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| 1 | Hepatocellular carcinoma in Egypt: A single center study over a decade显示文摘AIM: To identify the trend, possible risk factors and any pattern change of hepatocellular carcinoma (HCC) in Egyptover a decade.METHODS: All HCC patients attending Cairo Liver Center between January 1993 and December 2002, were enrolledin the study. Diagnosis of HCC was based on histopath ological examination and/or detection of hepatic focal lesions by two imaging techniques plus α-fetoprotein level above 200 ng/mL. The duration of the study was divided into two periods of 5 years each; period Ⅰ (1993-1997) and period Ⅱ (1998-2002). Trend, demographic features of patients (age, gender, and residence), risk factors (HBsAg,HCV-Ab, schistosomiasis and others) and pattern of the focal lesions were compared between the two periods.Logistic regression model was fitted to calculate the adjusted odds ratios for the potential risk factors. The population attributable risk percentage was calculated to estimate the proportion of HCC attributed to hepatitis B and C viral infections.RESULTS: Over a decade, 1 328 HCC patients out of 22 450 chronic liver disease (CLD) patients were diagnosed with an overall proportion of 5.9%. The annual proportion of HCC showed a significant rising trend from 4.0% in 1993 to 7.2% in 2002 (P = 0.000). A significant increase in male proportion from 82.5% to 87.6% (P = 0.009); M/F from 5:1 to 7:1 and a slight increase of the predominant age group (40-59 years) from 62.6% to 66.8% (P = 0.387)in periods Ⅰ and Ⅱ respectively, reflecting a shift to younger age group. In the bivariate analysis, HCC was significantly higher in rural residents, patients with history of schistosomiasis and/or blood transfusion. Yet, after adjustment, these variables did not have a significant risk for development of HCC. There was a significant decline of HBsAg from 38.6% to 20.5% (P = 0.000), and a slight increase of HCV-Ab from 85.6% to 87.9% in periods Ⅰ and Ⅱ respectively. HBV conferred a higher risk to develop HCC more than HCV in period Ⅰ (OR 1.9 vs 1.6) and period Ⅱ (OR 2.7 vs 2.0), but the relative contribution of HBV for development of HCC declined in period Ⅱ compared to period Ⅰ (PAR% 4.2%, 21.32%). At presentation,diagnostic α-fetoprotein level (≥200 ng/mL) was demonstrated in 15.6% vs28.9% and small HCC (≤3 cm)represented 14.9% vs 22.7% (P = 0.0002) in periods Ⅰ and Ⅱ respectively.CONCLUSION: Over a decade, there was nearly a twofold increase of the proportion of HCC among CLD patients in Egypt with a significant decline of HBV and slight increase of HCV as risk factors. α-Fetoprotein played a limited role in diagnosis of HCC, compared to imaging techniques.Increased detection of small lesions at presentation reflects increased awareness of the condition. | Adbel-Rahman El-Zayadi Hanaa M Badran Eman MF Barakat Mohy El-Deen Attia Sherine Shawky Mostafa K Mohamed Osaima Selim Ahmed Saeid | 2005 | World Journal of Gastroenterology2005，11，33： | 5 |
| 2 | TMS320F2812 digital signal processor(DSP)implementation of DPWM显示文摘 | Tajuddin MFN Ghazali NH Mohammed MF | 2009 | IEEE Student Conference on Research and Development2009，，： | 1 |
| 3 | Serum levels of ghrelin,tumor necrosis factor-alpha and interleukin-6 in infants and children with congenital heart disease显示文摘 | Afify MF Mohamed GB E1-Maboud MA | | 0，，06： | 1 |
| 4 | Plasma neutrophil gelatinase-associated lipocalin as an early biomarker for prediction of acute kidney injury after cardio-pulmonary bypass in pediatric cardiac surgery显示文摘 | Fadel FI Abdel Rahman AM Mohamed MF | 2012 | Arch Med Sci2012，8，2： | 1 |
| 5 | Obstruc- tive sleep apnea among express bus drivers in Malay- sia: Important Indicators for Screening显示文摘 | Yusoff MF Baki MM Mohamed N | 2010 | Traffie Inj Prey2010，11，： | 1 |
| 6 | Echinacea purpurea and Allium sativum as im- munostimulants in fish culture using Nile tilapia (Oreochromis niloticus)显示文摘 | Aly S M Mohamed MF | 2010 | Journal of Animal Physiology and Animal Nutrition2010，94，5： | 1 |
| 7 | Academic satis- faction among traditional and problem based learning medical students显示文摘 | Albarrak AI Mohammed R Abalhassan MF | 2013 | A comparative study Saudi Med J2013，34，11： | 1 |
| 8 | Comparative study of neuromuscular blocking and hemodynamic effects of rocuronium and cisatracurium under sevoflarane or total intravenous anesthesia显示文摘 | Amin AM Mohammed MY Ibrahim MF | 2009 | Middle East J Anaesthesiol2009，20，1： | 1 |
| 9 | Serum levels of ghrelin,tumor necrosis factor-alpha and interleukin-6 in infants and children with congenital heart disease显示文摘 | Afify MF Mohamed GB El-Maboud MA | 2009 | J Trop Pediatr2009，55，6： | 1 |
| 10 | Serum levels of ghrelin, tumor necrosis factor-alpha and interleukin-6 in infants and children with congenital heart disease 显示文摘 | Afify MF Mohamed GB El-Maboud MA | 2009 | J Trop Pediatr2009，55，6： | 1 |
| 11 | The impact of on- pump coronary artery bypass surgery vs off-pump coronary artery bypass surgery on sexual function 显示文摘 | Mohamed OA Bennett CJ Roaiah MF | 2009 | J Sex Med2009，6，4： | 1 |
| 12 | High-flux and low- flux dialysis membranes and levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in children with chronic kidney failure 显示文摘 | Sawires HK Mohamed WA Schaalan MF | 2012 | Iran J Kidney Dis2012，6，5： | 1 |
| 13 | Inhibition of intestinal and hepatic glucuronidation of mycophenolic acid by Ginkgo biloba extract and flavonoids显示文摘 | Mohamed MF Frye RF | 2010 | Drug Metab Dispos2010，38，27： | 1 |
| 14 | Plasma neutrophil gelatinase-associated lipocalin as an early bio- marker for prediction of acute kidney injury after cardio-pul- monary bypass in pediatric cardiac surgery 显示文摘 | Fade1 FI Abdel Rahman AM Mohamed MF | 2012 | Arch Med Sci2012，8，2： | 1 |
| 15 | Plasma neutrophil gelatinase-associated lipocalin as an early biomarker for prediction of acute kidney injury after cardio-pulmonary bypass in pediatric cardi- ac surgery显示文摘 | Fadel FI Abdel Rahman AM Mohamed MF | 2012 | Arch Med Sci2012，8，2： | 1 |
| 16 | Academic sa- tisfaction among traditional and problem based learning medical students :A comparative study 显示文摘 | Albarrak A1 Mohammed R Abalhassan MF | 2013 | Saudi Med J2013，34，11： | 1 |
| 17 | Timing of elective repeated cesarean delivery in patients with previous two or more cesarean section显示文摘 | Mohammed AB Bayo AI Abu-Jubara MF | 2013 | J Matern Fetal Neonatal Med2013，26，1： | 1 |
| 18 | Dark preconditioning,CPPU and thidiazuron promote shoot organogenesis on seedling node explants of common and faba beans显示文摘 | Read PE Coyne DP | 1992 | Amer Soc Hortic Sci1992，117，： | 1 |
| 19 | Prevention of hepa- tocellular carcinoma in hepatitis B virus infection 显示文摘 | Lim SG Mohammed R Yuen MF | 2009 | J Gastroenterol Hepato12009，24，8： | 1 |
| 20 | Prevention of hepatocellular carcinoma in hepatitis B virus infection显示文摘 | Lim SG Mohammed R Yuen MF | | 0，，： | 1 |
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