics, Peking Union Medical College, Beijing 100038. China ~6 WHO Collaborative Center for Research in Human Reproduction,Beijing 100038,China | 2006 | Cell Research2006，16，10： | 24 |
| 4 | 青蒿素及其衍生物在抗疟治疗中的应用显示文摘世界卫生组织于1998年6月10日至12日在日内瓦召开了关于青蒿素及其衍生物在抗疟治疗中应用的非正式咨询会议。会议的目的有3个:1)根据新近研究和现场应用的经验,讨论世界卫生组织已有的有关青蒿素及其衍生物的作用和使用的建议;2)世界卫生组织对在不同流行病学情况下正确选择和使用青蒿素及其衍生物提出指导性建议;3)确定今后需进行的研究和开发。本文摘要介绍了这次非正式咨询会议的主要内容。 | WHO/CTD/DMP/TDR 沈大康 | 1999 | 国外医学(寄生虫病分册)1999，26，5： | 18 |
| 5 | 2001年的食物链——食品安全是一个世界性的挑战显示文摘食品安全是一个十分重要的公共卫生问题 ,涉及到人们的健康和安危。美、日大肠杆菌O1 57∶H7食物中毒暴发流行 ,英国的“疯牛病” ,比利时的“二恶英事件” ,日本的雪印牌低脂牛奶大规模中毒等 ,都充分说明 ,即使高度发达的国家 ,食品安全也面临着严峻的挑战 ,而发展中国家的形势则更不容乐观。随着都市化、微生物发生突变和其他生态系统的改变、食品和新鲜水供应减少 ,尤其是环境卫生和人类环境恶化 ,加之其他人为因素 ,食品安全的形势会变得更加严峻。加强食品安全 ,提高食品卫生监督检验能力 ,及时发现隐患 ,防止大规模的食物中毒 ,是摆在世界各国面前的急迫任务。世界卫生组织总干事DrGroHarlemBrundtland在 2 0 0 1年 3月欧盟的有关会议上的讲话精辟地分析了 2 1世纪食品安全所面临的挑战以及转基因新食品的利弊。世界卫生组织的《2 1世纪的食品安全》一文分析了影响食品安全的主要因素 ,并提出应采取的对策。这里选登该讲话和这篇文章的译文 ,以飨读者。 | WHO 邵岩 齐津权 | 2002 | 国外医学(卫生学分册)2002，29，1： | 12 |
| 6 | WHO输血服务机构质量管理项目培训在我国的实施及启示显示文摘 为加强血站质量体系建设,确保血液安全,卫生部决定引入世界卫生组织输血服务机构质量管理项目(以下简称WHO/BTS/QMP).2001年12月召开了项目启动会,拉开了血站提高全员质量意识和能力,全面、系统、扎实地展开质量体系建设和持续改进的序幕.4年多来,该项目在我国的推进,血站的质量管理能力明显增强,同时也积累了丰富的培训工作经验.现就该项目产生背景、实施情况、实施特点、取得的成效、经验和体会,总结汇报如下.…… | 卫生部医政司WHO质量管理项目组 | 2006 | 中国输血杂志2006，19，z1： | 11 |
| 7 | 21世纪的食品安全显示文摘尽管食源性疾病的患病率不断上升 ,但是食品安全的全球重要意义尚未得到许多公共卫生当局的充分认识。沙门菌病、霍乱、肠出血性大肠杆菌感染、甲型肝炎和其他疾病在发达国家和发展中国家均有暴发流行 ,并且危害严重。此外 ,许多重新出现或新发现的病原体是食源性的或具有经食品和 或饮用水传播的潜能。由于生产方法、加工方法、实践和习惯的改变 ,可以预见会有更多的食源性病原体出现。预计 2 1世纪初期食源性疾病会增多 ,这尤其是在发展中国家 ,其中的部分原因是环境和人口统计学的变化。这些变化包括从气候变化、微生物和其他生态系统的变化到新鲜饮用水供应减少不等。然而 ,对食品安全的更大挑战来自直接引起环境卫生和直接的人类环境恶化的那些变化。这些变化包括人口老龄化、无计划的都市化和人口迁移、因人口增长而大量生产食品以及饮食习惯改变。大量的观光旅游以及大量的国际食品饲料贸易正在引起食源性病原体跨国扩散。随着新的有毒物质的鉴定和新的毒性作用被认识 ,食品中的有毒化学物质的健康和贸易后果也会产生全球性影响。为了应付 2 1世纪食品安全的巨大挑战 ,需要运用新方法鉴定、检测和评估食源性有害物质。保证食品安全的传统技术和新技术都应加以改进并充分利用。这需要通过法律措? | WHO 程远 | 2002 | 国外医学(卫生学分册)2002，29，1： | 10 |
| 8 | 缺血性心脏病命名及诊断标准[S]显示文摘 | 国际心脏病学会和协会及WHO命名标准化联合专题组 | 1981 | 中华心血管病杂志1981，9，1： | 9 |
| 9 | 缺血性心脏病命名及诊断标准[J]显示文摘 | 国际心脏病学会和协会及WHO命名标准化联合专题组 | 1981 | 中华心血管病杂志1981，，： | 9 |
| 10 | 中国提高其IUD技术等级显示文摘中国拥有12.8亿居民,正好占世界人口的五分之一,是已婚妇女使用现代避孕方法比例最高的国家,占83%,约为2.18亿(世界相应的平均水平仅为60%). | WHO/RHP 吴尚纯 王士娴 | 2003 | 中国计划生育学杂志2003，11，4： | 6 |
| 11 | 缺血性心脏病的命名及诊断标准[J]显示文摘 | WHO | | 中华内科杂志0，，： | 6 |
| 12 | 缺血性心脏病命名及诊断标准[J]显示文摘 | 国际心脏病学会和协会WHO命名标准化联合专题组 | | 中华心血管杂志0，，： | 5 |
| 13 | 缺血性心脏病的命名及诊断标准[J]显示文摘 | 国际心脏病学会和协会及WHO临床命名标准化联合专题组 | 1981 | 中华心血管杂志1981，9，1： | 5 |
| 14 | Effect of angiotensin Ⅱ type 1 receptor blocker and angiotensin converting enzyme inhibitor on the intraocular growth factors and their receptors in streptozotocin-induced diabetic rats显示文摘AIM: To investigate the effect of angiotensinⅡ type 1 receptor blocker(ARB) and angiotensin converting enzyme inhibitor(ACEI) on intraocular growth factors and their receptors in streptozotocin-induced diabetic rats. METHODS: Forty Sprague-Dawley rats were divided into 4 groups: control, diabetes mellitus(DM), candesartantreated DM, and enalapril-treated DM(each group, n=10). After the induction of DM by streptozotocin, candesartan [ARB, 5 mg/(kg·d)] and enalapril [ACEI, 10 mg/(kg·d)] were administered to rats orally for 4wk. Vascular endothelial growth factor(VEGF) and angiotensin Ⅱ(Ang Ⅱ) concentrations in the vitreous were measured using enzyme-linked immunosorbent assays, and VEGF receptor 2 and angiotensin II type 1 receptor(AT1R) levels were assessed at week 4 by Western blotting. RESULTS: Vitreous Ang Ⅱ levels were significantly higher in the DM group and candesartan-treated DM group than in the control(P=0.04 and 0.005, respectively). Vitreous AT1R increased significantly in DM compared to the other three groups(P<0.007). Candesartan-treated DM rats showed higher vitreal AT1R concentration than the enalapril-treated DM group and control(P<0.001 and P=0.005, respectively). No difference in vitreous Ang Ⅱ and AT1R concentration was found between the enalapriltreated DM group and control. VEGF and its receptor were below the minimum detection limit in all 4 groups.CONCLUSION: Increased Ang Ⅱ and AT1R in the hyperglycemic state indicate activated the intraocular renin-angiotensin system, which is inhibited more effectively by systemic ACEI than systemic ARB. | Ik Soo Byon Dong Hyun Lee Eun Sook Jun Min Kyu Shin Sung Who Park Ji Eun Lee | 2017 | International Journal of Ophthalmology(English edition)2017，10，6： | 5 |
| 15 | 患者为患者安全伦敦宣言显示文摘我们,患者为患者安全,希望实现一个无因医疗过失而受害的世界,我们作为合作伙伴,保护人们不受卫生保健中本可避免的伤害。风险与不确定性始终相伴。因此,我们走到一起进行对话,与医护人员一起参加卫生保健。我们将通力合作,倡导在发展中国家和发达国家消除卫生保健工作中发生的伤害. | WHO World Alliance for Patient Safety | 2006 | 中国循证医学杂志2006，6，7： | 4 |
| 16 | Fundus changes in pregnancy induced hypertension显示文摘AIM: To determine the prevalence of retinal changes in pregnancy induced hypertension (PIH) and any association between the retinal changes and blood pressure, proteinuria, and severity of the disease. METHODS: All the patients admitted with diagnosis of PIH were included in this study. Age, race, gravida, gestation period, blood pressure, and proteinuria were noted from the case records. After taking history for any eye symptoms, fundus examination was done after dilating the pupils with direct ophthalmoscope in the ward itself. All the findings were noted on a data sheet, and were analyzed using SPSS programme. RESULTS: A total of 78 patients of PIH were examined. Majority (75.6%) were Malays. The mean age of patients was 30.2 years (range 21-45 years). The gestation period ranged from 25 weeks to 41 weeks; 34 (43.5%) were primi gravida. Thirty (38.4%) patients had mild preeclampsia, 46 (59%) had severe preeclampsia and 2(2.5%) had eclampsia. Retinal changes (hypertensive retinopathy) were noted in 46 (59%) patients --- grade I in 41 (52.6%) and grade II in 5 (6.4%). Haemorrhages or exudates or retinal detachment were not seen in any patient. There was statistically significant positive association of retinal changes and blood pressure (P =0.001), proteinuria (P =0.018) and severity of the PIH (P =0.024). CONCLUSION: Retinal changes (grade I and II hypertensive retinopathy) were seen in 59% of patients with PIH and they were significantly associated with blood pressure, proteinuria and severity of the disease. Fundus examination helps in assessing the severity of PIH. | Sagili Chandrasekhara Reddy Sivalingam Nalliah Sheila Rani a/pKovil George Tham Seng Who | 2012 | International Journal of Ophthalmology(English edition)2012，5，6： | 3 |
| 17 | 缺血性心脏病的命名及诊断标准[J]显示文摘 | 国际心脏病学会和协会及WHO临床命名标准联合专题组 | | 中华心血管病杂志0，，： | 3 |
| 18 | 缺血性心脏病的命名及诊断标准显示文摘 | WHO | 1981 | 中华内科杂志1981，20，： | 3 |
| 19 | 缺血性心脏病的命名和诊断标准[J]显示文摘 | 国际心脏病学会和协会及WHO命名标准化联合专题组 | 1981 | 中华心血管病杂志1981，9，1： | 3 |
| 20 | 缺血性心脏病命名及诊断标准[J]显示文摘 | 国际心脑病学会和协会WHO命名标准联合专题组 | 1981 | 中华心血管病杂志1981，9，11： | 3 |
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