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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Zircon U-Pb dating and in-si- tu Hf isotopic analysis of Permian peraluminous granite in the Lha- sa terrane, southern Tibet: Implications for Permian collisional orogeny and paleogeography显示文摘 | Zhu D C Mo X X Niu Y L | 2009 | Tectonophysics2009，469，14： | 1 |
| 3 | Environmental and economic costs of soil erosion and conservation benefits显示文摘 | Pim entel D Harvey C Resos udar mo P | 1995 | Science1995，267，： | 1 |
| 4 | Thermal conductivity enhancement with different fillers for epoxy resin adhesives显示文摘 | Fu Y X He Z Xn Mo D C | 2014 | Applied Thermal Engineering2014，66，12： | 1 |
| 5 | 显示文摘 | Zhang L D Mo C M | 1995 | Nanostructured Materials1995，6，58： | 1 |
| 6 | Geochemical investigation of Early Cretaceous igneous rocks along an east-west traverse throughout the central Lhasa Terrane, Tibet显示文摘 | Zhu D C Mo X X Niu Y L Zhao Z D Wang L Q Liu Y S Wu F Y | 2009 | Chem Geol2009，268，34： | 1 |
| 7 | The Lhasa Terrane: Record of a microcontinent and its histories of drift and growth显示文摘 | Zhu D C Zhao Z D Niu Y L Mo X X Chung S-L Hou Z Q Wang L Q Wu F Y | 2011 | Earth Planet Sci Lett2011，301，12： | 1 |
| 8 | Phase II study of pegylated liposomal doxorubicin and oxaliplatin in relapsed advanced ovarian cancer显示文摘 | Nicoletto MO Falci C Pianalto D | 2006 | Gynecol Oncol2006，100，2： | 1 |
| 9 | Lipopolysaecha- ride-induced miR-1224 negatively regulates turnout necrosis fac- tor-alpha gene expression by modulating Spl 显示文摘 | Niu Y Mo D Qin L Wang C Li A Zhao X | 2011 | Immunology2011，，： | 1 |
| 10 | Presence of Permian exten- sion and arc- type magmatism in southern Tibet:PaIeogeographic implications显示文摘 | Zhu D C Mo X X Zhao Z D | 2010 | GSA Bulletin2010，，： | 1 |
| 11 | Petrogenesis of volcanic rocks in the Sangxiu Formation,central segment of Tethyan Himalaya:A probable example of plume-lithosphere interaction显示文摘 | ZHU D C PAN G T MO X X | 2007 | Journal of Asian Earth Sciences2007，29，23： | 1 |
| 12 | Nickel-catalyzed propylene dimerization in organochloroaluminate ionic liq uids: control of the isomerization reaction显示文摘 | SOUZA R F D LEAL B C MO D S | 2007 | J Mol Catal A: Chem2007，272，12： | 1 |
| 13 | gProximity: hierarchical GPU -basedoperations for collision and distance queries 显示文摘 | Lauterbach C Mo Q Manocha D | 2010 | Computer GraphicsForum2010，29，2： | 1 |
| 14 | The 132 Ma ComeiBunbury large igneous province:Remnants identified in presentday southeastern Tibet and southwestern Australia显示文摘 | ZHU D C CHUNG S L MO X X | 2009 | Geology2009，37，7： | 1 |
| 15 | Preparation of β-SiC nanorods with and without amporphous SiO2 wrapping layers 显示文摘 | Meng G W Zhang L D Mo C M | 1998 | J Mater Res1998，13，9： | 1 |
| 16 | Ophthalmologic signs in children with autism 显示文摘 | Denis D Burillon C Livet MO | 1997 | J Fr Ophtalmol1997，20，2： | 1 |
| 17 | The NCEP/NCAR 40-yeax reanalysis project 显示文摘 | E Kalnay M Kanamitsu R Kistler WCollins D Deaven L Gandin M Iredell S Saha G White J Woollen Y Zhu M Chelliah W Ebisuzaki W Higgins J Janowiak KC Mo C Ropelewski J Wang A Leetmaa R Reynolds R Jenne D Joseph | 1996 | Bulletin of the American Meteorological Society (S0003-0007)1996，77，3： | 1 |
| 18 | Scaffold development using 3D printing with a starch-based polymer 显示文摘 | LAM C X F MO X M TEOH S H HUTMACHER D W | 2002 | Mater Sci Eng C2002，20，12： | 1 |
| 19 | Preparation of β - SiC nanorods with and without amorphous Si02 wrapping layers显示文摘 | Meng G W Zhang L D Mo C M | 1998 | J Mater Res1998，13，9： | 1 |
| 20 | Expression of cancer/testis(CT)antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters显示文摘 | Peng J R Chen H S Mo D C | 2005 | Cancer Lett2005，219，2： | 1 |
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