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| 1 | Guanylyl cyclase C signaling axis and colon cancer prevention显示文摘Colorectal cancer(CRC) is a major cause of cancerrelated mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, and patient survival has seen little benefit. Consequently, additional advances in CRC treatments remain important, with an emphasis on preventative measures. Guanylyl cyclase C(GUCY2C), a transmembrane receptor expressed on intestinal epithelial cells, plays an important role in orchestrating intestinal homeostatic mechanisms. These effects are mediated by the endogenous hormones guanylin(GUCA2A) and uroguanylin(GUCA2B), which bind and activate GUCY2 C to regulate proliferation, metabolism and barrier function in intestine. Recent studies have demonstrated a link between GUCY2 C silencing and intestinal dysfunction, including tumorigenesis. Indeed, GUCY2 C silencing by the near universal loss of its paracrine hormone ligands increases colon cancer susceptibility in animals and humans. GUCY2C's role as a tumor suppressor has opened the door to a new paradigm for CRC prevention by hormone replacement therapy using synthetic hormone analogs, such as the FDA-approved oral GUCY2 C ligand linaclotide(Linzess^(TM)). Here we review the known contributions of the GUCY2 C signaling axis to CRC, and relate them to a novel clinical strategy targeting tumor chemoprevention. | Amanda M Pattison Dante J Merlino Erik S Blomain Scott A Waldman | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 2 | Nuclear progesterone receptors in the human pregnancy myometrium:Evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A显示文摘 | Welsh T N Tan H | 2007 | J Clin Endocrinol Metab2007，92，： | 1 |
| 3 | Machine learning of event segmentation for news on demand 显示文摘 | Boykin S Merlino A | 2000 | Communications of the ACM2000，43，2： | 1 |
| 4 | Role of calcium-channels in the protective effect of hydrogensulfide in ratcardiomyoblasts显示文摘 | Avanzato D Merlino A Porrera S | 2014 | Cell Physiol Biochem2014，33，4： | 1 |
| 5 | Antioxidant micronutrients and risk of rheumatoidarthritis in a cohort of older women显示文摘 | Cerhan J R Saag K G Merlino L A | 2003 | Am J Epidemiol2003，157，4： | 1 |
| 6 | Evidence for the direct action of thymulin on avian NK cells 显示文摘 | Merlino P G Marsh J A | 2001 | Devel Compar Immunol2001，25，： | 1 |
| 7 | Microbial commu- nity structure and dynamics in two -stage vs single - stage thermophilic anaerobic digestion of mixed swine slurry and market biowaste显示文摘 | Merlino G Rizzi A Sehievano A | 2013 | Water Research2013，47，： | 1 |
| 8 | The effects of triodothyronine and thymulin on avian NK cytolytic activity显示文摘 | Marsh J A Merlino P G Staeheli P | 2001 | Int Immunopharmaeol2001，1，910： | 1 |
| 9 | Laboratory observation of the dust-acoustic wave mode显示文摘 | Barkan A Merlino R L D′Angelo N | 1995 | Physics of Plasma1995，2，10： | 1 |
| 10 | Vitamin D in- take is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study显示文摘 | MERLINO L A CURTIS J MIKULS T R | 2004 | Arthritis Rheum2004，50，1： | 1 |
| 11 | Physiological and pharmacological features of the novel gasotransmitter: hydro- gen sulfide显示文摘 | Mancardi D Penna C Merlino A | 2009 | Biochim Biophys Aeta2009，1787，7： | 1 |
| 12 | Physiological and pharmacological features of the novel gasotransmitter: hydrogen sulfide 显示文摘 | Mancardi D Penna C Merlino A | 2009 | Biochim Biophys Acta2009，1787，： | 1 |
| 13 | A Fully Pipelined Architecture for The LOCO-I Compression Algrithm显示文摘 | Merlino P Abramo A | 2009 | IEEE Trans on Very Large Scale Integration (VLSI) Systems2009，17，7： | 1 |
| 14 | Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Lowa Women's Health Study 显示文摘 | MERLINO L A CURTIS J MIKULS T R | 2004 | Arthritis Rheum2004，50，1： | 1 |
| 15 | A proposed protocol for the surgical treatment of pressure sores based on a study of 337 cases 显示文摘 | Margara A Merlino G Borsetti M | 2003 | European J Plastic Surgery2003，26，2： | 1 |
| 16 | Sleep disorders in patients with end-stage renal disease undergoing dialysis therapy显示文摘 | Merlino G Piani A Dolso P | | 0，，： | 1 |
| 17 | 查看详情显示文摘 | Barkan A Merlino R L Angelo N D | | 0，，： | 1 |
| 18 | A fully pipelined architecture for the LOCO-I compression algorithm显示文摘 | Merlino P and Abramo A | 2009 | IEEE Transactions on Very Large Scale Integration Systems2009，17，7： | 1 |
| 19 | Nuclear progesterone receptor expression in the human fetal membranes and decidua at term before and after labour显示文摘 | Merlino A Welshe T Erdonmez T Madson G Zakar T Smith R | 2009 | Reprod Sci2009，16，： | 1 |
| 20 | Efficacy of two new systemic fungicides and thazole for control of Phytophthora root rot of Rhododendron, and spread of Phytophthora cinnamomi in progagation benches 显示文摘 | Englander L Merlino J A Mcguire J J | 1980 | Phytopathology1980，70，： | 1 |
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