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| 1 | A nomogramfor predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis显示文摘Background:Low-grade endometrial stromal sarcoma(LG-ESS)is a rare tumor that lacks a prognostic prediction model.Our study aimed to develop a nomogram to predict overall survival of LG-ESS patients.Methods:A total of 1172 patients confirmed to have LG-ESS between 1988 and 2015 were selected from the Surveillance,Epidemiology and End Results(SEER)database.They were further divided into a training cohort and a validation cohort.The Akaike information criterion was used to select variables for the nomogram.The discrimination and calibration of the nomogram were evaluated using concordance index(C-index),area under time-dependent receiver operating characteristic curve(time-dependent AUC),and calibration plots.The net benefits of the nomogram at different threshold probabilities were quantified and compared with those of the International Federation of Gynecology and Obstetrics(FIGO)criteria-based tumor staging using decision curve analysis(DCA).Net reclassification index(NRI)and integrated discrimination improvement(IDI)were also used to compare the nomogram’s clinical utilitywith that of the FIGO criteria-based tumor staging.The risk stratifications of the nomogram and the FIGO criteria-based tumor staging were compared.Results:Seven variables were selected to establish the nomogram for LG-ESS.The C-index(0.814 for the training cohort and 0.837 for the validation cohort)and the time-dependent AUC(>0.7)indicated satisfactory discriminative ability of the nomogram.The calibration plots showed favorable consistency between the prediction of the nomogram and actual observations in both the training and validation cohorts.The NRI values(training cohort:0.271 for 5-year and 0.433 for 10-year OS prediction;validation cohort:0.310 for 5-year and 0.383 for 10-year OS prediction)and IDI(training cohort:0.146 for 5-year and 0.185 for 10-year OS prediction;validation cohort:0.177 for 5-year and 0.191 for 10-year OS prediction)indicated that the established nomogram performed significantly better than the FIGO criteria-based tumor staging alone(P<0.05).Furthermore,DCA showed that the nomogram was clinically useful and had better discriminative ability to recognize patients at high risk than the FIGO criteria-based tumor staging.Conclusions:A prognostic nomogram was developed and validated to assist clinicians in evaluating prognosis of LG-ESS patients. | Jie Wu Huibo Zhang Lan Li Mengxue Hu Liang Chen Bin Xu Qibin Song | 2020 | Cancer Communications2020，40，7： | 35 |
| 2 | Bioassay-Guided Extraction of Crude Fucose-Containing Sulphated Polysaccharides from Sargassum fusiforme with Response Surface Methodology显示文摘The response surface methodology(RSM) combined with bioassays was employed to optimize the extraction process of crude fucose-containing sulphated polysaccharides(c FCSP) from Sargassum fusiforme. The central composite design(CCD) was used with four variables, five levels, and four responses. The four variables were p H value of hydrochloric acid solution, extraction temperature(℃), ratio of liquid to raw material(m L g^(-1)), and extraction time(h), respectively. Chemical and bioassay indices were used in combination as the response parameters, which included the yield of c FCSP, fucose content, proliferation rate of spleen cells, and lipopolysaccharide-induced proliferation of splenocytes. The experimental data were fitted to a second-order polynomial equation using multiple regression analysis, and examined using the appropriate statistical methods. The best extraction conditions were as follows: the p H value of hydrochloric acid solution was 3.50; the extraction temperature was 100℃; the ratio of liquid to raw material was 15.00 m L g^(-1) and the extraction time was 2.50 h. The experimental yield was close to the predicted from the model. The extract could promote spleen lymphocyte proliferation, especially the lipopolysaccharide-induced lymphocyte proliferation in vitro, which suggested that its immunomodulatory effect on B lymphocytes. Therefore, c FCSP extracted from S. fusiforme could be utilized as an immunostimulant in functional foods and pharmaceutical industry in future. | FU Zhifei LI Haihua LIU Hongbing HU Shuman LI Yueying WANG Mengxue GUAN Huashi | 2016 | Journal of Ocean University of China2016，15，3： | 2 |
| 3 | Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma显示文摘Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2007).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2005;Sung et al.,2008;Nitsche et al.,2013;Hugen et al.,2014;Inamura et al.,2015).A retrospective analysis of CRC patient's data at Fudan University Shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1). | Yaqi Li Jian Li Renjie Wang Long Zhang Guoxiang Fu Xueying Wang Yebin Wang Chuantao Fang Dandan Zhang Duo Du Xiaoji Ma Mengxue Pan Qiang Guo Xiaoya Xu Xiang Hu Yi Zhou Shaobo Mo Huijun Wang Jianjun Gao Shenglin Huang Yun Liu Sanjun Cai Guoqiang Hua Junjie Peng Fa-Xing Yu | 2020 | Protein & Cell2020，11，4： | 2 |
| 4 | ACOUSTIC AND ARTICULATORY ANALYSIS ON CHINESE AND JAPANESE VOWELS IN EMOTIONAL SPEECH显示文摘This research investigated the articulatory and acoustic cues of the emotional vowels from production/coding perspectives Chinese and Japanese emotional speech and EMA data were recorded.The acoustic and articulatory spaces of isolated vowels across different emotions were analyzed to understand the coding scheme in cross-cultural emotion production.The results suggest that,on the one hand,those two languages share some common features:(1) Significant differences of the acoustic space exist across emotions;(2) 'Sad' and 'Angry' vowels raise tongue position higher than other emotions;(3)The lip’s protrusion feature is shared by both 'Angry' and 'Sad' emotions,except[a]or[A].We suggested that the exception is caused by the increase of the mouth opening.The mouth opening and the degree of lip protrusion are a pair of complementary features.On the other hand,differences also exist between those two languages;(l)In Chinese,the acoustic space moves downwards with the increasing of emotion intensity;in Japanese,however, 'Angry' is characterized by a horizontally compressed acoustic space,and 'Sad' by a vertically compressed acoustic space.(2)In Chinese,emotional factors only cause tongue raising movement;in Japanese,emotional factors cause both tongue raising and significant tongue retraction,which can be enhanced by 'Angry' and 'Sad' emotions. | LI Aijun CAO Mengxue FANG Qiang HU Fang DANG Jianwu | 2013 | 中国语音学报2013，，1： | 1 |
| 5 | Simultaneous resonance of an axially moving ferromagnetic thin plate under a line load in a time-varying magnetic field显示文摘In this paper,the simultaneous resonance of a ferromagnetic thin plate in a time-varying magnetic field,having axial speed and being subjected to a periodic line load,is studied.Based on the large deflection theory of thin plates and electromagnetic field theory,the nonlinear vibration differential equation of the plate is obtained by using the Hamilton′s principle and the Galerkin method.Then the boundary condition in which the longer opposite sides are clamped and hinged is considered.The dimensionless nonlinear differential equations are solved by using the method of multiple scales,and the analytical solution is given.In addition,the stability analysis is also carried out by using Lyapunov stability theory.Through numerical analysis,the variation curves of system resonance amplitude with frequency tuning parameter,magnetic field strength and external excitation amplitude are obtained.Different parameters that have significant effects on the response of the system,such as the thickness,the axial velocity,the magnetic field intensity,the position,and the frequency of external excitation,are considered and analyzed.The results show that the system has multiple solution regions and obvious nonlinear coupled characteristics. | Xie Mengxue Hu Yuda Xu Haoran | 2023 | Earthquake Engineering and Engineering Vibration2023，22，4： | 0 |
| 6 | Microwave-assisted pyrolysis of waste plastics for their resource reuse:A technical review显示文摘Rapidly increasing plastics have been used and finally become wastes,resulting in increasing pressures to the environment.Microwave-assisted pyrolysis is a promising technology for converting organic wastes as waste plastics into value-added products.At present,many works on microwave-assisted pyrolysis of plastics have been published,but the achievements,challenges,and future directions of microwave-assisted pyrolysis of waste plastics have not been well summarized and discussed.In this work,the principle of microwave-assisted pyrolysis technology is introduced.Then,the progress of its application to recover useful products from plastics is reviewed and discussed in terms of key parameters including microwave power,pyrolysis temperature,reaction time,types of catalyst,microwave absorbents and feedstock mixing ratio.Especially,the yields and properties of the produced oil,gas and char are correlated with the process parameters.Finally,the existing challenges and prospects of disposal/reuse of waste plastics by microwave-assisted pyrolysis technology are discussed. | Xuan Hu Dachao Ma Guangyi Zhang Mengxue Ling Qiaoling Hu Kangyi Liang Jiacheng Lu Yifan Zheng | 2023 | Carbon Resources Conversion2023，6，3： | 0 |
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