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| 1 | MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells显示文摘 | Godlewski J Nowicki MO Bronisz A Nuovo G Palatini J De Lay M Van Brocklyn J Ostrowskl MC Chlocca EA Lawler SE. | 2010 | 中国神经肿瘤杂志2010，8，1： | 37 |
| 2 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 3 | The Late Mesozoic Orogenic Processes of Mongolia-Okhotsk Orogen: Evidence from Field Investigations into Deformation of the Mohe Area, NE China显示文摘Based on field investigation in 1999, two deformational domains with d ifferent dynamics have been distinguished from the Jurassic geological outcrops in the Mohe area of NE China, i.e. northern ductile and southern plastic-brittl e ones. Their deformational features are stated in this paper. And then, three st ages of structural deformation of the area relative to the late Mesozoic orogeni c processes of Mongolian-Okhotsk orogen are reconstructed as follows, (1) south w ards thrusting in the middle-late Jurassic, (2) eastwards thrusting and strike -s lipping parallel to the orogen in the late Jurassic, and (3) southeastwards thru sting in the early Cretaceous. | Li Jinyi, He Zhengjun, Mo Shenguo and (Institute of Geology, CAGS, Beijing 100037, China) Zheng Qingdao (Heilongjiang Bureau of Exploration and Exploitation of Geology and M ineral Resources, Ha’erbin 150036, China) | 1999 | Global Geology1999，4，2： | 26 |
| 4 | Juvenile ferric iron prevents microbiota dysbiosis and colitis in adult rodents显示文摘AIM: To assess whether juvenile chronic ferric iron ingestion limit colitis and dysbiosis at adulthood in rats and mice. METHODS: Two sets of experiments were designed. In the first set, recently weaned mice were either orally administered ferrous (Fe2+) iron salt or ferric (Fe3+) microencapsulated iron for 6 wk. The last week of experiments trinitrobenzene sulfonic acid (TNBS) colitis was induced. In the second set, juvenile rats received the microencapsulated ferric iron for 6 wk and were also submitted to TNBS colitis during the last week of experiments. In both sets of experiments, animals were sacrificed 7 d after TNBS instillation. Severity of the inflammation was assessed by scoring macroscopic lesions and quantifying colonic myeloperoxidase (MPO) activity. Alteration of the microflora profile was estimated usingquantitative polymerase chain reaction (qPCR) by measuring the evolution of total caecal microflora, Bacteroidetes, Firmicutes and enterobacteria. RESULTS: Neither ferrous nor ferric iron daily exposures at the juvenile period result in any effect in control animals at adulthood although ferrous iron repeated administration in infancy limited weight gain. Ferrous iron was unable to limit the experimental colitis (1.71 ± 0.27 MPO U/mg proteinvs 2.47 ± 0.22 MPO U/mg protein in colitic mice). In contrast, ferric iron significantly prevented the increase of MPO activity (1.64 ± 0.14 MPO U/mg protein) in TNBS-induced colitis. Moreover, this positive effect was observed at both the doses of ferric iron used (75 and 150 mg/kg per day po - 6 wk). In the study we also compared, in both rats and mice, the consequences of chronic repeated low level exposure to ferric iron (75 mg/kg per day po - 6 wk) on TNBS-induced colitis and its related dysbiosis. We confirmed that ferric iron limited the TNBS-induced increase of MPO activity in both the rodent species. Furthermore, we assessed the ferric iron incidence on TNBS-induced intestinal microbiota dysbiosis. At first, we needed to optimize the isolation and quantify DNA copy numbers using standard curves to perform by qPCR this interspecies comparison. Using this approach, we determined that total microflora was similar in control rats and mice and was mainly composed of Firmicutes and Bacteroidetes at a ratio of 10/1. Ferric juvenile administration did not modify the microflora profile in control animals. Total microflora numbers remained unchanged whichever experimental conditions studied. Following TNBS-induced colitis, the Firmicutes/Bacteroidetes ratio was altered resulting in a decrease of the Firmicutes numbers and an increase of the Bacteroidetes numbers typical of a gut inflammatory reaction. In parallel, the subdominant population, the enterobacteria was also increased. However, ferric iron supplementation for the juvenile period prevented the increase of Bacteroidetes and of enterobacteria numbers consecutive to the colitis in both the studied species at adulthood.CONCLUSION: Rats and mice juvenile chronic ferric iron ingestion prevents colitis and dysbiosis at adulthood as assessed by the first interspecies comparison. | Chourouk Ettreiki Pascale Gadonna-Widehem Irène Mangin Mose Coёffier Carine Delayre-Orthez Pauline M Anton | 2012 | World Journal of Gastroenterology2012，18，21： | 3 |
| 5 | Ubiquitin-dependent virus particle budding without viral protein ubiquitination显示文摘 | Zhadina M McClure MO Johnson MC Bieniasz PD | 2007 | Proc Natl Acad Sci USA2007，104，20： | 1 |
| 6 | 显示文摘 | Rajanayagam M Agostini RJD | 1999 | Endoerinology1999，140，12： | 1 |
| 7 | Study on multiplestep incremental air-bending forming of sheet metal with springback model and FEM simulation显示文摘 | Fu Z M Mo J H Zhang W X | 2009 | International Journal of Advanced Manufacturing Technology2009，45，： | 1 |
| 8 | Combining mapping and citation analysis for evaluative bibliometric purposes:A bibliometric study 显示文摘 | Noyons E C M Moed H F Luwel M | 1999 | Journal of the American Society for Information Science1999，50，2： | 1 |
| 9 | Nitrogen availability in disturbed,rehabilitated and mature forests of tropical China显示文摘 | MO J M BROWN S PENG S L | 2003 | Forest Ecology and Management2003，175，3： | 1 |
| 10 | High growth of SWNTs and MWNTs from C2H2 decomposition over Co-Mo/MgO catalysts显示文摘 | SHAJIHAN M MO Y H FAZLE KIBRIA A K M | 2004 | Carbon2004，42，： | 1 |
| 11 | Macrolide antibiotics as immu-nomodulatory medications: proposed mechanisms of action 显示文摘 | Shinkai M Henke MO Rubin BK | 2008 | Pharmacol Ther2008，117，： | 1 |
| 12 | Complete genome se- quences of two Chinese virulent avian coronavirus infec- tious bronchitis virus variants 显示文摘 | Mo M Huang B Wei P | 2012 | J Virol2012，86，10： | 1 |
| 13 | MicroRNA - 145 suppresses cell invasion and metastasis by directly targeting mucin 1 显示文摘 | Sachdeva M Mo YY | 2010 | Cancer Res2010，70，： | 1 |
| 14 | Quasimonoenergetic electron beams from laser wakefield acceleration in pure nitrogen显示文摘 | Mo M Z All A Fourmaux S | 2012 | Appl Phys Lett2012，104，07： | 1 |
| 15 | Sliding Tribological Behavior of A1CrNCoating显示文摘 | Mo J L Zhu M H | 2008 | Tribology International2008，41，12： | 1 |
| 16 | The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelio- ma显示文摘 | Giroux Leprieur E Hirata T Mo M | 2014 | Lung Cancer2014，85，3： | 1 |
| 17 | Effects of three dif-ferent dose regimens of magnesium on propofol requirements,haemodynamic variables and postoperative pain relief in gynecological surgery显示文摘 | Seyhan TO Tugrul M Sungur MO | 2006 | Br J Anaesth2006，96，2： | 1 |
| 18 | 显示文摘 | Cai W L Mo C M | 1999 | Appl Phys Lett1999，74，20： | 1 |
| 19 | Integrating research performance analysis and science mapping 显示文摘 | Noyons E C M Moed H F Van Raan A F J | 1999 | Scientometfics1999，46，3： | 1 |
| 20 | Publication delays in the science field and their relationship to the aging of scientific literature显示文摘 | Luwel M Moed H F | 1998 | Scientometrics1998，41，12： | 1 |
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