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| 1 | The treatment of Parkinson's disease with deep brain stimulation: current issues显示文摘Deep brain stimulation has become a well-established symptomatic treatment for Parkinson's disease during the last 25 years. Besides improving motor symptoms and long-term motor complications, positive effects on patients' mobility, activities of daily living, emotional well-being and health-related quality of life have been recognized. Apart from that, numerous clinical trials analyzed effects on non-motor symptoms and side effects of deep brain stimulation. Several technical issues and stimulation paradigms have been and are still being developed to optimize the therapeutic effects, minimize the side effects and facilitate handling. This review summarizes current therapeutic issues, i.e., patient and target selection, surgical procedure and programming paradigms. In addition it focuses on neuropsychological effects and side effects of deep brain stimulation. | Alexia-Sabine Moldovan Stefan Jun Groiss Saskia Elben Martin Südmeyer Alfons Schnitzler Lars Wojtecki | 2015 | Neural Regeneration Research2015，10，7： | 8 |
| 2 | The current role of prostate multiparametric magnetic resonance imaging显示文摘Prostate multi-parametric magnetic resonance imaging(mpMRI)has shown excellent sensitivity for Gleason7 cancers,especially when their volume is0.5 mL.As a result,performing an mpMRI before prostate biopsy could improve the detection of clinically significant prostate cancer(csPCa)by adding targeted biopsies to systematic biopsies.Currently,there is a consensus that targeted biopsies improve the detection of csPCa in the repeat biopsy setting and at confirmatory biopsy in patients considering active surveillance.Several prospective multicentric controlled trials recently showed that targeted biopsy also improved csPCa detection in biopsy-naǐve patients.The role of mpMRI and targeted biopsy during the follow-up of active surveillance remains unclear.Whether systematic biopsy could be omitted in case of negative mpMRI is also a matter of controversy.mpMRI did show excellent negative predictive values(NPV)in the literature,however,since NPV depends on the prevalence of the disease,negative mpMRI findings should be interpreted in the light of a priori risk for csPCa of the patient.Nomograms combining mpMRI findings and classical risk predictors(age,prostatespecific antigen density,digital rectal examination,etc.)will probably be developed in the future to decide whether a prostate biopsy should be obtained.mpMRI has a good specificity for detecting T3 stage cancers,but its sensitivity is low.It should therefore not be used routinely for staging purposes in low-risk patients.Nomograms combining mpMRI findings and other clinical and biochemical data will also probably be used in the future to better assess the risk of T3 stage disease. | Olivier Rouviere Paul Cezar Moldovan | 2019 | Asian Journal of Urology2019，6，2： | 4 |
| 3 | Roughning and smoothing dynamics during KOH silicon etching 显示文摘 | DIVAN R MOLDOVAN N CAMON H | 1999 | Sensor Actuators1999，74，13： | 1 |
| 4 | The NPV of bad news显示文摘 | GOLDENBERG J LIBAI B MOLDOVAN S MULLER E | 2007 | International Journal of Research in Marketing2007，24，3： | 1 |
| 5 | Pancreatic somatostatin inhibits insulin secretion via SSTR 5 in the isolated perfused mouse pancreas model 显示文摘 | Tirone TA Norman MA Moldovan S | 2003 | Pancreas2003，26，3： | 1 |
| 6 | IL28B is associated with response to chronic hepatitis C interferon-αand ribavirin therapy显示文摘 | SUPPIAH V MOLDOVAN M AHLENSTIEL G | 2009 | Nature genetics2009，41，10： | 1 |
| 7 | IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy显示文摘 | Suppiah V Moldovan M Ahlenstiel G et at | 2009 | Nat Genet2009，41，10： | 1 |
| 8 | Effects of grain growth on grain-boundary diffusion creep by molecular- dynamics simulation显示文摘 | Haslam A J Yamakov V Moldovan D | 2004 | Acta Materialia2004，52，7： | 1 |
| 9 | RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO 显示文摘 | Hoege C Pfander B Moldovan GL | 2002 | Nature2002，419，6903： | 1 |
| 10 | PCNA, the maestro of the replication fork 显示文摘 | Moldovan G L Pfander B Jentsch S | 2007 | Cell2007，129，： | 1 |
| 11 | In vtvo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression 显示文摘 | Fernandes J Tardif G Martel-Pelletier J Lascau CV Dupuis M Moldovan F | 1999 | Am J Pathol1999，154，4： | 1 |
| 12 | Nematic-isotropic interfacial tension anisotropy of calamitic lyotropic liquid crystal显示文摘 | Beica T Moldovan R Tintaru M | 2004 | Liquid Crystals2004，31，3： | 1 |
| 13 | Stress-enhanced grain growth in a nanocrystalline material by molecular-dynamics simulation显示文摘 | Haslam A J Moldovan D Yarnakov V | | 0，，： | 1 |
| 14 | SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase显示文摘 | Pfander B Moldovan G L Sacher M | 2005 | Nature2005，436，7049： | 1 |
| 15 | Tantalum Oxide Coatings as Candidate Environmental Barriers显示文摘 | Moldovan M Weyan C M Johnson D L | 2004 | Journal of Thermal Spray Technology2004，13，1： | 1 |
| 16 | Persistent Borna disease virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus 显示文摘 | Ovanesov M V Moldovan K Smith K | 2008 | J Neuroinflammation2008，5，： | 1 |
| 17 | 显示文摘 | Z. Moldovan L. Alexandrescu | 2002 | Analytical and Bioanalytical Chemistry2002，，1： | 1 |
| 18 | IL-28B is as-sociated with response to chronic hepatitis C interferon-alpha and ribavirin therapy显示文摘 | Suppiah V Moldovan M Ahlenstiel G | | 0，，： | 1 |
| 19 | On embeddings of hamiltonian paths and cycles in Extended Fibonacci cubes显示文摘 | Zelina I Moldovan G Tascu I | | 0，，11： | 1 |
| 20 | A nano fountain probe with sub-100 nm molecular writing resolution显示文摘 | Kim K H Moldovan N Espinosa H D | 2005 | Small2005，1，： | 1 |
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