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| 1 | Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase显示文摘Diabetes have been shown to cause progressive neuronal injury with pain and numbness via advanced glycation end-products(AGEs)-induced neuronal cell apoptosis;however, the valuable drug targets for diabetic neuropathy have been poorly reported so far. In this study, we discovered a natural small-molecule schisandrol A(SolA) with significant protective effect against AGEs-induced neuronal cell apoptosis. ATP6V0D1, a major subunit of vacuolar-type ATPase(V-ATPase) in lysosome was identified as a crucial cellular target of SolA. Moreover, SolA allosterically mediated ATP6V0D1 conformation via targeting a unique cysteine 335 residue to activate V-ATPase-dependent lysosomal acidification.Interestingly, SolA-induced lysosome pH downregulation resulted in a mitochondrial-lysosomal crosstalk by selectively promoting mitochondrial BH3-only protein BIM degradation, thereby preserving mitochondrial homeostasis and neuronal cells survival. Collectively, our findings reveal ATP6V0D1 is a valuable pharmacological target for diabetes-associated neuronal injury via controlling lysosomal acidification, and also provide the first small-molecule template allosterically activating V-ATPase for preventing diabetic neuropathy. | Xiaoqing Zhou Shaoyang Zhao Tingting Liu Lu Yao Meimei Zhao Xiaoming Ye Xiaowen Zhang Qiang Guo Pengfei Tu Kewu Zeng | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 3 |
| 2 | Thermothickening behavior of graft copolymerscontaining poly (N-isopropyl acrylamide-co-N , Ndimethylacrylamide)side chains in aqueous solution显示文摘 | Fan Guoqiang Guo Jintang Dong Meimei | 2014 | Journal of Macromolecular Science Part A:Pure andApplied Chemistry2014，51，11： | 1 |
| 3 | A chromosome-scale reference genome of Aquilegia oxysepala var.kansuensis显示文摘The genus Aquilegia(Ranunculaceae)has been cultivated as ornamental and medicinal plants for centuries.With petal spurs of strikingly diverse size and shape,Aquilegia has also been recognized as an excellent system for evolutionary studies.Pollinator‐mediated selection for longer spurs is believed to have shaped the evolution of this genus,especially the North American taxa.Recently,however,an opposite evolutionary trend was reported in an Asian lineage,where multiple origins of mini-or even nonspurred morphs have occurred.Interesting as it is,the lack of genomic resources has limited our ability to decipher the molecular and evolutionary mechanisms underlying spur reduction in this special lineage.Using long-read sequencing(PacBio Sequel),in combination with optical maps(BioNano DLS)and Hi–C,we assembled a high-quality reference genome of A.oxysepala var.kansuensis,a sister species to the nonspurred taxon.The final assembly is approximately 293.2 Mb,94.6%(277.4 Mb)of which has been anchored to 7 pseudochromosomes.A total of 25,571 protein-coding genes were predicted,with 97.2%being functionally annotated.When comparing this genome with that of A.coerulea,we detected a large rearrangement between Chr1 and Chr4,which might have caused the Chr4 of A.oxysepala var.kansuensis to partly deviate from the“decaying”path that was taken before the split of Aquilegia and Semiaquilegia.This high-quality reference genome is fundamental to further investigations on the development and evolution of petal spurs and provides a strong foundation for the breeding of new horticultural Aquilegia cultivars. | Jinghe Xie Haifeng Zhao Kunpeng Li Rui Zhang Yongchao Jiang Meimei Wang Xuelian Guo Ben Yu Hongzhi Kong Yuannian Jiao Guixia Xu | 2020 | Horticulture Research2020，7，1： | 1 |
| 4 | Anti-oxidant anti-inflammatory and antibacterial tannin-crosslinked citrate-based mussel-inspired bioadhesives facilitate scarless wound healing显示文摘The revolutionary role of tissue adhesives in wound closure,tissue sealing,and bleeding control necessitates the development of multifunctional materials capable of effective and scarless healing.In contrast to the use of traditionally utilized toxic oxidative crosslinking initiators(exemplified by sodium periodate and silver nitrate),herein,the natural polyphenolic compound tannic acid(TA)was used to achieve near instantaneous(<25s),hydrogen bond mediated gelation of citrate-based mussel-inspired bioadhesives combining anti-oxidant,anti-inflammatory,and antimicrobial activities(3A-TCMBAs).The resulting materials were self-healing and possessed low swelling ratios(<60%)as well as considerable mechanical strength(up to~1.0 MPa),elasticity(elongation~2700%),and adhesion(up to 40 kPa).The 3A-TCMBAs showed strong in vitro and in vivo anti-oxidant ability,favorable cytocompatibility and cell migration,as well as photothermal antimicrobial activity against both Staphylococcus aureus and Escherichia coli(>90%bacterial death upon near-infrared(NIR)irradiation).In vivo evaluation in both an infected full-thickness skin wound model and a rat skin incision model demonstrated that 3A-TCMBAs+NIR treatment could promote wound closure and collagen deposition and improve the collagen Ⅰ/Ⅲ ratio on wound sites while simultaneously inhibiting the expression of pro-inflammatory cytokines.Further,phased angiogenesis was observed via promotion in the early wound closure phases followed by inhibition and triggering of degradation&remodeling of the extracellular matrix(ECM)in the late stage(supported by phased CD31(platelet endothelial cell adhesion molecule-1)PDGF(platelet-derived growth factor)and VEGF(vascular endothelial growth factor)expression as well as elevated matrix metalloprotein-9(MMP-9)expression on day 21),resulting in scarless wound healing.The significant convergence of material and bioactive properties elucidated above warrant further exploration of 3A-TCMBAs as a significant,new class of bioadhesive. | Keke Wu Meimei Fu Yitao Zhao Ethan Gerhard Yue Li Jian Yang Jinshan Guo | 2023 | Bioactive Materials2023，，2： | 1 |
| 5 | Finger vein image segmentation based on an improved LBF active contour model显示文摘 | Chen MeiMei Guo ShuXu Qian XiaoHua | 2011 | Journal of Jinlin University(Engineering and Technology Edition)2011，41，4： | 1 |
| 6 | PCAF/GCN5介导的RPA1乙酰化促进核苷酸切除修复显示文摘文章简介本研究聚焦于DNA损伤修复。复制蛋白A(RPA,Replication protein A)是一类重要的单链DNA结合蛋白复合物,主要参与DNA的复制和修复。RPA复合物包含三个亚基,分别是RPA1、RPA2、RPA3。 | Meimei Zhao Rui Geng Xiang Guo Ruoshi Yuan Xiao Zhou Yanyan Zhong Yanfei Huo Mei Zhou Qinjian Shen Yinglu Li Weiguo Zhu 王嘉东 | 2018 | 科学新闻2018，0，4： | 0 |
| 7 | Facile ultrafine copper seed-mediated approach for fabricating quasi-two-dimensional palladium-copper bimetallic trigonal hierarchical nanoframes显示文摘有高度分叉的形态学的各向异性的 Pd nanoparticles 着急地由于他们的新奇结构和唯一的物理化学的性质为 nanoscale 设备,催化剂,和察觉到的材料作为积木被需要。然而,为这些材料认识到尺寸控制和分支操作是很挑战性的。在这研究,我们在水的阶段开发一条灵巧的极其细小的 Cu 调停种子的途径生产新奇 Pd-Cu 三角的层次 nanoframes (THNF ) 。大多数获得的 nanocrystals 的主要分支是像三脚架的,与沿着象有自我类似的框架单位的手臂的先进分支。在这个方法, Pd-Cu THNF 的尺寸能被操作包含 sub-3 nm Cu 种子的成核灵活地控制。这些 Pd-Cu THNF 关于他们的乙醇氧化表演超过 Pd 黑色,举办 9.7 和 6.6 分别地更高预定的一项特定的活动和集体活动。这研究为生产控制尺寸的各向异性的二金属的 nanoframes 提供一条万用的极其细小的调停种子的途径。 | Min Shen Yuanbiao Huang Dongshuang Wu Jian Lv Minna Cao Meimei Liu Yinglong Yang Hongfang Li Binbin Guo Rong Cao | 2017 | Nano Research2017，10，8： | 0 |
| 8 | TMED10-mediated unconventional secretion of IL-33 regulates intestinal epithelium differentiation and homeostasis显示文摘Dear Editor,Unconventional protein secretion(UcPS)refers to the release of non-signal peptide-containing secretory proteins independent of the ER–Golgi trafficking.1 Although two major pathways including vesicle-dependent and-independent UcPS have been revealed,1 the physiological role of each pathway is largely unclear due to the lack of molecular details.Previously,we identified a translocation pathway termed transmembrane p24 trafficking protein 10(TMED10)-channeled UcPS(THU),which regulates vesicle-dependent UcPS pathway.2,3 In THU,TMED10 is a protein translocator key for mediating secretory cargo translocation into the ER–Golgi intermediate compartment to initiate vesicle-dependent UcPS. | Yang Wang Meimei Huang Xiangyue Mu Wanlu Song Qing Guo Min Zhang Yuan Liu Ye-Guang Chen Liang Ge | 2024 | Cell Research2024，34，3： | 0 |
| 9 | Glacial Lake Area Changes in High Mountain Asia during 1990-2020 Using Satellite Remote Sensing显示文摘Changes in a large-scale glacial lake area directly reflect the regional glacier status and climate changes.However,long time series of glacial lake dataset and comprehensive investigation of the spatiotemporal changes in the glacial lake area in the whole High Mountain Asia(HMA)region remained elusive. | Meimei Zhang Fang Chen Huadong Guo Lu Yi Jiangyuan Zeng Bin Li | 2023 | Research2023，，2： | 0 |
| 10 | Integrated neural tracing and in-situ barcoded sequencing reveals the logic of SCN efferent circuits in regulating circadian behaviors显示文摘The circadian clock coordinates rhythms in numerous physiological processes to maintain organismal homeostasis. Since the suprachiasmatic nucleus(SCN) is widely accepted as the circadian pacemaker, it is critical to understand the neural mechanisms by which rhythmic information is transferred from the SCN to peripheral clocks. Here, we present the first comprehensive map of SCN efferent connections and suggest a molecular logic underlying these projections. The SCN projects broadly to most major regions of the brain, rather than solely to the hypothalamus and thalamus. The efferent projections from different subtypes of SCN neurons vary in distance and intensity, and blocking synaptic transmission of these circuits affects circadian rhythms in locomotion and feeding to different extents. We also developed a barcoding system to integrate retrograde tracing with in-situ sequencing, allowing us to link circuit anatomy and spatial patterns of gene expression. Analyses using this system revealed that brain regions functioning downstream of the SCN receive input from multiple neuropeptidergic cell types within the SCN, and that individual SCN neurons generally project to a single downstream brain region.This map of SCN efferent connections provides a critical foundation for future investigations into the neural circuits underlying SCNmediated rhythms in physiology. Further, our new barcoded tracing method provides a tool for revealing the molecular logic of neuronal circuits within heterogeneous brain regions. | Meimei Liao Xinwei Gao Chen Chen Qi Li Qingchun Guo He Huang Erquan Zhang Dapeng Ju | 2024 | Science China(Life Sciences)2024，67，3： | 0 |
| 11 | Preoperative Acute Sleep Deprivation Causes Postoperative Pain Hypersensitivity and Abnormal Cerebral Function显示文摘Preoperative sleep loss can amplify post-operative mechanical hyperalgesia.However,the underlying mechanisms are still largely unknown.In the current study,rats were randomly allocated to a control group and an acute sleep deprivation(ASD)group which experienced 6 h ASD before surgery.Then the variations in cerebral function and activity were investigated with multi-modal techniques,such as nuclear magnetic resonance,functional magnetic resonance imaging,c-Fos immunofluorescence,and electrophysiology.The results indicated that ASD induced hyperalgesia,and the metabolic kinetics were remarkably decreased in the striatum and midbrain.The functional connectivity(FC)between the nucleus accumbens(NAc,a subregion of the ventral striatum)and the ventrolateral periaqueductal gray(vLPAG)was significantly reduced,and the c-Fos expression in the NAc and the vLPAG was suppressed.Furthermore,the electrophysiological recordings demonstrated that both the neuronal activity in the NAc and the vLPAG,and the coherence of the NAc-vLPAG were suppressed in both resting and task states.This study showed that neuronal activity in the NAc and the vLPAG were weakened and the FC between the NAc and the vLPAG was also suppressed in rats with ASD-induced hyperalgesia.This study highlights the importance of preoperative sleep management for surgical patients. | Meimei Guo Yuxiang Wu Danhao Zheng Lei Chen Bingrui Xiong Jinfeng Wu Ke Li Li Wang Kangguang Lin Zongze Zhang Anne Manyande Fuqiang Xu Jie Wang Mian Peng | 2022 | Neuroscience Bulletin2022，38，12： | 0 |
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