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| 1 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 2 | Ability of terminal QRS notching to dis- tinguish benign from malignant electrocardiographic forms of early repolarization显示文摘 | MERCHANT F M NOSEWORTHY P A WEINER R B | 2009 | Am J Cardiol2009，104，： | 1 |
| 3 | Impact of segmental left ventricle lead position on cardiac resynchronization therapy outcomes显示文摘 | Merchant FM Heist EK Kumar P | 2010 | Heart Rhythm2010，7，5： | 1 |
| 4 | Micropapillary component in lung adenocarcinoma:a distinct histologic variant with biologic significance显示文摘 | Amin MB Tamboli P Merchant SH | 2000 | Am J Surg Pathol2000，26，3： | 1 |
| 5 | A case of childhood dermatofibrosarcoma protuberans without detected cytogenetic abnormality显示文摘 | Strauss R M Merchant W J Roberts P | 2003 | Br J Dermatol2003，148，5： | 1 |
| 6 | Micropapillary component in lung adenoeareinoma:a distinctive histologic feature with possible prognostic significance显示文摘 | Amin MB Tamboli P Merchant SH | 2002 | Am J Surg Pathol2002，26，3： | 1 |
| 7 | Impact Investing: A 21st Century Tool to Attractand Retain Donors 显示文摘 | Amy L Cheney C P A Kathryn E Merchant and Robert Killins Jr | 2012 | THE2012，，4： | 1 |
| 8 | Micropapillary component in lung ad a distinctive histologic feature with possible prognostic significance显示文摘 | Amin MB Tamboli P Merchant SH | 2002 | Am J Surg Pathol2002，26，3： | 1 |
| 9 | Pilot and safety trial of carboplatin, paclitaxel, and thalidomide in advanced non small- cell lung cancer显示文摘 | Merchant J J Kim K Mehta M P | 2000 | Clin Lung Cancer2000，2，1： | 1 |
| 10 | Pclock: an arrival curve based approach for QoS guarantees in shared storage systems显示文摘 | GULATI A MERCHANT A VARMAN P J | 2007 | SIGMETRICS Performance Evaluation Rev2007，35，1： | 1 |
| 11 | Primary signet-ring cell carcinoma of lung: immunohistochemical study and comparison with non--pulmonary signet-ring cell carcinomas显示文摘 | Merchant SH Amin MB Tamboli P | 2001 | Am J Surg Pathol2001，25，12： | 1 |
| 12 | Determination and comparison of heavy metals in selected seafood, water, vegetation and sediments by inductively coupled plasma -optical emission spectrometry from an industrialized and pristine waterway in Southwest Louisiana 显示文摘 | HAMILTON M A RODE P W MERCHANT M E | 2008 | Microchemical Journal2008，88，1： | 1 |
| 13 | Engineering antibodies for imaging and therapy 显示文摘 | Carter P Merchant AM | 1997 | Curr Opin Biotechnol1997，8，4： | 1 |
| 14 | Preliminary results from a phase Ⅱ trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymona显示文摘 | Merchant T E Zhu Y P Thompson S J | 2004 | J Clin Oncol2004，22，15： | 1 |
| 15 | primary signet-ring cell carcinoma of lung:immunohistoehemical study and sore parison with non-puhnonary signet-ring cell carcinomas显示文摘 | Merchant S H Amin MB Tamboil P | | 0，，12： | 1 |
| 16 | Host cells in the spiral canal of Taenia solium (Cestoda) cysticerci显示文摘 | De la Torre P Merchant MT Willms K | 1998 | J Parasitol1998，84，： | 1 |
| 17 | Improving performance in pulse radar detection using Bayesian regularization for neural network training显示文摘 | Kumar P Merchant S N Desai D B | 2004 | Digital Signal Processing2004，14，： | 1 |
| 18 | Micromachined thin film bulk acoustic resonators显示文摘 | Ruby R Merchant P | 1994 | IEEE International frequency control symposium1994，，13： | 1 |
| 19 | Liver stiffness predicts clinical outcome in human immunodeficiency virus/hepatitis C virus‐coinfected patients with compensated liver cirrhosis显示文摘 | Nicolás Merchante Antonio Rivero‐Juárez Francisco Téllez Dolores Merino Maria José Ríos‐Villegas Manuel Márquez‐Solero Mohamed Omar Juan Macías ángela Camacho Montserrat Pérez‐Pérez Jesús Gómez‐Mateos Antonio Rivero Juan Antonio Pineda | 2012 | Hepatology2012，，1： | 1 |
| 20 | Takotsubo cardiomyopathy:a case series and review of the literature显示文摘 | Merchant EE Johnson SW Nguyen P | 2008 | West J Emerg Med2008，9，2： | 1 |
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