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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Genistein induces G2/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells 显示文摘 | Li Z Li J Mo B | 2008 | Cell Biol Toxicol2008，24，5： | 1 |
| 3 | Cyclohexylene-bridged porphyrin quinones with variable acceptor strength as biomimetic models for photosynthesis: Evidence for twist-boat conformation 显示文摘 | DIEKS H SENGE MO KIRSTE B | 1997 | J Org Chem1997，62，25： | 1 |
| 4 | Computed tomographic assessment of fractures of the posterior wall of the acetabulum after operative treatment显示文摘 | Moed B R Willson Carr S E Gruson K I | 2007 | J Bone Joint Surg Am2007，85，3： | 1 |
| 5 | Complete nucleotide sequence and genome organization of a chinese isolate of tobacco vein distorting virus 显示文摘 | MO X H CHEN Z B CHEN J P | 2010 | Virus Genes2010，41，3： | 1 |
| 6 | Complete genome se- quences of two Chinese virulent avian coronavirus infec- tious bronchitis virus variants 显示文摘 | Mo M Huang B Wei P | 2012 | J Virol2012，86，10： | 1 |
| 7 | Profiles of pro-inflammatory cytokines in the serum of rabbits after experimentally induced acute pancreatitis显示文摘 | Osman MO Gesser B Mortensen JT | 2002 | Cytokine2002，17，1： | 1 |
| 8 | Down-regulation of the expression of rat inhibitor-of-apoptosis protein-1 and -3 during transforming growth factor-betal-mediated apoptosis in rat brain microglia显示文摘 | Jung B Kim MO Yun SJ | 2003 | Neuroreport2003，14，6： | 1 |
| 9 | Volatile isoprenoid constituents of fruits, vegetables and herbs cumulatively suppress the proliferation of murine B16 melanoma and human HL-60 leukemia cells显示文摘 | Tatman D Mo H B | 2002 | Cancer Lett2002，175，2： | 1 |
| 10 | Research on High Performance Concrete-Filled Steel Tube Columns Structure Experiments for Guangzhou Xita Project 显示文摘 | Yang Y B Liang S Mo H H | 2009 | Key Engineering Materials2009，，405406： | 1 |
| 11 | Bladder perfora- tion related to intrauterine device 显示文摘 | Istanbulluoglu MO Ozcimen EE Ozturk B | 2008 | J Chin Med Assoc2008，71，4： | 1 |
| 12 | Pilon fractures:treatment protocol based on severity of soft tissue injury显示文摘 | Watson J T Moed B R Karges D E | 2000 | Clin Orthop Relat Res2000，375，6： | 1 |
| 13 | The effect of different blood components on exchange transfusion outcomes显示文摘 | Ghaemi S Saneian H Mo’ayedi B | 2012 | J Pak Med Assoc2012，62，32： | 1 |
| 14 | Application of particle image ve- locimetry for the measurement of the airflow characteristics in an aircraft cabin 显示文摘 | Mo H Hosni M Jones B | 2003 | ASHRAE Transactions2003，109，2： | 1 |
| 15 | Numerical simulationof the NOx emissions in a 1,000,MW tangentially firedpulverized-coal boiler:Influence of the multi-group arrangementof the separated over fire air 显示文摘 | Zhou H Mo G Y Si D B | 2011 | Energy &Fuels2011，25，5： | 1 |
| 16 | Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition显示文摘 | LI H B YANG Y R MO Z J | 2015 | Braz J Med Biol Res2015，48，5： | 1 |
| 17 | Profiles of proinflammatory cytokines in the serum of rabbits after experimentally induced acute pancreatitis显示文摘 | Osman MO Gesser B Mortensen J T | 2002 | Cytokine2002，17，1： | 1 |
| 18 | Late salvage of failed open reduction and internal fixation of posterior wall fractures of the acetabulum显示文摘 | Dean D B Moed B R | 2009 | J Orthop Trauma2009，23，3： | 1 |
| 19 | Profiles of proinflammatory cytokines in the serum of rabbits after experimentally induced acute pancreatitis显示文摘 | Osman MO Gesser B Mortensen JT | 2002 | Cytokine2002，6，3： | 1 |
| 20 | The in vivo and in vitro effects of chicken interferon on infectious bursal disease virus and New castle disease virus infection 显示文摘 | Mo C W Cao Y C Lim B L | 2001 | Avian Diseases2001，5，： | 1 |
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