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| 1 | Comparative study of gas accumulations in the Permian Changxing reefs and Triassic Feixianguan oolitic reservoirs between Longgang and Luojiazhai-Puguang in the Sichuan Basin显示文摘Reef and oolitic gas reservoirs in the Permian Changxing and Triassic Feixianguan formations have been discovered in both the Luojiazhai-Puguang and Longgang areas of the Sichuan Basin, but the accumulation scale, abundance and distribution patterns differ greatly. In fact, the two areas have more differences than they have similarities. Similarities include: (1) the lithology, properties and types of porosity of the reef and oolitic reservoirs are primarily consistent in the two areas; (2) well-developed regional caprocks that seal the fluid system; and (3) accumulation process histories, with liquid hydrocarbon charging at an early stage, cracking into gas at a high to over-mature stage, adjustment of gas reservoirs at an uplifting stage, and final reservoir generation at a late stage. Differences include: (1) gas accumulations in the Luojiazhai-Puguang area that are dominated by oil-type cracked gas, with multiple and sufficient gas sources, contrasting with gas accumulations in the Longgang area that are dominated by coal-sourced gas with insufficient gas sources; (2) heterogeneity and horizontal diversity of reservoirs in the Longgang area that are stronger than in the Luojiazhai-Puguang area; and (3) the development of deep and large faults in the Luojiazhai-Puguang area that link source, reservoir and migration pathways, contrasting with poorly developed faults in Longgang area, where laterally variable fractures are the major migration pathway. Because of these differences, abundant large-scale structurally-controlled gas accumulations are developed in the Luojiazhai-Puguang area, whereas lithology plays a more important role in gas accumulation in the Longgang area where accumulations are smaller-scale and have lower gas-bearing abundance. We suggest that future exploration for reef and oolitic gas accumulations should be strengthened in NE Sichuan and NW Sichuan Jiulongshan. In particular, the transitional zone between Longgang and Kaijiang-Liangping Bay has the best potential for new discoveries. | ZHAO WenZhi XU ChunChun WANG TongShan WANG HongJun WANG ZeCheng BIAN CongSheng LI Xia | 2011 | Chinese Science Bulletin2011，56，31： | 21 |
| 2 | A comprehensive review of integrative pharmacology-based investigation:A paradigm shift in traditional Chinese medicine显示文摘Over the past decade,traditional Chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization.Thus,integrative pharmacology-based traditional Chinese medicine(TCMIP) was proposed as a paradigm shift in TCM.This review focuses on the presentation of this novel concept and the main research contents,methodologies and applications of TCMIP.First,TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics(PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes in vivo.Then,the main research contents of TCMIP are introduced as follows:chemical and ADME/PK profiles of TCM formulas;confirming the three forms of active substances and the three action modes;establishing the qualitative PK-PD correlation;and building the quantitative PK-PD correlations,etc.After that,we summarize the existing data resources,computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental methods.Finally,we further discuss the applications of TCMIP for the improvement of TCM quality control,clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs,especially TCM-related combination drug disco very. | Haiyu Xu Yanqiong Zhang Ping Wang Junhong Zhang Hong Chen Luoqi Zhang Xia Du Chunhui Zhao Dan Wu Feng Liu Hongjun Yang Changxiao Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 18 |
| 3 | Risk assessment of malaria transmission at the border area of China and Myanmar显示文摘Background:In order to achieve the goal of malaria elimination,the Chinese government launched the National Malaria Elimination Programme in 2010.However,as a result of increasing cross-border population movements,the risk of imported malaria cases still exists at the border areas of China,resulting in a potential threat of local transmission.The focus of this paper is to assess the Plasmodium vivax incidences in Tengchong,Yunnan Province,at the border areas of China and Myanmar.Methods:Time series of P.vivax incidences in Tengchong from 2006 to 2010 are collected from the web-based China Information System for Disease Control and Prevention,which are further separated into time series of imported and local cases.First,the seasonal and trend decomposition are performed on time series of imported cases using Loess method.Then,the impact of climatic factors on the local transmission of P.vivax is assessed using both linear regression models(LRM)and generalized additive models(GAM).Specifically,the notion of vectorial capacity(VCAP)is used to estimate the transmission potential of P.vivax at different locations,which is calculated based on temperature and rainfall collected from China Meteorological Administration.Results:Comparing with Ruili County,the seasonal pattern of imported cases in Tengchong is different:Tengchong has only one peak,while Ruili has two peaks during each year.This may be due to the different cross-border behaviors of peoples in two locations.The vectorial capacity together with the imported cases and the average humidity,can well explain the local incidences of P.vivax through both LRM and GAM methods.Moreover,the maximum daily temperature is verified to be more suitable to calculate VCAP than the minimal and average temperature in Tengchong County.Conclusion:To achieve malaria elimination in China,the assessment results in this paper will provide further guidance in active surveillance and control of malaria at the border areas of China and Myanmar. | Benyun Shi Jinxin Zheng Hongjun Qiu Guo-Jing Yang Shang Xia Xiao-Nong Zhou | 2017 | Infectious Diseases of Poverty2017，6，1： | 6 |
| 4 | Functional design of wind turbine airfoils based on roughness sensitivity characteristics显示文摘To improve aerodynamic performance of wind turbine airfoils,the shape profile characteristic of the airfoil is investigated.Application of conformal transformation,one functional and integrated expression of wind turbine airfoils is presented.Using the boundary layer theory,the aerodynamic model with roughness of wind turbine airfoils is introduced by studying flow separation around the airfoil.Based on the shape expression and aerodynamic performance of airfoils,the function design of wind turbine airfoils is carried out that the maximum lift-drag ratio and low roughness sensitivity are designed objects.Three wind turbines airfoils with different thickness are gained which are used at tip part of blades.As an example,the aerodynamic performance of one designed airfoil with relative thickness of 15%is simulated in different conditions of clean surface,rough surface,laminar flow and turbulent flow.The comparison of aerodynamic performance between the designed airfoil and one popular NACA airfoil is completed which can verify the better performance of the designed airfoil and reliability of the designed method. | 王旭东 Xia Hongjun | 2014 | High Technology Letters2014，20，4： | 4 |
| 5 | Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout显示文摘 | Dong, Zheng Li, Yuan Zhou, Jingru Jiang, Shuai Wang, Yi Chen, Yulin Zhao, Dongbao Yang, Chengde Qian, Qiaoxia Ma, Yanyun He, Hongjun Ji, Hengdong Yang, Yajun Wang, Xiaofeng Xu, Xia Pang, Yafei Zou, Hejian Jin, Li Zhang, Feng Wang, Jiucun | 2017 | Protein & Cell2017，8，6： | 3 |
| 6 | ETCM v2.0:An update with comprehensive resource and rich annotations for traditional Chinese medicine显示文摘Existing traditional Chinese medicine(TCM)-related databases are still insufficient in data standardization,integrity and precision,and need to be updated urgently.Herein,an Encyclopedia of Traditional Chinese Medicine version 2.0(ETCM v2.0,http://gffzz3ff3e9d9e9f64aa3h9pcbpw6fx6xx66cn.ffgz.tsg.suse.edu.cn/ETCM2/front/#/)was constructed as the latest curated database hosting 48,442 TCM formulas recorded by ancient Chinese medical books,9872 Chinese patent drugs,2079 Chinese medicinal materials and 38,298 ingredients.To facilitate the mechanistic research and new drug discovery,we improved the target identification method based on a two-dimensional ligand similarity search module,which provides the confirmed and/or potential targets of each ingredient,as well as their binding activities.Importantly,five TCM formulas/Chinese patent drugs/herbs/ingredients with the highest Jaccard similarity scores to the submitted drugs are offered in ETCM v2.0,which may be of significance to identify prescriptions/herbs/ingredients with similar clinical efficacy,to summarize the rules of prescription use,and to find alternative drugs for endangered Chinese medicinal materials.Moreover,ETCM v2.0 provides an enhanced Java Script-based network visualization tool for creating,modifying and exploring multi-scale biological networks.ETCM v2.0 may be a major data warehouse for the quality marker identification of TCMs,the TCM-derived drug discovery and repurposing,and the pharmacological mechanism investigation of TCMs against various human diseases. | Yanqiong Zhang Xin Li Yulong Shi Tong Chen Zhijian Xu Ping Wang Meng Yu Wenjia Chen Bing Li Zhiwei Jing Hong Jiang Lu Fu Wenjing Gao Yanhua Jiang Xia Du Zipeng Gong Weiliang Zhu Hongjun Yang Haiyu Xu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 3 |
| 7 | Dissection of heterosis for yield and related traits using populations derived from introgression lines in rice显示文摘Despite the great success achieved by the exploitation of heterosis in rice,the genetic basis of heterosis is still not well understood.We adopted an advanced-backcross breeding strategy to dissect the genetic basis of heterosis for yield and eight related traits.Four testcross(TC) populations with 228 testcross F1 combinations were developed by crossing57 introgression lines with four types of widely used male sterile lines using a North Carolina II mating design.Analysis of variance indicated that the effects of testcross F1 combinations and their parents were significant or highly significant for most of the traits in both years,and all interaction effects with year were significant for most of the traits.Positive midparent heterosis(HMP) was observed for most traits in the four TC populations in the two years.The relative HMPlevels for most traits varied from highly negative to highly positive.Sixty-two dominant-effect QTL were identified for HMPof the nine traits in the four TC populations in the two years.Of these,22 QTL were also identified for the performance of testcross F1.Most dominant-effect QTL could individually explain more than 10% of the phenotypic variation.Four QTL clusters were observed including the region surrounding the RM9–RM297 region on chromosome 1,the RM110–RM279–RM8–RM5699–RM452 region on chromosome 2,the RM5463 locus on chromosome 6 and the RM1146–RM147 region on chromosome 10.The identified QTL for heterosis provide valuable information for dissecting the genetic basis of heterosis. | Chao Xiang Hongjun Zhang Hui Wang Shaobo Wei Binying Fu Jiafa Xia Zefu Li Yongming Gao Guoyou Ye | 2016 | The Crop Journal2016，4，6： | 3 |
| 8 | Laser-induced oxidation assisted micro milling of high aspect ratio microgroove on WC-Co cemented carbide显示文摘Severe tool wear and poor surface quality are the main problems during micro machining of cemented carbide.In this work,an innovative hybrid process of laser-induced oxidation assisted micro milling(LOMM)was proposed to solve the problems.A nanosecond laser was utilized to induce oxidation of the WC-20%Co material,producing loose oxide which was easy to remove.The micro machinability of the material was improved by laser-induced oxidation.The oxidation mechanisms of cemented carbide were studied.A microgroove with a depth of 2.5 mm and aspect ratio of 5 was fabricated successfully.The milling force,surface quality and tool wear mechanisms were investigated.For comparison,a microgroove was also fabricated with conventional micro milling(COMM)using identical milling parameters.Results revealed that in LOMM the milling force and tool wear rate were extremely low during removing the oxide.The machined surface quality and dimensional accuracy achieved by LOMM were superior to those obtained by COMM.The surface roughness Saof the microgroove bottom reached 88 nm in LOMM,while the cross-sectional geometry of the microgroove was a trapezoid.Perpendicularity of the microgroove sidewall machined by LOMM was better than that by COMM.The tool wear forms in LOMM were coating spalling and slight tool nose breakage.Compared with COMM,the tool life in LOMM was prolonged significantly.It indicates that the proposed hybrid process is an effective and efficient way to fabricate high aspect ratio micro-features with high dimensional accuracy. | Guolong ZHAO Hongjun XIA Yang ZHANG Liang LI Ning HE Hans Nφrgaard HANSEN | 2021 | Chinese Journal of Aeronautics2021，34，4： | 3 |
| 9 | Isolation of fucoxanthin from Sargassum thunbergii and preparation of microcapsules based on palm stearin solid lipid core显示文摘 | Xuanxuan WANG Hongyan LI Fangqin WANG Guixue XIA Hongjun LIU Xiaojie CHENG Ming KONG Ya LIU Chao FENG Xiguang CHEN Ying WANG | 2017 | Frontiers of Materials Science2017，11，1： | 3 |
| 10 | Identifying accident black spots based on the accident spacing distribution显示文摘The identification of accident black spots is of great significance for the prevention of traffic accidents.Commonly used accident black spot identification methods divide road sections for the analysis of accident data,the direct result of which is the splitting of accident black spots,which affects the results.This paper is based on three years of traffic accident data from the Beijing-Harbin Expressway,including the time and location of traffic accidents,form of the accident fatalities,severe injuries,slight injuries,and property damage only(PDO).To avoid road division effects,an identification method based on the accident spacing distribution is established by using quality control theory.The results show that the average number of accidents per kilometer by the method proposed in this paper is 42,which is much higher than 10,identified by other identification methods.The method proposed in this paper improves the accuracy of the identification results.This method avoids the problem of road segmentation found in other common methods and can more accurately reflect the spatial distribution of traffic accidents.Thus making the identification of accidents more scientific and accurate. | Hongjun Cui Jianguo Dong Minqing Zhu Xia Li Qingzhou Wang | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，6： | 2 |
| 11 | Few-mode fibre-optic microwave photonic links显示文摘The fibre-optic microwave photonic link has become one of the basic building blocks for microwave photonics.Increasing the optical power at the receiver is the best way to improve all link performance metrics including gain,noise figure and dynamic range.Even though lasers can produce and photodetectors can receive optical powers on the order of a Watt or more,the power-handling capability of optical fibres is orders-of-magnitude lower.In this paper,we propose and demonstrate the use of few-mode fibres to bridge this power-handling gap,exploiting their unique features of small acousto-optic effective area,large effective areas of optical modes,as well as orthogonality and walk-off among spatial modes.Using specially designed few-mode fibres,we demonstrate order-of-magnitude improvements in link performances for single-channel and multiplexed transmission.This work represents the first step in few-mode microwave photonics.The spatial degrees of freedom can also offer other functionalities such as large,tunable delays based on modal dispersion and wavelength-independent lossless signal combining,which are indispensable in microwave photonics. | He Wen Hongjun Zheng Qi Mo Amado Manuel Velázquez-Benítez Cen Xia Bin Huang Huiyuan Liu Huang Yu Pierre Sillard Jose Enrique Antonio Lopez Rodrigo Amezcua Correa Guifang Li | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 12 | Adjustable proportional hybrid SVPWM strategy for neutral-point-clamped three-Level inverters显示文摘 | Xia Changliang Shao Hongjun Zhang Yun | 2013 | IEEE Transactions on Industrial Electronics2013，60，10： | 1 |
| 13 | Portable near-infrared diffusive light imager for breast cancer detection 显示文摘 | CHEN Nanguang HUANG Minming XIA Hongjun | 2004 | Journal of Biomedical Optics2004，9，3： | 1 |
| 14 | Simultaneous improvement and genetic dissection of grain yield and its related traits in a backbone parent of hybrid rice ( Oryza sativa L.) using selective introgression显示文摘 | Hongjun Zhang Hui Wang Yiliang Qian Jiafa Xia Zefu Li Yingyao Shi Linghua Zhu Jauhar Ali Yongming Gao Zhikang Li | 2013 | Molecular Breeding2013，，1： | 1 |
| 15 | A highly sensitive and robust UPLC-MS with electrospray ioniza- tion method for quantitation of taxifolin in rat plasma显示文摘 | Xiaodan Wang Hongjun Xia Feng Xing | 2009 | Journal of Chromatography B2009，，877： | 1 |
| 16 | A highly sensitive and robust UPLC - MS with electros- pray ionization method for quantitation of taxifolin in rat plasma 显示文摘 | Xiaodan Wang Hongjun Xia Feng Xing Guifeng Deng Qi Shen Su Zeng | 2009 | Chromatography B2009，，： | 1 |
| 17 | Object-oriented Battlefield Environment Simulation Process Object Model Based on Task-driven显示文摘Battlefield environment simulation process is an important part of battlefield environment information support, which needs to be built around the task process. At present, the interoperability between battlefield environment simulation system and command and control system is still imperfect, and the traditional simulation data model cannot meet war fighters’ high-efficient and accurate understanding and analysis on battlefield environment’s information. Therefore, a kind of task-orientated battlefield environment simulation process model needs to be construed to effectively analyze the key information demands of the command and control system. The structured characteristics of tasks and simulation process are analyzed, and the simulation process concept model is constructed with the method of object-orientated. The data model and formal syntax of GeoBML are analyzed, and the logical model of simulation process is constructed with formal language. The object data structure of simulation process is defined and the object model of simulation process which maps tasks is constructed. In the end, the battlefield environment simulation platform modules are designed and applied based on this model, verifying that the model can effectively express the real-time dynamic correlation between battlefield environment simulation data and operational tasks. | Jie ZHU Xiong YOU Qing XIA Hongjun ZHANG | 2019 | Journal of Geodesy and Geoinformation Science2019，2，3： | 1 |
| 18 | Shape design and performance test for small wind turbine blade显示文摘Based on the 1D-blade element momentum theory (BEM) with the improved tip loss correction introduced, a new aerodynamic model of wind turbine is developed. Using one high aerodynamic performance airfoil with 18% relative thickness, one small wind turbine blade is designed and the distribution of the chord and twist angle of the blade are determined. According to the shape parameters of the blade, a method to set up the 3D model is presented by investigating the coordinate position of each section of the blade. Based on the fiber reinforced polymer (FRP) molding technology, the manufacturing process of wind turbine blade is put forward. Using fiber reinforced polymer, the wind turbine blades are manufactured by the mold making and layer process. A test platform and method of wind turbine output power are carried out, the output powers at different speeds of the wind turbine are obtained and discussed. The comparison between the designed and one existing wind turbine rotor is completed to show the reliability and superiority of the design and test method presented in this paper. | 王旭东 Xia Hongjun Li Ping | 2019 | High Technology Letters2019，25，2： | 0 |
| 19 | Synthesis of SiO_2@SiO_2 core-shell microspheres using urea-formaldehyde polymers as the templates for fast separation of small solutes and proteins显示文摘Superficially porous core-shell silica microspheres(CSSMs) have been a great success for the fast separation of small molecules and proteins in recent years. In this paper, the CSSMs were synthesized by an improved polymerization-induced colloid aggregation(PICA) method using urea-formaldehyde polymers as the templates. The agglomeration of the functionalized silica core was avoided by the surface modification through reflux with ureidopropyltrimethoxysilane in the neutral ethanol solution at 80℃,and the secondary nucleation of the silica nanoparticles during the preparation process could also be inhibited via the optimization of the reaction conditions, such as pH, temperature, colloidal silica sol concentration and the reaction time. The controllable shell thickness and pore size of the synthesized monodisperse CSSMs were successfully obtained by adjusting the weight ratio of silica core/colloidal silica sol and the particle size of colloidal silica sol, respectively. The C18-modified CSSMs with different pore sizes were used to separate small solutes and proteins. The higher efficient separation and relatively low back pressure of the synthesized core-shell column demonstrate that the CSSMs have a great potential application for fast | Guangping Wan Hongjun Xia Jun Wang Jiawei Liu Botao Song Ying Yang Quan Bai | 2018 | Chinese Chemical Letters2018，29，1： | 0 |
| 20 | Prognostic nomogram incorporating radiological features for predicting overall survival in patients with AIDS-related non-Hodgkin lymphoma显示文摘Background: Acquired immune deficiency syndrome (AIDS)-related non-Hodgkin lymphoma (AR-NHL) is a high-risk factor for morbidity and mortality in patients with AIDS. This study aimed to determine the prognostic factors associated with overall survival (OS) and to develop a prognostic nomogram incorporating computed tomography imaging features in patients with acquired immune deficiency syndrome-related non-Hodgkin lymphoma (AR-NHL).Methods: A total of 121 AR-NHL patients between July 2012 and November 2019 were retrospectively reviewed. Clinical and radiological independent predictors of OS were confirmed using multivariable Cox analysis. A prognostic nomogram was constructed based on the above clinical and radiological factors and then provided optimum accuracy in predicting OS. The predictive accuracy of the nomogram was determined by Harrell C-statistic. Kaplan-Meier survival analysis was used to determine median OS. The prognostic value of adjuvant therapy was evaluated in different subgroups.Results: In the multivariate Cox regression analysis, involvement of mediastinal or hilar lymph nodes, liver, necrosis in the lesions, the treatment with chemotherapy, and the CD4 ≤100 cells/μL were independent risk factors for poor OS (allP < 0.050). The predictive nomogram based on Cox regression has good discrimination (Harrell C-index = 0.716) and good calibration (Hosmer-Lemeshow test,P = 0.620) in high- and low-risk groups. Only patients in the high-risk group who received adjuvant chemotherapy had a significantly better survival outcome.Conclusion: A survival-predicting nomogram was developed in this study, which was effective in assessing the survival outcomes of patients with AR-NHL. Notably, decision-making of chemotherapy regimens and more frequent follow-up should be considered in the high-risk group determined by this model. | Xueqin Li Ziang Pan Xing Wang Tianli Hu Wen Ye Dongmei Jiang Wen Shen Jinxin Liu Yuxin Shi Shuang Xia Hongjun Li | 2022 | Chinese Medical Journal2022，，1： | 0 |
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