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| 1 | INVESTIGATION OF RATTLING THRESHOLD IN GEAR SYSTEM显示文摘A lumped mass gear-rattling model with backlash is established by considering the time varying mesh stiffness, composite transmission error and the torque fluctuation. Based on the principle that no separation will occur if the response amplitude is not larger than the static response,the threshold is obtained by theoretical derivation. The validity of the theoretical derivation is verified by the numerical method. The results show that the time-varying mesh stiffness has little effect on the threshold. When the exciting frequency is less than the system natural frequency, the theoretical agrees well with the numerical one. The higher the exciting frequency or the smaller the average input torque is, the easier the separation will occur. When the exciting frequency is larger than the natural frequency by a certain value, the theoretical threshold does not agree with the numerical results. The numerical results show that the motion state will change from the meshing state to the separating state directly. The phenomenon that the gear pair sometimes separates and sometimes meshes occurs only when the exciting frequency is smaller. | Dong Haijun Shen Yunwen Liu Mengjun Wang Sanmin | 2005 | Chinese Journal of Mechanical Engineering2005，18，4： | 6 |
| 2 | A Day-ahead Economic Dispatch Method Considering Extreme Scenarios Based on Wind Power Uncertainty显示文摘As the intermittency of wind power is a growing concern in the day-ahead economic dispatch,this paper proposes a day-ahead economic dispatch method considering extreme scenarios of wind power by using an uncertainty set.The uncertainty set inspired by robust optimization is used to describe wind power intermittency in this paper.Four extreme scenarios based on the uncertainty set are formulated to represent the worst cases of wind power fluctuation.An economic dispatch method considering the costs of both load shedding and wind curtailment is proposed.The economic dispatch model can be easily solved by a quadratic programming method owing to the introduction of four extreme scenarios and the uncertainty set of wind power.Simulation is done using the IEEE 30-bus system and the results verify the effectiveness of the proposed method. | Jian Xu Bao Wang Yuanzhang Sun Qi Xu Ji Liu Huiqiu Cao Haiyan Jiang Ruobing Lei Mengjun Shen | 2019 | CSEE Journal of Power and Energy Systems2019，5，2： | 5 |
| 3 | Global behavior of gear system using mixed cell mapping显示文摘In some mechanical nonlinear systems, the transient motion will be undergoing a very long process and the attractor-basin boundaries are so complicated that some difficulties occur in analyzing the system global behavior. To solve this problem a mixed cell mapping method based on the point mapping and the principle of simple cell mapping is developed. The algorithm of the mixed cell mapping is studied. A dynamic model of a gear pair is established with the backlash, damping, transmission error and the time-varying stiffness taken into consideration. The global behaviors of this system are analyzed. The coexistence of the system attractors and the respective attractor-basin of each attractor with different parameters are obtained, thus laying a theoretical basis for improvement of the dynamic behaviors of gear system. | SHEN Yunwen LIU Mengjun DONG Haijun | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，z1： | 1 |
| 4 | Discovery of an orally effective double-stapled peptide for reducing ovariectomy-induced bone loss in mice显示文摘Stapled peptides with significantly enhanced pharmacological profiles have emerged as promising therapeutic molecules due to their remarkable resistance to proteolysis and performance to penetrate cells.The all-hydrocarbon peptide stapling technique has already widely adopted with great success,yielding numerous potent peptide-based molecules.Based on our prior efforts,we conceived and prepared a double-stapled peptide in this study,termed FRNC-1,which effectively attenuated the bone resorption capacity of mature osteoclasts in vitro through specific inhibition of phosphorylated GSK-3β.The double-stapled peptide FRNC-1 displayed notably improved helical contents and resistance to proteolysis than its linear form.Additionally,FRNC-1 effectively prevented osteoclast activation and improved bone density for ovariectomized(OVX)mice after intravenous injection and importantly,after oral(intragastric)administration.The double-stapled peptide FRNC-1 is the first orally effective peptide that has been validated to date as a therapeutic candidate for postmenopausal osteoporosis(PMOP). | Wei Cong Huaxing Shen Xiufei Liao Mengjun Zheng Xianglong Kong Zhe Wang Si Chen Yulei Li Honggang Hu Xiang Li | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 5 | Injectable hydrogels for spinal cord injury repair显示文摘Spinal cord injury(SCI)often causes severe functional impairment of body,which leads to a huge burden to the patient and the whole society.Many strategies,especially biomaterials,have been employed for SCI repair.Among various biomaterials,injectable hydrogels have attracted much attention because of their ability to load functional components and be injected into the lesioned area without surgeries.In this review,we summarize the recent progress in injectable hydrogels for SCI repair.We firstly introduce the pathophysiology of SCI,which reveals the mechanism of clinical manifestations and determines the therapeutic schedule.Then,we describe the original sources of polymers and the crosslinking manners in forming hydrogels.After that,we focus on the in vivo therapeutic strategies and effects of injectable hydrogels.Finally,the recent challenges and future outlook of injectable hydrogel for SCI repair are concluded and discussed.We believe this review can be helpful and inspire the further development of injectable hydrogels for SCI repair. | Huan Wang Hui Zhang Zhongyu Xie Keng Chen Mengjun Ma Yuejiao Huang Minli Li Zhaopeng Cai Peng Wang Huiyong Shen | 2022 | Engineered Regeneration2022，3，4： | 0 |
| 6 | Unimpaired immunogenicity of yeast-expressed hepatitis B surface antigen stored at elevated temperatures显示文摘病毒(HBV ) 疫苗极大地减少了的肝炎 B 的全球采纳新 HBV 感染。当前的 HBV 疫苗是与铝磷酸盐或铝氢氧化物混合的液体暂停包含 recombinant 肝炎 B 表面抗原(HBsAg ) 粒子。制冷(2-8 楳湯? | Zhongliang Shen Yuliang Rao Shuai Tao Mengjun Luo Lijun Ming Jing Liu Shaokun Pan Youhua Xie | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 0 |
| 7 | Fast Solution Method for the Large-scale Unit Commitment Problem with Long-term Storage显示文摘Long-term storage(LTS)can provide various services to address seasonal fluctuations in variable renewable energy by reducing energy curtailment.However,long-term unit commitment(UC)with LTS involves mixed-integer programming with large-scale coupling constraints between consecutive intervals(state-of-charge(SOC)constraint of LTS,ramping rate,and minimum up/down time constraints of thermal units),resulting in a significant computational burden.Herein,an iterative-based fast solution method is proposed to solve the long-term UC with LTS.First,the UC with coupling constraints is split into several sub problems that can be solved in parallel.Second,the solutions of the sub problems are adjusted to obtain a feasible solution that satisfies the coupling constraints.Third,a decoupling method for long-term time-series coupling constraints is proposed to determine the global optimization of the SOC of the LTS.The price-arbitrage model of the LTS determines the SOC boundary of the LTS for each sub problem.Finally,the sub problem with the SOC boundary of the LTS is iteratively solved independently.The proposed method was verified using a modified IEEE 24-bus system.The results showed that the computation time of the unit combination problem can be reduced by 97.8%,with a relative error of 3.62%. | Bo Li Chunjie Qin Ruotao Yu Wei Dai Mengjun Shen Ziming Ma Jianxiao Wang | 2023 | Chinese Journal of Electrical Engineering2023，9，3： | 0 |
| 8 | Mpox(formerly monkeypox):pathogenesis,prevention,and treatment显示文摘In 2022,a global outbreak of Mpox(formerly monkeypox)occurred in various countries across Europe and America and rapidly spread to more than 100 countries and regions.The World Health Organization declared the outbreak to be a public health emergency of international concern due to the rapid spread of the Mpox virus.Consequently,nations intensified their efforts to explore treatment strategies aimed at combating the infection and its dissemination.Nevertheless,the available therapeutic options for Mpox virus infection remain limited.So far,only a few numbers of antiviral compounds have been approved by regulatory authorities.Given the high mutability of the Mpox virus,certain mutant strains have shown resistance to existing pharmaceutical interventions.This highlights the urgent need to develop novel antiviral drugs that can combat both drug resistance and the potential threat of bioterrorism.Currently,there is a lack of comprehensive literature on the pathophysiology and treatment of Mpox.To address this issue,we conducted a review covering the physiological and pathological processes of Mpox infection,summarizing the latest progress of anti-Mpox drugs.Our analysis encompasses approved drugs currently employed in clinical settings,as well as newly identified small-molecule compounds and antibody drugs displaying potential antiviral efficacy against Mpox.Furthermore,we have gained valuable insights from the process of Mpox drug development,including strategies for repurposing drugs,the discovery of drug targets driven by artificial intelligence,and preclinical drug development.The purpose of this review is to provide readers with a comprehensive overview of the current knowledge on Mpox. | Junjie Lu Hui Xing Chunhua Wang Mengjun Tang Changcheng Wu Fan Ye Lijuan Yin Yang Yang Wenjie Tan Liang Shen | 2024 | Signal Transduction and Targeted Therapy2024，9，1： | 0 |
| 9 | The spatial transcriptomic landscape of human gingiva in health and periodontitis显示文摘The gingiva is a key oral barrier that protects oral tissues from various stimuli.A loss of gingival tissue homeostasis causes periodontitis,one of the most prevalent inflammatory diseases in humans.The human gingiva exists as a complex cell network comprising specialized structures.To understand the tissue-specific pathophysiology of the gingiva,we applied a recently developed spatial enhanced resolution omics-sequencing(Stereo-seq)technique to obtain a spatial transcriptome(ST)atlas of the gingiva in healthy individuals and periodontitis patients.By utilizing Stereo-seq,we identified the major cell types present in the gingiva,which included epithelial cells,fibroblasts,endothelial cells,and immune cells,as well as subgroups of epithelial cells and immune cells.We further observed that inflammation-related signalling pathways,such as the JAK-STAT and NF-κB signalling pathways,were significantly upregulated in the endothelial cells of the gingiva of periodontitis patients compared with those of healthy individuals.Additionally,we characterized the spatial distribution of periodontitis risk genes in the gingiva and found that the expression of IFI16 was significantly increased in endothelial cells of inflamed gingiva.In conclusion,our Stereo-seq findings may facilitate the development of innovative therapeutic strategies for periodontitis by mapping periodontitis-relevant genes and pathways and effector cells. | Zongshan Shen Ran Zhang Yunjia Huang Jiayao Chen Mengjun Yu Chunhua Li Yong Zhang Lingling Chen Xin Huang Jichen Yang Zhengmei Lin Songlin Wang Bin Cheng | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
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