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| 1 | Guanylyl cyclase C signaling axis and colon cancer prevention显示文摘Colorectal cancer(CRC) is a major cause of cancerrelated mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, and patient survival has seen little benefit. Consequently, additional advances in CRC treatments remain important, with an emphasis on preventative measures. Guanylyl cyclase C(GUCY2C), a transmembrane receptor expressed on intestinal epithelial cells, plays an important role in orchestrating intestinal homeostatic mechanisms. These effects are mediated by the endogenous hormones guanylin(GUCA2A) and uroguanylin(GUCA2B), which bind and activate GUCY2 C to regulate proliferation, metabolism and barrier function in intestine. Recent studies have demonstrated a link between GUCY2 C silencing and intestinal dysfunction, including tumorigenesis. Indeed, GUCY2 C silencing by the near universal loss of its paracrine hormone ligands increases colon cancer susceptibility in animals and humans. GUCY2C's role as a tumor suppressor has opened the door to a new paradigm for CRC prevention by hormone replacement therapy using synthetic hormone analogs, such as the FDA-approved oral GUCY2 C ligand linaclotide(Linzess^(TM)). Here we review the known contributions of the GUCY2 C signaling axis to CRC, and relate them to a novel clinical strategy targeting tumor chemoprevention. | Amanda M Pattison Dante J Merlino Erik S Blomain Scott A Waldman | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 2 | Investigational approach- es to therapies for restless legs syndrome 显示文摘 | de Blase S Merlino G Lorenzut S | 2014 | Expert Opin Investig Drugs2014，23，： | 1 |
| 3 | A mitochondrial DNA mutation (A3243G mtDNA)in a family with cyclic vomiting 显示文摘 | Salpietro CD Briuglia S Merlino MV | 2003 | Eur J Pediatr2003，162，10： | 1 |
| 4 | Machine learning of event segmentation for news on demand 显示文摘 | Boykin S Merlino A | 2000 | Communications of the ACM2000，43，2： | 1 |
| 5 | Role of calcium-channels in the protective effect of hydrogensulfide in ratcardiomyoblasts显示文摘 | Avanzato D Merlino A Porrera S | 2014 | Cell Physiol Biochem2014，33，4： | 1 |
| 6 | Electrocardiographic score and short-term outcomes of acute pulmonary embolism显示文摘 | TOOSI M S MERLINO J D LEEPER K V | 2007 | Am J Cardiol2007，100，： | 1 |
| 7 | Evaluation of chromogenic orientation for differentiation and presumptive identification of gram-negative bacilli and enterococcus species显示文摘 | Merlino J Siarakas S Robertson GJ | 1996 | J Clin Microbiol1996，34，1： | 1 |
| 8 | Tobermorites:their real structure and order-disorder(OD)character显示文摘 | Merlino S Bonaccorsi E Armbruster T | 1999 | American Mineralogist1999，84，： | 1 |
| 9 | Tobermorites:their real structure and order-disorder(OD)character显示文摘 | Merlino S Bonaccorsi E Armbruster T | 1999 | American Mineralogist1999，84，： | 1 |
| 10 | Restless legs syndrome in dialysis patients:a comparison between hemodialysis and continuous ambulatory peritoneal dialysis显示文摘 | Merlino G Lorenzut S Romano G | 2012 | Neurol Sci2012，33，6： | 1 |
| 11 | A simple modification of the Bakhach's eponychial flap for nail lengthening after fingertip amputation显示文摘 | Merlino G Carlucci S | | 0，，： | 1 |
| 12 | Machine learning of event segmentation for news on demand显示文摘 | Boyk in S Merlino A | 2000 | Communications of the ACM2000，43，2： | 1 |
| 13 | The real struc- tures of clinotobermorite and tobermorite 9 A: OD character, polytypes, and structural relationships 显示文摘 | MERLINO S BONACCORSI E ARMBRUSTER T | 2000 | Eur J Miner2000，12，2： | 1 |
| 14 | Methylation status of epidermal growth factor receptor gene in lung carcinoma cells 显示文摘 | Gamou S Shimosato Y Merlino GT | 1988 | Jpn J Cancer Res1988，79，9： | 1 |
| 15 | Machine learning of event segmentation for news on demand显示文摘 | Boykin S Merlino A | 2000 | Communications of the ACM2000，43，2： | 1 |
| 16 | Results of the Predictors of Response to CRT (PROSPECT) trial显示文摘 | Chung E S Leon A R Tavazzi L Sun J P Nihoyannopoulos P Merlino J | 2008 | Circulation2008，117，： | 1 |
| 17 | Interferon-γ links ultraviolet radiation to melanomagenesis in mice显示文摘 | Zaidi M R Davis S Noonan F P Graff-Cherry C Hawley T S Walker R L Feigenbaum L Fuchs E Lyakh L Young H A Hornyak T J Amheiter H Trinchieri G Meltzer P S De Fabo E C Merlino G | | 0，，7331： | 1 |
| 18 | Quantitative PCR in EBV-infected renal transplant patients显示文摘 | Merlino C Cavallo R Bergallo M Giorgi S Forgnone F Re D Sinesi F Musso T Negro Ponzi A | 2001 | New Microbiol2001，24，3： | 1 |
| 19 | The real structure of tobermorite 11:normal and anomalous forms,OD character and polytypic modifications显示文摘 | Merlino S Bonaccorsi E Armbruster T | 2001 | European Journal of Mineralogy2001，13，： | 1 |
| 20 | ADMET considerations for restless leg syndrome drug treatments显示文摘 | de Biase S Merlino G Lorenzut S | 2012 | Expert Opin Drug Metab Toxieol2012，8，10： | 1 |
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