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| 1 | Anchor Self-Localization Algorithm Based on UWB Ranging and Inertial Measurements显示文摘Localization systems utilizing Ultra-WideBand(UWB) have been widely used in dense urban and indoor environments. A moving UWB tag can be located by ranging to fixed UWB anchors whose positions are surveyed in advance. However, manually surveying the anchors is typically a dull and time-consuming process and prone to artificial errors. In this paper, we present an accurate and easy-to-use method for UWB anchor self-localization,using the UWB ranging measurements and readings from a low-cost Inertial Measurement Unit(IMU). The locations of the anchors are automatically estimated by freely moving the tag in the environment. The method is inspired by the Simultaneous Localization And Mapping(SLAM) technique used by the robotics community. A tightly-coupled Error-State Kalman Filter(ESKF) is utilized to fuse UWB and inertial measurements, producing UWB anchor position estimates and six Degrees of Freedom(6 DoF) tag pose estimates. Simulated experiments demonstrate that our proposed method enables accurate self-localization for UWB anchors and smooth tracking of the tag. | Qin Shi Sihao Zhao Xiaowei Cui Mingquan Lu Mengdi Jia | 2019 | Tsinghua Science and Technology2019，24，6： | 11 |
| 2 | CO_2 absorption with ionic liquids at elevated temperatures显示文摘CO_2 capture with ionic liquids(ILs) has attracted many attentions, and most works focused on absorption ability at ambient temperatures, while seldom research was concerned at elevated temperatures.This not only limits the CO_2 absorption application at elevated temperature, but also the determination of the operation condition of the CO_2 desorption generally occurring at higher temperature. This work mainly reported CO_2 solubilities in ILs at elevated temperatures and related properties were also provided. 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide([CnMIm][Tf_2N]) ILs were selected as physical absorbents for CO_2 capture in this work due to their relative higher CO_2 absorption capacities and good thermal stabilities. The long-term stability tests showed that [CnMIm][Tf_2N] is thermally stable at 393.15 K for long time. CO_2 solubilities in [CnMIm][Tf_2N] were systematically determined at temperatures from 353.15 K to 393.15 K. It demonstrated that CO_2 solubility obviously increases with the increase of pressure while slightly decreases with increase of temperature. As the length of alkyl chain on the cation increases, CO_2 solubility in ILs increases. Additionally, the thermodynamic properties including the Gibbs free energy, enthalpy, and entropy of CO_2 were also calculated. | Lu Bai Dawei Shang Mengdie Li Zhongde Dai Liyuan Deng Xiangping Zhang | 2017 | Journal of Energy Chemistry2017，26，5： | 5 |
| 3 | Design and performance evaluation of additively manufactured composite lattice structures of commercially pure Ti(CP-Ti)显示文摘Ti alloys with lattice structures are garnering more and more attention in the field of bone repair or regeneration due to their superior structural,mechanical,and biological properties.In this study,six types of composite lattice structures with different strut radius that consist of simple cubic(structure A),body-centered cubic(structure B),and edge-centered cubic(structure C)unit cells are designed.The designed structures are firstly simulated and analysed by the finite element(FE)method.Commercially pure Ti(CP-Ti)lattice structures with optimized unit cells and strut radius are then fabricated by selective laser melting(SLM),and the dimensions,microtopography,and mechanical properties are characterised.The results show that among the six types of composite lattice structures,combined BA,CA,and CB structures exhibit smaller maximum von-Mises stress,indicating that these structures have higher strength.Based on the fitting curves of stress/specific surface area versus strut radius,the optimized strut radius of BA,CA,and CB structures is 0.28,0.23,and 0.30 mm respectively.Their corresponding compressive yield strength and compressive modulus are 42.28,30.11,and 176.96 MPa,and 4.13,2.16,and 7.84 GPa,respectively.The CP-Ti with CB unit structure presents a similar strength and compressive modulus to the cortical bone,which makes it a potential candidate for subchondral bone restorations. | Wei Xu Aihua Yu Xin Lu Maryam Tamaddon Mengdi Wang Jiazhen Zhang Jianliang Zhang Xuanhui Qu Chaozong Liu Bo Su | 2021 | Bioactive Materials2021，6，5： | 2 |
| 4 | Anti-arthritic effects of microneedling with bee venom gel显示文摘Objective:To combine with transdermal drug delivery using microneedle to simulate the bee venom therapy to evaluate the permeation of bee venom gel.Methods:In this study,the sodium urate and LPS were used on rats and mice to construct the model.Bee venom gelemicroneedle combination effect on the model is to determine the role of microneedle gel permeation by observing inflammation factors.Results:Compared with the model group,the bee venom gelemicroneedle combination group can reduce the level of serum nitric oxide of the acute gouty inflammation model caused by sodium urate,and on LPS induced mouse model of acute inflammation effect and the micro.Conclusions:Bee venom can significantly suppress the occurrence of gouty arthritis inflammation in rats and mice LPS inflammatory reaction.Choose the 750 mm microneedle with 10N force on skin about 3 minutes,bee venom can play the optimal role,and the anti-inflammatory effect is obvious.Microneedles can promote the percutaneous absorption of the active macromolecules bee venom gel. | Mengdi Zhao Jie Bai Yang Lu Shouying Du Kexin Shang Pengyue Li Liu Yang Boyu Dong Ning Tan | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，4： | 2 |
| 5 | Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans显示文摘Whether adult hippocampal neurogenesis(AHN)persists in adult and aged humans continues to be extensively debated.A major question is whether the markers identified in rodents are reliable enough to reveal new neurons and the neurogenic trajectory in primates.Here,to provide a better understanding of AHN in primates and to reveal more novel markers for distinct cell types,droplet-based single-nucleus RNA sequencing(snRNA-seq)is used to investigate the cellular heterogeneity and molecular characteristics of the hippocampi in macaques across the lifespan and in aged humans.All of the major cell types in the hippocampus and their expression profiles were identified.The dynamics of the neurogenic lineage was revealed and the diversity of astrocytes and microglia was delineated.In the neurogenic lineage,the regulatory continuum from adult neural stem cells(NSCs)to immature and mature granule cells was investigated.A group of primate-specific markers were identified.We validated ETNPPL as a primate-specific NSC marker and verified STMN1 and STMN2 as immature neuron markers in primates.Furthermore,we illustrate a cluster of active astrocytes and microglia exhibiting proinflammatory responses in aged samples.The interaction analysis and the comparative investigation on published datasets and ours imply that astrocytes provide signals inducing the proliferation,quiescence and inflammation of adult NSCs at different stages and that the proinflammatory status of astrocytes probably contributes to the decrease and variability of AHN in adults and elderly individuals. | Wei Wang Mengdi Wang Meng Yang Bo Zeng Wenying Qiu Qiang Ma Xiaoxi Jing Qianqian Zhang Bosong Wang Chonghai Yin Jiyao Zhang Yuxin Ge Yufeng Lu Weizhi Ji Qian Wu Chao Ma Xiaoqun Wang | 2022 | Cell Research2022，32，8： | 2 |
| 6 | A single-cell transcriptome atlas of the aging human and macaque retina显示文摘The human retina is a complex neural tissue that detects light and sends visual information to the brain.However,the molecular and cellular processes that underlie aging primate retina remain unclear.Here,we provide a comprehensive transcriptomic atlas based on 119520 single cells of the foveal and peripheral retina of humans and macaques covering different ages.The molecular features of retinal cells differed between the two species,suggesting distinct regional and species specializations of the human and macaque retinae.In addition,human retinal aging occurred in a region-and cell-type-specific manner.Aging of human retina exhibited a foveal to peripheral gradient.MYO9A-rods and a horizontal cell subtype were greatly reduced in aging retina,indicating their vulnerability to aging.Moreover,we generated a dataset showing the cell-type-and region-specific gene expression associated with 55 types of human retinal disease,which provides a foundation to understanding of the molecular and cellular mechanisms underlying human retinal diseases.Such datasets are valuable to understanding of the molecular characteristics of primate retina,as well as molecular regulation of aging progression and related diseases. | Wenyang Yi Yufeng Lu Suijuan Zhong Mei Zhang Le Sun Hao Dong Mengdi Wang Min Wei Haohuan Xie Hongqiang Qu Rongmei Peng Jing Hong Ziqin Yao Yunyun Tong Wei Wang Qiang Ma Zeyuan Liu Yuqian Ma Shouzhen Li Chonghai Yin Jianwei Liu Chao Ma Xiaoqun Wang Qian Wu Tian Xue | 2021 | National Science Review2021，8，4： | 1 |
| 7 | 4-Mercaptopyridine Modified Fiber Optic Plasmonic Sensor for Sub-nM Mercury(II)Detection显示文摘In this paper,we propose and demonstrate a high-performance mercury ion sensor with sub-nM detection limit,high selectivity,and strong practicability based on the small molecule of the 4-mercaptopyridine(4-MPY)modified tilted fiber Bragg grating surface plasmon resonance(TFBG-SPR)sensing platform.The TFBG-SPR sensor has a rich mode field distribution and a narrow bandw idth,which can detect the microscopic physical and chemical reactions on the sensor surface with high sensitivity without being disturbed by the external temperature.For the environmental compatibility and highly efficient capture of the toxic mercury ion,4-MPY is modified on the sensor surface forming a stable(4-MPY)-Hg-(4-MPY)structure due to the specific combination between the nitrogen of the pyridine moiety and the Hg+via multidentate N-bonding.Moreover,gold nanoparticles(AuNPs)are connected to the sensor surface through the(4-MPY)-Hg-(4-MPY)structure,which could play an important role for signal amplification.Under the optimized conditions,the limit of detection of the sensor for mercury ions detection in the solution is as low as 1.643×10^(-10)M(0.1643 nM),and the detection range is 1×10^(-9)M-1×10^(-5)M.At the same time,the mercury ion spiked detection with tap water shows that the sensor has the good selectivity and reliability in actual water samples.We develop a valuable sensing technology for on-time environmental Hg t detection and in-vivo point of care testing in clinic applications. | Yifan DUAN Yang ZHANG Fang WANG Yuting SUN Ming CHEN Zhenguo JING Qiao WANG Mengdi LU Wei PENG | 2022 | Photonic Sensors2022，12，1： | 1 |
| 8 | Lighted up by hydrogen-bonding: luminescence behavior and applications of AIEgen-doped interpenetrating network hydrogel显示文摘The interaction between the aggregation-induced emissive(AIE) luminogens(AIEgen) and the polymer is the key scientific question in the design of functional AIE hydrogels. In this study, we report the AIE behavior of a poly(acrylic acid)(PAAc) and poly(acrylamide)(PAAm) interpenetrating network(IPN) hydrogel doped with tetra-cationic tetraphenylethene(TCTPE). The cationic AIEgen can bind with PAAc through ionic interaction, while PAAc and PAAm chains can associate with each other through hydrogen-bonds(H-bonds). These two interactions can restrict the intramolecular rotation and thus activate the luminescence of the AIEgen. The PAAc-PAAm H-bonds can be broken by increasing temperature or p H, restoring the intramolecular rotation of the AIEgen and quenching the fluorescence of the hydrogel. Therefore, the TCTPE-doped IPN hydrogel is designed as temperature-and p H-sensitive displayers which can record information imprinted by photo-printing or iono-printing with good switchability and reversibility. Another application of this TCTPE-doped hydrogel is demonstrated as a luminescent soft actuator, which has fast shape deformation and editable fluorescence pattern. The above results reveal a pathway to tune the emission behavior through tuning polymer-polymer and polymer-AIEgen interactions, which may inspire new design strategies of aggregation-induced emissive polymers and broaden their applications. | Mengdi Xu Luqin Hua Lihao Gong Jianlei Lu Jinhui Wang Chuanzhuang Zhao | 2021 | Science China Chemistry2021，64，10： | 1 |
| 9 | Bioresorbable Multilayer Photonic Cavities as Temporary Implants for Tether-Free Measurements of Regional Tissue Temperatures显示文摘Objective and Impact Statement.Real-time monitoring of the temperatures of regional tissue microenvironments can serve as the diagnostic basis for treating various health conditions and diseases.Introduction.Traditional thermal sensors allow measurements at surfaces or at near-surface regions of the skin or of certain body cavities.Evaluations at depth require implanted devices connected to external readout electronics via physical interfaces that lead to risks for infection and movement constraints for the patient.Also,surgical extraction procedures after a period of need can introduce additional risks and costs.Methods.Here,we report a wireless,bioresorbable class of temperature sensor that exploits multilayer photonic cavities,for continuous optical measurements of regional,deep-tissue microenvironments over a timeframe of interest followed by complete clearance via natural body processes.Results.The designs decouple the influence of detection angle from temperature on the reflection spectra,to enable high accuracy in sensing,as supported by in vitro experiments and optical simulations.Studies with devices implanted into subcutaneous tissues of both awake,freely moving and asleep animal models illustrate the applicability of this technology for in vivo measurements.Conclusion.The results demonstrate the use of bioresorbable materials in advanced photonic structures with unique capabilities in tracking of thermal signatures of tissue microenvironments,with potential relevance to human healthcare. | Wubin Bai Masahiro Irie Zhonghe Liu Haiwen Luan Daniel Franklin Khizar Nandoliya Hexia Guo Hao Zang Yang Weng Di Lu Di Wu Yixin Wu Joseph Song Mengdi Han Enming Song Yiyuan Yang Xuexian Chen Hangbo Zhao Wei Lu Giuditta Monti Iwona Stepien Irawati Kandela Chad R.Haney Changsheng Wu Sang Min Won Hanjun Ryu Alina Rwei Haixu Shen Jihye Kim Hong-Joon Yoon Wei Ouyang Yihan Liu Emily Suen Huang-yu Chen Jerry Okina Jushen Liang Yonggang Huang Guillermo A.Ameer Weidong Zhou John A.Rogers | 2021 | Biomedical Engineering Frontiers2021，2，1： | 0 |
| 10 | Analysis of China’s PM_(2.5)and ozone coordinated control strategy based on the observation data from 2015 to 2020显示文摘The coordinated control of PM_(2.5)and ozone has become the strategic goal of national air pollution control.Considering the gradual decline in PM_(2.5)concentration and the aggravation of ozone pollution,a better understanding of the coordinated control of PM_(2.5)and ozone is urgently needed.Here,we collected and sorted air pollutant data for 337 cities from 2015 to 2020 to explore the characteristics of PM_(2.5)and ozone pollution based on China’s five major air pollution regions.The results show that it is necessary to continue to strengthen the emission reduction in PM_(2.5)and ozone precursors,and control NO_(x) and VOCs while promoting a dramatic emission reduction in PM_(2.5).The primary method of curbing ozone pollution is to strengthen the emission control of VOCs,with a long-term strategy of achieving substantial emission reductions in NO_(x),because VOCs and NO_(x) are also precursors to PM_(2.5);hence,their reductions also contribute to the reduction in PM_(2.5).Therefore,the implementation of a multipollutant emission reduction control strategy aimed at the prevention and control of PM_(2.5)and ozone pollution is the only means to realize the coordinated control of PM_(2.5)and ozone. | Liuwei Kong Mengdi Song Xin Li Ying Liu Sihua Lu Limin Zeng Yuanhang Zhang | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 11 | Decoding the spatiotemporal regulation of transcription factors during human spinal cord development显示文摘The spinal cord is a crucial component of the central nervous system that facilitates sensory processing and motor performance.Despite its importance,the spatiotemporal codes underlying human spinal cord development have remained elusive.In this study,we have introduced an image-based single-cell transcription factor(TF)expression decoding spatial transcriptome method(TF-seqFISH)to investigate the spatial expression and regulation of TFs during human spinal cord development.By combining spatial transcriptomic data from TF-seqFISH and single-cell RNA-sequencing data,we uncovered the spatial distribution of neural progenitor cells characterized by combinatorial TFs along the dorsoventral axis,as well as the molecular and spatial features governing neuronal generation,migration,and differentiation along the mediolateral axis.Notably,we observed a sandwich-like organization of excitatory and inhibitory interneurons transiently appearing in the dorsal horns of the developing human spinal cord.In addition,we integrated data from 10×Visium to identify early and late waves of neurogenesis in the dorsal horn,revealing the formation of laminas in the dorsal horns.Our study also illuminated the spatial differences and molecular cues underlying motor neuron(MN)diversification,and the enrichment of Amyotrophic Lateral Sclerosis(ALS)risk genes in MNs and microglia.Interestingly,we detected disease-associated microglia(DAM)-like microglia groups in the developing human spinal cord,which are predicted to be vulnerable to ALS and engaged in the TYROBP causal network and response to unfolded proteins.These findings provide spatiotemporal transcriptomic resources on the developing human spinal cord and potential strategies for spinal cord injury repair and ALS treatment. | Yingchao Shi Luwei Huang Hao Dong Meng Yang Wenyu Ding Xiang Zhou Tian Lu Zeyuan Liu Xin Zhou Mengdi Wang Bo Zeng Yinuo Sun Suijuan Zhong Bosong Wang Wei Wang Chonghai Yin Xiaoqun Wang Qian Wu | 2024 | Cell Research2024，34，3： | 0 |
| 12 | Quasi-One-Dimensional van der Waals Transition Metal Trichalcogenides显示文摘The transition metal trichalcogenides(TMTCs)are quasi-one-dimensional(1D)MX_(3)-type van der Waals layered semiconductors,where M is a transition metal element of groups IV and V,and X indicates chalcogen element.Due to the unique quasi-1D crystalline structures,they possess several novel electrical properties such as variable bandgaps,charge density waves,and superconductivity,and highly anisotropic optical,thermoelectric,and magnetic properties.The study of TMTCs plays an essential role in the 1D quantum materials field,enabling new opportunities in the material research dimension.Currently,tremendous progress in both materials and solid-state devices has been made,demonstrating promising applications in the realization of nanoelectronic devices.This review provides a comprehensive overview to survey the state of the art in materials,devices,and applications based on TMTCs.Firstly,the symbolic structure,current primary synthesis methods,and physical properties of TMTCs have been discussed.Secondly,examples of TMTC applications in various fields are presented,such as photodetectors,energy storage devices,catalysts,and sensors.Finally,we give an overview of the opportunities and future perspectives for the research of TMTCs,as well as the challenges in both basic research and practical applications. | Mengdi Chen Lei Li Manzhang Xu Weiwei Li Lu Zheng Xuewen Wang | 2023 | Research2023，，4： | 0 |
| 13 | History dynamics of unified empire in China(770 BC to 476 BC)显示文摘The laws and regulations in human history can be revealed by computational models.From 221 before Christ(BC)to 1912 Anno Domini(AD),the unification pattern has dominated the main part of Chinese history for 2132 years.Before the emergence of the first unified empire,the Qin Empire in 221 BC,there existed the Eastern Zhou dynasty(770 BC to 221 BC).This long dynasty has two stages,and here we focus on the first stage.This Spring-Autumn stage was from 770 BC(with 148 states)to 476 BC(with 32 states).The whole country(China)is modelled as a multi‐agent system,which contains multiple local states.They behave autonomously under certain action rules(wars and conflicts),which forms the main reason for the annexations and disappearance of most states.Key factors(power,loyalty,bellicosity and alliance)have been considered in our model settings,and simulation outcomes will be monitored and collected.Eventually,an optimal solution is obtained,which well unveils the internal mechanism and statistical features of real big history.Furthermore,counterfactuals are used to explore the non‐linear effects of the key factors,which deepens the authors’understanding of civilisa-tion evolutions in human history. | Peng Lu Mengdi Li Jiawen Lu Zhuo Zhang | 2023 | CAAI Transactions on Intelligence Technology2023，8，3： | 0 |
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