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| 1 | Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats显示文摘AIM: To investigate the preventive effect of kefir on colitis induced with dextran sulfate sodium(DSS) in rats.METHODS: Twenty-four male Wistar-albino rats were randomized into four groups: normal control,kefircontrol,colitis,and kefir-colitis groups. Rats in the normal and kefir-control groups were administered tap water as drinking water for 14 d. Rats in the colitis and kefir-colitis groups were administered a 3% DSS solution as drinking water for 8-14 d to induce colitis. Rats in the kefir-control and kefir-colitis groups were administered 5 m L kefir once a day for 14 d while rats in the normal control and colitis group were administered an identical volume of the placebo(skim milk) using an orogastric feeding tube. Clinical colitis was evaluated with reference to the disease activity index(DAI),based on daily weight loss,stool consistency,and presence of bleeding in feces. Rats were sacrificed on the 15 th day,blood specimens were collected,and colon tissues were rapidly removed. Levels of myeloperoxidase(MPO),tumor necrosisfactor(TNF)-α,interleukin(IL)-10,malondialdehyde,and inducible nitric oxide synthase(i NOS) were measured in colon tissue.RESULTS: The DAI was lower in the kefir-colitis group than in the colitis group(on the 3rd and 5th days of colitis induction; P < 0.01). The DAI was also significantly higher in the colitis group between days 2 and 6 of colitis induction when compared to the normal control and kefir-control groups. The DAI was statistically higher only on the 6th day in the kefircolitis group when compared to that in the normal control groups. Increased colon weight and decreased colon length were observed in colitis-induced rats. Mean colon length in the colitis group was significantly shorter than that of the kefir-control group. Kefir treatment significantly decreased histologic colitis scores(P < 0.05). MPO activity in the colitis group was significantly higher than in the kefir-control group(P < 0.05). Kefir treatment significantly reduced the DSS colitis-induced TNF-α increase(P < 0.01). No statistically significant differences were observed among groups for IL-10 and MDA levels. Colon tissue i NOS levels in the colitis group were significantly higher than those in the control and kefir-colitis groups(P < 0.05).CONCLUSION: Kefir reduces the clinical DAI and histologic colitis scores in a DSS-induced colitis model,possibly via reduction of MPO,TNF-α,and i NOS levels. | Altug Senol Mehmet Isler Recep Sutcu Mete Akin Ebru Cakir Betul M Ceyhan M Cem Kockar | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 2 | Food allergy due to olive显示文摘 | Unsel M Ardeniz 0 Mete N | 2009 | J Investing Allergol Clin Immunol2009，19，6： | 1 |
| 3 | Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes : the SANDS ( Stop Atherosclerosis in Native Diabetics Study) trial显示文摘 | Fleg JL Mete M Howard BV | 2008 | J Am Coil Cardlol2008，52，25： | 1 |
| 4 | Capacity of human monocytes to phagocytose approved iron oxide MR contrast agents in vitro 显示文摘 | METE S BONATERRA G RUDELIUS M | 2004 | Europ Radiol2004，14，7： | 1 |
| 5 | Tuberculous, brucellar and pyogenic spondylitis: comparison of magnetic resonance imaging findings and assessment of its value 显示文摘 | YILMAZ M H METE B KANTARCI F | 2007 | South Med J2007，100，6： | 1 |
| 6 | A structural approach for finding functional modules from large biological networks显示文摘 | Mete M Tang Fusheng Xu Xiaowei | 2008 | BMC Bioinformatics2008，9，9： | 1 |
| 7 | Neurotoxic effects of local anesthetics on the mouse neuroblastoma NB2acell line显示文摘 | Mete M Aydemir I Tuglu IM | 2015 | Biotech Histochem2015，90，3： | 1 |
| 8 | Intracranial paradoxical reaction during treatment of kidney tuberculosis显示文摘 | Yemisen M Mete B Ozaras R | 2011 | Intern Med2011，50，18： | 1 |
| 9 | Comparison of efficiencies of michigan neuropathy screening instrument,neurothesiometer,and electromyography for diagnosis of diabetic neuropathy显示文摘 | Mete T Aydin Y Saka M | 2013 | Int J Endocrinol2013，2013，82： | 1 |
| 10 | Uric acid, hypertension, and chronic kidney disease among Alaska Eskimos :the Genetics of Coronary Artery Disease in Alaska Natives ( GO - CADAN ) study 显示文摘 | JOLLY S E METE M WANGH | 2012 | J Clin Hypertens (Greenwich)2012，14，2： | 1 |
| 11 | Tuberculous,brucellar and pyogenic spondylitis:comparison of magnetic resonance ima-ging findings and assessment of its value显示文摘 | Yilmaz M H Mete B Kantarci F | 2007 | South Med J2007，100，6： | 1 |
| 12 | Soluble P - selectin and the success of thrombolysis in acute myocardial infarction显示文摘 | KAYIKCIOGLU M CAN L METE - ERDEM N | 2001 | Int J Cardiol2001，79，23： | 1 |
| 13 | Soluble P - selectin and the success of thromblysis in acute myocardial infarction显示文摘 | Kayikcioglu M Can L Mete - Erdem N | 2001 | Int J Cardiol2001，79，23： | 1 |
| 14 | Diagnostic value of specific IgE a-nalysis in latex allergy 显示文摘 | Unsel M Mete N Ardeniz 0 | 2012 | Int Arch Allergy Immunol2012，158，3： | 1 |
| 15 | The role of invasive and non-invasive procedures in diagnosing fever of unknown origin 显示文摘 | Mete B Yanli E Yemisen M | 2012 | Int J Med Sci2012，9，8： | 1 |
| 16 | Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes : the SANDS (Stop Atherosclerosis in Native Diabetics Study)trial显示文摘 | Fleg JL Mete M Howard BV | 2008 | J Am Coil Car- diol2008，52，25： | 1 |
| 17 | Effect of statins alone versus statins plus Ezetimibe on carotid atherosclerosis in type 2 diabetes: The SANDS (Stop Atherosclerosis in Native Diabetics Study) trial显示文摘 | Fleg JL Mete M Howard BV | 2008 | J Am Coll Cardiol2008，52，25： | 1 |
| 18 | Effect of acute salittomycin-tiamulin toxicity on the lipid peroxide and antioxidant status of broiter chickens显示文摘 | Metes M Salyi G Banhidi G Y | 1992 | Acta Veterinaria Hungarica1992，40，4： | 1 |
| 19 | Endoscopictyansnasal dacryocystorhio- nostomy显示文摘 | Mcdonogh M Meting J | 1989 | J Laryngol Otol1989，103，： | 1 |
| 20 | Physical and functional association of Fc mu receptor on human natural killer cells with the ze- ta- and Fc epsilon RI gamma-chains and with src family protein tyro- sine kinases显示文摘 | Rabinowich H Manciulea M Metes D | 1996 | J hmnunol1996，157，： | 1 |
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