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| 1 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 2 | Influences of water treatment agents on oil-water interfacial properties of oilfield produced water显示文摘The emulsion stability of oilfield produced water is related to the oil-water interfacial film strength and the zeta potential of the oil droplets. We investigated the effects of water treatment agents (corrosion inhibitor SL-2, scale inhibitor HEDP, germicide 1227, and flocculant polyaluminium chloride PAC) on the stability of oilfield produced water. The influence of these treatment agents on oil-water interfacial properties and the mechanism of these agents acting on the oilfield produced water were studied by measuring the interfacial shear viscosity, interfacial tension and zeta electric potential. The results indicated that the scale inhibitor HEDP could increase the oil-water interfacial film strength, and it could also increase the absolute value of the zeta potential of oil droplets. HEDP played an important role in the stability of the emulsion. Polyaluminum chloride (PAC) reduced the stability of the emulsion by considerably decreasing the absolute value of the zeta potential of oil droplets. Corrosion inhibitor SL-2 and germicide 1227 could decrease the oil-water interfacial tension, whereas they had little influence on oil-water interfacial shear viscosity and oil-water interfacial electricity properties. | Guo Jixiang Cao Jingjing Li Mingyuan Xia Haiying | 2013 | Petroleum Science2013，10，3： | 9 |
| 3 | Development and Preliminary Evaluation of a Double-cell Ozonesonde显示文摘Ozonesondes are widely used to obtain ozone concentration profiles from the surface to the upper atmosphere. A kind of double-cell ozonesonde has been developed at the Institute of Atmospheric Physics(IAP), Chinese Academy of Sciences(named the 'IAP ozonesonde') based on previous experience over the past 20 years of developing the singlecell GPSO3 ozonesonde. The IAP ozonesonde is of the Electrochemical Concentration Cell(ECC) type. A detailed description of the IAP ozonesonde is firstly provided in the present paper, followed by a presentation of results from a series of launches carried out to evaluate its performance. The analysis involved comparing its observations with measurements from the GPSO3 and ECC ozonesondes(Model type ENSCI-Z) as well as a Brewer spectrophotometer. The results showed that the IAP ozonesonde is a vast improvement over the GPSO3 ozonesonde, able to capture vertical ozone structures very well and in good agreement with ECC ozonesonde measurements. The average difference in the ozone partial pressure between the IAP and ECC ozonesondes was 0.3 mPa from the surface to 2.5 km, close to zero from 2.5 to 9 km and generally less than 1 mPa for layers higher than 9 km. The apparent deviation is likely caused by a decreasing pump flow rate in the IAP ozonesonde which needs further improvement. The total ozone amounts measured by the IAP ozonesonde profiles were highly comparable with the Brewer data with a relative difference of 6%. The development of the IAP ozonesonde and its strong performance will surely accelerate the process of conventional observations of ozone profiles over China in the near future as well as provide more data for ozone research in general. | ZHANG Jinqiang XUAN Yuejian YAN Xiaolu LIU Mingyuan TIAN Hongmin XIA Xiang'ao PANG Li ZHENG Xiangdong | 2014 | Advances in Atmospheric Sciences2014，31，4： | 7 |
| 4 | Antioxidant activity and oxygen-scavenging system in orange pulp during fruit ripening and maturation显示文摘 | Renhua Huang Renxue Xia Liming Hu Yunmei Lu Mingyuan Wang | 2007 | Scientia Horticulturae2007，，2： | 1 |
| 5 | An infinite class of supplementary difference sets and Williamson matrices显示文摘 | | 1991 | J Combin1991，1991，58： | 1 |
| 6 | A new of supplementary difference sets and Hadamard matrices显示文摘 | | 1996 | J Statistical Planning and Inference1996，，51： | 1 |
| 7 | Induced Generalized Intuitionistic fuzzy OWA Operator for Multi-attribute Group Decision Making显示文摘 | ZHIXIN SU GUOPING XIA MINGYUAN CHEN | 2012 | Expert Systems with Applications2012，39，： | 1 |
| 8 | Microwave absorption and thermal properties of coral-like SiC aerogel composites prepared by water glass as a silicon source显示文摘As a heat-resistant wave-absorbing material,silicon carbide(SiC)aerogel has become a research hotspot at present.However,the most common silicon sources are organosilanes,which are costly and toxic.In this work,SiC aerogels were successfully prepared by using water glass as the silicon source.Specifically,the microstructure and chemical composition of SiC aerogels were controlled by adjusting the Si to C molar ratio during the sol–gel process,and the effect on SiC aerogel microwave absorption properties was investigated.The SiC aerogels prepared with Si:C molar ratio of 1:1 have an effective electromagnetic wave absorption capacity,with a minimum reflection loss value of-46.30 dB at 12.88 GHz and an effective frequency bandwidth of 4.02 GHz.They also have good physical properties,such as the density of0.0444 g/cm^(3),the thermal conductivity of 0.0621 W/(m·K),and the specific surface area of 1099 m^(2)/g.These lightweight composites with microwave-absorbing properties and low thermal conductivity can be used as thermal protection materials for space shuttles and reusable carriers. | Xinyuan Zhang Chenkang Xia Weihai Liu Mingyuan Hao Yang Miao Feng Gao | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，7： | 0 |
| 9 | Atomically-precise Au_(24)Ag_(1) Clusterzymes with Enhanced Peroxidase-like Activity for Bioanalysis显示文摘Atomically-precise clusterzymes have been widely studied for their special physicochemical properties,but it is still a challenge to enhance their peroxidase-like activity.Herein,we demonstrated that by substituting a single Ag atom into Au25 nanoclusters to form Au_(24)Ag_(1) nanoclusters,the peroxidase-like activity was enhanced greatly.In the presence of H_(2)O_(2),Au_(24)Ag_(1) could produce reactive oxygen species(ROS)to oxidize colorless 3,3'5,5'-tetramethylbenzidine(TMB)to the blue oxidized TMB(oxTMB).It is worth mentioning that pyrophosphate compounds inhibit the activity of Au_(24)Ag_(1).Since alkaline phosphatase(ALP)can dephosphorylate the substrate phosphate compound,that is,remove the phosphate group on the substrate by hydrolysis,the enzymatic activity of the clusterzyme is restored.Based on this,we have developed a sensitive and reliable colorimetric sensing system for the detection of pyrophosphate ion(PPi),adenosine triphosphate(ATP),adenosine diphosphate(ADP)and ALP,respectively.Importantly,the detection limit of the assay system is lower than those of most of the assays that have been reported.In addition,we also built a simple optical logic gate on this basis,further extending the application of metal nanoclusters as peroxidase mimics in bioanalysis.This work could help to shed light on the structure-activity relationship of nanozyme. | WANG Shuna LI Zhe XIA Mingyuan ZHAO Xiaoxue CHEN Chuanxia JIANG Yuanyuan NI Pengjuan LU Yizhong | 2023 | Chemical Research in Chinese Universities2023，39，6： | 0 |
| 10 | MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis显示文摘Objective:In various cancers,migration and invasion inhibitory protein(MIIP)is expressed at low level and is involved in cancer pathogenesis.Herein,we sought to explore the function of MIIP in clear cell renal cell carcinoma(ccRCC).Methods:CCK-8,colony formation,cell cycle,and endothelial cell tube formation assays were performed to evaluate the roles of MIIP in ccRCC proliferation and angiogenesis.To explore the underlyi ng mechanism,we con ducted RNA-sequencing,GSEA,qRT-PCR,Western blot,ELISA,cell transfection,coimmunoprecipitation,and ubiquitination assays in ccRCC cell lines.Furthermore,xenograft tumor growth in nude mice,and Ki-67 and CD31 staining in xenograft tissues were examined.Finally,the association of MIIP expression with clinical pathology and the expression status of HIF-2a and cysteine-rich 61(CYR61)were further analyzed in human RCC tissues through Western blot and immunohistochemistry.Results:Both in vitro and in vivo functional experiments indicated that forced expression of MIIP inhibited ccRCC proliferation and angiogenesis,whereas silencing MIIP either in normal HK-2 cells or in ccRCC cells had the opposite effect(P<0.05).Mechanistically,CYR61 was identified as a gene significantly downregulated by MIIP overexpression,and was required for the suppressive role of MIIP in ccRCC.MIIP was found to promote HSP90 acetylation and thus impair its chaperone function toward HIF-2a.Consequently,RACK1 binds HIF-2a and causes its ubiquitination and proteasomal degradation,thus decreasing the transcription of its target,CYR61.Finally,analyses of clinical samples demonstrated that MIIP is significantly downregulated in cancer vs.normal tissues in RCC cases,and its expression is negatively associated with histological grade,metastasis,the prognosis of patients with RCC,and the expression of HIF-2a and CYR61(P<0.05).Conclusions:MIIP is a novel tumor suppressor in ccRCC via negative regulation of HIF-2a-CYR61 axis. | Fengqi Yan Qinhao Wang Mingyuan Xia Yi Ru Wei Hu Guang Yan Xin Xiong Mei Zhang Jiancai Wang Qi Li Bo Zhang He Wang Wei Lin Guojun Wu Xia Li | 2022 | Cancer Biology & Medicine2022，19，6： | 0 |
| 11 | 基于内镜图像深度学习的鼻咽恶性肿瘤检测模型的建立与验证显示文摘背景与目的由于鼻咽部解剖位置隐匿且腺体增生频发,活检时恶性肿瘤的阳性率较低,从而导致初诊时鼻咽恶性肿瘤确诊延时或漏诊。本文旨在建立一种人工智能工具——基于深度学习的内镜检查,来检测鼻咽恶性肿瘤。方法建立了一种基于内镜图像的鼻咽恶性肿瘤检测模型(endoscopic imagesbased nasopharyngeal malignancies detection model,eNPM-DM),该模型由基于空间结构的全卷积网络构成,采用单独训练集和验证集对分类和分割进行微调。总共收集了28,966张合格图像。其中,自2008年1月1日至2016年12月31日,从7951例个体中获得了27,536张经活检证实的图像,按照7∶1∶2的比例随机分为训练、验证和测试集。此外,将2017年1月1日到2017年3月31日获得的1430张图像纳入预测集,用以对建立模型的性能与肿瘤专家的评价进行比较。以鼻咽镜图像为背景,对自动分割和专家手工分割进行比较,采用dice相似系数(dice similarity coefficient,DSC)评价eNPM-DM从鼻咽部内镜图像的背景中自动分割出恶性肿瘤区域的效率。结果所有图像经过病理组织学验证,包括正常对照5713(19.7%)例、鼻咽癌(nasopharyngeal carcinoma,NPC)19,107(66.0%)例、其他恶性肿瘤335(1.2%)例和3811(13.2%)例良性病变。在测试集中,eNPM-DM检测恶性肿瘤的总准确率达88.7%[95%置信区间(confidence interval,CI):87.8%–89.5%]。在预测比较阶段,eNPM-DM表现优于专家:总准确率分别为88.0%(95%CI:86.1%–89.6%)和80.5%(95%CI:77.0%–84.0%)。eNPM-DM耗时更短(40 s vs. 110.0±5.8 min),且从背景中自动分割出鼻咽恶性肿瘤区域方面表现优秀,测试集和预测集中的平均DSC分别为0.78±0.24和0.75±0.26。结论 eNPM-DM在鼻咽肿块良性/恶性诊断分类方面优于肿瘤学家评估,并且实现了从鼻咽内镜图像背景中对恶性区域自动分割。 | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2019 | 癌症2019，38，7： | 0 |
| 12 | Hepatocyte growth factor protects pulmonary endothelial barrier against oxidative stress and mitochondria-dependent apoptosis显示文摘Background:Pulmonary microvascular endothelial cells(PMVECs)were not complex,and the endothelial barrier was destroyed in the pathogenesis progress of acute lung injury(ALI)/acute respiratory distress syndrome(ARDS).Previous studies have demonstrated that hepatocyte growth factor(HGF),which was secreted by bone marrow mesenchymal stem cells,could decrease endothelial apoptosis.We investigated whether mTOR/STAT3 signaling acted in HGF protective effects against oxidative stress and mitochondria-dependent apoptosis in lipopolysaccharide(LPS)-induced endothelial barrier dysfunction and ALI mice.Methods:In our current study,we introduced LPS-induced PMEVCs with HGF treatment.To investigate the effects of mammalian target of rapamycin(mTOR)/signal transducer and activator of transcription 3(STAT3)pathway in endothelial oxidative stress and mitochondria-dependent apoptosis,mTOR inhibitor rapamycin and STAT3 inhibitor S3I-201 were,respectively,used to inhibit mTOR/STAT3 signaling.Moreover,lentivirus vector-mediatedmTORC1(Raptor)andmTORC2(Rictor)gene knockdown modifications were introduced to evaluatemTORC1 andmTORC1 pathways.Calcium measurement,reactive oxygen species(ROS)production,mitochondrial membrane potential and protein,cell proliferation,apoptosis,and endothelial junction protein were detected to evaluate HGF effects.Moreover,we used the ALI mouse model to observe the mitochondria pathological changes with an electron microscopein vivo.Results:Our study demonstrated that HGF protected the endothelium via the suppression of ROS production and intracellular calcium uptake,which lead to increased mitochondrial membrane potential(JC-1 and mitochondria tracker green detection)and specific proteins(complex I),raised anti-apoptosis Messenger Ribonucleic Acid level(B-cell lymphoma 2 and Bcl-xL),and increased endothelial junction proteins(VE-cadherin and occludin).Reversely,mTOR inhibitor rapamycin and STAT3 inhibitor S3I-201 could raise oxidative stress and mitochondria-dependent apoptosis even with HGF treatment in LPS-induced endothelial cells.Similarly,mTORC1 as well as mTORC2 have the same protective effects in mitochondria damage and apoptosis.Inin vivo experiments of ALI mouse,HGF also increased mitochondria structural integrity via the mTOR/STAT3 pathway.Conclusion:In all,these reveal that mTOR/STAT3 signaling mediates the HGF suppression effects to oxidative level,mitochondria-dependent apoptosis,and endothelial junction protein in ARDS,contributing to the pulmonary endothelial survival and barrier integrity. | Shanshan Meng Feiping Xia Jingyuan Xu Xiwen Zhang Ming Xue Mingyuan Gu Fengmei Guo Yingzi Huang Haibo Qiu Yi Yang | 2022 | Chinese Medical Journal2022，，7： | 0 |
| 13 | Crop classification based on the spectrotemporal signature derived from vegetation indices and accumulated temperature显示文摘Due to differences in environmental factors,the phenology of the same crop is different every year,causing divergent performances of the classifier built by spectral or time-series features Here,we proposed a random forest classifier(RFC)based on an asymmetric double S curve model fitted by accumulated temperature(AT)and Vegetation Index(VI),which can be applied in different years without ground samples.We built AT and VI time series from Moderate Resolution Imaging Spectroradiometer 8-day composites of land surface temperatures and Sentinel-2 and Landsat-8,respectively.The RFC was trained by characteristics from the asymmetric double S curve.We prepared RFC by ground samples of 2018 and 2019 and then mapped crops of the same region in 2017.Results indicated that,compared with diverse VI-AT series,the overall accuracy based on universal normalized vegetation index(UNVI)was the best of all(2017:F1=0.91,2018:F1=0.92,2019:F1=0.91)and better than that based on the UNVI-TIME series(2017:F1=0.84,2018:F1=0.81,2019:F1=0.88).It proved that the classification features from the VI-AT series have smaller intra-class differences in 2017,2018,and 2019. | Lifu Zhang Liaoran Gao Changping Huang Nan Wang Sa Wang Mingyuan Peng Xia Zhang Qingxi Tong | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
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