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| 1 | MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells显示文摘 | Godlewski J Nowicki MO Bronisz A Nuovo G Palatini J De Lay M Van Brocklyn J Ostrowskl MC Chlocca EA Lawler SE. | 2010 | 中国神经肿瘤杂志2010，8，1： | 37 |
| 2 | Early Cretaceous extensional structures in the Liaodong Peninsula:Structural associations,geochronological constraints and regional tectonic implications显示文摘Various extensional structures,e.g.,half grabens,detachment faults,and metamorphic core complexes,were formed in the Liaodong Peninsula.There are two metamorphic core complexes (mcc's) in the western part of the Peninsula,i.e.the Liaonan mcc and the Wanfu mcc.They share the same lower plate and constitute a conjugate mcc pair.The Dayingzi detachment fault system and the three half grabens are exposed in the central and eastern parts,respectively.U-Pb dating of zircons from syntectonic plutons in the lower plates of the detachment faults and volcanic rocks from half graben basins indicates that their formation spans from 135 to 106 Ma,although the individual structure may be formed at a particular stage.Despite the differences in age of formation,in the regional attitudes,and in rooting depths,the extensional structures have great similarities in their kinematics,geometrical asymmetry,and coeval tectono-magmatic activities etc.Macroscopically,the extensional structures constitute conjugate associations,but a particular one generally has asymmetric patterns.Early Cretaceous extensional structures extend from the Liaodong Peninsula to North China,Northeast China,South China,and eastern Mongolia and Transbaikal area in Russia.The extensional structures from different areas share many common features.The Liaodong Peninsula is the miniature of the East Asia with respect to the formation of extensional structures in Early Cretaceous.It is suggested that the interaction of the Izanagi Plate with Eurasia Plate is responsible for the extension of crust.The structural mobility of the lithosphere,partly attributed to the fluid flow at the depth,and detachment faulting in both the crustal and mantle lithosphere provide important constraints on the development of Early Cretaceous extensional structures in the East Asia. | LIU JunLai JI Mo SHEN Liang GUAN HuiMei Gregory A DAVIS | 2011 | Science China Earth Sciences2011，54，6： | 38 |
| 3 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 4 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 5 | The Dayingzi detachment fault system in Liaodong Peninsula and its regional tectonic significance显示文摘Large scale lithosphere thinning is an important characteristic of the destruction of the North China Craton (NCC) during the late Mesozoic. A series of extensional structures were developed under extensional setting, among which is the Dayingzi detachment fault system (DFS). The DFS is constituted by three parts, volcano-sedimentary basins at the hanging wall, the Dayingzi-Huanghuadian detachment fault zone, and Paleoproterozoic metamorphic rock series and Mesozoic plutons at the foot-wall. In the section across the detachment fault zone, there is a sequence of tectonites including fault gouge, microbreccia, cataclastic-mylonites, mylonites, and gneissic biotite monzonite granite. Microstructural characteristics of tectonites and electron backscatter diffraction (EBSD) patterns of quartz indicate that the rocks from the footwall experienced a process from upper greenschist facies to lower greenschist facies. SHRIMP and LA-ICP MS U-Pb dating of zircons from the volcanic rocks in the basins, the tectonic evolution of the DFS is summarized as follows: 1) regional extension started at 135.0±1.2 Ma ago, when the detachment fault cut through the middle crust. Faulting induced the upwelling of magma and eruption of volcanic rocks and deformed a series of medium-acid volcanic rocks; 2) after 135.0±1.2 Ma, a large scale detachment faulting was active cross-cutting the mid-upper crust. The western margin of Jurassic and Triassic granite was ductilly and brittly sheared; besides, the Cretaceous volcano-sedimentary rocks were tilted when the master fault approached the surface; 3) at around 127±1 Ma, the detachment fault stopped its activity and was intruded by the unsheared Cretaceous granite near Chaoyang. Comparison with the Liaonan metamorphic core complex (MCC) and other extensional structures in Liaodong Peninsula led to a general trend of including three zones in the Peninsula: MCC zone, detachment fault systems (DFS) zone, and half graben zone. MCC commonly cuts through the mid-lower crust, DFS through the mid-upper crust, and half graben through the upper crust. Therefore, development of the extensional structures in Liaodong Peninsula indicates that they are the results of crustal extension and thinning at different crustal levels. They may provide a deep insight into the dynamic mechanism, history of destruction and lithosphere thinning of the North China Craton (NCC). | SHEN Liang LIU JunLai HU Ling JI Mo GUAN HuiMei Gregory A DAVIS | 2011 | Science China Earth Sciences2011，54，10： | 17 |
| 6 | Case study of ionospheric fluctuation over mid-latitude region during one large magnetic storm显示文摘From Nov. 6 to 10, 2004, a large number of solar events occurred, which triggered many solar flares and coronal mass ejections (CMEs). These CMEs caused two large geomagnetic storms and continuous energy proton events. During this period, one large positive ionospheric storm happened over the East-Asian region on Nov. 8, 2004. On Nov. 10, 2004, a strong spread-F was observed by the ionosonde located in the mid-latitude region of East China and Japan, and the ionospheric fluctuation over the ionosonde stations derived from GPS observation was also obvious. In this report, the characteristics of the spatial distribution of the ionosphere fluctuation and its temporal evolution are studied using the parameter of the rate of total electron content (ROT) derived from dual-frequency GPS measurement. Strong fluctuating activity of the ionosphere was found over the mid-latitude region in the southern and northern hemispheres between longitudes of 100°E and 180°E during the magnetic storm period on Nov. 10, 2004, and a regular movement of the disturbing region was observed. In the end, the reason of the ionospheric fluctuation during this magnetic storm is analyzed. | ZHANG DongHe MO XiaoHua A Ercha HAO YongQiang | 2012 | Science China(Technological Sciences)2012，55，5： | 10 |
| 7 | 热处理对Zn−40Al−2Cu−2Si合金力学性能和磨损性能的影响显示文摘为了研究热处理对Zn−40Al−2Cu−2Si合金力学性能和磨损性能的影响,采用不同工艺对其进行热处理,包括均匀化后空冷(H1)、均匀化后炉冷(H2)、稳定化(T5)和淬火−时效(T6和T7)。通过金相、力学实验和磨损实验,研究不同热处理工艺对该合金力学性能和摩擦学性能的影响,并于SAE 65青铜进行对比。磨损实验使用环块式实验装置。结果表明,采用H1和T6热处理可提高合金的硬度、抗拉强度和抗压强度,除T6热处理外的其他热处理均可提高合金的断裂伸长率。经H1、T5和T6热处理后,合金的摩擦因数和磨损量减小,其中T6热处理后合金的摩擦因数和磨损量最低。因此,T6热处理为该合金应用于14 MPa压力下润滑摩擦的最佳工艺。与青铜相比,铸态和热处理态的Zn−40Al−2Cu−2Si合金磨损量较低、耐磨性较高。 | Temel SAVAŞKAN Zeki AZAKLI Ali Paşa HEKÌMOĞLU | 2021 | Transactions of Nonferrous Metals Society of China2021，31，9： | 3 |
| 8 | Transcatheter closure of interatrial communications for secondary prevention of paradoxical embolism: single-center experience显示文摘 | Bruch L Parsi A Grad MO | 2002 | Circulation2002，105，24： | 2 |
| 9 | Review: Improving our knowledge of male mosquito biology in relation to genetic control programmes显示文摘 | Rosemary Susan Lees Bart Knols Romeo Bellini Mark Q. Benedict Ambicadutt Bheecarry Hervé Christophe Bossin Dave D. Chadee Jacques Charlwood Roch K. Dabiré Luc Djogbenou Alexander Egyir-Yawson René Gato Louis Clément Gouagna Mo’awia Mukhtar Hassan Shakil A | 2013 | Acta Tropica2013，，： | 2 |
| 10 | 添加钛对Al-25Zn-3Cu和Al-25Zn-3Cu-3Si合金的结构、力学、摩擦学和腐蚀性能的影响(英文)显示文摘为了研究晶粒细化对新开发的Al-25Zn-3Cu基合金性能的影响,采用金属型铸造法制备Al-25Zn-3Cu、Al-25Zn-3Cu-0.01Ti、Al-25Zn-3Cu-3Si和Al-25Zn-3Cu-3Si-0.01Ti合金。用扫描电镜(SEM)观察合金的显微组织,分别用布氏硬度法和拉伸试验测定合金的硬度和力学性能,用球盘式摩擦试验机研究合金的摩擦学特性,用电化学腐蚀实验装置研究合金的腐蚀性能。结果显示,A1-25Zn-3Cu三元合金的显微组织含有α、α+η和θ(Al2Cu)相。添加3%Si(质量分数)的A1-25Zn-3Cu合金显微组织中形成硅颗粒。添加0.01%Ti(质量分数)的Al-25Zn-3Cu和Al-25Zn-3Cu-3Si合金的晶粒尺寸分别减小约20%和39%,硬度分别从HRB130和HRB141增加到HRB 137和HRB 156,合金的屈服强度分别从278 MPa和320 MPa增加到297 MPa和336 MPa,抗拉强度分别从317 MPa和334 MPa增加到340 MPa和352 MPa。随着钛含量的增加,合金的磨性提高,但耐腐蚀性降低。 | Ali Pa?a HEK?MO?LU Merve ?ALI? | 2020 | Transactions of Nonferrous Metals Society of China2020，30，2： | 2 |
| 11 | Adenovims-mediated extracellular superoxide dismutase gene therapy reduces neointima formation in balloon-denuded rabbit aorta显示文摘 | Kivela A Rissanen T | 2002 | Circulation2002，106，15： | 1 |
| 12 | Advance in apoptosis research显示文摘 | Hengartner MO | 1997 | Proc Natl Acad Sci USA1997，94，12： | 1 |
| 13 | Targeting of the BMI-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal显示文摘 | Godlewski J Nowicki MO Bronisz A | 2008 | Cancer Res2008，68，22： | 1 |
| 14 | Oral decontamination for prevention of pneumonia in mechanically ventilated adults:systematic review and meta-analysis显示文摘 | Chan EY Ruest A Meade MO | 2007 | BMJ2007，334，7599： | 1 |
| 15 | High growth of SWNTs and MWNTs from C2H2 decomposition over Co-Mo/MgO catalysts显示文摘 | SHAJIHAN M MO Y H FAZLE KIBRIA A K M | 2004 | Carbon2004，42，： | 1 |
| 16 | The secondary alcohol metabolite of doxorubicin irreversibly inactivates conitase iron regulatory protein 1 in cytosolic fractions from human my ocardium显示文摘 | Minotti G Recalcati S Mo rdente A | 1998 | FA SEB J1998，12，7： | 1 |
| 17 | Posterior fossa epidural hema- tomas in children: clinical experience with 40 cases显示文摘 | Seneer A Aras Y Akcakaya MO | 2012 | Neurosurg Pediatr2012，9，2： | 1 |
| 18 | Quasimonoenergetic electron beams from laser wakefield acceleration in pure nitrogen显示文摘 | Mo M Z All A Fourmaux S | 2012 | Appl Phys Lett2012，104，07： | 1 |
| 19 | Oxidized low-density lipoprotein 显示文摘 | Parthasarathy S Raghavamenon A Garelnabi MO | 2010 | Methods Mol Biol2010，610，： | 1 |
| 20 | DNA damage in the nucleosome core is refractory to repair by human excision nuclease显示文摘 | HARA R MO J SANCAR A | 2000 | Mol Cell Biol2000，20，24： | 1 |
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