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| 1 | Contrast-enhanced endoscopic ultrasound in discrimination between focal pancreatitis and pancreatic cancer显示文摘瞄准:作为基于微容器的灌注特征把发炎区分开来与胰腺的癌的一个方法评估提高对比的 endosonography。方法:在有怀疑的慢性胰炎的 86 个病人(变老:62+/-12 年;性别:f/m 38/48 ) ,胰腺的损害被常规内视镜的 B 模式,力量 Doppler 超声和提高对比的力量模式检验(日立 EUB 525, SonoVue, 2.4 mL, Bracco ) 用为恶意的损害的下列标准:用常规力量 Doppler 的没有可检测的 vascularisation 在用 SonoVue 提高对比的技术和没有可检测的静脉的容器里面的短距离上的动脉的容器的扫描、不规则的外观损害。如果所有标准是可检测的,恶意的损害被假定[内视镜的超声(EUS ) 指导了的标准答案好针渴望细胞学,操作] 。没有瘤形成的慢性胰炎的标准在 SonoVue 的注射前被定义为没有可检测的 vascularisation,在在 SonoVue 的注射和动脉、静脉的容器的察觉以后的至少 20 公里的距离上的容器的常规外观。结果:常规 EUS 的敏感和特性为胰腺的癌症分别地是 73.2% 和 83.3% 。与恶意的胰腺的损害和特性在 56 个病人中的 51 个增加到 91.1% 的提高对比的 EUS 的敏感与长期的煽动性的胰腺的疾病在 30 个病人中的 28 个增加了到 93.3% 。结论:提高对比的内视镜的超声改进在慢性胰炎和胰腺的癌之间的区别。 | Michael Hocke Ewald Schulze Peter Gottschalk Theodor Topalidis Christoph F Dietrich | 2006 | World Journal of Gastroenterology2006，12，2： | 43 |
| 2 | The clinical impact of bacterial biofilms显示文摘Bacteria survive in nature by forming biofilms on surfaces and probably most, if not all, bacteria (and fungi) are capable of forming biofilms. A biofilm is a structured consortium of bacteria embedded in a self-produced polymer matrix consisting of polysaccharide, protein and extracellular DNA. Bacterial biofilms are resistant to antibiotics, disinfectant chemicals and to phagocytosis and other components of the innate and adaptive inflammatory defense system of the body. It is known, for example, that persistence of staphylococcal infections related to foreign bodies is due to biofilm formation. Likewise, chronic Pseudomonas aeruginosa lung infections in cystic fibrosis patients are caused by biofilm growing mucoid strains. Gradients of nutrients and oxygen exist from the top to the bottom of biofilms and the bacterial cells located in nutrient poor areas have decreased metabolic activity and increased doubling times. These more or less dormant cells are therefore responsible for some of the tolerance to antibiotics. Biofilm growth is associated with an increased level of mutations. Bacteria in biofilms communicate by means of molecules, which activates certain genes responsible for production of virulence factors and, to some extent, biofilm structure. This phenomenon is called quorum sensing and depends upon the concentration of the quorum sensing molecules in a certain niche, which depends on the number of the bacteria. Biofilms can be prevented by antibiotic prophylaxis or early aggressive antibiotic therapy and they can be treated by chronic suppressive antibiotic therapy. Promising strategies may include the use of compounds which can dissolve the biofilm matrix and quorum sensing inhibitors, which increases biofilm susceptibility to antibiotics and phagocytosis. | Niels Hoiby Oana Ciofu Helle Krogh Johansen Zhi-jun Song Claus Moser Peter Ostrup Jenser Soren Molin Michael Givskov Tim Tolker-Nieisen Thomas Bjamsholt | 2011 | International Journal of Oral Science2011，3，2： | 48 |
| 3 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 4 | Measurement and Interpretation of Connectivity of Chinese Cities in World City Network,2010显示文摘This is an empirical paper that measures and interprets the position of Chinese cities in the world city network in 2010. Building on a specification of the world city network as a′interlocking network′in which business services firms play the crucial role in city network formation, information is gathered about the presence of global service firms in cities. This information is converted into data to provide the′service value′of a city for a firm′s provision of corporate services in a 526(cities)×175(firms) matrix. These data are then used as the input to the interlocking network model in order to measure cities′connectivity and its predominant geographical orientation. Here we focus on the position of some key Chinese cities in this regard, and discuss and interpret results in the context of the urban dimensions of the′opening up′of the Chinese economy. | Ben DERUDDER Peter J TAYLOR Michael HOYLER NI Pengfei LIU Xingjian ZHAO Miaoxi SHEN Wei Frank WITLOX | 2013 | Chinese Geographical Science2013，23，3： | 40 |
| 5 | Bone Regeneration Based on Tissue Engineering Conceptions – A 21st Century Perspective显示文摘The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades.Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction.However,improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity.Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone.Specifically,novel bioactive(second generation)biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment,whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue.Future generations of biomaterials(third generation)are designed to be not only osteoconductive but also osteoinductive,i.e.to stimulate regeneration of host tissues by combining tissue engineering and in situ tissue regeneration methods with a focus on novel applications.These techniques will lead to novel possibilities for tissue regeneration and repair.At present,tissue engineered constructs that may find future use as bone grafts for complex skeletal defects,whether from post-traumatic,degenerative,neoplastic or congenital/developmental'origin'require osseous reconstruction to ensure structural and functional integrity.Engineering functional bone using combinations of cells,scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties.This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts. | Jan Henkel Maria A.Woodruff Devakara R.Epari Roland Steck Vaida Glatt Ian C.Dickinson Peter F.M.Choong Michael A.Schuetz Dietmar W.Hutmacher | 2013 | Bone Research2013，1，3： | 33 |
| 6 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 7 | On the combined effect of soil fertility and topography on tree growth in subtropical forest ecosystems—a study from SE China显示文摘Aims The aim of our research was to understand small-scale effects of topography and soil fertility on tree growth in a forest biodiversity and ecosystem functioning(BEF)experiment in subtropical SE China.Methods Geomorphometric terrain analyses were carried out at a spatial resolution of 5×5 m.Soil samples of different depth increments and data on tree height were collected from a total of 566 plots(667 m2 each).The soils were analyzed for carbon(soil organic carbon[SOC]),nitrogen,acidity,cation exchange capacity(CEC),exchangeable cations and base saturation as soil fertility attributes.All plots were classified into geomorphological units.Analyses of variance and linear regressions were applied to all terrain,soil fertility and tree growth attributes.Important Findings In general,young and shallow soils and relatively small differences in stable soil properties suggest that soil erosion has truncated the soils to a large extent over the whole area of the experiment.This explains the concurrently increasing CEC and SOC stocks downslope,in hollows and in valleys.However,colluvial,carbon-rich sediments are missing widely due to the convexity of the footslopes caused by uplift and removal of eroded sediments by adjacent waterways.The results showed that soil fertility is mainly influenced by topography.Monte-Carlo flow accumulation(MCCA),curvature,slope and aspect significantly affected soil fertility.Furthermore,soil fertility was affected by the different geomorphological positions on the experimental sites with ridge and spur positions showing lower exchangeable base cation contents,especially potassium(K),due to leaching.This geomorphological effect of soil fertility is most pronounced in the topsoil and decreases when considering the subsoil down to 50 cm depth.Few soil fertility attributes affect tree height after 1-2 years of growth,among which C stocks proved to be most important while pH_(KCl)and CEC only played minor roles.Nevertheless,soil acidity and a high proportion of Al on the exchange complex affected tree height even after only 1-2 years growth.Hence,our study showed that forest nutrition is coupled to a recycling of litter nutrients,and does not only depend on subsequent supply of nutrients from the mineral soil.Besides soil fertility,topography affected tree height.We found that especially MCCA as indicator of water availability affected tree growth at small-scale,as well as aspect.Overall,our synthesis on the interrelation between fertility,topography and tree growth in a subtropical forest ecosystem in SE China showed that topographic heterogeneity lead to ecological gradients across geomorphological positions.In this respect,small-scale soil-plant interactions in a young forest can serve as a driver for the future development of vegetation and biodiversity control on soil fertility.In addition,it shows that terrain attributes should be accounted for in ecological research. | Thomas Scholten Philipp Goebes Peter Kühn Steffen Seitz Thorsten Assmann Jürgen Bauhus Helge Bruelheide Francois Buscot Alexandra Erfmeier Markus Fischer Werner Härdtle Jin-Sheng He Keping Ma Pascal A.Niklaus Michael Scherer-Lorenzen Bernhard Schmid Xuezheng Shi Zhengshan Song Goddert von Oheimb Christian Wirth Tesfaye Wubet Karsten Schmidt | 2017 | Journal of Plant Ecology2017，10，1： | 22 |
| 8 | 动脉粥样硬化血栓形成门诊患者1年内心血管事件的发生率显示文摘背景:目前,有关社区中动脉粥样硬化血栓形成稳定患者心血管(cardiovascular,CV)事件发生率的资料比较少,既往也无国际性队列研究对冠状动脉病(coronary artery disease,CAD)、脑血管病(cerebrovascular disease,CVD)、外周动脉病(peripheral arterial disease,PAD)确诊患者以及此类疾病高危患者不同事件的发生率进行评估。
目的:在患有动脉疾病的门诊患者或存在多个动脉粥样硬化血栓形成危险因素的门诊患者中确定当今世界1年内CV事件的发生率。
设计、地点及参试者:“减少动脉粥样硬化血栓形成维系健康(Reduction of Artherotllrombosis for Continued Health,REACH)”注册研究是一项国际前瞻性队列研究。研究人员于2003—2004年从44个国家、5587名医生入选68236例已确诊的动脉粥样硬化性血管病患者(CAD、PAD、CVD;n=55814)以及至少存在3个动脉粥样硬化血栓形成危险因素的患者(n=12422)。
主要观测指标:CV死亡、心肌梗死(myocardial infarction,MI)及卒中的发生率。结果:截至2006年7月,共有95.22%的患者(n=64977)提供了1年内的结局。心血管死亡、MI及卒中的总体发生率为4.24%;动脉粥样硬化性血管病患者为4.69%,仅存在多个危险因素的患者为2.15%。CAD、CVD及PAD患者CV死亡、MI及卒中的总体发生率分别为4.52%、6.47%和5.35%。CAD、CVD及PAD患者发生终点事件(即CV死亡、MI、卒中)以及因动脉粥样硬化血栓形成事件入院的几率分别为15.20%、14.53%和21.14%。上述事件发生率随症状性动脉疾病病变部位数量的增加而增加,仅存在危险因素的患者为5.31%,有1处症状性动脉疾病的患者为12.58%,有2处症状性动脉疾病的患者为21.14%,有3处症状性动脉疾病的患者为26.27%(趋势P〈0.001)。
结论:在这项当代大型国际研究中,患有动脉粥样硬化性血管病的门诊患者以及有动脉粥样硬化血栓形成危险的门诊患者CV事件的年发生率相对较高。存在多部位病变者CV事件的1年发生率升高。 | Gabriel Steg Deepak L. Bhatt Peter W. F. Wilson Ralph D' Agostino E. Magnus Ohman Joachim Roether Chiau-Suong Liau Alan T. Hirsch Jean-Louis Mas Yasuo Ikeda Michael J. Pencina Shinya Goto 徐成斌(译) 李呈亿(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 20 |
| 9 | 南海张裂过程及其对晚中生代以来东南亚构造的启示--IODP建议书735-Full介绍显示文摘南海的形成揭示了大陆边缘张裂和盆地形成的复杂模式,尽管已经进行了广泛研究,但是关于基底岩石和深海盆沉积层的精确年代数据还很缺乏,这使得对南海张裂年代的估计存在很大的误差,对张裂机制和历史的各种假设没有得到验证。同时只有对南海的张裂过程有了精确地分析与刻画,才能更好地理解西太平洋边缘海盆地的形成以及它们在印支块体受印度—欧亚板块碰撞而向东南挤出、青藏高原隆升中可能起到的作用。2009年正式提交的国际综合大洋钻探计划(IODP)建议书735-Full建议在南海深海盆内的4个站位上实施钻探。这4个站位分布在南海盆地4个不同的次级构造单元上(南海东北部、西北次海盆、东部次海盆和西南次海盆),这样的站位设计会确保完成本建议书的整体研究目标,即揭示南海的张裂历史和它对晚中生代以来东南亚构造的启示。位于南海盆地最东北部的站位有助于确定该区域地壳的属性和验证古南海是否存在,位于西北次海盆的站位可能会提供南海的最早张裂年代,另外2个分别位于东部次海盆和西南次海盆的站位将重点确定2个次海盆的绝对年龄、基底矿物成分与磁化率以及2个次海盆的相对张裂次序。这些站位的水深大约在2910~4400m,钻探深度预计到海底以下大约700~2200m,总的钻透深度为5959m,其中5359m穿透沉积层,另外600m或400m钻入基底。所有这些站位的位置是由已有的地球物理观测数据所确定,目前计划收集更多的地质与地球物理数据以满足IODP对井位调查数据的要求。 | 李春峰 汪品先 Dieter Franke 李家彪 Randell Stephenson 许树坤 Peter Michael 周祖翼 翦知湣 李前裕 刘志飞 耿建华 木村学 阎贫 丘学林 王嘹亮 解习农 吴时国 吴能友 | 2009 | 地球科学进展2009，24，12： | 20 |
| 10 | Proposal of an ultrasonographic classification for hepatic alveolar echinococcosis: Echinococcosis multilocularis Ulm classification-ultrasound显示文摘AIM: To establish an ultrasonographic classification based on a large sample of patients with confirmed hepatic alveolar echinococcosis(AE).METHODS: Clinical data and ultrasonography(US) findings of 185 patients(100 males; 85 females; mean age at diagnosis: 51.4 ± 17.6 years; mean age at time of US examination: 58.7 ± 18.2 years) were retrospectively reviewed with respect to the US morphology of hepatic AE lesions. The sonomorphological findings were grouped according to a five-part classification scheme.RESULTS: Application of the new classification resulted in the following distribution of sonomorphological patterns among the patients examined: hailstorm(54.1%); pseudocystic(13.5%); ossification(13.0%); hemangioma-like(8.1%); and metastasis-like(6.5%). Only 4.9% of lesions could not be assigned to a sonomorphological pattern.CONCLUSION: The sonomorphological classification proposed in the present study facilitates the diagnosis,interpretation and comparison of hepatic alveolar echinococcosis in routine practice and in the context of scientific studies. | Wolfgang Kratzer Beate Gruener Tanja EM Kaltenbach Sarina Ansari-Bitzenberger Peter Kern Michael Fuchs Richard A Mason Thomas FE Barth Mark M Haenle Andreas Hillenbrand Suemeyra Oeztuerk Tilmann Graeter | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 11 | Immune response after photodynamic therapy increases anti-cancer and anti-bacterial effects显示文摘Photodynamic therapy(PDT) is a clinically approved procedure for treatment of cancer and infections. PDT involves systemic or topical administration of a photosensitizer(PS), followed by irradiation of the diseased area with light of a wavelength corresponding to an absorbance band of the PS. In the presence of oxygen, a photochemical reaction is initiated, leading to the generation of reactive oxygen species and cell death. Besides causing direct cytotoxic effects on illuminated tumor cells, PDT is known to cause damage to the tumor vasculature and induce the release of pro-inflammatory molecules. Pre-clinical and clinical studies have demonstrated that PDT is capable of affecting both the innate and adaptive arms of the immune system. Immune stimulatory properties of PDT may increase its beneficial effects giving the therapy wider potential to become more extensively used in clinical practice. Be-sides stimulating tumor-specific cytotoxic T-cells capable to destroy distant untreated tumor cells, PDT leads to development of anti-tumor memory immunity that can potentially prevent the recurrence of cancer. The immunological effects of PDT make the therapy more effective also when used for treatment of bacterial infections, due to an augmented infiltration of neutrophils into the infected regions that seems to potentiate the outcome of the treatment. | Eleonora Reginato Peter Wolf Michael R Hamblin | 2014 | World Journal of Immunology2014，4，1： | 14 |
| 12 | The Deep-Time Digital Earth program:data-driven discovery in geosciences显示文摘Current barriers hindering data-driven discoveries in deep-time Earth(DE)include:substantial volumes of DE data are not digitized;many DE databases do not adhere to FAIR(findable,accessible,interoperable and reusable)principles;we lack a systematic knowledge graph for DE;existing DE databases are geographically heterogeneous;a significant fraction of DE data is not in open-access formats;tailored tools are needed.These challenges motivate the Deep-Time Digital Earth(DDE)program initiated by the International Union of Geological Sciences and developed in cooperation with national geological surveys,professional associations,academic institutions and scientists around the world.DDE’s mission is to build on previous research to develop a systematic DE knowledge graph,a FAIR data infrastructure that links existing databases and makes dark data visible,and tailored tools for DE data,which are universally accessible.DDE aims to harmonize DE data,share global geoscience knowledge and facilitate data-driven discovery in the understanding of Earth’s evolution. | Chengshan Wang Robert MHazen Qiuming Cheng Michael HStephenson Chenghu Zhou Peter Fox Shu-zhong Shen Roland Oberhansli Zengqian Hou Xiaogang Ma Zhiqiang Feng Junxuan Fan Chao Ma Xiumian Hu Bin Luo Juanle Wang Craig M.Schiffries | 2021 | National Science Review2021，8，9： | 14 |
| 13 | Endoscopic ultrasonography guided celiac plexus neurolysis and celiac plexus block in the management of pain due to pancreatic cancer and chronic pancreatitis显示文摘Pain is a common symptom of pancreatic disease and is frequently difficult to manage. Pain relief provided by narcotics is often suboptimal and is associated with significant side effects. An alternative approach to pain management in pancreatic disease is the use of celiac plexus block (CPB) or neurolysis (CPN). Originally performed by anesthesiologists and radiologists via a posterior approach,recent advances in endoscopic ultrasonography (EUS) have made this technique an attractive alternative. EUS guided celiac plexus block/ neurolysis is simple to perform and avoids serious complications such as paraplegia or pneumothorax that are associated with the posterior approach. EUS guided CPN should be considered first line therapy in patients with pain due to pancreatic cancer. It provides superior pain control compared to traditional management with narcotics. A trend for improved survival in pancreatic cancer patients treated with CPN has been reported,but larger studies are needed to confirm this finding. At this time,the use of EUS guided CPB cannot be recommended as routine therapy for pain in chronic pancreatitis since only one-half of the patients experience pain reduction and the beneficial effect tends to be short lived. EUS guided CPB and CPN should be used as part of a multidisciplinary team approach for pain management. | Anthony J Michaels Peter V Draganov | 2007 | World Journal of Gastroenterology2007，13，26： | 10 |
| 14 | Inflammatory bowel disease serology in Asia and the West显示文摘AIM:To study serological antibodies in Caucasians and Asians,in health and inflammatory bowel disease(IBD),in Australia and Hong Kong(HK).METHODS:Anti-glycan antibodies[anti-chitobioside(ACCA),anti-laminaribioside(ALCA)],and anti-mannobioside(AMCA),anti-Saccharomyces cervisiae(gASCA);and atypical perinuclear anti-neutrophil cytoplasmic antibody(pANCA)were tested in IBD patients,their unaffected relatives,and healthy controls in Australia and HK(China).Antibody status(positive or negative)and titre was compared between subjects of different geography,ethnicity and disease state.RESULTS:Ninety subjects were evaluated:21 Crohn’s disease(CD),32 ulcerative colitis(UC),29 healthy controls,and 8 IBD patient relatives.Forty eight subjects were Australian(29 Caucasian and 19 ethnic Han Chinese)and 42 were from HK(all Han Chinese).Caucasian CD patients had a significantly higher antibody prevalence of gASCA(67%vs 3%,P<0.001),ALCA(44%vs 6%,P=0.005),and AMCA(67%vs 15%,P=0.002),whereas HK CD patients had a higher prevalence of only AMCA(58%vs 25%,P=0.035),when compared with UC and healthy subjects in both countries.Caucasian CD had significantly higher gASCA prevalence(67%vs 0%,P<0.001)and titre(median59 vs 9,P=0.002)than HK CD patients.Prevalence and titres of ALCA,ACCA and AMCA did not differ between CD in the two countries.Presence of at least one antibody was higher in Caucasian than HK CD patients(100%vs 58%,P=0.045).pANCA did not differ between countries or ethnicity.CONCLUSION:Serologic CD responses differ between HK Asian and Australian Caucasian patients.Different genetic,environmental or disease pathogenic factors may account for these differences. | Lani Prideaux Michael A Kamm Peter De Cruz Daniel R van Langenberg Siew C Ng Iris Dotan | 2013 | World Journal of Gastroenterology2013，19，37： | 10 |
| 15 | Different antibiotic susceptibility between antrum and corpus of the stomach,a possible reason for treatment failure of Helicobacter pylori infection显示文摘AIM:To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori(H.pylori)therapy-naive or pre-treated.METHODS:H.pylori strains were isolated from antrum and corpus biopsies from 66 patients that received a diagnostic gastroduodenoscopy for variant clinical indications.Antimicrobial susceptibility to amoxicillin,clarithromycin,tetracycline,metronidazole,levofloxacin and rifabutin was tested with the E-test method on IsoSensitest agar with 10 vol%defibrinated horse blood.In patients with a different antibiotic susceptibility pattern between the isolates from the antrum and corpus,DNA fingerprinting via random amplified polymorphic DNA analysis was performed to detect differences among DNA patterns of H.pylori isolates.RESULTS:Primary,secondary and tertiary resistance to clarithromycin was 6.9%,53.8%and 83.3%,retrospectively.Metronidazole and levofloxacin resistance also increased according to the number of previous treatments(17.2%,69.2%,83.3%;13.8%,23.1%,33.3%).Tertiary resistance to rifabutin was detected in12.5%of patients.In none of the 66 patients a resistance against amoxicillin or tetracycline was detectable.Discordant antibiotic susceptibility between antrum and corpus isolates for different antibiotics was seen in 15.2%(10/66)of the patients.Two out of those ten patients were naive to any H.pylori antibiotic treatment.The remaining eight patients previously received at least one eradication therapy.DNA fingerprinting analysis revealed no substantial differences among DNA patterns between antrum and corpus isolates in the majority of patients suggesting an infection with a single H.pylori strain.CONCLUSION:Different antibiotic susceptibility between antrum and corpus biopsies is a common phenomenon and a possible explanation for treatment failure.Resistant H.pylori strains may be missed if just one biopsy from one anatomic site of the stomach is taken for H.pylori susceptibility testing. | Michael Selgrad Ina Tammer Cosima Langner Jan Bornschein Julia Mei?le Arne Kandulski Mariya Varbanova Thomas Wex Dirk Schlüter Peter Malfertheiner | 2014 | World Journal of Gastroenterology2014，20，43： | 10 |
| 16 | Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease显示文摘AIM: Pathological prion protein (PrPSC) is responsible for the development of transmissible spongiform encephalopathies (TSE). While PrPc enters the organism via the oral route, less data is available to know about its uptake and the role of gastrointestinal inflammation on the expression of prion precursor PrPc, which is constitutively expressed in the gastric mucosa.METHODS: We studied PrPc expression in the gastric mucosa of 10 Helicobacter pylori-positive patients before and after successful H pylori eradication compared to non-infected controls using RT-PCR and Western blotting.The effect of central mediators of gastric inflammation,i.e., gastrin, prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) on PrPc expression was analyzed in gastric cell lines.RESULTS: PrPc expression was increased in H pyloriinfection compared with non-infected controls and decreased to normal after successful eradication. Gastrin,PGE2, and IL-1β dose-dependently upregulated PrPc in gastric cells, while TNF-α had no effect.CONCLUSION: H pylori infection leads to the upregulation of gastric PrPc expression. This can be linked to H pylori induced hypergastrinemia and increased mucosal PGE2 and IL-1β synthesis.H pylori creates a milieu for enhanced propagation of prions in the gastrointestinal tract. | Peter C Konturek Karolina Bazela Vitally Kukharskyy Michael Bauer Eckhart G Hahn Detlef Schuppan | 2005 | World Journal of Gastroenterology2005，11，48： | 9 |
| 17 | Fecal markers of inflammation used as surrogate markers for treatment outcome in relapsing inflammatory bowel disease显示文摘AIM: To evaluate fecal calprotectin (FC) as a surrogate marker of treatment outcome of relapse of inflammatory bowel disease (IBD) and, to compare FC with fecal myeloperoxidase (MPO) and fecal eosinophil protein X (EPX). METHODS: Thirty eight patients with IBD, comprising of 27 with ulcerative colitis (UC) and 11 with Crohn’s disease (CD) were investigated before treatment (inclusion), and after 4 and 8 wk of treatment. Treatment outcomes were evaluated by clinical features of disease activity and endoscopy in UC patients, and disease activity in CD patients. In addition, fecal samples were analyzed for FC by enzyme-linked immunosorbent assay (ELISA), and for MPO and EPX with radioimmunoassay (RIA). RESULTS: At inclusion 37 of 38 (97%) patients had elevated FC levels (> 94.7 μg/g). At the end of the study, 31 of 38 (82%) patients fulfilled predefined criteria of a complete response [UC 21/27 (78%); CD 10/11 (91%)]. Overall, a normalised FC level at the end of the study predicted a complete response in 100% patients, whereas elevated FC level predicted incomplete response in 30%. Normalised MPO or EPX levels predicted a complete response in 100% and90% of the patients, respectively. However, elevated MPO or EPX levels predicted incomplete response in 23% and 22%, respectively. CONCLUSION: A normalised FC level has the potential to be used as a surrogate marker for successful treatment outcome in IBD patients. However, patients with persistent elevation of FC levels need further evaluation. FC and MPO provide superior discrimination than EPX in IBD treatment outcome. | Michael Wagner Christer GB Peterson Peter Ridefelt Per Sangfelt Marie Carlson | 2008 | World Journal of Gastroenterology2008，14，36： | 9 |
| 18 | Nature:通过控制血管生长来开发治疗癌症等多种疾病的新型疗法显示文摘最近,一项刊登在国际杂志Nature上的研究报告中,来自耶鲁大学的研究人员通过研究揭示了如何通过控制血管发育来帮助开发治疗心血管疾病以及癌症的新型疗法。 | Yu, Pengchun Wilhelm, Kerstin Dubrac, Alexandre Tung, Joe K. Alves, Tiago C. Fang, Jennifer S. Xie, Yi Zhu, Jie Chen, Zehua De Smet, Frederik Zhang, Jiasheng Jin, Suk-Won Sun, Lele Sun, Hongye Kibbey, Richard G. Hirschi, Karen K. Hay, Nissim Carmeliet, Peter Chittenden, Thomas W. Eichmann, Anne Potente, Michael Simons, Michael | 2017 | 现代生物医学进展2017，17，22： | 9 |
| 19 | Digital Earth 2020:towards the vision for the next decade显示文摘This position paper is the outcome of a brainstorming workshop organised by the International Society for Digital Earth(ISDE)in Beijing in March 2011.It argues that the vision of Digital Earth(DE)put forward by Vice-President Al Gore 13 years ago needs to be re-evaluated in the light of the many developments in the fields of information technology,data infrastructures and earth observation that have taken place since.The paper identifies the main policy,scientific and societal drivers for the development of DE and illustrates the multi-faceted nature of a new vision of DE grounding it with a few examples of potential applications.Because no single organisation can on its own develop all the aspects of DE,it is essential to develop a series of collaborations at the global level to turn the vision outlined in this paper into reality. | Max Craglia Kees de Bie Davina Jackson Martino Pesaresi Gabor Remetey-Fulopp Changlin Wang Alessandro Annoni Ling Bian Fred Campbell Manfred Ehlers John van Genderen Michael Goodchild Huadong Guo Anthony Lewis Richard Simpson Andrew Skidmore Peter Woodgate | 2012 | International Journal of Digital Earth2012，5，1： | 8 |
| 20 | Corporate performance and CEO compensation in China显示文摘 | Michael Firth Peter M.Y. Fung Oliver M. Rui | 2005 | Journal of Corporate Finance2005，，4： | 8 |
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