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| 1 | Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach: Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)显示文摘 | Inzucchi Silvio E Bergenstal Richard M Buse John B Diamant Michaela Ferrannini Ele Nauck Michael Peters Anne L Tsapas Apostolos Wender Richard Matthews David R | 2012 | EN2012，，3： | 6 |
| 2 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 3 | Defining the nature of human pluripotent stem cell progeny显示文摘当人的 pluripotent 干细胞(hPSCs ) 能区分产生各种各样的房间类型的一件礼服,是清楚的时,在 vitro,开发怎么仔细反射那,是未知的哪个发生在 vivo。决定人的胚胎的干细胞(hESCs ) 和导致人的 pluripotent 干细胞(hiPSCs ) 是否做相等的子孙,并且是否也使房间成为那类似于导出织物的房间,我们执行了净化的 PSC 衍生物和他们的导出织物的对应物介绍的全面 transcriptome。表示介绍证明 hESCs 和 hiPSCs 在 hiPSC 子孙用外长的 reprogramming 因素为重新表示的神经、肝、间充质的系,和缺席做将近相同的子孙。不管多么与一个导出织物的对应物相比, hESCs 和 hiPSCs 的子孙维持了通常与早哺乳动物的开发联系的基因的一个子集的表示,不管产生的房间的类型。当 pluripotent 基因(OCT4, SOX2, REX1,和 NANOG ) 看起来在从 hPSCs 的区别之上立即是 silenced 时,对早胚胎(LIN28A, LIN28B, DPPA4,和其它) 通常独特的基因不是充分在 hPSC 衍生物的 silenced。从在早人的胎儿的织物(开发的 3-16 星期) 的表达式模式的这些数据和证据建议 hPSCs 的区分的子孙很早人的开发是反射的(< 6 个星期) 。这些调查结果为 hPSCs 能在早人的开发的 vitro 模型作为有用服务的想法提供支持,而且为疾病建模和 hPSC 衍生物的临床的申请提出重要问题。 | Michaela Patterson David N Chan IrisHa Dana Case Yongyan Cui Ben Van Hande Hanna KA Mikkola William E Lowry | 2012 | Cell Research2012，22，1： | 2 |
| 4 | Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach: Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)显示文摘 | Inzucchi Silvio E Bergenstal Richard M Buse John B Diamant Michaela Ferrannini Ele Nauck Michael Peters Anne L Tsapas Apostolos Wender Richard Matthews David R | 2012 | EN2012，，3： | 1 |
| 5 | Highly compatible metal and enzyme catalysts for efficient dynamic ki netic resolution of alcohols at ambient temperature显示文摘 | Belén M M Michaela E Krisztián B | 2004 | Angewandte Chemie International Edition2004，43，47： | 1 |
| 6 | Elimination of endemic measles transmission in Australia 显示文摘 | Anita E Heywood Heather F Gidding Michaela A Riddell | 2009 | Bull WHO2009，87，1： | 1 |
| 7 | Longitudinal association be-tween prostatitis and development of benign prostatic hyperplasia显示文摘 | Jennifer L Debra J Michaela E | | 0，，03： | 1 |
| 8 | Analysis of Benzopyrene metabolites Formed by Rat Hepatic Microsomes using High Pressure Liquid Chromatography :Optimization of the Method显示文摘 | Michaela M V e ra K Dagmar A | 2009 | Interdisc Toxicol2009，2，4： | 1 |
| 9 | Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach: Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)显示文摘 | Inzucchi Silvio E Bergenstal Richard M Buse John B Diamant Michaela Ferrannini Ele Nauck Michael Peters Anne L Tsapas Apostolos Wender Richard Matthews David R | 2012 | EN2012，，3： | 1 |
| 10 | Evaluation of the BD MAX Cdiff assay for the detection of the toxin B gene of Clostridium difficile out of faecal specimens显示文摘 | Leitner E Michaela E Grisold AJ | 2013 | Diagn Microbiol Infect Dis2013，76，3： | 1 |
| 11 | Solar photo-Fenton process on the abatement of antibiotics at a pilot scale:degradation kinetics,ecotoxicity and phytotoxicity assessment and removal of antibiotic resistant enterococci显示文摘 | Michaela I Hapeshia E Michael C | 2012 | Water Research2012，46，17： | 1 |
| 12 | Indications for pedogenie formation of perylene in a terrestrial soil profile : depth distribution and first results from stable carbon isotope ratios 显示文摘 | TILMAN G JOHANNES A C B MICHAELA E | | Applied Geochemistry0，55，12： | 1 |
| 13 | Soil hypha-me- diated movement of allelochemicals : arbuscular mycorrhi- zae extend the bioactive zone of juglone显示文摘 | Michaela A E Kathryn M Frank M | 2014 | Funct Ecol2014，28，4： | 1 |
| 14 | An Examination of Existing Data for the Industrial Manufacture and Use of Nanocomponents and Their Role in the Life Cycle Impact of Nanoproducts 显示文摘 | David E M Mary A C Michaela A G | 2009 | Environmental Science & Technology2009，43，5： | 1 |
| 15 | Elimination of endemic measles transmission in Australia显示文摘 | Anita E Heywood Heather F Gidding Michaela A Riddell | 2009 | BullWHO2009，87，1： | 1 |
| 16 | MicroRNA and lung Cancer显示文摘 | Matthias E Michaela S | 2005 | J New Engl Med2005，，： | 1 |
| 17 | Determination of the Peltier coefficient of germanium in a vertical Bridgman-Stockbarger furnace 显示文摘 | Michaela W E K Matthiesen H D | 1997 | Journal of Crystal Growth1997，174，12： | 1 |
| 18 | Presumed circle area ratio of the prostate in a community-based group of men显示文摘 | Jennifer L Debra J Michaela E | 2009 | BJU Int2009，104，： | 1 |
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