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| 1 | Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney显示文摘Despite the introduction of potent immunosuppressive medications within recent decades, acute rejection still accounts for up to 12% of all graft losses, and is generally associated with an increased risk of late graft failure. Current detection of acute rejection relies on frequent monitoring of the serum creatinine followed by a diagnostic renal biopsy. This strategy is flawed since an alteration in the serum creatinine is a late clinical event and significant irreversible histologic damage has often already occurred. Furthermore, biopsies are invasive procedures that carry their own inherent risk. The discovery of non-invasive urinary biomarkers to help diagnose acute rejection has been the subject of a significant amount of investigation. We review the literature on urinary biomarkers here, focusing on specific markers perforin and granzyme B m RNAs, FOXP3 m RNA, CXCL9/CXCL10 and mi RNAs. These and other biomarkers are not yet widely used in clinical settings, but our review of the literature suggests that biomarkers may correlate with biopsy findings and provide an important early indicator of rejection, allowing more rapid treatment and better graft survival. | Basma Merhi George Bayliss Reginald Y Gohh | 2015 | World Journal of Transplantation2015，5，4： | 4 |
| 2 | 肌酸激酶活性与大鼠衰老关系的研究显示文摘目的 :证实衰老过程中肌酸激酶活性的变化 ,探讨与衰老的关系。方法 :应用 2 4月龄和 8周Sprague-Dawley大鼠作为老年组和青年组 ,过量麻醉处死后 ,测定心脏、脑组织和膀胱重量 ,并用酶法测定血清、心脏、脑组织、膀胱和趾长伸肌肌酸激酶活性。结果 :老年大鼠心脏重量与体重的比值、脑组织重量与体重的比值以及膀胱重量与体重的比值均显著降低 (P <0 .0 0 1) ,老年大鼠血清、心脏、脑组织和骨骼肌肌酸激酶活性显著降低 (P <0 .0 0 1- 0 .0 5 ) ,但膀胱肌酸激酶活性降低无统计学意义。结论 :肌酸激酶活性降低使能量代谢降低 ,可能影响对自由基造成损伤的修复能力 ,从而促进衰老进程 ; | 赵昕 尉秀荣 刘楠 RobertD.Helme Merhi Merhi Maryam Bassirat Khalil Zeinab | 2000 | 中国康复医学杂志2000，15，2： | 3 |
| 3 | Challenging oral contraception after weight loss by bariatric surgery 显示文摘 | Merhi Z O | 2007 | Gynecol Obstet Invest2007，64，2： | 1 |
| 4 | Hypothalamic insulin-like growth factor-I receptors are necessary for hormone-dependent luteinizing hormone surges: implications for female reproductive aging 显示文摘 | TODD B J MERHI Z O SHU J | 2010 | Endo- crinology2010，151，3： | 1 |
| 5 | Thmmboelasto- graphy (TEG) Cups and Pins with Different PECVD Coatings :Effect on the Coagulation Cas- cade in Platelet-poor Blood Plasma显示文摘 | ANGEL CONTRERAS-GARCIA YAHYE MERHI JUANCAR- LOS RUIZ | 2013 | Plasma processes and polymers2013，10，9： | 1 |
| 6 | Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis显示文摘 | David H. Adams Jeffrey J. Popma Michael J. Reardon Steven J. Yakubov Joseph S. Coselli G. Michael Deeb Thomas G. Gleason Maurice Buchbinder James Hermiller Neal S. Kleiman Stan Chetcuti John Heiser William Merhi George Zorn Peter Tadros Newell Robinson Ge | 2014 | The New England Journal of Medicine2014，，19： | 1 |
| 7 | Depot-medroxyprogesterone acetate:an update显示文摘 | Bakry S Merhi ZO scalise TJ | 2008 | Arch Gynecol Obstet2008，278，1： | 1 |
| 8 | Impact of inflammation,gene variants,and cigarette smoking on coronary artery disease risk显示文摘 | Merhi M Demirdjian S Hariri E | 2015 | Inflamm Res2015，64，6： | 1 |
| 9 | BW775C,a dual lipoxygenasel,cyclooxygenase inhibitor,reduces mural platelet and neutrophil deposition and vasoconstriction after angioplasty injury pigs显示文摘 | Merhi Y | 1996 | J Pharmacol Exp Ther1996，227，1： | 1 |
| 10 | Advanced glycation end products and their relevance in female reproduction显示文摘 | Merhi Z | 2014 | Hum Reprod2014，29，1： | 1 |
| 11 | CD40 ligand: a neo - inflammatory molecule in vascular diseases 显示文摘 | HASSAN G S MERHI Y MOURAD W | 2012 | Immunobiology2012，217，5： | 1 |
| 12 | A lightweight collaborative fault tolerant target localization system for wireless sensor networks 显示文摘 | Merhi Z Elgamel M Bayoumi M | 2009 | IEEE Transactions on Mobile Computing2009，32，8： | 1 |
| 13 | A lightweight collaborative fault tolerant target localization system for wireless sensor networks显示文摘 | MERHI Z ELGAMEL M BAYOUMI M | 2009 | IEEE Transactions on Mobile Computing2009，8，12： | 1 |
| 14 | Impact of inflammation,gene variants,and cigarette smoking on coronary artery disease risk显示文摘 | Merhi M Demirdjian S Hariri E | 2015 | Inflamm Res2015，64，6： | 1 |
| 15 | Application of segmented 2-D probabilistic occupancy maps for robot sensing and navigation 显示文摘 | Merhy B A Payeur P Petriu E M | 2008 | IEEE Transactions on Instrumentation and Measurement2008，57，12： | 1 |
| 16 | Increase of neutrophil adhesion and vasoconstriction with platelet deposition after deep arterial injury by angioplasty显示文摘 | Merhi Y Guidoin R Provost P | 1995 | Am Heart J1995，129，3： | 1 |
| 17 | Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells显示文摘 | Faten Merhi Ruoping Tang Mario Piedfer | 2011 | PLoS One2011，6，25： | 1 |
| 18 | Computed tomography-assisted laparoscopic removal of intraabdominally migrated levonorgestrel-releasing intrauterine systems显示文摘 | Mohamad S. Mahmoud Zaher O. Merhi | 2010 | Archives of Gynecology and Obstetrics2010，，4： | 1 |
| 19 | Biodegradable membrane-covered stent from chitosan-based polymers 显示文摘 | Thierry B Merhi Y Silver J | 2005 | J Biomed Mater Res A2005，75，3： | 1 |
| 20 | Ovarian hypers- timulation syndrome after a molarpregnancy evacuation 显示文摘 | Arora R Merhi ZO Khulpateea N | 2008 | Fertil Steril2008，90，4： | 1 |
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