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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | A typicial Pasteurella haemolytica type A from poultry显示文摘 | Addo P B Mohan K | 1984 | Avian Diseases1984，29，： | 1 |
| 3 | Rapid diagnosis of tuberculous menin gitis by polymerase chain reaction显示文摘 | Shankar P Manjunath N Mohan K | 1991 | Lancet1991，3375，： | 1 |
| 4 | Effects of cadmium salt on phosphomonoesterases activity and fertilizing ability of fowl spermatozoa显示文摘 | Mohan J Moudgal R P Panda J N | 1992 | Indian J Experi Biol1992，30，： | 1 |
| 5 | Studies on distribution and fractionation of heavy metals in Gomti river sediments-a tributary of the Ganges, india显示文摘 | SINGH K P MOHAN D SINGH V K | 2005 | Journal of Hydrology2005，312，： | 1 |
| 6 | Synthesis, characterization and effect of reaction parameters on swelling properties of acrylamide-sodium methacrylate superabsorbent copolymers 显示文摘 | Mohan Y M Murthy P S K Raju K M | 2005 | Reactive & Functional Polymers2005，63，： | 1 |
| 7 | Pathogenesis of cholangitis in obstructive jaundice-revisited显示文摘 | Navaneethan U Jayanthi V Mohan P | 2011 | Minerva Gastroenterol Dietol2011，57，1： | 1 |
| 8 | 查看详情显示文摘 | Mohan P Motohisa J Fukui T | | 0，，： | 1 |
| 9 | Angiographic embolization for intractable obstetrical bleeding显示文摘 | Tandon P Juneja SK Mohan B | 2014 | Int J Appl Basic Med Res2014，4，1： | 1 |
| 10 | Lupus nephritis:treatment of resistant disease显示文摘 | Kalloo S Aggarwal N Mohan P | 2013 | Clin J Am Soc Nephrol2013，8，1： | 1 |
| 11 | Preparation and swelling behavior of macroporous poly (acrylamide-co-sodium methacrylate) superabsorbent hydrogels显示文摘 | Mohan Y M Murthy P S K Raju K M | 2006 | Journal of Applied Polymer Science2006，101，5： | 1 |
| 12 | Trivalent chromium removal from wastewater using low cost activated carbon derived from agricultural waste material and activated carbon fabric cloth显示文摘 | Mohan D Singh K P Singh V K | 2006 | Hazard Mater2006，135，： | 1 |
| 13 | Natural killer cell cytokine production, not cytotoxicity, contributes to resistance against blood-stage Plasmodium chabaudi AS intection显示文摘 | Mohan k Moulin P Stevenson NM | 1997 | J Immunol1997，159，： | 1 |
| 14 | Temporal uncertainty reasoning networks for evidence fusion with applications to object detection and tracking显示文摘 | MOHAN C K MEHROTRA K G VARSHNEY P K | 2007 | Information Fusion2007，8，3： | 1 |
| 15 | Semi-IPNs of starch and poly (aerylamide-eo-sodium methacrylate) : Preparation, swelling and diffusion characteristics evaluation 显示文摘 | Keshava Murthy P S Murali Mohan Y Sreeramulu J | 2006 | Reactive & Functional Polymers2006，66，： | 1 |
| 16 | Studies on distribution and fractionation of heavy metals in Gomti river sediments-a rributary of the Ganges,India显示文摘 | SINGH K P MOHAN D SINGH V K | 2005 | Journal of Hydrology2005，312，： | 1 |
| 17 | Design and fabrication of an automated technique: measurement of spontaneous polarization in two new schiff'base ferroelectric liquid crystals 显示文摘 | Madhu Mohan M L N Goud B V S Kumar P A | 1999 | Materials Research Bulletin1999，34，1415： | 1 |
| 18 | Com-pact multiple-valued multiplexers using negative differen-tial resistance devices 显示文摘 | CHAN H L MOHAN S MAZUMDER P | 1996 | IEEE Journal of Sold-StateCircuits1996，31，8： | 1 |
| 19 | Laparoscopic inguinal hernia repair in children:A single-centre experience over 7 years显示文摘 | Mohan KA Abdulrasheed AN Ramakrishnan P | | 0，，02： | 1 |
| 20 | 显示文摘 | MOHAN C KUMAR V MAHAJAN M P | 2004 | Tetrahedron Lett2004，45，31： | 1 |
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