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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | <ce:link locator='fx1'/> <ce:link locator='fx2'/> Insulin Resistance in Chronic Hepatitis C: Association With Genotypes 1 and 4, Serum HCV RNA Level, and Liver Fibrosis显示文摘 | Rami Moucari Tarik Asselah Dominique Cazals–Hatem Hélène Voitot Nathalie Boyer Marie–Pierre Ripault Rodolphe Sobesky Michèle Martinot–Peignoux Sarah Maylin Marie–Hélène Nicolas–Chanoine Valérie Paradis Michel Vidaud Dominique Valla Pierre Bedossa Patrick | 2008 | Gastroenterology2008，，2： | 2 |
| 3 | Evaluating and designing Web site quality显示文摘 | Mich L Franch M Gaio L | 2003 | IEEE MultiMedia2003，10，1： | 1 |
| 4 | Networks on chips: a new SoC paradigm 显示文摘 | BENINI L MICHELI G D | 2002 | IEEE Computer2002，35，1： | 1 |
| 5 | A decision-maker-centred supplier selection ap- proach for critical supplies显示文摘 | Guido J L Micheli | 2008 | Management Decision2008，46，6： | 1 |
| 6 | An electrochemical immunosensor for aflatoxin M1 determination in milk using screenprinted electrodes显示文摘 | MICHELI L GRECCO R BADEA R | 2005 | Biosensors and Bioelectronics2005，21，4： | 1 |
| 7 | An electrochemical immunosensor for aflatoxin M1 determination in milk using screen-printed electrodes 显示文摘 | Micheli L Grecco R Badea M | 2005 | Biosens Bioelectron2005，21，4： | 1 |
| 8 | A survey of design techniques for system-level dynamic power management 显示文摘 | Benini L Bogliolo A Micheli G D | 2000 | IEEE Transactions on VLSI Systems2000，8，3： | 1 |
| 9 | Severe hypoglycemia associ ated with levofloxacin in type 2 diabetic patients receiving polytherapy:two case reports 显示文摘 | Micheli L Sbrilli M Nencini C | 2012 | Int J Clin Pharmacol Ther2012，50，4： | 1 |
| 10 | Packetization and routing analysis of on chip rnultiprocessor networks显示文摘 | Ye T Benini L De Micheli G | 2004 | Journal of Systems Architecture2004，50，223： | 1 |
| 11 | Recurrent thrombo embolismin patients with vena cava filters显示文摘 | Green field L J Proctor M C Mich A A | 2001 | J Vasc Surg2001，33，3： | 1 |
| 12 | Networks on chip: a new SoC paradigm显示文摘 | L Benini G De Micheli | 2002 | IEEE Computer2002，，35： | 1 |
| 13 | A survey of design techniques for system-level dynamic power management 显示文摘 | Benini L Bogliolo A Micheli G D | 2000 | IEEE Trans on Very Large Scale Integration (VLSI) Systems2000，8，3： | 1 |
| 14 | Production of antibodies and development of highly sensitive formats of en zyme immunoassay for saxitoxin analysis显示文摘 | Micheli L Di Stefano S Moscone D | 2002 | Analy Bioanaly Chem2002，373，8： | 1 |
| 15 | System-level power optimization:techniques and tools显示文摘 | L Benini G Micheli | 2000 | ACM Transactions on Design Automation of Electric Systems2000，5，2： | 1 |
| 16 | Networks on chips: a new SoC paradigm 显示文摘 | Benini L Micheli G D | 2002 | IEEE Computer2002，35，1： | 1 |
| 17 | Disposable immunosensor for the determination of domoic acid in shellfish 显示文摘 | MICHELI L RADOI A GUARINA R | 2004 | Biosens Bioelectron2004，20，： | 1 |
| 18 | Networks on chips:a new SoCparadigm显示文摘 | Benini L Micheli G D | 2002 | IEEE Computer2002，35，1： | 1 |
| 19 | An Electrochemical Immunosensor for Aflatoxin M1 Determinantion in Milk Using Screen-Printed Electrodes显示文摘 | Micheli L Grecco R Badea M | 2005 | Biosensors and Bioelectronics2005，21，4： | 1 |
| 20 | Use of combined digital elevation model and satellite radiometric data for regional soil mapping 显示文摘 | DOBOS E MICHELI E BAUMGARDNER M F BIEHL L AND HELT T | 2000 | Geoderma2000，97，： | 1 |
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