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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 3 | Simulation of moving boundary of the reaction shaft in a flash smelting furnace显示文摘As to solve the online monitoring of the inner temperatur e and freezing profile of the reaction shaft of flash smelting furnace, simulation of the wall in the reaction shaft in a flash smelting furnace was made through numerical computation. The computational results are very near the data got in s ite. The error of the moving boundary is approximately 3%, and that of the tempe rature is less than 5%. It is proved that the simulation software is applicable for practice to monitor the temperature and moving boundary inside the hearth on line. Based on a large number of the data computed, the relation between the cha nge of the moving boundary and inner temperature is summarized, and the great in fluence of the cooling system on the forming and stability of the moving boundar y inside the hearth is emphasized, which provide the theoretical bases for optim izing the flash smelting operation. | CHEN Zhuo 1,MEI Chi 1,CHEN Hong-rong 1,MO Jiao 2 (1 Institute on Simulation and Optimization of Pyro-installation, Central Sout h University, Changsha 410083, China 2 Science School, Beijing University of Posts and Telecommunications, Beijing 1 | 2001 | Journal of Central South University2001，13，3： | 3 |
| 4 | Atomic bonding of precipitate and phase transformation of Al-Cu-Mg alloy 显示文摘 | CAO Y J HOU X H MO Q F | 2007 | J Alloys Compd2007，441，： | 1 |
| 5 | Cyclohexylene-bridged porphyrin quinones with variable acceptor strength as biomimetic models for photosynthesis: Evidence for twist-boat conformation 显示文摘 | DIEKS H SENGE MO KIRSTE B | 1997 | J Org Chem1997，62，25： | 1 |
| 6 | Prediction of crop yield, water consumption and water use efficiency with a SVAT-crop growth model using remotely sensed data on the North China Plain显示文摘 | Mo X G Liu S X Lin Z H | 2005 | Ecological Modelling2005，183，： | 1 |
| 7 | Study on multiplestep incremental air-bending forming of sheet metal with springback model and FEM simulation显示文摘 | Fu Z M Mo J H Zhang W X | 2009 | International Journal of Advanced Manufacturing Technology2009，45，： | 1 |
| 8 | Combining mapping and citation analysis for evaluative bibliometric purposes:A bibliometric study 显示文摘 | Noyons E C M Moed H F Luwel M | 1999 | Journal of the American Society for Information Science1999，50，2： | 1 |
| 9 | Utilization of a metabolic un- coupler,3 ,3' ,4' ,5-tetrachlorosalicylanilide (TCS) to re- duce sludge growth in activated sludge culture 显示文摘 | Chen G H Mo H K Liu Y | 2002 | Water Res2002，36，8： | 1 |
| 10 | Complete nucleotide sequence and genome organization of a chinese isolate of tobacco vein distorting virus 显示文摘 | MO X H CHEN Z B CHEN J P | 2010 | Virus Genes2010，41，3： | 1 |
| 11 | High growth of SWNTs and MWNTs from C2H2 decomposition over Co-Mo/MgO catalysts显示文摘 | SHAJIHAN M MO Y H FAZLE KIBRIA A K M | 2004 | Carbon2004，42，： | 1 |
| 12 | Suppression of allergic response by CpG motif oligodeoxynucleotide-house-dust mite conjugate in animal model of allergic rhinitis显示文摘 | Mo J H Park S W Rhee C S | 2006 | Am J Rhinol2006，20，2： | 1 |
| 13 | Spatiotemporal evolution of China's railway network in the 20th century=An accessibility approach显示文摘 | WANG J E JINA F J MO H H | 2009 | Transportation Research Part A2009，，43： | 1 |
| 14 | Sliding Tribological Behavior of A1CrNCoating显示文摘 | Mo J L Zhu M H | 2008 | Tribology International2008，41，12： | 1 |
| 15 | Kimuras disease:the CT and MRI characteristics in fifteen cases显示文摘 | Zhang R Ban X H Mo Y X | 2011 | Eur J Radioi2011，80，2： | 1 |
| 16 | Effect of mineral composition on macroscopic and microscopic consolidation properties of soft soil 显示文摘 | Wang ] Mo H H | 2014 | Soil Mechanics and Foundation Engineering2014，50，6： | 1 |
| 17 | Statistical Relationships Between Downloads and Ci- tations at the Level of Individual Documents Within a Single Journal显示文摘 | Moed H F | 2005 | Journal of the American Society for Information Sci- ence and Technology2005，56，10： | 1 |
| 18 | An evaluation of the condylar position of the temporomandibular joint by computerized tomography in Class Ⅲ malocclusions: A preliminary study 显示文摘 | Seren E Akan H Toiler MO | 1994 | Am J Orthod Dentofacial Orthop1994，105，5： | 1 |
| 19 | A novel mutation of -73(A - - > T) in the CCAAT box of the beta - globin gene identified in a patient with the mild beta -thalassemia intermedia显示文摘 | CHEN X W MO Q H LI Q | 2007 | Ann Hematol2007，86，： | 1 |
| 20 | Simulating temporal and spatial variation of evapotranspiration over the Lushi basin 显示文摘 | Mo X G Liu S X Lin Z H | 2004 | Journal of Hydrology2004，285，： | 1 |
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