|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing显示文摘前列腺癌症是全球癌症相关的死亡的一个领先的原因,但是试图改善诊断并且开发新奇治疗被重要耐心的异质惊讶。在最近的年里,到几百个前列腺瘤的下一代的定序的应用程序定义新奇分子的子类型并且描绘了位于疾病开始和前进下面的广泛的 genomic 错误。在诊所观察的异质是由与复杂性流行的一处分子的风景的 underpinned,现在是清楚的,在 genomic 重新整理和稀罕变化联合放大 transcriptomic 差异的地方。这评论把我们前列腺癌症 ‘ 的当前的理解; omic 的包括拷贝数字变化的哨兵角色, oncogenic 熔化基因, chromothripsis 的潜在的影响,和在定义联系变化的子类型的突破的成长光谱。增加的证据建议损害经常在特定的细胞的功能和发信号的小径上集成的那 genomic,还周期性的基因错误显得稀罕。因此,我们继续定义单个瘤染色体,是批评的,特别在他们的表示 transcriptome 的上下文。仅仅通过到瘤可变性罐头的瘤的改进描述,我们前进到精确治疗和个性化的肿瘤学的年龄。 | Alexander W Wyatt Fan Mo Yuzhuo Wang Colin C Collins | 2013 | Asian Journal of Andrology2013，15，3： | 5 |
| 3 | Biosynthesis of Unsaturated Fatty Acids via Mortierella Isabellina Cultivated in a Medium Containing Butanol显示文摘Mortierella isabellina was found to accumulate large amounts of unsaturated fatty acids when it was grown in a medium containing butanol(5 g/L) and yeast extract(10 g/L) and cultivated at 25 ℃ for 5 d during which additional feeding butanol of 2 g/L was fed after being cultivated for 48 h . The resultant mycelial lipids accounted for 40 1% of the dry mycelia, while about 34% of butanol in the medium was converted. The mycelial lipids contained four kinds of unsaturated fatty acids, i.e ., palmitoleic(4 9%), oleic(54 1%), linoleic(10 4%) and linolenic(5 4%) acids. Those accounted for 74 8% of the total fatty acids. The effects of the culture conditions, such as cultivation temperature, initial pH of the medium and additional feeding butanol in the course of cultivation, on the production of mycelial lipids by M. isabellina were studied. | XIAN Mo 1, YAN Ji chang 2, CHENG Tie xin 1, KANG Yi jian 3, LI Wen xing 1, BI Ying li 1 and ZHEN Kai ji 1** 1. College of Chemistry, Jilin University, Changchun 130023, P. R. China 2. College of Chemistry, Northeast Normal University, C | 2002 | Chemical Research in Chinese Universities2002，18，3： | 3 |
| 4 | Intra-growth retardation and postnatal growth failure associated deletion of the insulin-like growth factor I gene 显示文摘 | Woods KA Camacho-Hubner C Savage MO | 1996 | A Engl J1996，335，： | 2 |
| 5 | Combining mapping and citation analysis for evaluative bibliometric purposes:A bibliometric study 显示文摘 | Noyons E C M Moed H F Luwel M | 1999 | Journal of the American Society for Information Science1999，50，2： | 1 |
| 6 | Petri net modeling and design of task oriented messaging system for robot control显示文摘 | Mo John P T Tang Bryan C K | 1998 | Computers & Industrial Engineering1998，34，4： | 1 |
| 7 | Suppression of allergic response by CpG motif oligodeoxynucleotide-house-dust mite conjugate in animal model of allergic rhinitis显示文摘 | Mo J H Park S W Rhee C S | 2006 | Am J Rhinol2006，20，2： | 1 |
| 8 | Biochemical complementation of chalcone synthase mutants defines a role for flavonols in functional pollen显示文摘 | Mo Y Nagel C Taylor L P | 1992 | Proceedings of the National Academy of Sciences1992，89，15： | 1 |
| 9 | Prog- nostic significance of aberrantly silenced ANPEP expres- sion in prostate cancer显示文摘 | SCrensen KD Abildgaard MO Haldrup C | 2013 | Br J Cancer2013，108，2： | 1 |
| 10 | Zircon U-Pb dating and in-si- tu Hf isotopic analysis of Permian peraluminous granite in the Lha- sa terrane, southern Tibet: Implications for Permian collisional orogeny and paleogeography显示文摘 | Zhu D C Mo X X Niu Y L | 2009 | Tectonophysics2009，469，14： | 1 |
| 11 | Environmental and economic costs of soil erosion and conservation benefits显示文摘 | Pim entel D Harvey C Resos udar mo P | 1995 | Science1995，267，： | 1 |
| 12 | 显示文摘 | Cai W L Mo C M | 1999 | Appl Phys Lett1999，74，20： | 1 |
| 13 | Integrating research performance analysis and science mapping 显示文摘 | Noyons E C M Moed H F Van Raan A F J | 1999 | Scientometfics1999，46，3： | 1 |
| 14 | The effect of attached fragments on dense layer of electroless Ni/P deposition on the electromagnetic interference shielding effectiveness of carbon fibre/aerylonitrile-butadiene-styrene composites显示文摘 | Huang C Y Mo W W | 2002 | Surface and Coatings Technology2002，154，1： | 1 |
| 15 | Calcium pectinate capsules for colon-specific drug delivery显示文摘 | Xu C Zhang JS Mo Y | 2005 | Drug Dev Ind Pharm2005，31，2： | 1 |
| 16 | Biological marker compounds as indicators of depositional history of the Maoming oil shale显示文摘 | Brassell S C Eglinton G Mo F J | 1986 | Organic Geochemistry1986，10，： | 1 |
| 17 | A double-blind randomized control study to determine the effect of VisthesiaTM viscoelastic substance on pain following LASEK显示文摘 | Kirwan C Mulqueen C Keefe MO | 2008 | Ophthalmologica2008，222，： | 1 |
| 18 | Relationship between socio-demographic and anthropometric variables and number of erupted primary teeth in suburban Nigerian children显示文摘 | Oziegbe EO Adekoya-Sofowora C Folayan MO | | 0，，01： | 1 |
| 19 | Thermal conductivity enhancement with different fillers for epoxy resin adhesives显示文摘 | Fu Y X He Z Xn Mo D C | 2014 | Applied Thermal Engineering2014，66，12： | 1 |
| 20 | Skeletal and dental changes with fixed slow maxillary expansion treatment: a system- atic review 显示文摘 | Lagravere MO Major PW Flores-Mir C | 2005 | J Am Dent Assoe2005，136，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员