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| 1 | Spatio-temporal Changes of ≥10℃ Accumulated Temperature in Northeastern China since 1961显示文摘The objective of this study was to provide reliable basis for decision making for national food security and layout and structure adjustment of grain production in the northeastern China. The data of mean daily air temperature of 1961-2009 from 106 meteorological stations in the northeastern China were chosen in this study. Using statistical methods and isoline method, the spatio-temporal changes of various decadal ≥ 10℃ accumulated temperature and the climatic means of ≥ 10℃ accumulated temperature were studied in this paper. The results showed that 1) The geo-graphical distribution of ≥ 10℃ accumulated temperature in the northeastern China could be influenced directly by the latitude, longitude and altitude. If latitude moved one degree northward, the average decrease amplitude of the climatic means was 101.9℃ in the study area. 2) The means of decadal ≥ 10℃ accumulated temperature rose since the 1980s, and their increase amplitudes became larger in the 1990s and the 2010s obviously. Compared with those of the 1980s, ≥ 10℃ accumulated temperature increased by about 100℃ in the mountainous and plain areas in the 1990s; compared with those of the 1990s, ≥ 10℃ accumulated temperature increased by about 200℃ in the Hulun Buir High Plain and the Songnen Plain, and 100℃ in the Sanjiang Plain and the Liaohe Plain in the 2010s. 3) The means of the decadal ≥ 10℃ accumulated temperature for 106 meteorological stations in the northeastern China increased with the rate of 145.57℃/10yr in 1961-2009. 4) The climatic means of ≥ 10℃ accumulated temperature increased from 1961-1990 to 1971-2000 and 1981-2009. Compared with the climatic mean of 1971-2000, that of 1981-2009 had increased by above 50℃ in most of the study area, even up to 156℃. Compared with the climatic mean of 1961-1990, that of 1981-2009 increased by above 100℃ in most parts of the study area, even up to 200℃. 5) The maximum northward shift, eastward and westward extension amplitudes of 3100℃, 3300℃ and 3500℃ isolines were larger among all isoli-nes for the climatic means of the three phases. Compared with the positions of the isolines of 1961-1990, those ampli-tudes of 3100℃ isoline of 1981-2009 were 145 km, 109 km and 64 km, respectively; those of 3300℃ isoline were 154 km, 54 km and 64 km, respectively; and the maximum northward shift of 3500℃ isoline was about 100 km. | YAN Minhua LIU Xingtu ZHANG Wei LI Xiujun LIU Shi | 2011 | Chinese Geographical Science2011，21，1： | 21 |
| 2 | Construction and Properties of Structure-and Size-controlled Micro/Nano-energetic Materials显示文摘The recent research progress of structure- and size-controlled micro/nano-energetic materials is reviewed, which properties are fundamentally different from those of their corresponding bulk materials. The development of the construction strategies for achieving zero-dimensional (0D), one-dimensional (1D), two-dimensional (2D), and three-dimensional (3D) micro/nanostructures from energetic molecules is introduced. Also, an overview of the unique properties induced by micro/nanostructures and size effects is provided. Special emphasis is focused on the size-dependent properties that are different from those of the conventional micro-sized energetic materials, such as thermal decomposition, sensitivity, combustion and detonation, and compaction behaviors. A conclusion and our view of the future development of micro/nano-energetic materials and devices are given. | HUANG Bing CAO Minhua NIE Fude HUANG Hui HU Changwen | 2013 | Defence Technology(防务技术)2013，9，2： | 20 |
| 3 | Role of contrast-enhanced ultrasonography in percutaneous radiofrequency ablation of liver metastases and efficacy evaluation显示文摘Objective: To retrospectively investigate the role of contrast-enhanced ultrasonography (CEUS) in percutaneous radiofrequency ablation (RFA) in patients with liver metastases and evaluate the therapeutic efficacy of RFA assisted by CEUS. Methods: From May 2004 to September 2010, 136 patients with 219 liver metastatic lesions received CEUS examination 1 h before RFA (CEUS group), and other 126 patients with 216 lesions without CEUS examination in the earlier period were served as a historical control group. The mean tumor size was 3.2 cm and the mean tumor number was 1.6 in the CEUS group, while 3.4 cm and 1.7 in the control group, respectively (P>0.05). The clinical characteristics, recurrence results and survival outcomes were compared between two groups. Results: In the CEUS group, two isoechoic tumors were not demonstrated on unenhanced ultrasonography (US), and 63 (47%) of 134 tumors examined with CEUS were 0.3 cm larger than with unenhanced US. Furthermore, in 18.4% of 136 patients, additional 1-3 tumors were detected on CEUS. The CEUS group showed higher early tumor necrosis and lower intrahepatic recurrence than the control group. The 3-year overall survival (OS) rate and the 3-year local recurrence-free survival (LRFS) rate in the CEUS group were 50.1% and 38.3%, in contrast to 25.3% and 19.3% in the control group, respectively (P=0.002 and P<0.001). Conclusions: CEUS provides important information for RFA treatment in patients with liver metastases and better therapeutic effect could be attained. | Jie Wu Wei Yang Shanshan Yin Jinyu Wu Wei Wu Kun Yan Minhua Chen | 2013 | Chinese Journal of Cancer Research2013，25，2： | 17 |
| 4 | Evaluation of contrast-enhanced ultrasound for diagnosis of dysplastic nodules with a focus of hepatocellular carcinoma in liver cirrhosis patients显示文摘Objective: To compare the enhancement features of dysplastic nodules with a focus of hepatocellular carcinoma(DN-HCC) versus HCC and regenerative nodules(RN) in cirrhotic patients.Methods: One hundred and ninety-three cirrhotic patients were enrolled in this study; they had 215 focal liver lesions, 1.0-3.5 cm in size, which were examined using contrast-enhanced ultrasound(CEUS) with Sono Vue?and diagnosed as HCC, RN or DN-HCC by biopsy. Samples were obtained using 18-gauge needles in the different enhanced areas. The enhancement features of DN-HCC, HCC and RN were evaluated.Results: There were 86 HCC lesions, 102 RN lesions, and 27 DN-HCC lesions diagnosed by biopsy. Of 86 HCC lesions, 87.2%(75/86) showed complete enhancement during the arterial phase, and 12.8%(11/86) had inhomogeneous enhancement, with no enhancement in the central area during the arterial phase; 100%(86/86) exhibited washout during the late phase. Of 102 RN lesions, 95.1%(97/102) had delayed or simultaneous enhancement during the arterial phase, and 4.9%(5/102) displayed slight enhancement during the arterial phase; 26.5%(27/102) exhibited washout and 73.5%(75/102) exhibited no washout during the late phase. In 27 DN-HCC lesions, only part of the lesions enhanced during the arterial phase and washed out during the late phase; the other areas had delayed or simultaneous enhancement during the arterial phase, and 29.6%(8/27) exhibited slight washout in the late phase. In 86 HCCs, the pathological feature was HCC in the enhanced area of 75 lesions, hepatocellular fatty degeneration in the slightly enhanced area of 7 lesions, and hepatocellular necrosis in the unenhanced area and HCC in the enhanced area of 4 lesions. In 102 RNs, the pathological diagnosis was hepatocyte proliferation with or without fatty degeneration. In 27 DN-HCCs, the pathological feature was HCC in the enhanced area and hepatocyte regeneration in the unenhanced area.Conclusions: CEUS is useful for the diagnosis of focal liver lesions in cirrhotic patients. CEUS can help determine the progression from RN to DN-HCC to HCC by analyzing the hemodynamics. CEUS can promote the diagnostic accuracy of a biopsy by providing more accurate information on the site of the biopsy. | Wei Wu Minhua Chen Kun Yan Yin Dai Shanshan Yin Wei Yang Zhihui Fan | 2015 | Chinese Journal of Cancer Research2015，27，1： | 15 |
| 5 | Effect of contrast-enhanced ultrasound on differential diagnosis of intrahepatic cholangiocarcinoma and arterial phase enhanced hepatic inflammatory lesions显示文摘Objective: To investigate differential diagnosis between intrahepatic cholangiocarcinoma(ICC) and arterial phase enhanced hepatic inflammatory lesions in patients without liver cirrhosis using contrast-enhanced ultrasound(CEUS).Methods: ICC and hepatic inflammatory lesions cases with CEUS and pathological diagnosis between Sep 2013 and Oct 2016 were investigated retrospectively. Imaging features of conventional ultrasound and CEUS were analyzed. The parameters of time intensity curve(TIC), including the arrival time, peak intensity(PI) in the lesions, the starting time for washout, and the intensity difference at 3 min(ΔI_3) after contrast agent infection between the lesion and the liver parenchyma, were compared between ICC and hepatic inflammatory lesions.Results: Twenty-five ICC and fifteen inflammatory patients were included in this study. Seventeen ICC(68.0%)and two inflammatory cases(13.3%) showed bile duct dilatation on conventional ultrasound. Using CEUS, three ICC cases(12.0%) were misdiagnosed as inflammatory lesions and three inflammatory lesions(20.0%) as ICC; two ICC(8.0%) and one inflammatory case(6.7%) could not be made definite diagnosis. Washout started at 34.5±3.5 s and 61.5±12.9 s for ICC and inflammatory lesions respectively(P<0.001). The intensity difference between lesion and liver parenchyma at 3 min after contrast agent injection was 10.8±3.1 dB in ICC and 4.2±2.3 dB in inflammatory group(P<0.001). The sensitivity and specificity differentiating ICC and inflammatory lesions were76% and 87% if the cut-off value of the intensity difference was 7.7 d B.Conclusions: Combined with TIC analysis, and particularly with the characteristic of the early-starting and obvious washout in ICC, CEUS can be useful in differential diagnosis between hepatic inflammatory lesions and ICC. | Shanshan Yin Qiuli Cui Kun Yan Wei Yang Wei Wu Liping Bao Minhua Chen | 2017 | Chinese Journal of Cancer Research2017，29，3： | 13 |
| 6 | The Notch signaling pathway in retinal dysplasia and retina vascular homeostasis显示文摘The retina is one of the most essential elements of vision pathway in vertebrate. The dysplasia of retina cause congenital blindness or vision disability in individuals, and the misbalance in adult retinal vascular homeostasis leads to neovascularization-associated diseases in adults, such as diabetic retinopathy or age-related macular degeneration. Many developmental signaling pathways are involved in the process of retinal development and vascular homeostasis. Among them, Notch signaling pathway has long been studied, and Notch signaling-interfered mouse models show both neural retina dysplasia and vascular abnormality. In this review, we discuss the roles of Notch signaling in the maintenance of retinal progenitor cells, specification of retinal neurons and glial cells, and the sustaining of retina vascular homeostasis, especially from the aspects of conditional knockout mouse models. The potential of Notch signal manipulation may provide a powerful cell fate- and neovascularization-controlling tool that could have important applications in treatment of retinal diseases. | Minhua Zheng Zifeng Zhang Xingcheng Zhao Yuqiang Ding Hua Han | 2010 | Journal of Genetics and Genomics2010，37，9： | 13 |
| 7 | Synthesis of High Purity SiC Powder for High-resistivity SiC Single Crystals Growth显示文摘高纯净硅碳化物(原文如此)粉末被在硅之间的 chemicalreaction 在原处综合,保证 theresulting 的杂质集中原文如此搽粉的碳 powder.In 顺序对高抵抗力的原文如此单个的水晶生长合适, preparationtechnology 原文如此搽粉与的不同原文如此形态学和阶段作文上的形状和 sizeof 碳粒子的 ceramic.The 影响原文如此获得了粉末 werediscussed.The | Li WANG Xiaobu HU Xiangang XU Shouzheng JIANG Lina NING Minhua JIANG | 2007 | Journal of Materials Science & Technology2007，23，1： | 13 |
| 8 | Investigation of cubic Pt alloys for ammonia oxidation reaction显示文摘As a promising fuel candidate,ammonia has been successtully used as anode feed in alkaline fuel cells.However,current technology in catalysts for ammonia electro-oxidation reaction(AOR)with respect to both cost and performance is inadequate to ensure large scale commercial application of direct ammonia fuel cells.Recent studies found that alloying Pt with different transition metals and controlling the morphology of catalysts can improve the AOR activity,and thus potentially can solve the cost issue.Herein,(100)-terminated Pt-M nanocubes(M=3d-transition metals Fe,Co,Ni,Zn)are synthesized via wet-chemistry method and their catalytic activities toward AOR are evaluated.The addition of Fe,Co,Ni and Zn elements can enhance the AOR activity due to decrease in oxophilicity of platinum and bifunctional mechanism.Pt-Zn exhibits the maximum mass activity and specific ativity with values of 0.41 A/mgpt and 169 mA/cm2 that are 1.6 and 1.8 times higher than Pt nanocubes,respectively.Pt-Fe,Pt-Co and PI-Ni nanocubes also ilustrate higher mass and specific activities compared to Pt nanocubes. | Yat Tung Chan Kumar Siddharth Minhua Shao | 2020 | Nano Research2020，13，7： | 10 |
| 9 | Endovascular treatment of blood blister-like aneurysms in the internal carotid artery using a Willis covered stent显示文摘Background Despite the current availability of flow diverter devices(FDD), problems remains regarding optimal endovascular treatment(EVT) for blood blister-like aneurysms(BBAs) of the internal carotid artery(ICA). Objective To evaluate the safety and efficacy of EVT of BBAs in the ICA with a Willis covered stent. Methods 20 consecutive patients(5 men and 15 women) with ruptured BBAs underwent EVT using a Willis covered stent in two institutions from March 2013 to March 2018. Clinical observations, angiographic characteristics, and procedural and follow-up outcomes were retrospectively evaluated. Results 20 consecutive patients(5 men and 15 women) with ruptured BBAs underwent EVT using a Willis covered stent in two institutions from March 2013 to March 2018. Clinical observations, angiographic characteristics, and procedural and follow-up outcomes were retrospectively evaluated. Conclusion Our initial results demonstrate that reconstructive EVT using a Willis covered stent provides a viable approach to treat ICA BBAs. However, an expanded clinical evaluation and larger cohort are needed to confirm the results. | Yi Gu Binxian Gu Yongdong Li Yueqi Zhu Haitao Lu Liming Wei Mo Chen Minhua Li Jieqing Wan Wu Wang | 2018 | Journal of Interventional Medicine2018，1，3： | 8 |
| 10 | Research progress in the SO2 resistance of the catalysts for selective catalytic reduction of NOx显示文摘The selective catalytic reduction(SCR) of NO_x with NH_3 has been proven to be an efficient technology for NO_x conversion to N_2. However, the catalysts used for SCR usually suffer from the problem of sulfur poisoning which seriously limits their practical application. This review summarized sulfur poisoning mechanisms of various SCR de NO_x catalysts and strategies to reduce deactivation caused by SO_2 such as doping metals, controlling the structures and morphologies of the catalysts, and selecting appropriate supports. The methods and procedures of catalysts preparation and the reaction conditions also have effect on SO_2-resistance of the catalysts.Several novel catalyst systems that exhibited good SO_2 resistance are also introduced. This paper could provide guidance for the development of highly efficient sulfur-tolerant de NO_x catalysts. | Minhua Zhang Baojuan Huang Haoxi Jiang Yifei Chen | 2017 | Chinese Journal of Chemical Engineering2017，25，12： | 8 |
| 11 | Clinical value of contrast-enhanced ultrasound in improving diagnostic accuracy rate of transthoracic biopsy of anteriormedial mediastinal lesions显示文摘Objective: To evaluate the clinical value of contrast-enhanced ultrasound(CEUS) in transthoracic biopsy of anterior-medial mediastinal lesions.Methods: A total of 123 patients with anterior or middle mediastinum lesions required ultrasound guided transthoracic biopsy for pathological diagnosis. Among them, 72 patients received CEUS examinations before biopsy. After CEUS, 8 patients were excluded from biopsy and the rest 64 patients underwent biopsy(CEUS group). During the same period, 51 patients received biopsy without CEUS examination(US group). The ultrasonography characteristics, the number of biopsy puncture attempts, diagnostic accuracy rate and the incidence of complications were recorded and compared between the two groups.Results: A large portion of necrosis area or superficial large vessels was found in 8 patients, so the biopsy was cancelled. The internal necrosis was demonstrated in 43.8% of the lesions in CEUS group and in 11.8% of US group(P>0.001). For thymic carcinoma, CEUS increased the detection rate of internal necrosis and pericardial effusion than conventional ultrasound(62.5% vs. 18.8%, P=0.012; 56.3% vs. 12.5%, P=0.023). The average number of punctures in CEUS group and US group was 2.36±0.70 and 2.21±0.51 times, respectively(P>0.05). The diagnostic accuracy rate of biopsy in CEUS group(96.9%, 62/64) was significantly higher than that in US group(84.3%, 43/51)(P=0.022). In US group, 2 patients suffered from mediastinal bleeding(3.9%), while no major complications occurred in CEUS group.Conclusions: CEUS examination provided important information before transthoracic mediastinum biopsy and improved diagnostic accuracy rate in biopsy of anterior and middle mediastinum lesions than conventional ultrasound. | Jingjing Fu Wei Yang Song Wang Jing Bai Hao Wu Haiyue Wang Kun Yan Minhua Chen | 2016 | Chinese Journal of Cancer Research2016，28，6： | 5 |
| 12 | Direct synthesis of L10-FePt nanopartides from single-source bimetallic complex and their electrocatalytic applications in oxygen reduction and hydrogen evolution reactions显示文摘L10-FePt nan oparticles(NPs)with high chemical ordering represent effective electrocatalysts to reduce the cost and enhance theircatalytic performanee in fuel cells.A molecular strategy of preparing highly ordered FePt NPs was used by direct pyrolysis of a Fe,Pt-containing bimetallic complex.The resultant L10-FePt NPs had very high crystallinity as reflected by the obvious diffractionpatterns,clear lattice fringes and characteristic X-ray diffraction peaks,etc.Besides,the strong ferromagnetism with room temperaturecoercivity of 27 kOe further confirmed the face-centered tetrag on al(fet)phase in good agreement with the ordered nano structures.TheFePt NPs can be used as electrocatalysts to catalyze oxygen reduction reaction(ORR)in an O2·saturated 0.1 M HClO4 solution andhydrogen evolution reaction(HER)in the 0.5 M H2SO4 electrolyte with much better performance than commercial Pt/C,and showedquite high stability after 10,000 cycles.The strategy utilizing orga no metallic precursors to prepare metal alloy NPs was dem on strated tobe a reliable approach for improving the catalytic efficiency in fuel cells. | Zhengong Meng Fei Xiao Zhuoxun Wei Xuyun Guo Ye Zhu Yurong Liu Guijun Li Zhen-Qiang Yu Minhua Shao Wai-Yeung Wong | 2019 | Nano Research2019，12，12： | 5 |
| 13 | Laboratory Evaluation for Utilization of Phosphogypsum through Carbide Slag Highly-Effective Activating Anhydrous Phosphogypsum显示文摘Carbide slag was used as an activator to improve the activity of anhydrous phosphogypsum.Carbide slag could greatly improve the mechanical strength of anhydrous phosphogypsum than K_(2)SO_(4).The compressive strength of 11 wt%carbide slag and 1 wt%K_(2)SO_(4)activated anhydrous phosphogypsum increased greatly to 8.6 MPa at 3 d,and 11.9 MPa at 7 d,and 16.0 MPa at 28 d,respectively.The rate of hydration heat was accelerated and the total hydration heat was increased,and more calcium sulfate dihydrate was formed and cross-linked with other parts which improved the compressive strength of anhydrous phosphogypsum under the effects of different activators.It was indicated that carbide slag was a highly effective and cost-efficient activator.The result provides a highly effective and low-cost method which results in a novel and high value-added method for the utilization of phosphogypsum in the future. | 陈顺 XIONG Guoqing 苏英 HE Xingyang XIE Yunxuan WANG Yunfeng GONG Minhua | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，3： | 4 |
| 14 | Fine Machining of Large-Diameter 6H-SiC Wafers显示文摘大直径的 6H-SiC 晶片的三主要用机器制造进程在这篇论文被介绍。这些过程包括切,舔并且擦亮。舔的原因伟人剩余压力和能与随后的擦亮的过程逐渐地被减少的深损坏层。机械擦亮准备的表面(MP ) 出现了有 5-8 nm 的深度的很多擦伤。这些擦伤能被 chemo-mechanicalpolishing (CMP ) 有效地移开。在 CMP 以后,有粗糙 R_a=0.3 nmwas 的极其光滑、低的损坏层表面获得了。原子力量显微镜学(AFM ) 和光显微镜学被用来观察到样品和高分辨率 X 光检查衍射计(HRXRD ) 的表面形态学被用于表面下的区域的水晶格子完美。表面剩余压力的变化被 HRXRD 在用机器制造过程期间调查。 | Xiufang CHEN Juan LI Deying MA Xiaobo HU Xiangang XU Minhua JIANG | 2006 | Journal of Materials Science & Technology2006，22，5： | 4 |
| 15 | Surface Polishing of 6H-SiC Substrates显示文摘为硅碳化物擦亮的表面(原文如此)底层被调查 andresults 为机械擦亮被介绍( MP )并且chemo机械的擦亮( CMP ) .High qualitysurfaces 在 CMP 期间在物理的 MP anddetailed 和化学过程与擦伤的胶体的 silica.The 移动机制在 CMP 以后被获得是 MP 和 CMP 的 analyzed.The 效果在 thesurface 上,粗糙被光显微镜学( OM )估计,原子力量显微镜学( AFM )和高分辨率 | Xiufang CHEN Xiangang XU Juan LI Shouzhen JIANG Lina NING Yingmin WANG Deying MA Xiaobo HU Minhua JIANG | 2007 | Journal of Materials Science & Technology2007，23，3： | 4 |
| 16 | Preparation and characteristics of indium tin oxide (ITO) thin films at low temperature by r.f. magnetron sputtering显示文摘Low resistivity and highly transparent ITO conducting films for solar cell applications were fabricated at low temperature by r.f. magnetron sputtering. ITO films were deposited on glass and silicon substrate. Electrical, optical, structural and morphological properties of the ITO films were investigated in terms of the preparation conditions. The annealing treatment has improved the properties of the ITO films at different degree. The maximum transmittance of the obtained ITO films in the visible range is over 92%, and the low resistivity for the ITO films are about 3.85×10-4 Ω·cm at 80 ℃, 80 W after annealing. | REN Bingyan LIU Xiaoping WANG Minhua XU Ying | 2006 | Rare Metals2006，25，z1： | 4 |
| 17 | Thermally removable in-situ formed ZnO template for synthesis of hierarchically porous N-doped carbon nanofibers for enhanced electrocatalysis显示文摘合理设计和有高特定的表面区域和层次地多孔的结构的一个维的 nanofibers 的简单合成仍然是挑战性的。在现在的工作,利用一个热地可移动的模板的新奇策略被开发综合通过简单 electrospinning 技术的使用的层次地多孔的做 N 的碳 nanofibers (HP-NCNFs ) 结合了随后的热分解。在热分解进程期间, ZnO nanoparticles 能在 situ 被形成并且在高温度的条件下面由于他们的分解和升华充当一个热地可移动的模板。产生 HP-NCNFs 与 300 nm 的一条平均直径有一些多达几百测微计并且全部拥有层次地多孔的结构。如此的唯一的结构赋予 HP-NCNFs 以多达 829.5 m 2 评价到 functionalized MNP 的表面上,在微波导致消化反应的更高的效率试验。而且, functionalized MNP 能充当一个微波吸收器在时间的一个短时期加速并且充实蛋白质碎片(30-50 ? s ) 。各种各样的试验性的条件象 enzyme-to-protein 比率 1:30 那样, MNP 集中 600?? | Shuguang Wang Zhentao Cui Jinwen Qin Minhua Cao | 2016 | Nano Research2016，9，8： | 4 |
| 18 | Pt-Ni nanourchins as electrocatalysts for oxygen reduction reaction显示文摘 | Qiaowan CHANG Yuan XU Shangqian ZHU Fei XIAO Minhua SHAO | 2017 | Frontiers in Energy2017，11，3： | 3 |
| 19 | Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy显示文摘Here,we describe a combination strategy of black phosphorus(BP)-based photothermal therapy together with anti-CD47 antibody(aCD47)-based immunotherapy to synergistically enhance cancer treatment.Tumour resistance to immune checkpoint blockades in most cancers due to immune escape from host surveillance,along with the initiation of metastasis through immunosuppressive cells in the tumour microenvironment,remains a significant challenge for cancer immunotherapy.aCD47,an agent for CD47/SIRPαaxis blockade,induces modest phagocytic activity and a low response rate for monotherapy,resulting in failures in clinical trials.We showed that BP-mediated ablation of tumours through photothermal effects could serve as an effective strategy for specific immunological stimulation,improving the inherently poor immunogenicity of tumours,which is particularly useful for enhancing cancer immunotherapy.BP in combination with aCD47 blockade activates both innate and adaptive immunities and promotes local and systemic anticancer immune responses,thus offering a synergistically enhanced effect in suppression of tumour progression and in inducing abscopal effects for inhibition of metastatic cancers.Our combination strategy provides a promising platform in which photothermal agents could help to enhance the therapeutic efficacy of immunotherapy. | Zhongjian Xie Minhua Peng Ruitao Lu Xiangying Meng Weiyuan Liang Zhongjun Li Meng Qiu Bin Zhang Guohui Nie Ni Xie Han Zhang Paras N.Prasad | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 20 | Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D显示文摘Phospholipase D(PLD)hydrolyzes the phosphodiester bond of glycerophospholipids and produces phosphatidic acid(PA),which acts as a second messenger in many living organisms.A large number of PLDs have been identified in eukaryotes,and are viewed as promising targets for drug design because these enzymes are known to be tightly regulated and to function in the pathophysiology of many human diseases.However,the underlying molecular mechanisms of catalysis and regulation of eukaryotic PLD remain elusive.Here,we determined the crystal structure of full-length plant PLDα1 in the apo state and in complex with PA.The structure shows that the N-terminal C2 domain hydrophobically interacts with the C-terminal catalytic domain that features two HKD motifs.Our analysis reveals the catalytic site,substrate-binding mechanism,and a new Ca2+-binding site that is required for the activation of PLD.In addition,we tested several efficient small-molecule inhibitors against PLDα1,and suggested a possible competitive inhibition mechanism according to structure-based docking analysis.This study explains many long-standing questions about PLDs and provides structural insights into PLD-targeted inhibitor/drug design. | Jianxu Li Fang Yu Hui Guo Renxue Xiong Wenjing Zhang Fangyuan He Minhua Zhang Peng Zhang | 2020 | Cell Research2020，30，1： | 3 |
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