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| 1 | TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation显示文摘Transforming growth factor-beta(TGF-β)/bone morphogenetic protein(BMP) plays a fundamental role in the regulation of bone organogenesis through the activation of receptor serine/threonine kinases. Perturbations of TGF-β/BMP activity are almost invariably linked to a wide variety of clinical outcomes, i.e., skeletal, extra skeletal anomalies, autoimmune, cancer, and cardiovascular diseases. Phosphorylation of TGF-β(I/II) or BMP receptors activates intracellular downstream Smads, the transducer of TGF-β/BMP signals. This signaling is modulated by various factors and pathways, including transcription factor Runx2. The signaling network in skeletal development and bone formation is overwhelmingly complex and highly time and space specific.Additive, positive, negative, or synergistic effects are observed when TGF-β/BMP interacts with the pathways of MAPK, Wnt, Hedgehog(Hh), Notch, Akt/m TOR, and mi RNA to regulate the effects of BMP-induced signaling in bone dynamics. Accumulating evidence indicates that Runx2 is the key integrator, whereas Hh is a possible modulator, mi RNAs are regulators, and b-catenin is a mediator/regulator within the extensive intracellular network. This review focuses on the activation of BMP signaling and interaction with other regulatory components and pathways highlighting the molecular mechanisms regarding TGF-β/BMP function and regulation that could allow understanding the complexity of bone tissue dynamics. | Md Shaifur Rahman Naznin Akhtar Hossen Mohammad Jamil Rajat Suvra Banik Sikder M Asaduzzaman | 2015 | Bone Research2015，3，1： | 53 |
| 2 | Influence of ellagic acid on prostate cancer cell proliferation:A caspase-dependent pathway显示文摘Objective:To evaluate the effect of allagic acid treatment on the cell viability of human prostate cancer cells.Methods:Ellagic acid(10-100 mol/L) treatment(48 h) of human prostate carcinoma PC3 cells was found to result in a dose-dependent inhibition of cell growth and apoptosis of PC3 cells as assessed by MTT assay,western blotting.flow cytometry and confocal microscopy.Results:We observed that ellagic acid treatment of PC3 cells resulted in a dose dependent inhibition of cell growth/cell viability.This ellagic acid caused cell growth inhibition was found to be accompanied by induction of apoptosis,as assessed by the cleavage of poly (ADP-ribose) polymerase(PARP) and morphological changes.Further,induction of apoptosis accompanied a decrease in the levels of antiapoptotic protein Bcl-2 and increase in proapoptotic protein Bax.thus shifting the Bax:Bcl-2 ratio in favor of apoptosis.Ellagic acid treatment of PC3 cells was also found to result in significant activation of caspases,as shown by the dose dependent decrease in the protein expression of procaspase-3,-6.-8 and -9.This ellagic acid-mediated induction of apoptosis was significantly(80%-90%) inhibited by the caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone(Z-VAD-FMK).Thus these data suggested an essential role of caspases in ellagic acid-mediated apoptosis of PC3 cells.Conclusions:It is tempting to suggest that consumption of tropical pigmented fruits and vegetables could be an effective strategy to combat prostate cancer. | Arshi Malik Sarah Afaq Mohammad Shahid Kafil Akhtar Abdullah Assiri | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，7： | 18 |
| 3 | Interaction of cetyltrimethylammonium bromide with drug in aqueous/electrolyte solution:A combined conductometric and molecular dynamics method study显示文摘Interaction between beta-lactum antibiotic drug ciprofloxacin hydrochloride(CFH)and cationic surfactant cetyltrimethylammonium bromide(CTAB)was performed conductometrically in aqueous as well as in the occurrence of different salts(NaCl,KCl as well as NH_4Cl)over the temperature range of 298.15–323.15 K at the regular interval of 5 K.CFH drug has been suggested for the treatment of bacterial infections such as urinary tract infections and acute sinusitis.A clear critical micelle concentration(CMC)was obtained for pure CTAB as well as(CFH+CTAB)mixed systems.The decrease in CMC values of CTAB caused by the addition of CFH reveals the existence of the interaction between the components and therefore it is the indication of micelle formation at lower concentration of CTAB and their CMC values further decrease in attendance of salts.A nonlinear behavior in the CMC versus T plot was observed in all the cases.The ΔG_m^0 values are found to be negative in present study systems demonstrated the stability of the solution.The values of ΔH_m^0 and ΔS_m^0 reveal the existence of hydrophobic and electrostatic interactions between CFH and CTAB.The thermodynamic properties of transfer for the micellization were also evaluated and discussed in detail.Molecular dynamic simulation disclosed that environment of water and salts have impact on the hydrophobic interaction between CFH and CTAB.In water and salts,CTAB adopts spherical micelle in which charged hydrophilic groups are interacted with waters whereas hydrophobic tails form the core of the micelle.This hydrophobic core region is highly conserved and protected.In addition,micelle formation is more favorable in aqueous Na Cl solution than other solutions. | Md.Anamul Hoque Md.Masud Alam Mohammad Robel Molla Shahed Rana Malik Abdul Rub Mohammad A.Halim Mohammed Abdullah Khan Farida Akhtar | 2018 | Chinese Journal of Chemical Engineering2018，26，1： | 3 |
| 4 | Roles of organic soil amendments and soil organisms in the biological control of plant-parasitic nematodes: a review显示文摘 | Mohammad Akhtar Abdul Malik | 2000 | Bioresource Technology2000，，1： | 2 |
| 5 | Disseminated cysticercosis incidentally diagnosed in a patient of low backache:A case report and concise review of literature显示文摘Disseminated cysticercosis is an uncommon presentation of a common disease.Asymptomatic disseminated cysticercosis is rarely reported in literature.Here,we are reporting a case of asymptomatic disseminated cysticercosis incidentally diagnosed in a patient of low backache. Magnetic resonance imaging of lumbosacral spine and neuroimaging done subsequently during the course of evaluation revealed diffuse cysticercosis involving abdominal,paraspinal,pelvic and gluteal muscles along with neurocysticercosis.Such a disseminated cysticercosis was diagnosed incidentally in this patient of low backache with right sciatica and radiculopathy at L5-S1 prolapsed intervertebral disc and was subsequently managed by L5-S1 interlaminar fenestration and discectomy. | Mohammad Nasim Akhtar Sharat Agarwal | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，7： | 1 |
| 6 | X-efficiency Analysis of Commercial Banks in Pakistan:A Preliminary Investigation显示文摘 | Mohammad Hanif Akhtar | | 0，，04： | 1 |
| 7 | Physiological changes in Labeo rohita during nitrite exposure: Detoxification through dietary vitamin E显示文摘 | Alexander Ciji Narottam Prasad Sahu Asim Kumar Pal Mohammad Shahbaz Akhtar | 2013 | Comparative Biochemistry and Physiology, Part C2013，，2： | 1 |
| 8 | Knowledge, attitude and practice of patients with type 2 diabetes mellitus towards complementary and alternative medicine显示文摘OBJECTIVE: The use of complementary and alternative medicine(CAM) is relatively common among patients with type 2 diabetes mellitus(T2DM) around the world. Like many other countries, Saudi Arabia has a high incidence of T2DM, and incorporates the use of CAM in its treatment. This study explores the knowledge, attitude and practice(KAP) of CAM therapies among patients with T2DM and explores the relationships between sociodemographics and the KAP of CAM modalities. METHODS: This is a hospital-based, observational, cross-sectional study that selected 302 outpatients with T2DM, from Diabetic Center of King Salman bin Abdul-Aziz Hospital, in Riyadh city, in May 2014. Patients were interviewed using a predesigned questionnaire. RESULTS: The mean age of patients was(51.6 ± 10.6) years and 43.4% of them were males. The prevalence of CAM practices was 30.5%; 30.39% of them used herbs, 20.58% used wet cupping and 17.64% used nutritional supplements and other therapies. The factors found to predict the use of CAM therapies among patients with T2DM were: age above 51 years, unemployment and the participants' knowledge about the effectiveness of CAM products. CONCLUSION: This preliminary study estimated the prevalence of CAM use, revealed positive attitude towards CAM and found three significant predictors of CAM use among patients with T2DM, which is consistent with regional data. A community-based research with a larger sample that targets T2DM population is needed in Saudi Arabia. | Sulaiman Al-Eidi Salwa Tayel Fatima Al-Slail Naseem Akhtar Qureshi Imen Sohaibani Mohamed Khalil Abdullah Mohammad Al-Bedah | 2016 | Journal of Integrative Medicine2016，14，3： | 1 |
| 9 | Design and synthesis of 3-[3-(substituted phenyl)-4-piperidin-1-ylmethyl/-4-morpholin-4-ylmethyl-4,5-dihydro-isoxazol-5-yl]-1H-indoles as potent anti-inflammatory agents显示文摘 | Mohammad Amir Sadique Akhtar Javed Harish Kumar | 2010 | Medicinal Chemistry Research2010，，3： | 1 |
| 10 | 成熟运营商成功实现无缝移动计划显示文摘 | Paul Norkus Mohammad Akhtar | 2005 | 通信世界2005，，13： | 1 |
| 11 | A Study of Neutron and Gamma Radiation Effects on Transmissionof Various Types of Glasses, Optical Coatings, Cemented Optics and Fiber显示文摘 | Javed Akhtar S M Mohammad Ashraf Shaukat Hameed Khan | 2007 | Optical Materials2007，29，： | 1 |
| 12 | Seasonality in pulmonary tuberculosis among migrant workers entering Kuwait 显示文摘 | Akhtar S Mohammad HG | 2008 | BMC Infect Dis2008，8，： | 1 |
| 13 | Roles of Organic Soil Amendments and Soil Organisms in the Biological Control of Plant-parasitic Nematodes显示文摘 | Mohammad Akhtar and Abdul Malik | 2000 | Bioresource Technology2000，74，1： | 1 |
| 14 | Risk factors of diabetic retinopathy in Bangladeshi type 2 diabetic patients显示文摘 | Kazi R. Ahmed Md N. Karim Mohammad S. Bukht Bishwajit Bhowmik Amitava Acharyya Liaquat Ali Akhtar Hussain | 2012 | Diabetes & Metabolic Syndrome: Clinical Research & Reviews2012，，4： | 1 |
| 15 | TD-LTE:抢占无线全新商机 带动全球发展势态显示文摘LTE是目前大部分电信运营商首选的下一代移动通信技术,已有100多家运营商承诺将于2010开始部署LTE。不过,在非成对频段部署LTE的商机却常被忽略。作为支撑电信语音和移动宽带服务发展的最核心因素,频谱资源往往是有限的。如今,为了努力满足用户对移动数据日益增长的需求,大部分运营商的网络和频段都在满负荷运行。据相关数据显示,2010年用户每月使用的数据流量已经超过了5GB。 | Mohammad Akhtar | 2010 | 通信世界2010，，40： | 0 |
| 16 | Generalized*-Lie Higher Derivable Mappings on*-Rings显示文摘Let R be a*-ring with the center Z(R)and N be the set of nonnegative integers.In this paper,it is shown that if R contains a nontrivial self-adjoint idempotent which admits a generalized Lie higher derivable mapping△={G_(n)}_(n∈N)associated with a*-Lie higher derivable mapping L={L_(n)}_(n∈N),then for any X,Y in R and for each n in N there exists an element Z_(X,Y)(depending on X and Y)in the center Z(R)such that G_(n)(X+Y)=G_(n)(X)+G_(n)(Y)+Z_(X,Y). | Mohammad Ashraf Mohd Shuaib Akhtar Bilal Ahmad Wani | 2020 | Algebra Colloquium2020，27，3： | 0 |
| 17 | TD-LTE:抢占无线全新商机带动全球发展势态显示文摘LTE是目前大部分电信运营商首选的下一代移动通信技术,已有100多家运营商承诺将干2010开始部署LTE。懂得注意的是在非成对频段部署LTE的商机却常被忽略。 | Mohammad Akhtar | 2010 | 数字通信世界2010，，11： | 0 |
| 18 | TD-LTE:抢占无线全新商机 带动全球发展势态显示文摘LTE是目前大部分电信运营商首选的下一代移动通信技术,已有100多家运营商承诺将于2010开始部署LTE。不过,在非成对频段部署LTE的商机却常被忽略。 | Mohammad Akhtar | 2010 | 通讯世界2010，，10： | 0 |
| 19 | TD-LTE抢占无线全新商机显示文摘如今,为了努力满足用户对移动数据日益增长的需求,大部分运营商的网络和频段都在满负荷运行。据相关数据显示,2010年用户每月使用的数据流量已经超过了5GB。由于数据增长的关键驱动因素——smartphone的普及率在全球仍低于20%,运营商预计用户每月使用的数据流量仍将继续增长。因此,如何充分利用自身的频谱资源、开发包括TD-LTE在内的不同技术选择的潜力,就成为运营商极为关注的重要课题。 | Mohammad Akhtar | 2010 | 中国电信业2010，，11： | 0 |
| 20 | Diagnosis and Recommendation Integrated System Assessment of the Nutrients Limiting and Nutritional Status of Tomato显示文摘Tomato is an important field crop,and nutritional imbalances frequently reduce its yield.Diagnosis and Recommendation Integrated System(DRIS),uses ratios for nutrient deficiency diagnosis instead of absolute concentration in plant tests.In this study,local DRIS norms for the field tomatoes were established and the nutrient(s)limiting tomatoes yield were determined.Tomato leaves were analyzed for nutrients,to identify nutritional status using the DRIS approach.One hundred tomatoes fields were selected from Chatter Plain Khyber Pakhtunkhwa and the Sheikupura Punjab Pakistan.The first fully matured leaf was sampled,rinsed,dried and ground for analyzing P,K,Ca,Mg,Cu,Fe,Mn and Zn using an Inductively Coupled Plasma Atomic Emission Spectrophotometer(ICP AES).Plant tissue N and S were measured by the combustion method.The tomatoes yields were recorded at each location.The data were divided into high-yielding(≥3.79 kg/10 plant)and low-yielding(<3.79 kg/10 plant)populations and norms were computed using standard DRIS procedures.High-yielding plant population had a statistically greater mean S and Fe than the low-yielding population.The average balance index,the sum of functions,for S and Fe were−11.04 and−5.17 which reflected deficiency of S and Fe.Plant nutrients norms established may optimize plant nutrition in field tomatoes for high yield. | Rabia Manzoor Mohammad Saleem Akhtar Khalid Saifullah Khan Taqi Raza Muhammad Ishaq Asif Rehmani Carl Rosen Muhammad Khalil ur Rehman Nahla Zidan Fahad MAlzuaibr Nisreen MAbdulsalam Najla AKhateeb Majid Alhomrani Abdulhakeem SAlamri Javeed Ahmad Lone Muhammad Ammar Raza Ayman El Sabagh | 2022 | Phyton-International Journal of Experimental Botany2022，91，12： | 0 |
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