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| 1 | Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner显示文摘Cardiovascular disease is still the leading cause of mortality worldwide.Vascular endothelial dysfunction is viewed as the initial step of most cardiovascular diseases.Many studies have indicated that periodontal pathogens,especially Porphyromonas gingivalis,are closely correlated with vascular endothelial homeostasis,but the function of P.gingivalis and the underlying mechanisms are still elusive.To illuminate the effects and elucidate the mechanisms of P.gingivalis on endothelial structural integrity,we developed P.gingivalis infection models in vivo and in vitro.Endothelial cell proliferation,differentiation and apoptosis were detected.Here,we showed that P.gingivalis can impair endothelial integrity by inhibiting cell proliferation and inducing endothelial mesenchymal transformation and apoptosis of endothelial cells,which reduce the cell levels and cause the endothelium to lose its ability to repair itself.A mechanistic analysis showed that TLR antagonist or NF-κB signalling inhibitor can largely rescue the damaged integrity of the endothelium caused by P.gingivalis,suggesting that TLR-NF-κB signalling plays a vital role in vascular endothelial homeostasis destroyed by P.gingivalis.These results suggest a potential intervention method for the prevention and treatment of cardiovascular disease. | Mengru Xie Qingming Tang Shaoling Yu Jiwei Sun Feng Mei Jiajia Zhao Lili Chen | 2020 | International Journal of Oral Science2020，12，3： | 9 |
| 2 | Collaborative assembly-mediated siRNA delivery for relieving inflammation-induced insulin resistance显示文摘Obesity plays a primary causative role in insulin resistance and hyperglycemia that contributes to type 2 diabetes.Excess lipid storage in the liver renders activation of the resident macrophages and chronic secretion of inflammatory mediators,therefore causing or aggravating insulin resistance.Herein,we develop collaborative assemblies using a“one-pot”synthesis method for macrophage-specific delivery of small interfering RNAs(siRNAs)that target the inflammatory proteins.Ternary nanocomplex(NC)composed of the siRNA molecule,a synthetic thiol-bearing methacrylated hyaluronic acid(sm-HA)and protamine forms through an electrostatic-driven physical assembly,which is chemically crosslinked to acquire the collaboratively assembled nanocapsule(cNC)concurrently.The obtained cNC displays significantly higher stability than NC.Functional moieties as flexible assembly units can be easily equipped on cNC for long circulation,active targeting,or controlled siRNA release.cNC-F decorated with folic acid,a macrophage-targeting ligand promotes the siRNA accumulation in the activated macrophages in the liver of the obese mouse model.cNC-F loaded with siRNA targeting inflammatory indicators efficiently control the macrophage inflammatory response by reducing the expression of the inflammatory proteins(>40%reduction)and ameliorating the insulin resistance symptoms of the obese mice. | Shiyang Shen Li Zhang Mengru Li Zhizi Feng Huixia Li Xiao Xu Shiqi Lin Ping Li Can Zhang Xiaojun Xu Ran Mo | 2020 | Nano Research2020，13，11： | 2 |
| 3 | An Objective Identification Method for Wintertime Cold Fronts in Eurasia显示文摘The present study identifies wintertime cold fronts in Eurasia from gridded datasets using a new objective two-step identification scheme.The simple and classic conception of a front is adopted,where a cold front is identified as the warm boundary of the frontal zone with a suitable horizontal temperature gradient and cold advection.We combine the traditional thermal front parameter with temperature advection to first identify the cold frontal zone,and then its eastern and southern boundaries are objectively plotted as a cold front in Eurasia.By comparing different cold front identification methods,the results from this two-step cold front identification method and subjective analysis are more consistent,and the positions of the cold front identified with our method are more reasonable.This objective technique is also applied to a nationwide cold wave event over China.Results show that the horizontal extent and movement of the cold front are in good agreement with the related circulation and the associated cold weather.The proposed method and results in this study may shed light on the rapid identification of cold fronts in operational weather analysis and facilitate further research on the long-term activity characteristics of continental cold fronts. | Mengru FENG Yujing QIN Chuhan LU | 2021 | Advances in Atmospheric Sciences2021，38，10： | 1 |
| 4 | Role of CD36 in central nervous system diseases显示文摘CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger receptor class B family and regulates the pathological progress of metabolic diseases.CD36 was recently found to be widely expressed in various cell types in the nervous system,including endothelial cells,pericytes,astrocytes,and microglia.CD36 mediates a number of regulatory processes,such as endothelial dysfunction,oxidative stress,mitochondrial dysfunction,and inflammatory responses,which are involved in many central nervous system diseases,such as stroke,Alzheimer’s disease,Parkinson’s disease,and spinal cord injury.CD36 antagonists can suppress CD36 expression or prevent CD36 binding to its ligand,thereby achieving inhibition of CD36-mediated pathways or functions.Here,we reviewed the mechanisms of action of CD36 antagonists,such as Salvianolic acid B,tanshinone IIA,curcumin,sulfosuccinimidyl oleate,antioxidants,and small-molecule compounds.Moreover,we predicted the structures of binding sites between CD36 and antagonists.These sites can provide targets for more efficient and safer CD36 antagonists for the treatment of central nervous system diseases. | Min Feng Qiang Zhou Huimin Xie Chang Liu Mengru Zheng Shuyu Zhang Songlin Zhou Jian Zhao | 2024 | Neural Regeneration Research2024，19，3： | 0 |
| 5 | WATER POLLUTION AND AGRICULTURE:MULTI-POLLUTANT PERSPECTIVES显示文摘Agriculture is an important cause of multiple pollutants in water.With population growth and increasing food demand,more nutrients,plastics,pesticides,pathogens and antibiotics are expected to enter water systems in the 21st century.As a result,water science has been shifting from singlepollutant to multi-pollutant perspectives for large-scale water quality assessments.This perspective paper summarizes and discusses four main highlights related to water pollution and agriculture from the multi-pollutant perspective.These highlights reveal the spatial and temporal distribution and main sources of multiple pollutants in waters.Based on the highlights,a scientific agenda is proposed to prioritize solutions for sustainable agriculture(UN Sustainable Development Goal 2)and clean water(UN Sustainable Development Goals 6 and 14).This agenda points out that when formulating solutions for water pollution,it is essential to take into account multiple pollutants and their interactions beyond biogeochemistry. | Mengru WANG Qi ZHANG Yanan LI Mirjam P.BAK Sijie FENG Carolien KROEZE Fanlei MENG Ilaria MICELLA Vita STROKAL Aslhan URAL-JANSSEN Maryna STROKAL | 2023 | Frontiers of Agricultural Science and Engineering2023，10，4： | 0 |
| 6 | A mutation in CsKTN1 for the Katanin p60 protein results in miniature plant in cucumber,Cucumis sativus L.显示文摘Katanin,a microtubule shearing protein,plays an important role in plant architecture formation.However,little is known about its mechanisms in regulating plant architecture in cucumber.In the present study,through EMS mutagenesis,we identified a novel micro-plant(mp)mutant in the North China type inbred line CCMC that may be of value for cucumber breeding.The size and number of stem cells were altered in the mp mutant.Through bulked segregant analysis(BSA)sequencing approach combined with genetic mapping,the mp locus was delimited to an interval of 130.9-kb.Multiple lines of evidence suggested that the mp mutation is due to a single nucleotide polymorphism in Csa7G435510 that is predicted to encode the Katanin p60 subunit protein(CsKTN1).The expression levels of CsKTN1 decreased significantly in all tissues except the tendril of mp mutant.Subcellular localization showed that both wild-type and mutant CsKTN1 proteins were located in cell membrane,cytoplasm and nucleus of tobacco leaf cells.The mutant protein lost part of its ability to bind and shear microtubule in vitro.These findings provide new insight into the regulatory function of microtubule-shearing protein,Katanin p60,in plant architecture of cucumber. | MengFei Song WenYuan Fu YuHui Wang Feng Cheng MengRu Zhang JinFeng Chen QunFeng Lou | 2022 | Vegetable Research2022，2，1： | 0 |
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