|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2016年WHO泌尿系统和男性生殖器官肿瘤分类指南--第二部分:前列腺和膀胱肿瘤显示文摘自上次世界卫生组织(world health organization,WHO)公布前列腺和膀胱肿瘤分类,已有12年。在此期间,关于这些肿瘤的病理和遗传学出现了大量知识更新。2016年WHO分类指南中新增了前列腺导管内癌的内容。在大多数情况下,前列腺导管内癌是一种在导管内扩散且具有侵袭性的前列腺癌,需与高级别前列腺上皮内瘤进行区分。前列腺腺泡腺癌新增了两种类型,包括微囊腺癌和多形性巨细胞腺癌。修改后的Gleason分级系统也增补至新分类的前列腺癌分级中;对于评分为Gleason 7分的腺癌,建议诊断报告列出结构类型为4级(pattern 4)的比例。新分类进一步推荐近来提出的前列腺癌5级分类。对于膀胱癌,2016年WHO分类继续沿用国际泌尿病理协会(International Society of Urological Pathology,ISUP)1997年的分类指南。本次修订中更好地定义了非侵袭性的尿路上皮病变,包括尿路上皮异型增生和未知恶性潜能的尿路上皮增生,常见于有尿路上皮癌病史的患者,侵袭性尿路上皮癌的异向分化,指一定比例的'常见型'尿路上皮癌和其他形态变化同时存在。病理医生在病理报告中需注明不同组织的比例。 | Peter A.Humphrey Holger Moch Antonio L.Cubilla Thomas M.Ulbright Victor E.Reuter 张繁(译) 江宗睿(译) 王焕军(校) | 2018 | 影像诊断与介入放射学2018，27，2： | 62 |
| 2 | 使用cDNA微阵列和组织微阵列对三种上皮性卵巢肿瘤基因表达的分析显示文摘背景与目的卵巢癌是在妇科恶性肿瘤中死亡率最高的肿瘤,主要原因是由于缺乏有效的早期诊断方法。为了发现新的、特异性癌基因和进一步探索上皮性卵巢癌的临床意义,本文探索出一种新方法,通过结合cDNA微阵列和RNA原位杂交冰冻组织微阵列的方法寻找特异性卵巢癌基因。方法利用cDNA微阵列筛选在3种不同卵巢癌中(卵巢浆液性交界性肿瘤、卵巢浆液性腺癌和卵巢子宫内膜样腺癌)显示有意义表达的基因,并由RNA原位杂交冰冻组织微阵列证实其结果。结果40个基因和ESTs显示出在卵巢浆液性交界性肿瘤、浆液性和子宫内膜样卵巢癌3种类型之间基因表达有明显的差异;EPHB6、PTPRF、GFER、ERG25、PLRP1,FLJ22060和WISP2被进一步用于RNA原位杂交冰冻组织微阵列研究,其结果与cDNA微阵列研究结果相符合。结论cDNA微阵列和RNA原位杂交冰冻组织微阵列相结合是一种理想的寻找癌相关基因的方法,EPHB6,PTPRF,GFER,ERG25,PLRP1,FLJ22060和WISP2有可能成为新的上皮性卵巢癌候选基因。 | 郑敏 Simon R Kononen J Sauter G Mihatsch MJ Moch H | 2004 | 癌症2004，23，7： | 8 |
| 3 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 4 | QSPR study about sampling rates of semipermeable membrane devices for monitoring of organochlorine pesticides in Alps air显示文摘Organochlorine pesticides (OCP) were monitored at the Weissfluhjoch site (Switzerland) and the top of Mt. Sonnblick (Austria) with a low volume active air sampler and semipermeable membrane devices (SPMD). The air sampling rates (Rair) of the SPMD for OCP were calculated. Statistical tests showed that there was no significant difference between Rair at the two different sampling sites. Quantitative structure-property relationship (QSPR) models of the Rair of the SPMD were developed for OCP using partial least square (PLS) regression. Quantum chemical descriptors computed by the semi-empirical PM6 method were used as predictor variables. The cumulative variance of the dependent variable explained by the PLS components and determined by cross-validation (Q2cum) was >0.818 for each optimal model. This indicates that the model has good predictive ability and robustness. The Rair of the SPMD for OCP is related to the total energy, the van der Waals area and the total dipole moment of the OCP molecules. The main factors governing Rair values of OCP are intermolecular interactions and the energy required for cavity-formation in dissolution of OCP into triolein of the SPMD. The linear correlation coefficient between predicted and experimental values were all >0.921. | ZHU XiuHua DING GuangHui LEVY Walkiria JAKOBI Gert OFFENTHALER Ivo MOCHE Wolfang WEISS Peter SCHRAMM Karl-Werner | 2011 | Chinese Science Bulletin2011，56，18： | 5 |
| 5 | 2016年WHO泌尿系统和男性生殖器官肿瘤分类--第一部分:肾、阴茎和睾丸肿瘤显示文摘2015年于瑞士苏黎世召开的WHO共识会议上确定通过后,2016年发布的第四版世界卫生组织(World Health Organization,WHO)泌尿生殖系统肿瘤分类('蓝皮书')(图1)进行了重要修订。本综述总结了新版分类与之前版本在肾、阴茎和睾丸肿瘤方面的主要差异。最新确定的肾上皮性肿瘤包括遗传性平滑肌瘤病和肾细胞癌综合征相关性肾细胞癌(hereditary leiomyomatosis and renal cell carcinoma syndrome-associated RCC,HLRCC-associated RCC)、琥珀酸脱氢酶缺陷型肾细胞癌(succinate dehydrogenase-deficient RCC,SDH-deficient RCC)、管状囊性肾细胞癌、获得性囊性疾病相关性肾细胞癌(acquired cystic disease-associated RCC)和透明细胞乳头状肾细胞癌(clear cell papillary RCC)。蓝皮书推荐WHO/国际泌尿病理学会肾肿瘤分级系统供临床采用,并修改了肾乳头状腺瘤的定义。基于人乳头状瘤病毒的合并感染情况,WHO对阴茎鳞状细胞癌重新分类,确定了相应的组织学亚型。对于侵袭性生殖细胞肿瘤的前驱病变,WHO推荐使用睾丸原位生殖细胞瘤(germ cell neoplasia in situ,GCNIS)作为规范术语,并将睾丸生殖细胞肿瘤分为完全不同的两类:源自GCNIS的睾丸生殖细胞肿瘤和与CNIS无关的睾丸生殖细胞肿瘤。在2016年WHO分类中,精母细胞性精原细胞瘤(spermatocytic seminoma)被认定为精母细胞性肿瘤,并隶属于非GCNIS相关性肿瘤。 | holger moch antonio l.cubilla peter a.humphrey victor e.reuter thomas m.ulbright 彭洋(译) 关键(校) | 2018 | 影像诊断与介入放射学2018，27，1： | 3 |
| 6 | Computed Tomography Perfusion Imaging of Renal Cell Carcinoma: Systematic Comparison With Histopathological Angiogenic and Prognostic Markers显示文摘 | Caecilia S. Reiner Matthias Roessle Thore Thiesler Daniel Eberli Ernst Klotz Thomas Frauenfelder Tullio Sulser Holger Moch Hatem Alkadhi | 2013 | Investigative Radiology2013，，4： | 2 |
| 7 | 使用组织微阵列对浸润性膀胱癌癌基因的研究显示文摘目的:比较基因杂交(CGH)研究发现染色体5p扩增与膀胱癌的发展有关;TRIO基因位于扩增区,其编码的蛋白在细胞周期调节中起主导作用。本研究在于了解TRIO的扩增和表达是否与膀胱癌的发展有关。方法:荧光原位杂交(FISH)、RNA原位杂交、NorthernBlot分析。结果:微小组织微阵列(TMA)FISH显示:12/14例膀胱癌组织显示TRIO扩增;含有1636例膀胱癌的组织微阵列FISH研究发现TRIO扩增与肿瘤浸润表现型、低分化密切相关。TRIO扩增仅见于1.5%早期膀胱肿瘤(pTaG1/G2)(7/456例),而在膀胱癌(pT1~4)高达12.8%(62/485例)。RNA原位杂交和NorthernBlot法证实TRIO在膀胱癌组织高表达。结论:TRIO扩增和高表达常发生在浸润性生长膀胱癌(pT1~4),可能在膀胱癌的发展过程中发挥重要作用。 | 郑敏 Moch Holger | 2007 | 中国肿瘤临床2007，34，1： | 2 |
| 8 | Liver resection for hepatocellular carcinoma in patients without cirrhosis显示文摘 | A. Thelen C. Benckert H.‐M. Tautenhahn H.‐M. Hau M. Bartels J. Linnemann J. Bertolini M. Moche C. Wittekind S. Jonas | 2012 | Br J Surg2012，，1： | 2 |
| 9 | Segmental intrahepatic cholestasis as a technical complication of the transjugular intrahepatic porto-systemic shunt显示文摘BACKGROUND Segmental intrahepatic cholestasis caused by transjugular intrahepatic portosystemic shunt(TIPS)(SIC-T),is a rare complication of this technique and only referred by case reports.Thus,we conducted a systematic,retrospective analysis to provide evidence regarding prevalence and consequences of this TIPS-induced bile duct compression.AIM To assess prevalence and outcome of SIC-T in a large TIPS-cohort.METHODS In this retrospective cohort study,we screened the institutional databases for all consecutive patients that were treated by TIPS-placement or TIPS-revision between January 2005 and August 2013.We analyzed radiologic images for signs of biliary congestion.Cases that were indicative of SIC-T were reviewed by two independent radiologists and additional patient data was collected.Descriptive statistics of patient demographics,indications for TIPS and procedural details were registered.Logistic regression analysis was performed to identify predictors for the development of SIC-T.RESULTS We analyzed 135 cirrhotic patients who underwent TIPS(mean age 55 years,79%male gender).Etiology of cirrhosis was alcohol in most cases and indications for TIPS were mainly refractory ascites and recurrent variceal bleeding.TIPS revision was necessary in 31 patients.We identified 4 cases(2.9%)of SIC-T in direct proximity of the TIPS-stent.Diagnosis was confirmed by CT-scan,MRI or endoscopic retrograde cholangio pancreaticography(ERCP).In two patients TIPS was implanted via the right and in one through the medial hepatic vein.One patient received TIPS-prolongation by multiple revisions.Most patients were asymptomatic but one cholangitic abscess necessitated a transhepatic drain.Logistic regression analysis identified TIPS-placement other than from medial hepatic vein to right portal vein as risk factor(OR 21.0)for SIC-T.CONCLUSION SIC-T ads to(mostly late)complications in the interventional treatment of cirrhotic portal hypertensions and can lead to cholangitic abscesses.Patients,particularly with multiple interventions,should be screened for SIC-T. | Julian Nikolaus Bucher Marcus Hollenbach Steffen Strocka Gereon Gaebelein Michael Moche Thorsten Kaiser Michael Bartels Albrecht Hoffmeister | 2019 | World Journal of Gastroenterology2019，25，43： | 2 |
| 10 | Heavy metal extractable forms in sludge from wastewater treatment plants显示文摘 | E.Alonso álvarez M.Callejón Mochón J.C.Jiménez Sánchez M.Ternero Rodr??guez | 2002 | Chemosphere2002，，7： | 2 |
| 11 | Meningiomas involving the optic nerve:technical aspects and outcomes for a series of 50 patients显示文摘 | Margalit NS Lesser JB Moche J | 2003 | Neurosurgery2003，53，3： | 1 |
| 12 | Heavy metal extractable forms in sludge from wastewater treatment plants显示文摘 | E.Alonso álvarez M.Callejón Mochón J.C.Jiménez Sánchez M.Ternero Rodr??guez | 2002 | Chemosphere2002，，7： | 1 |
| 13 | Innovation and information technology in services显示文摘 | Licht G Moch D | 1999 | The Canadian Journal of Economics/Revue canadienned''Economique1999，32，2： | 1 |
| 14 | Surgical management of nasal obstruction显示文摘 | Moche JA Palmer O | 2012 | Oral Maxillofac Surg Clin North Am2012，24，2： | 1 |
| 15 | Highthroughput tissue microarray analysis to evaluate genes uncovered by cDNA microarray screening in renal cell carcinoma显示文摘 | Moch H Schraml P Bubendorf L | 1999 | Am J Pathol1999，154，4： | 1 |
| 16 | An overview of renal cell cancer: Pathology and genetics 显示文摘 | Moch H | 2013 | Semin Cancer Bial2013，23，1： | 1 |
| 17 | Predictors of prescrip- tion errors involving anticancer chemotherapy agents显示文摘 | Ranchon F Moch C You B | 2012 | EurJCancer2012，48，8： | 1 |
| 18 | Tissue microar rays: what will they bring to molecular and anatomic pathology 显示文摘 | Moch H Kononen T Kallioniemi O P | 2001 | AdvAnat Pathol2001，8，1： | 1 |
| 19 | Periostin expression and pithelial- mesenchymal transition in cancer: a review and an update 显示文摘 | Laura Morra & Holger Moch | 2011 | Virch-ows Arch2011，459，： | 1 |
| 20 | Sarcomatoid differentiation in renal cell carcinoma显示文摘 | PARALTA-VENTURINA M MOCH H AMIN M | 2001 | Am J Surg Pathol2001，25，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员