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| 1 | Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats显示文摘AIM:To investigate the effects of long term pretreatment with low-,medium-and high-dose aspirin(acetylsalicylic acid,ASA) on a model of acute pancreatitis(AP) induced in rats.METHODS:Forty male Wistar rats were used.Three experimental groups,each consisting of eight animals,received low-(5 mg/kg per day),medium-(150 mg/kg per day) and high-dose(350 mg/kg per day) ASA in supplemented pellet chow for 100 d.Eight animals,serving as the AP-control group,and another eight,serving as reference value(RV) group,were fed with standard pellet chow for the same period.After pretreatment,AP was induced in the experimental animals by intraperitoneal administration of cerulein(2 × 50 μg/kg),while the RV group received saline in the same way.Twelve hours after the second injection,the animals were sacrificed.Pancreatic tissue and plasma samples were collected.One part of the collected pancreatic tissues was used for histopathological evaluation,and the remaining portion was homogenized.Cytokine levels [tumor necrosis factor,interleukin(IL)1β,IL-6],hemogram parameters,biochemical parameters(amylase and lipase),nuclear factor-κB,aspirin triggered lipoxins and parameters related to the antioxidant system(malondialdehyde,nitric oxide,hemeoxygenase-1,catalase and superoxide dismutase) were measured.RESULTS:Cerulein administration induced mild pancreatitis,characterized by interstitial edema(total histopathological score of 5.88 ± 0.44vs 0.25 ± 0.16,P < 0.001).Subsequent pancreatic tissue damage resulted in an increase in amylase(2829.71 ± 772.48 vs 984.57 ± 49.22 U/L,P = 0.001) and lipase(110.14 ± 75.84 U/L vs 4.71 ± 0.78 U/L,P < 0.001) in plasma,and leucocytes(6.89 ± 0.48 vs 4.36 ± 0.23,P = 0.001) in peripheral blood.Cytokines,IL-1β(18.81 ± 2.55 pg/μg vs 6.65 ± 0.24 pg/μg,P = 0.002) and IL-6(14.62 ± 1.98 pg/μg vs 9.09 ± 1.36 pg/μg,P = 0.04) in pancreatic tissue also increased.Aspirin pretreatment reduced the increase in the aforementioned parameters to a certain degree and partially improved the histopathological alterations caused by cerulein.No evidence of side effects related to chronic ASA administration(e.g.,inflammation or bleeding) was observed in the gastrointestinal tract in macroscopic and histopathological examination.CONCLUSION:Long term ASA pretreatment could prevent and/or ameliorate certain hematological,serological and histological alterations caused by ceruleininduced AP. | Ibrahim Akyazi Evren Eraslan Ahmet Gülubuk Elif Ergül Ekiz Zeynep L rakli Damla Haktanir Deniz Aktaran Bala Mete zkurt Erdal Matur Mukaddes zcan | 2013 | World Journal of Gastroenterology2013，19，19： | 5 |
| 2 | Capacity of human monocytes to phagocytose approved iron oxide MR contrast agents in vitro 显示文摘 | METE S BONATERRA G RUDELIUS M | 2004 | Europ Radiol2004，14，7： | 1 |
| 3 | Management of cesarean scar pregnancy with suction curettage: a report of four cases and review of the literature 显示文摘 | Bayoglu Tekin Y Mete Ural U Balik G | 2014 | Arch Gynecol Obstet2014，25，： | 1 |
| 4 | Option pricing with transaction costs and a nonlinear Blaek--Scholes equation显示文摘 | Barles G Mete H | 1998 | Journal of Stochast1998，72，2： | 1 |
| 5 | Electron microscopy of psoriatic skin before and after PUVA treatment显示文摘 | Mete U O Denli Y G | 1996 | Cutis1996，58，1： | 1 |
| 6 | Experiences with Nausea and Vomiting During Pregnancy in Turkish Women Based on Roy Adaptation Model: A Content Analysis 显示文摘 | sbir G G Mete S | 2013 | Asian Nursing Research2013，7，4： | 1 |
| 7 | A study on the seismic behavior of a retrofitted building based on nonlinear static and dynamic analyses显示文摘This study describes the seismic performance of an existing five storey reinforced concrete building which represents the typical properties of low-rise non-ductile buildings in Turkey. The effectiveness of shear walls and the steel bracings in retrofitting the building was examined through nonlinear static and dynamic analyses. By using the nonlinear static analysis, retrofitted buildings seismic performances under lateral seismic load were compared with each other.Moreover, the performance points and response levels of the existing and retrofitting cases were determined by way of the capacity-spectrum method described in ATC-40 (1996). For the nonlinear dynamic analysis the records were selected to represent wide ranges of duration and frequency content. Considering the change in the stiffness and the energy dissipation capacities, the performance of the existing and retrofitted buildings were evaluated in terms of story drifts and damage states.It was found that each earthquake record exhibited its own peculiarities, dictated by frequency content, duration, sequence of peaks and their amplitude. The seismic performance of retrofitted buildings resulted in lower displacements and higher energy dissipation capacity depending mainly on the properties of the ground motions and the retrofitting strategies. Moreover,severe structural damage (irreparable or collapse) was observed for the existing building. However, buildings with retrofit alternatives exhibited lower damage levels changing from no damage to irreparable damage states. | Esra Mete Güneyisi Gülay Altay | 2005 | Earthquake Engineering and Engineering Vibration2005，4，1： | 1 |
| 8 | Option pricing with transaction costs and a nonlinear Black-Scholes equation显示文摘 | Barles G Mete H | 1998 | Journal of Stochast1998，72，2： | 1 |
| 9 | Effect of acute salittomycin-tiamulin toxicity on the lipid peroxide and antioxidant status of broiter chickens显示文摘 | Metes M Salyi G Banhidi G Y | 1992 | Acta Veterinaria Hungarica1992，40，4： | 1 |
| 10 | Can renal oncoeytoma be differentiated from its renal mimics? The utility of anti-mitoehondrial, eaveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis显示文摘 | Mete O Kilieaslan I Gulluoglu M G | 2005 | Virehows Arch2005，447，6： | 1 |
| 11 | Modulation of Postoperative Scarring with Tacrolimus and Octreotide in Experimental Glaucoma Filtration Surgery显示文摘 | Sermal Arslan Orhan Aydemir Mete Gü ler Adile Ferda Da&gbreve l&inodot | 2012 | Current Eye Research2012，，： | 1 |
| 12 | Option pricing with transaction costs and a nonlinear Black-Scholes equation 显示文摘 | Barles G Mete H | 1998 | Journal of Stochastic1998，72，2： | 1 |
| 13 | Stearoyl-coenzyme A desat- urase gene polymorphism and milk fatty acid composition in Ital- ian Holsteins显示文摘 | Mete M Conte G Castiglioni B | 2007 | Journal of dairy science2007，90，9： | 1 |
| 14 | Management of cesarean scar pregnancy with suction curettage: a report of four cases and review of the literature显示文摘 | Bayoglu Tekin Y Mete Ural U Bahk G | 2014 | Arch Gyneeol Ob- stet2014，289，6： | 1 |
| 15 | Could platelet distribution width be a predictive marker for unexplained recurrent miscarriage?显示文摘 | ülkü Mete Ural Ye?im Bayo?lu Tekin Gül?ah Balik Figen Kir ?ahin Sabri ?olak | 2014 | Archives of Gynecology and Obstetrics2014，，2： | 1 |
| 16 | (+)-Oxoturkiyenine:an isoquinoline-derived alkaloid from Hypecoum pendulum显示文摘 | Mete I E G?zler T | 1988 | J Nat Prod1988，51，2： | 1 |
| 17 | Has outsourcing gone too far显示文摘 | Grainer R Metes G | 1996 | Business Week1996，，1： | 1 |
| 18 | Option pricing with transaction costs and a nonlinear Black-Scholes equation显示文摘 | Barles G Mete H | 1998 | Journal of Stochast1998，72，2： | 1 |
| 19 | A Placebo-Controlled Comparison of the Efficiency of Triple- and Monotherapy in Category III B Chronic Pelvic Pain Syndrome (CPPS) <ce:link locator='eulogo1'/>显示文摘 | Volkan Tu?cu Ali ?hsan Ta??? Adem Fazl?o?lu G?khan Gürbüz Emin ?zbek Sel?uk ?ahin Fatih Kurtulu? Mete ?ek | 2006 | European Urology2006，，4： | 1 |
| 20 | Option Pricing with Transaction Costs and a Nonlinear Black-scholes Equation显示文摘 | Mete H | 1998 | Journal of Stochastic1998，72，2： | 1 |
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