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| 1 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 2 | Pasteurization of apple juice by using microwaves 显示文摘 | JUAN A C JOSE'E C JOHANNES D B | 2002 | Lebensmittel- Wissenschaft und-Technologie2002，35，5： | 1 |
| 3 | Erectile dys- function and coronary risk factors:prospective results from the Massachusetts male aging study 显示文摘 | Feldman H A Johannes C B Derby C A | 2000 | Prey Med2000，30，4： | 1 |
| 4 | RTX toxin genotypes and phenotypes in Actinobacillus pleuropueumoniae field strains显示文摘 | Marianne B Johannes F D B Ingrid M C A J | 1994 | Journal of Clinical Microbiology1994，32，11： | 1 |
| 5 | Retrospective analysis of oral peripheral nerve sheath tumors in Brazilians显示文摘 | Salla J T Johann A C Garcia B G | 2009 | Braz Oral Res2009，23，1： | 1 |
| 6 | 生物工程化的2′-fucosyllactose和3-fucosyllactose抑制绿脓杆菌和肠道病原体黏附于人体肠道和呼吸道细胞系中显示文摘 | Stefan Weicherta Stefan Jennewein b Eric Hufnerb Christel Weiss c Julia Borkowski a Johannes Putze a 1 Horst Schroten a 1 | 2013 | NUTRITION-RESEARCH2013，，33： | 1 |
| 7 | Functional significance of the activation-associated receptors CD25 and CD69 on human NK-cells and NK-like T2cdls显示文摘 | Johannes C B irgit M M artina A | | 0，，02： | 1 |
| 8 | Recent progress in the development of gamma titanium aluminide alloys 显示文摘 | FRITZ A ULRICH B ULRICH C STEFAN E PETER J UWE L JOHANN M MICHAEL 0 PAUL J 0 H | 2000 | Advanced Engineering Materials2000，2，11： | 1 |
| 9 | The risk of non- vertebral fracturerelated to inhaled corticosterioid exposure amongadults with chronic respiratory disease显示文摘 | Johannes C B Schmeider G A Dube T J | 2005 | Chest2005，127，1： | 1 |
| 10 | Indications for pedogenie formation of perylene in a terrestrial soil profile : depth distribution and first results from stable carbon isotope ratios 显示文摘 | TILMAN G JOHANNES A C B MICHAELA E | | Applied Geochemistry0，55，12： | 1 |
| 11 | Computing and rendering point set surfaces 显示文摘 | Marc A Johannes B Daniel C | 2003 | mER Transactions on Visualization and Computer Graphics2003，9，1： | 1 |
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