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| 1 | Antimicrobial susceptibility of Gram-negative bacteria causing intra-abdominal infections in China: SMART China 2011显示文摘 | Zhang Hui Yang Qiwen Xiao Meng Chen Minjun Robert E. Badal Xu Yingchun | 2014 | Chinese Medical Journal2014，，13： | 10 |
| 2 | An IOanalysis of the trend in virtual water trade and the impacton water resources and uses in China 显示文摘 | ZHANG Zhuoying SHI Minjun YANG Hong | 2011 | EconomicSystems Research2011，23，4： | 1 |
| 3 | Understanding Beijing's water challenge: a decomposition analysis of changes in Beijing's water footprint between 1997 and 2007 显示文摘 | Zhang Zhuoying Shi Minjun Yang Hong | 2012 | Environmental Science & Technology2012，46，12： | 1 |
| 4 | Analyses of water footprint of Beijing in an interregional input–output framework显示文摘 | Zhuoying Zhang Hong Yang Minjun Shi | 2011 | Ecological Economics2011，，12： | 1 |
| 5 | Construction of a Monascus purpureus mutant showing lower citrinin and higher pigment production by replacement of ctnA with pksl without using vector and resistance gene显示文摘 | XU Minjun YANG Zeliang LIANG Zhizhou | 2009 | Journal of Agricultural and Food Chemistry2009，57，20： | 1 |
| 6 | Therapeutic Effect and Mechanism of New Maixian Powder on DSS-induced UC Rats显示文摘[Objectives] To study the therapeutic effect and mechanism of New Maixian Powder on ulcerative colitis( UC) rats through observing its regulatory effect on the protein kinase R-like endoplasmic reticulum kinase( PERK)/eukaryotic translation initiation factor-2α( e IF-2α)/nuclear transcription factor-kappa B( NF-κB) signaling pathway. [Methods]First,60 SD rats were randomly divided into normal group,model group,mesalazine group,and New Maixian Powder low,medium and high dose groups,10 rats each group. Then,dextran sulfate sodium( DSS) was used to induce UC rats. The mesalazine group was given 0. 42 g/( kg·d) of mesalazine sustained-release granule suspension,New Maixian Powder low,medium and high dose groups were given 1. 5,3,and 6 g/( kg·d) of New Maixian Powder suspension,respectively,and other groups were given an equal volume of physiological saline,continuous intragastric administration for 14 d. Next,the disease activity index( DAI) of UC rats was evaluated; the expression of NF-κB in serum was measured by enzyme-linked immunosorbent assay( ELISA); the expression of PERK and e IF-2α protein and m RNA in colon tissue was detected by Western blot and real-time quantitative polymerase chain reaction( RT q-PCR). [Results] Compared with the normal group,the DAI score and serum NF-κB level in the model group were significantly higher( P < 0. 05),and PERK and e IF-2α protein and m RNA levels in the colon tissue were increased( P < 0. 05); compared with the model group,the DAI score decreased and serum NF-κB level declined in the New Maixian Powder group,and the expression of PERK and e IF-2α protein and m RNA in New Maixian Powder medium dose and high dose groups declined( P < 0. 05). [Conclusions]New Maixian Powder has good therapeutic effect on UC rats,and its mechanism may be connected with the inhibition of the activation of PERK/e IF-2α/NF-κB signaling pathway. | Minjun FU Rongzhen SHI Jianjun SHEN Meixia YANG Hongbin ZHENG | 2018 | Medicinal Plant2018，9，3： | 1 |
| 7 | Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer’s disease显示文摘Compromised autophagy and defective lysosomal clearance significantly contribute to impaired neuronal proteostasis,which represents a hallmark of Alzheimer’s disease(AD)and other age-related neurodegenerative disorders.Growing evidence has implicated that modulating autophagic flux,instead of inducing autophagosome formation alone,would be more reliable to rescue neuronal proteostasis.Concurrently,selectively enhancing drug concentrations in the leision areas,instead of the whole brain,will maximize therapeutic efficacy while reduing non-selective autophagy induction.Herein,we design a ROS-responsive targeted micelle system(TT-NM/Rapa)to enhance the delivery efficiency of rapamycin to neurons in AD lesions guided by the fusion peptide TPL,and facilitate its intracellular release via ROS-mediated disassembly of micelles,thereby maximizing autophagic flux modulating efficacy of rapamycin in neurons.Consequently,it promotes the efficient clearance of intracellular neurotoxic proteins,β-amyloid and hyperphosphorylated tau proteins,and ameliorates memory defects and neuronal damage in 3×Tg-AD transgenic mice.Our studies demonstrate a promising strategy to restore autophagic flux and improve neuronal proteostasis by rationally-engineered nano-systems for delaying the progression of AD. | Shuting Xu Peng Yang Kang Qian Yixian Li Qian Guo Pengzhen Wang Ran Meng Jing Wu Jinxu Cao Yunlong Cheng Minjun Xu Qizhi Zhang | 2022 | Bioactive Materials2022，7，5： | 1 |
| 8 | Analyses of water footprint of Beijing in an interregional input–output framework显示文摘 | Zhuoying Zhang Hong Yang Minjun Shi | 2011 | Ecological Economics2011，，12： | 1 |
| 9 | In vitro activity of cefditoren and other comparators against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis causing community-acquired respiratory tract infections in China显示文摘 | Qiwen Yang Yingchun Xu Minjun Chen | 2012 | Diagnostic Microbiology and InfectiousDisease2012，73，2： | 1 |
| 10 | Understanding Beijing's water challenge: a decompositionanalysis of changes in Beijing's water footprint between1997 and 2007 显示文摘 | ZHANG Zhuoying SHI Minjun YANG Hong | 2012 | Environmental Science &Technology2012，46，12： | 1 |
| 11 | Observing single cells in whole organs with optical imaging显示文摘Cells are the basic unit of human organs that are not fully understood.The revolutionary advancements of optical imaging alowed us to observe single cells in whole organs,revealing the complicated composition of cells with spatial information.Therefore,in this review,we revisit the principles of optical contrast related to those biomolecules and the optical techniques that transform optical contrast into detectable optical signals.Then,we describe optical imaging to achieve threedimensional spatial discrimination for biological tisutes.Due to the milky appearance of tissues,the spatial information burred deep in the whole organ.Fortunately,strategies developed in the last decade could circumvent this issue and lead us into a new era of investigation of the cells with their original spatial information. | Xiaoquan Yang Tao Jiang Lirui Liu Xiaojun Zhao Ximiao Yu Minjun Yang Guangcai Liu Qingming Luo | 2023 | Journal of Innovative Optical Health Sciences2023，16，1： | 0 |
| 12 | Substrate mediated dissolution of redox active nanoparticles;electron transfer over long distances显示文摘Reflective dark field microscopy is used to observe the decrease in the light scattered from Ag nanoparticles immobilised on differing solid substrates.The nanoparticles are exposed to solutions containing halide ions,both at open circuit and under potentiostatic control,leading to the loss of the nanomaterial.By coupling optical and electrochemical techniques the physical origin of this transformation is demonstrated to be the electrochemical dissolution of the metal nanoparticles driven by electron transfer to ultra-trace dissolved oxygen.The dissolution kinetics of the surface-supported metal nanoparticles is compared on four substrate materials(i.e.,glass,indium titanium oxide,glassy carbon and platinum)with different electrical conductivity.The three conductive substrates catalyse the redox-driven dissolution of Ag nanoparticles with the electrons transferred from the nanoparticles,via the macroscopic electrode to the dioxygen electron acceptor. | Ruo-Chen Xie Christopher Batchelor-McAuley Minjun Yang Richard G.Compton | 2022 | Nano Research2022，15，1： | 0 |
| 13 | Insights on evolution of virulence and resistance from the whole-genome analysis of a predominant methicillin-resistant Staphylococcus aureus clone sequence type 239 in China显示文摘Earlier, we reported that ST239 was the15-year predominant methicillin-resistant Staphylococcus aureus(MRSA) clone in China. In this study, MRSA strain CN79 belonging to ST239 and isolated from blood was used to determine the whole genome sequence. Comparative genomics analysis was done between MRSA CN79and 25 sequenced S. aureus in the NCBI GenBank database. A total of 2,734 protein-encoding genes were identified in the MRSA CN79 genome, which carries 11antibiotic resistance genes and 65 virulence genes. Two prophages phiCN79A and phiNM3-like were found on the MRSA CN79 genome. MRSA CN79 carries 30 specific genes that are absent from the 25 sequenced S. aureus genomes. Most of them were prophage-related genes.Several antibiotic resistance genes, such as b-lactamase and ABC-type multidrug transport system gene, were located on the genomic island mSab. The antibiotic resistance genes, such as tet(M), ermA1, and blaZ, were also located on different transposons. The virulence genes sea,map, hlb, and sak are located on phiNM3-like prophage and the exotoxin genes are carried on the genomic island mSaa. These results suggest that ST239 MRSA strains are widespread owing to horizontal acquisition of the mobile genetic elements harbored antibiotic resistance genes and virulence genes in response to environmental selective pressures, such as antibiotics and the human immune system during evolution. | Hongbin Chen Xi Yang Qi Wang Chunjiang Zhao Henan Li Wenqiang He Xiaojuan Wang Feifei Zhang Zhanwei Wang Minjun Chen Baoli Zhu Hui Wang | 2014 | Chinese Science Bulletin2014，59，11： | 0 |
| 14 | Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis显示文摘Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer’s disease(AD)collectively culminate in neuronal deterioration.In the context of AD,autophagy dysfunction,a multi-link obstacle involving autophagy downregulation and lysosome defects in neurons/microglia is highly implicated in intra/extraneuronal pathological processes.Therefore,multidimensional autophagy regulation strategies co-manipulating“autophagy induction”and“lysosome degradation”in dual targets(neuron and microglia)are more reliable for AD treatment.Accordingly,we designed an RP-1 peptide-modified reactive oxygen species(ROS)-responsive micelles(RT-NM)loading rapamycin or gypenoside XVII.Guided by RP-1 peptide,the ligand of receptor for advanced glycation end products(RAGE),RT-NM efficiently targeted neurons and microglia in AD-affected region.This nanocombination therapy activated the whole autophagy-lysosome pathway by autophagy induction(rapamycin)and lysosome improvement(gypenoside XVII),thus enhancing autophagic degradation of neurotoxic aggregates and inflammasomes,and promoting Aβ phagocytosis.Resultantly,it decreased aberrant protein burden,alleviated neuroinflammation,and eventually ameliorated memory defects in 3×Tg-AD transgenic mice.Our research developed a multidimensional autophagy nano-regulator to boost the efficacy of autophagy-centered AD therapy. | Yixian Li Peng Yang Ran Meng Shuting Xu Lingling Zhou Kang Qian Pengzhen Wang Yunlong Cheng Dongyu Sheng Minjun Xu Tianying Wang Jing Wu Jinxu Cao Qizhi Zhang | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 15 | Endocannabinoid 2-arachidonoylglycerol protects inflammatory insults from sulfur dioxide inhalation via cannabinoid receptors in the brain显示文摘Sulfur dioxide(SO_2) pollution in the atmospheric environment causes brain inflammatory insult and inflammatory-related microvasculature dysfunction.However,there are currently no effective medications targeting the harmful outcomes from chemical inhalation.Endocannabinoids(eCBs) are involved in neuronal protection against inflammation-induced neuronal injury.The 2-arachidonoylglycerol(2-AG),the most abundant eCBs and a full agonist for cannabinoid receptors(CB1 and CB2),is also capable of suppressing proinflammatory stimuli and improving microvasculature dysfunction.Here,we indicated that endogenous 2-AG protected against neuroinflammation in response to SO_2 inhalation by inhibiting the activation of microglia and astrocytes and attenuating the overexpression of inflammatory cytokines,including tumor necrosis factor alpha(TNF-a),interleukin(IL)-1β,and inducible nitric oxide synthase(iNOS).In addition,endogenous 2-AG prevented cerebral vasculature dysfunction following SO_2 inhalation by inhibiting endothelin 1(ET-1),vascular cell adhesion molecule-1(VCAM-1) and intercellular adhesion molecule 1(ICAM-1) expression,elevating endothelial nitric oxide synthase(eNOS) level,and restoring the imbalance between thromboxane A2(TXA2) and prostaglandin 12(PGI2).In addition,the action of endogenous 2-AG on the suppression of inflammatory insult and inflammatory-related microvasculature dysfunction appeared to be mainly mediated by CB1 and CB2 receptors.Our results provided a mechanistic basis for the development of new therapeutic approaches for protecting brain injuries from SO_2 inhalation. | Ben Li Minjun Chen Lin Guo Yang Yun Guangke Li Nan Sang | 2017 | Journal of Environmental Sciences2017，29，1： | 0 |
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