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| 1 | Unexpected alliance between syndecan-1 and innatelike T cells to protect host from autoimmune effects of interleukin-17显示文摘Innate-like T cells, namely natural killer T(NKT) and γδ T cells, play critical roles in linking innate and adaptive immune responses through rapid production of cytokines. Prominent among these cytokines is interleukin-17(IL-17), which is a potent proinflammatory cytokine that plays a critical role in host defense against fungi and extracellular bacteria. However, excessive IL-17-production promotes autoimmune diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus. IL-17 has also been implicated in regulating body fat, which is highly relevant given rises in obesity and type 2 diabetes. NKT cells, γδ T cells and mucosal-associated invariant T cells(MAIT) are the major sources of IL-17 involved in protection of mucosal surfaces from opportunistic infections and causing autoimmunity when become dysregulated. Given the pathogenic effects of IL-17, efforts have been directed towards understanding mechanisms that guard against IL-17 overproduction. One novel potent mechanism is mediated by the heparan sulfate proteoglycan, syndecan-1(sdc1), which is selectively expressed by IL-17-producing subsets of NKT and γδ T cells. This unexpected role for sdc1 is uncovered by analysis of NKT and γδ T cells in sdc1-deficient mice. In this mini-review, we discuss selective expression of sdc1 by these innate T cells and consequences of its absence on IL-17 homeostasis and pathological implications. | Anil Kumar Jaiswal Mohanraj Sadasivam Abdel Rahim A Hamad | 2018 | World Journal of Diabetes2018，9，12： | 5 |
| 2 | Rare earth(Gd,La) co-doped ZnO nanoflowers for direct sunlight driven photocatalytic activity显示文摘In this work Gd/La@ZnO nanoflower photocatalyst was successfully synthesized by a co-precipitation method and applied for rhodamine B(Rh B) and tetracycline(TCN) degradation under direct sunlight irradiation.The doping of rare earth elements extends the optical absorption wavelength of ZnO from UV region(390 nm) to visible-light region(401 nm).In addition,the co-doped ZnO nanoflower exhibits a lower charge recombination efficiency which was confirmed by photoluminescence emission analysis.Moreover,the co-doped ZnO nanoflower exhibits the maximum degradation efficiency of 91% for Rh B and 74% for TCN under sunlight irradiation.The calculated synergistic index of co-doped ZnO is higher than that of the pure ZnO.Reactive radicals’ production was confirmed by terephthalic acid(TA) and nitro-blue tetrazolium(NBT) tests.The holes and hydroxyl(·OH) radicals play the major role in degradation reaction and it was confirmed by scavenger’s test.Moreover,the recycling test confirms the stability of the photocatalyst. | Baskaran Palanivel Romulo R.Macadangdang Jr Md Shahadat Hossain Fahad A.Alharthi Mohanraj Kumar Jih-Hsing Chang Sreedevi Gedi | 2023 | Journal of Rare Earths2023，41，1： | 3 |
| 3 | Applications of artificial neural networks for refrigeration, air-conditioning and heat pump systems-- A review 显示文摘 | Mohanraj M Jayaraj S Muraleedharan C | 2012 | Renewable and Sustainable Energy Reviews2012，16，： | 1 |
| 4 | Chitosan-dextran sulfate nanoparticles for delivery of an anti-angiogenesis peptide显示文摘 | Chen Y Mohanraj VJ Parkin JE | 2003 | Lett Pept Sci2003，10，： | 1 |
| 5 | Endostatin induce endothelial cell apoptosis显示文摘 | Mohanraj D Ramani R Waterman MJF | 1999 | J Biol Chem1999，274，11： | 1 |
| 6 | Renewable energy source water pumping systems--a literature review 显示文摘 | GOPAL C MOHANRAJ M CHANDRAMOHAN P | 2013 | Renewable and Sustainable Energy Reviews2013，，25： | 1 |
| 7 | AC impedance analysis and EMI shielding effectiveness of conductive SBR composites显示文摘 | G T Mohanraj | 2006 | Polymer Engineering and Science2006，10，： | 1 |
| 8 | Lack of association between the C3435T Polymorphism in the human multidrug resistance (MDR1) gene and response to antipileptic drug treatment显示文摘 | Sills J Mohanraj R Butler E | 2005 | Epilepsia2005，46，5： | 1 |
| 9 | Compara- tive assessment of environment-friendly alternatives to R134a in domestic refrigerators显示文摘 | Mohanraj M S Jayaraj C Muraleedharan | 2008 | Energy Effi- ciency2008，1，3： | 1 |
| 10 | Performance analysis of AODV, DSR and ZRP protocols in vehicular ad-hoc network using qualnet显示文摘 | Suresh M Mohanraj S Kamalnathan C | 2013 | International Journal of Application or Innovation in Engi- neering & Management2013，12，4： | 1 |
| 11 | Predictors of pharmacoresistant epilepsy显示文摘 | Hitiris N Mohanraj R Norrie J | 2007 | Epilepsy Res2007，75，23： | 1 |
| 12 | Anaesthesia and epileps显示文摘 | Perks A Cheema S Mohanraj R | | 0，，04： | 1 |
| 13 | A novel method to purify recombinant vascular endothelial growth factor (VEGF121)Expressed in Yeast显示文摘 | Mohanraj D Olson T Ramakrishnan S | 1995 | Biochem Biophys Res Commun1995，215，2： | 1 |
| 14 | Heavy metals in airborne particulate matter of urban Coimbatore显示文摘 | Mohanraj R Azeezpa P | 2004 | Archives of Environmental Contamination and Toxicology2004，47，2： | 1 |
| 15 | Antibiofilm activity ofthree irrigation protocols activated by ultrasonic, diode laser or Er:YAG laser in vitro显示文摘 | Neelakantan P Cheng CQ Mohanraj R ef al | 2015 | Int Endod J2015，48，6： | 1 |
| 16 | High levels of fusidic acid-resistant Staphylococcus aureus despite restrictions on antibiotic use显示文摘 | Mitra A Mohanraj M Shah M | 2009 | Clin Exp Dennatol2009，34，2： | 1 |
| 17 | Wild-type p53 and p73 negatively regulate expression of proliferation related genes显示文摘 | CARCHMAN E H MOHANRAJ L | 2008 | Oneogene2008，27，18： | 1 |
| 18 | Histological staining: an effective method for sugarcane smut screening显示文摘 | Nallathambi P Padmanaban P Mohanraj D | 1998 | Sugar Cane1998，，2： | 1 |
| 19 | IGFBP-3 inhibits cytokine-induced insulin resistance and early manifestations of atheroselerosls显示文摘 | Mohanraj L Kim HS Li W | 2013 | PLoS One2013，8，55： | 1 |
| 20 | A fixed point theorem for a pair of maps satisfying a general contractive condition of integral type显示文摘 | Vijaraju P Rhoades B E Mohanraj R | 2005 | Int J Math Math Sci2005，15，9： | 1 |
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