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| 1 | MELD score,insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease显示文摘AIM:To determine the contributions of insulin-like growth factor 1 (IGF-1),cytokines and liver disease severity to bone mineral density in patients pre-transplantation.METHODS:Serum IGF-1,tumor necrosis factor-α (TNFα) and interleukin 6 (IL-6) were measured and the Model for End-Stage Liver Disease (MELD) score calculated in 121 adult patients referred to a single centre for liver transplantation.Bone mineral density (BMD) of the lumbar spine and femoral neck were assessed via dual energy X-ray absorptiometry.Demographics,liver disease etiology,medication use and relevant biochemistry were recorded.RESULTS:A total of 117 subjects were included,with low BMD seen in 68.6%,irrespective of disease etiol-ogy.In multivariable analysis,low body mass index (BMI),increased bone turnover and low IGF-1 were independent predictors of low spinal bone density.At the hip,BMI,IGF-1 and vitamin D status were predictive.Despite prevalent elevations of TNFα and IL-6,levels did not correlate with degree of bone loss.The MELD score failed to predict low BMD in this pre-transplant population.CONCLUSION:Osteopenia/osteoporosis is common in advanced liver disease.Low serum IGF-1 is weakly predictive but serum cytokine and MELD score fail to predict the severity of bone disease. | Rebecca Mitchell Jill McDermid Mang M Ma Constance L Chik | 2011 | World Journal of Hepatology2011，3，6： | 5 |
| 2 | Loss expression of active fragile sites genes associated with the severity of breast epithelial abnormalities显示文摘背景 WWOX 和 FHIT 是位于活跃易碎的地点,其损坏与乳癌的发展被联系了的二候选人肿瘤 suppressor 基因。这些基因的表达式和乳癌的开发的协会充分没被探索。我们与正常组织学的外观在胸织物评估了 mRNA 和 WWOX 和 FHIT 的蛋白质表示,不正常的 ductal 增生,在 situ 的 ductal 癌,并且看在表示的进步衰落是否是 present.Methods 颠倒抄写聚合酶链反应并且西方的弄污的侵略癌症被用来为 mRNA 和蛋白质表示评估标本包括有正常织物的 28 个标本,有不正常的 ductal 增生的 28 个标本,有 ductal 的 33 个标本汽车结果与相比在 situ 和侵略癌症标本,正常、不正常的增生标本有可检测的 mRNA 的更大的率(WWOX 率 ratio=2.95, 95% CI 1.24-7.08;FHIT 率 ratio=4.58, 95% Cl 1.82-11.81 ) 并且西方的弄污的可检测的蛋白质(WWOX 率 ratio=4.12, 95% Cl 1.63-10.73;FHIT 率 ratio=3.76, 95% Cl 1.44-10.06 ) 。为两蛋白质,正常、不正常的增生标本之间并且在之间的差别在 situ 和侵略的癌,标本碰巧是可解说的(P > 0.05 为每分析) 。在每个组织学的范畴以内,在标本的部分之中的差别显示出那 FHIT 和 WWOX mRNA。并且蛋白质表示碰巧是可解说的(P > 0.05 为每分析) FHIT 和 WWOX 的 .Conclusion 表示从正常组织学的外观与胸织物进步一起减少到不正常的 ductal 增生在 situ 癌症,并且最后的侵略癌症。 | WANG Tian-tian Eldo E Frezza MA Rong HU San-yuan LIU Chong-zhong ZHANG Guang-yong Mitchell S. Wachtel LU Xiao-mei FENG Jin-bo LU Cui-xia | 2008 | Chinese Medical Journal2008，，20： | 2 |
| 3 | Problem-based learning:a review of literature on its outcomes and implementation issues显示文摘 | Albanese MA Mitchell S | 1993 | Acad Med1993，68，： | 1 |
| 4 | Multiple myeloma complicated byrestrictive cardiomyopathy and cardiac tamponade显示文摘 | Mitchell MA Horneffer MD Standiford TJ | 1993 | Chest1993，103，3： | 1 |
| 5 | Comparison of techniques for measuring pulse-wave velocity in the rat显示文摘 | Mitchell GF Pfeffer MA Finn PV | 1982 | Appl Physiol1982，，： | 1 |
| 6 | Modeling char oxidation behavior under Zone II burning conditions at elevated pressures 显示文摘 | MA L MITCHELL R | 2009 | Combustion and Flame2009，156，1： | 1 |
| 7 | Linear atrial ablations in a canine model of chronic atrial fibrillation:morphological and electrophysiological observations显示文摘 | Mitchell MA Mcrury ID Haines DE | 1998 | Circulation1998，97，： | 1 |
| 8 | Daily Travel behavior in beijing, china : an analysis of workers' trip chains, and the role of socio-demographics and urban form 显示文摘 | MA Jing MITCHELL G H | 2014 | Habitat International2014，，43： | 1 |
| 9 | Comparative study of fluoroscopy and intracardiac echocardiographic guidance for the creation of linear atrial lesions显示文摘 | Laurence ME Mitchell MA | 1998 | Circulation1998，98，13： | 1 |
| 10 | Nonuniform heating during radiofrequency catheter ablation with long electrodes monitoring the edge effect 显示文摘 | McRury ID Panescu D Mitchell MA | 1997 | Circulation1997，96，40： | 1 |
| 11 | Problem based learning:a review of literature on its outcome and implementation issues显示文摘 | Albanese MA Mitchell S | 1993 | Acad Med1993，68，： | 1 |
| 12 | Problem-based learning:a review of literature on its outcomes and implementation issues显示文摘 | Albanese MA Mitchell S | | 0，，01： | 1 |
| 13 | Thioredoxin catalyzes the S- nitrosation of the caspase-3 active site cysteine 显示文摘 | Mitchell DA Marietta MA | 2005 | Nat C hem Biol2005，1，3： | 1 |
| 14 | The ABC' s of comparative genomics in the Brassicaceae: building blocks of crueifer genomes显示文摘 | Schranz ME Lysak MA Mitchell - Olds T | 2006 | Trends in Plant Science2006，11，11： | 1 |
| 15 | Hospital sanitation : the massive bacterial contamination of the wet mop显示文摘 | Westwood JC Mitchell MA Legace S | 1971 | Appl Micro- bio11971，21，4： | 1 |
| 16 | Inhibition of platelet deposition and lysis of intracoronary thrmbus during balloon angioplasty using urokinase-coated hydrogel balloons显示文摘 | Azrin MA Fram DB | 1994 | Circulation1994，90，5： | 1 |
| 17 | Randomized phase 2 sequencing and pharmacokinetic study of gemcitabine and oxali- platin in advanced non - small cell lung cancer 显示文摘 | Mitchell PL Broad A Rosenthal MA | 2011 | Asia Pac J Clin Oncol2011，7，4： | 1 |
| 18 | Sorafenib and vorinostat kill colon cancer cells by cd95-dependent and-independent mechanisms显示文摘 | Walker T Mitchell C Park MA | 2009 | Mol Pharmacol2009，76，2： | 1 |
| 19 | Past, present and future land-use in Xishuangbanna, China and the implications for carbon dynamics显示文摘 | Hongmei Li Youxin Ma T. Mitchell Aide Wenjun Liu | 2007 | Forest Ecology and Management2007，，1： | 1 |
| 20 | Inventorying heavy metal pollution in redeveloped brownfield and its policy contribution: Case study from Tiexi District, Shenyang, China显示文摘 | Wanxia Ren Bing Xue Yong Geng Lina Sun Zhixiao Ma Yunsong Zhang Bruce Mitchell Liming Zhang | 2014 | Land Use Policy2014，，： | 1 |
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