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82篇 您的检索式:作者名="Merritt P"
    题名 作者 年代 出处 被引量
1PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance显示文摘前列腺癌症(PCa ) 是在在世界上的人之中的第二很普通的恶意。阉割抵抗的前列腺癌症(CRPC ) 是疾病的致命的形式,它在抵抗之上发展首先衬里雄激素剥夺治疗(ADT ) 。新兴的证据为在 CRPC 的发展和维护表明轴的 PI3K-AKT-mTOR 表明一个关键角色。这条小径,是在先进 PCas 的多数的 deregulated,与象蛋白质合成,增长,幸存,新陈代谢和区别那样的下游地细胞的过程为生长信号的集成用作批评连结,因此提供机制让癌症细胞克服压力与雄激素剥夺联系了。而且,现出症状之前的潜的研究阐明了在发信号的 PI3K-AKT-mTOR 和雄激素受体(AR ) 之间的一个直接连接削减,在 ADT 抵抗的发展期间揭示在这些小径之间的动态相互影响。因此,为 PI3K 小径的很多个新奇禁止者的继续的临床的发展有一个清楚的基本原理,它提供堵住 CRPC 生长和幸存的潜力。在这评论,我们将在 PCa 前进和阉割抵抗探索 PI3K-AKT-mTOR 小径的关联以便在先进 PCa 通知临床的发展特定的小径禁止者。另外,我们将在我们的临床的知识加亮当前的缺乏,最尤其是对能精确地为对 PI3K 小径禁止者的反应预言的 biomarkers 的需要。Merritt P Edlind Andrew C Hsieh 2014Asian Journal of Andrology2014,16,3:20
2Performance and optimization of a combustion interface for isotope ratio monitoring gas chromatography mass spectrometry 显示文摘Merritt D A Freeman K H Ricci M P Studley S A Hayes J M 1995Analytical Chemistry1995,67,14:1
3Displaced acetabular fracture显示文摘Matta J M Merritt P O 1988Clin Orthop Relat Res1988,,230:1
4The Effect of Preparation on the Stability of Frozen Unbaked, Yeast Leavened Boughs 显示文摘Merritt P P 1960Baker''s Dig1960,34,4:1
5Low Exposure Concentrations of Atrazine Increase Male Production in Daphnia显示文摘Donson S L Merritt C M Shannahan J P 1999Environ Toxicol and Chem1999,18,7:1
6A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis显示文摘Shao F Merritt P M Bao Z 2002Cell2002,109,:1
7Identification of genes as- sociated with mutacin I production in Streptococcus mutans using random insertional mutagenesis 显示文摘Tsang P Merritt J Nguyen T 2005Microbiology2005,151,12:1
8The effect of preparation on the stability of frozen unbaked, yeast leavened boughs显示文摘Merritt P P 1960Baker''s Dig1960,34,4:1
9Displaced acetabular fractures 显示文摘Matta J M Merritt P O 1998Clin Orthop1998,230,:1
10Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A (H1N1) pdm09 influenza in Australia显示文摘Hurt A C Hardie K Wilson N J Deng Y M Oshourn M Leang S K Lee R T Iannello P Gehrig N Shaw R Wark P Caldwell N Givney R C Xue L Maurer- Stroh S Dwyer D E Wang B Smith D W Levy A Booy R Dixit R Merritt T Kelso A Dalton C Durrheim D Barr I G 2012J Infect Dis2012,206,2:1
11Displaced acetabular fractures显示文摘MATTA J M MERRITT P O 1988Clin Orth1988,230,:1
12Episodic represen-tations support early semantic learning : evidence from mid-azolam induced amnesia 显示文摘Merritt P Hirshman E Zamani S 2006Brain and Cognition2006,61,2:1
13Identification of genes associated with mutacin Ⅰ production in Streptococcus mutans using random insertional mutagenesis显示文摘Tsang P Merritt J Nguyen T 2005Microbiology2005,151,12:1
14Beam control for high-energy laser devices 显示文摘MERRITT P H ALBERTINE J R 2013Optical Engineering2013,52,2:1
15Episodic representations support early semantic learning:evidence from midazolam induced amnesia显示文摘Merritt P Hirshman E Zamani S 2006Brain Cogn2006,61,2:1
16Displaced acetabular fractures显示文摘MATTA J M MERRITT P O 1998Clin Orthop1998,,230:1
17Critical thinking and interdisciplinarity in environmental higher education显示文摘Jones P Merritt Q 1999Geography in Higher Education1999,,3:1
18Low exposure concentration of atrazine increase mail production on Daphnia pulicaria显示文摘S I Dodson C M Merritt J P Shannahan 1999Environmental Toxicology Chemistry1999,18,7:1
19Associations between sleep disorders, sleep duration, quality of sleep, and hypertension: results from the National Health and Nutrition Examination Survey, 2005 to 2008显示文摘Bansil P Kuklina EV Merritt RK 2011J Clin Hypertens (Greenwich)2011,13,10:1
20A comparison of levels of burden in Indian and white parents with a son or daughter with schizophrenia显示文摘Lloyd H Singh P Merritt R 2011Int J Soc Psychiatry2011,57,3:1
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