|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Targeting calcium signaling in cancer therapy显示文摘The intracellular calcium ions(Ca^(2+)) act as second messenger to regulate gene transcription,cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca^(2+)homeostasis is altered in cancer cells and the alteration is involved in tumor initiation, angiogenesis,progression and metastasis. Targeting derailed Ca^(2+)signaling for cancer therapy has become an emerging research area. This review summarizes some important Ca^(2+)channels, transporters and Ca^(2+)-ATPases,which have been reported to be altered in human cancer patients. It discusses the current research effort toward evaluation of the blockers, inhibitors or regulators for Ca^(2+)channels/transporters or Ca^(2+)-ATPase pumps as anti-cancer drugs. This review is also aimed to stimulate interest in, and support for researchinto the understanding of cellular mechanisms underlying the regulation of Ca^(2+)signaling in different cancer cells, and to search for novel therapies to cure these malignancies by targeting Ca^(2+)channels or transporters. | Chaochu Cui Robert Merritt Liwu Fu Zui Pan | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 32 |
| 2 | PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance显示文摘前列腺癌症(PCa ) 是在在世界上的人之中的第二很普通的恶意。阉割抵抗的前列腺癌症(CRPC ) 是疾病的致命的形式,它在抵抗之上发展首先衬里雄激素剥夺治疗(ADT ) 。新兴的证据为在 CRPC 的发展和维护表明轴的 PI3K-AKT-mTOR 表明一个关键角色。这条小径,是在先进 PCas 的多数的 deregulated,与象蛋白质合成,增长,幸存,新陈代谢和区别那样的下游地细胞的过程为生长信号的集成用作批评连结,因此提供机制让癌症细胞克服压力与雄激素剥夺联系了。而且,现出症状之前的潜的研究阐明了在发信号的 PI3K-AKT-mTOR 和雄激素受体(AR ) 之间的一个直接连接削减,在 ADT 抵抗的发展期间揭示在这些小径之间的动态相互影响。因此,为 PI3K 小径的很多个新奇禁止者的继续的临床的发展有一个清楚的基本原理,它提供堵住 CRPC 生长和幸存的潜力。在这评论,我们将在 PCa 前进和阉割抵抗探索 PI3K-AKT-mTOR 小径的关联以便在先进 PCa 通知临床的发展特定的小径禁止者。另外,我们将在我们的临床的知识加亮当前的缺乏,最尤其是对能精确地为对 PI3K 小径禁止者的反应预言的 biomarkers 的需要。 | Merritt P Edlind Andrew C Hsieh | 2014 | Asian Journal of Andrology2014，16，3： | 20 |
| 3 | Rifaximin Alters Intestinal Bacteria and Prevents Stress-Induced Gut Inflammation and Visceral Hyperalgesia in Rats显示文摘 | Dabo Xu Jun Gao Merritt Gillilland Xiaoyin Wu Il Song John Y. Kao Chung Owyang | 2014 | Gastroenterology2014，，2： | 4 |
| 4 | Karrikin and Cyanohydrin Smoke Signals Provide Clues to New Endogenous Plant Signaling Compounds显示文摘表明混合物的二种新类型由于他们刺激种子萌芽的能力在野火烟被发现了。第一发现了是 karrikins,它与植物荷尔蒙的 strigolactone 类分享某结构的类似,并且两个都通过普通 F 盒子蛋白质发信号。然而, karrikins 和 strigolactones 通过不那样不同的发信号的小径操作,各由特定的 / hydrolase 蛋白质区分了。基因分析建议植物包含通过 karrikin 小径明确地发信号的内长的混合物。在烟发现的另外的活跃混合物是在水解作用之上释放刺激萌芽的氰化物的氰醇。氰醇在植物广泛地发生并且在内长的氰化物发信号对另外的有机体,而是一个另外的角色在防卫有一个角色现在应该也被考虑。 | Gavin R. Flematti Mark T. Waters Adrian Scaffidi David J. Merritt Emilio L. Ghisalberti' Kingsley W.Dixon Steven M. Smith | 2013 | Molecular Plant2013，6，1： | 3 |
| 5 | Big Earth Data:a comprehensive analysis of visualization analytics issues显示文摘Big Earth Data analysis is a complex task requiring the integration of many skills and technologies.This paper provides a comprehensive review of the technology and terminology within the Big Earth Data problem space and presents examples of state-of-the-art projects in each major branch of Big Earth Data research.Current issues within Big Earth Data research are highlighted and potential future solutions identified. | Patrick Merritt Haixia Bi Bradley Davis Christopher Windmill Yong Xue | 2018 | Big Earth Data2018，2，4： | 2 |
| 6 | Targeting EGFR and sonic hedgehog pathways for locally advanced eyelid and periocular carcinomas显示文摘For patients with metastatic or locally advanced eyelid and periocular carcinoma not amenable to surgical excision, targeted therapies have shown efficacy with better tolerability compared to cytotoxic chemotherapy. Overexpression of epithelial growth factor receptor was found in squamous cell carcinomas. Vismodegib targets the mutation in the hedgehog pathway identified in basal cell carcinoma and basal cell nevus syndrome. Targeted therapies provide a novel and potentially effective treatment alternative for patients with eyelid carcinoma not amendable for surgery, including those with metastatic, locally advanced disease, advanced age, and significant comorbidities. High cost, need for long-term treatment, and toxicity are relative limitations. | Vivian T Yin Helen Merritt Bita Esmaeli | 2014 | World Journal of Clinical Cases2014，2，9： | 2 |
| 7 | Emission mechanism in rubrenedoped molecular organic light-emitting diodes:direct carrier recombination at luminescentcenters显示文摘 | Murata H Merritt C D Kafafi Z H | 1998 | Selected Topics in Quantum Electronics lEEE Journal of1998，4，1： | 1 |
| 8 | Targeting aurora kinase with MK-0457 inhibits ovarian cancer growth显示文摘 | Lin YG Immaneni A Merritt WM | 2008 | Clin Cancer Res2008，14，17： | 1 |
| 9 | Performance and optimization of a combustion interface for isotope ratio monitoring gas chromatography mass spectrometry 显示文摘 | Merritt D A Freeman K H Ricci M P Studley S A Hayes J M | 1995 | Analytical Chemistry1995，67，14： | 1 |
| 10 | Displaced acetabular fracture显示文摘 | Matta J M Merritt P O | 1988 | Clin Orthop Relat Res1988，，230： | 1 |
| 11 | The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice显示文摘 | Merritt A J Potten C S Kemp C J | 1994 | Cancer Research1994，54，： | 1 |
| 12 | The Effect of Preparation on the Stability of Frozen Unbaked, Yeast Leavened Boughs 显示文摘 | Merritt P P | 1960 | Baker''s Dig1960，34，4： | 1 |
| 13 | Evolution of pulmonary surfactants for the treatment of neonatal respiratory distress syndrome and paediatric lung diseases显示文摘 | Mazela J Merritt TA Gadzinowski J | 2006 | Acta Paediatr2006，95，9： | 1 |
| 14 | Low Exposure Concentrations of Atrazine Increase Male Production in Daphnia显示文摘 | Donson S L Merritt C M Shannahan J P | 1999 | Environ Toxicol and Chem1999，18，7： | 1 |
| 15 | A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis显示文摘 | Shao F Merritt P M Bao Z | 2002 | Cell2002，109，： | 1 |
| 16 | Cooperative hydrogen bond interactions in the streptavidin-biotin system显示文摘 | Hyre DE Le Trong I Merritt EA | 2006 | Protein Sci2006，15，： | 1 |
| 17 | Metabolism and liver transplantation: review of perioperative issues显示文摘 | Merritt WT | 2000 | Liver Transpl2000，6，4： | 1 |
| 18 | ~chanics of tunnelling machine screw conveyors : A theoretical model 显示文摘 | A S Merritt R J Mair | 2008 | Geotechnique2008，58，2： | 1 |
| 19 | In vivo elastographic investigation of ethanolinduced hepatic lesions显示文摘 | Hoyt K Forsberg F Merritt CRB | | 0，，05： | 1 |
| 20 | Use of isotretinoin forache vulgaris 显示文摘 | Merritt B Burkhart C N Morrell D S | 2009 | Pediatr Ann2009，38，38： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员