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| 1 | Expression profile of cholecystokinin type-A receptor in gallbladder cancer and gallstone disease显示文摘BACKGROUND:Regulatory peptide receptors have attracted the interest of oncologists as a new promising approach for cancer pathology,imaging and therapy.Although cholecystokinin (CCK) is a potent modulator of gallbladder contractility and plays a potential role in pancreatic carcinogenesis through CCK type-A receptor (CCKAR),its role in gallbladder cancer (GBC) is still unknown and immunohistochemical detection of CCKAR in the gallbladder has not yet been reported.This novel case-control study aimed to investigate the expression profile of CCKAR in GBC and gallstone disease (GSD).METHODS:This study included 162 samples of gallbladder:94 from GBC and 68 from GSD.Expression of CCKAR was analyzed by immunohistochemistry and immunoblotting.The results were statistically correlated with disease history including age,sex,presence of gallstone,stage and differentiation.RESULTS:CCKAR was positive in 30/68 (44.1%) of GSD and 72/94 (76.6%) of GBC samples.Fifty-one of the 72 (70.8%) CCKAR-positive GBC samples showed over-expression.Interestingly,consistent results also appeared in the immunoblotting study.CONCLUSIONS:CCKAR expression was significantly increased in GBC compared to GSD.Moreover,CCKAR expression was associated with the degree of tumor differentiation,i.e.,less expression in poorly-differentiated tumors.Thus,it has future prognostic and therapeutic implications in the management of GBC. | Rajani Rai Mallika Tewari Mohan Kumar Tej Bali Singh Hari S Shukla | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 2 | Design and fabrication of an automated technique: measurement of spontaneous polarization in two new schiff'base ferroelectric liquid crystals 显示文摘 | Madhu Mohan M L N Goud B V S Kumar P A | 1999 | Materials Research Bulletin1999，34，1415： | 1 |
| 3 | A comparative study of burns treated with topical heparin and without heparin 显示文摘 | Venakatachalapathy TS Mohan Kumar S Saliba MJ | 2007 | Ann Burns Fire Disast2007，20，4： | 1 |
| 4 | Skeletal asymmetry显示文摘 | Kanchan T Mohan Kumar T S Pradeep Kumar G | 2008 | J Forensic Leg Med2008，15，3： | 1 |
| 5 | Reduction of acrylamide formation in sweet bread with L-asparaginase treatment 显示文摘 | Mohan Kumar N S Shimray C A Indrani D | 2014 | Food Bioprocess Technology2014，，7： | 1 |
| 6 | Artificial neural network - based peak load forecasting using conjugate gradient methods 显示文摘 | Mohan A L Kumar S M | 2002 | IEEE Transactions on Power Systems2002，17，3： | 1 |
| 7 | Electricity generation u- sing microbial fuel cells 显示文摘 | Mohan Y Kumar S M Das D | 2008 | Int J Hydr Eng2008，33，： | 1 |
| 8 | Prognostic implications of circulat-ing anti - p53 antibodies in lung cancer - a review 显示文摘 | Kumar S Mohan A Guleria R | 2009 | Eur JCancer Care (Engl)2009，18，3： | 1 |
| 9 | Estima- ting groundwater recharge using land use and soil data: A case study in South India显示文摘 | Anuraga T S Ruiz L Mohan Kumar M S | 2006 | Agricultural water manage- ment2006，84，1： | 1 |
| 10 | Arfificial neural network-based peak load forecasting using conjugate gradient methods显示文摘 | Mohan A L Kumar S M | 2002 | IEEE Transactions on Power Systems2002，17，3： | 1 |
| 11 | Compressive strength of fiber reinforced highly compressible clay 显示文摘 | Kumar A Walia B S Mohan J | 2006 | Construction and Building Materials2006，20，： | 1 |
| 12 | Utility of plasma tumour necrosis factor-alpha and transforming growth fac- tor-betal as predictors of survival and treatment outcome in advanced non-small cell lung carcinoma 显示文摘 | Kumar S Guleria R Mohan A | 2010 | Biomarkers2010，15，5： | 1 |
| 13 | Efficacy of plasma TGF-β1 level in predicting therapeutic efficacy and progno- sis in patients with advanced non-small cell lung cancer 显示文摘 | Kumar S Guleria R Mohan A | 2011 | Cancer Invest2011，29，3： | 1 |
| 14 | Outcome of Ankle Arthrodesis in posttraumatic arthritis显示文摘 | Narayana Gowda B S Mohan Kumar J | 2012 | Indian Journal of Orhtopaedics2012，46，3： | 1 |
| 15 | Calorimetric studies and kinetic parameters of solid state reactions in 7017 AI-Zn-Mg alloy显示文摘 | GHOSH K S KUMAR A K MOHAN M K | 2008 | Trans Indian Inst Met2008，61，6： | 1 |
| 16 | Human Protein Reference Database- -2009 update显示文摘 | Keshava Prasad TS Goel R Kandasamy K Keerthikumar S Kumar S Mathivanan S Telikicherla D Raju R Shafreen B Venugopal A Balakrishnan L Mafimuthu A Banerjee S So- manathan DS Sebastian A Rani S Ray S Harrys Kishore C J Kanth S Ahmed M Kashyap MK Mohmood R Ramachandra YL Krishna V Rahiman BA Mohan S Ranganathan P Ram- abadran S Chaerkady R Pandey A | 2009 | Nucleic Acids Res2009，37，： | 1 |
| 17 | Efficacy of plasma TGF-β1 level in predicting therapeutic efficacy and prognosis in patients with advanced non-small cell lung cancer显示文摘 | Kumar S Guleria R Mohan A | 2011 | Cancer Invest2011，29，3： | 1 |
| 18 | Clinical and angiographic pro- file of patients presenting with first acute myocardial infarction in a tertiary care center in northern india 显示文摘 | Kumar N Sharma S Mohan B | 2008 | Indian Heart2008，60，3： | 1 |
| 19 | Extreme reduction of disease in oats transformed with the 5' half of the Barley yellow dwarf virus-PAV genome 显示文摘 | Koev G Mohan B R Dinesh Kumar S P | 1998 | Phytopathology1998，88，： | 1 |
| 20 | Prognostic implications of circulating anti-p53 antibodies in lung eancer--a review 显示文摘 | Kumar S Mohan A Guleria R | 2009 | Eur J Cancer Care2009，18，3： | 1 |
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