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| 1 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 2 | Is the schatzki ring a unique esophageal entity?显示文摘AIM:To study,whether the association of Schatzki rings with other esophageal disorders support one of the theories about its etiology.METHODS:From 1987 until 2007,all patients with newly diagnosed symptomatic Schatzki rings (SRs) were prospectively registered and followed.All of them underwent structured interviews with regards to clinical symptoms,as well as endoscopic and/or radiographic examinations.Endoscopic and radiographic studies determined the presence of an SR and additional morphological abnormalities.RESULTS:One hundred and sixty-seven patients (125 male,42 female) with a mean age of 57.1±14.6 years were studied.All patients complained of intermittent dysphagia for solid food and 113 (79.6%) patients had a history of food impaction.Patients experienced symptoms for a mean of 4.7±5.2 years before diagnosis.Only in 23.4% of the 64 patients who had endoscopic and/or radiological examinations before their first presentation to our clinic,was the SR previously diagnosed.At presentation,the mean ring diameter was 13.9±4.97 mm.One hundred and sixty-two (97%) patients showed a sliding hiatal hernia.Erosive reflux esophagitis was found in 47 (28.1%) patients.Twenty-six (15.6%) of 167 patients showed single or multiple esophageal webs;five (3.0%) patients exhibited eosinophilic esophagitis;and four (2.4%) had esophageal diverticula.Four (7%) of 57 patients undergoing esophageal manometry had nonspecific esophageal motility disorders.CONCLUSION:Schatzki rings are frequently associated with additional esophageal disorders,which support the assumption of a multifactorial etiology.Despite typical symptoms,SRs might be overlooked. | Michaela Müller Ines Gockel Philip Hedwig Alexander J Eckardt Kathrin Kuhr Jochem Knig Volker F Eckardt | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 3 | Like Phoenix from the Ashes? The Renewal of Clusters in Old Industrial Areas显示文摘 | TODTLING F MICHAELA TRIPPL M | 2004 | Urban Studies2004，41，56： | 1 |
| 4 | Rapid and sensitive detection of enhanced green fluorescent protein expression in paraffin sections by confocal laser scanning microscopy显示文摘 | Ingrid W Michaela F Dieter K | 2002 | Histoche J2002，32，： | 1 |
| 5 | Elimination of endemic measles transmission in Australia 显示文摘 | Anita E Heywood Heather F Gidding Michaela A Riddell | 2009 | Bull WHO2009，87，1： | 1 |
| 6 | Phyloge - netic relationships of the Genus Paramecium Inferred from Small subunltRrna Cello Sequences 显示文摘 | MICHAELA C ADDRE - DENIS G SERGEIL F | 2000 | Molecular Phyloge - netics and Evolution2000，14，1： | 1 |
| 7 | Long-term results after video-assisted thoracoscopic surgery for first-time and recurrent spontaneous pneumothorax显示文摘 | Rudolf A Hatz Michaela F Kaps Georgios Meimarakis Florian Loehe Christian Müller Heinrich Fürst | 2000 | The Annals of Thoracic Surgery2000，，1： | 1 |
| 8 | Myc regulates keratinocyte adhesion and differentiation via complex formation with Mizl 显示文摘 | Anneli G Michaela F Steffi H | 2006 | J Cell Biol2006，172，1： | 1 |
| 9 | Fucoidan reduces secretion and expression of vascular endothelial growth factor in the retinal pigment epithelium and reduces angiogenesis in vitro显示文摘 | Michaela D Sabine F Yang S | 2014 | Plos One2014，9，89： | 1 |
| 10 | Financial policy and capital structure choice in UK SMEs: Empirical evi- dence from company panel data 显示文摘 | Michaelas N Chittenden F Poutziouris P | 1999 | Small Business Eco- nomics1999，12，2： | 1 |
| 11 | Like phoenix from the ashes? The renewal of clusters in old industrial areas 显示文摘 | Todtling F Michaela Trippl M | 2004 | Urban Studies2004，41，56： | 1 |
| 12 | Like Phoenix from the Ashes? The Renewal of Clusters in Old Industrial Areas显示文摘 | Todtling F Michaela Trippl M | 2004 | Urban Studies2004，41，56： | 1 |
| 13 | Elimination of endemic measles transmission in Australia显示文摘 | Anita E Heywood Heather F Gidding Michaela A Riddell | 2009 | BullWHO2009，87，1： | 1 |
| 14 | Like phoenix from the a- shes the renewal of clusters in old industrial areas显示文摘 | TODTLING F MICHAELA T M | 2004 | Urban Studies2004，41，56： | 1 |
| 15 | Phylogenetic relationships of the Genus Paramecium Inferred from Small subunit rRNA Gene Sequences 显示文摘 | MICHAELA C ADDRE-DENIS G SERGEIL F | 2000 | Molecular Phylogenetics and Evolution2000，14，1： | 1 |
| 16 | Financial policy and capital structure choice in UK SMEs: Empirical evidence from company panel data显示文摘 | Michaelas N Chittenden F Poutziouris P | 1999 | Small Business Economics1999，12，2： | 1 |
| 17 | A VASP-Rac–Soluble Guanylyl Cyclase Pathway Controls cGMP Production in Adipocytes显示文摘 | Katja Jennissen Franziska Siegel Michaela Liebig-Gonglach Michaela-Rosemarie Hermann Stefanie Kipschull Sander van Dooren Wolfram S. Kunz Reinhard F?ssler Alexander Pfeifer | 2012 | Science Signaling2012，，239： | 1 |
| 18 | Financial Policy and Capital Structure Choice in UK SMEs: Empirical Evidence from Company Panel Data 显示文摘 | Michaelas N Chittenden F Poutziouris P | 1999 | Small Business Economics1999，12，2： | 1 |
| 19 | Finan- cial Policy and Capital Structure Choice in UK SMEs: Empirical Evidencefrom Company Panel Da- ta显示文摘 | Michaelas N Chittenden F Poutziouris P | 1999 | Small Business Economics1999，12，2： | 1 |
| 20 | Polybrominated Diphenyl Ethers Induce Developmental Neurotoxicity in a Human in Vitro Model: Evidence for Endocrine Disruption显示文摘 | Schreiber Timm Gassmann Kathrin G?tz Christine Hübenthal Ulrike Moors Michaela Krause Guido Merk Hans F Nguyen Ngoc-Ha Scanlan Thomas S Abel Josef Rose Christine R Fritsche Ellen | 2010 | Environmental Health Perspectives2010，，4： | 1 |
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