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| 1 | Synthesis and characterization of an environmentally friendly PHBV/PEG copolymer network as a phase change material显示文摘Novel environmentally friendly poly(hydroxybutyrate-co-hydroxyvalerate) and poly(ethylene glycol) (PHBV/PEG) copolymer networks were synthesized through free-radical solution polymerization with PHBV diacrylate (PHBVDA) and polyethylene glycol diacrylate (PEGDA) as macromers. The molecular structure of PHBV/PEG copolymer network was characterized by Fourier transform infrared (FT-IR) and 1 H nuclear magnetic resonance ( 1 H NMR). The morphology of the PHBV/PEG copolymer network was characterized by polarization optical microscopy. Thermal energy storage properties, thermal reliability and thermal stability were investigated by differential scanning calorimetry (DSC) and thermogravimetric analysis. The results indicated that the PHBV/PEG copolymer network hindered the growth of PEG crystalline segments or PHBV segments. PHBV/PEG copolymer network had a higher latent heat enthalpy, which didn't reduce with the components of PHBV increased. Moreover, PHBV/PEG copolymer network still had good thermal stability even at 300 ℃. These results suggested that such environmentally friendly copolymer network would have wide applications in phase change energy storage materials. | XIANG HengXue WANG ShiChao WANG RenLin ZHOU Zhe PENG Cheng ZHU MeiFang | 2013 | Science China Chemistry2013，56，6： | 18 |
| 2 | Isoliquiritigenin inhibits TGF-β1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells显示文摘Isoliquiritigenin(ISL),a natural flavonoid derived from the root of liquorice,has been reported to possess anti-inflammatory and antioxidant activities.Previous studies have found that ISL plays a crucial role in anti-fibrosis of adipose tissue and renal tissue;however,its effect on pulmonary fibrogenesis has not been demonstrated.In this study,we aimed to explore the roles and the underlying mechanisms of ISL in TGF-β1-induced fibrogenesis using human lung fibroblast-derived MRC-5 cells.Cell proliferation and migration were determined by MTT and wound healing assay,respectively.The expression levels of alpha-smooth muscle actin(α-SMA),collagen type I alpha 1(COLIA1)and fibronectin(FN),microtubule-associated protein light chain 3(LC3)and related signaling molecules were detected by quantitative real-time PCR,western blot and immunofluorescence assay,correspondingly.EGFP-LC3 transfection was used for autophagy analysis.The results showed that ISL inhibited the TGF-β1-induced proliferation and migration,and down-regulated the expressions ofα-SMA,COLIA1 and FN.ISL treatment led to up-regulation of LC3 in TGF-β1-treated MRC-5 cells,accompanied by significant decrease in the phosphorylation levels of phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),and mammalian target of rapamycin(mTOR).In addition,the inhibitory effects of ISL on TGF-β1-induced fibrogenic features in MRC-5 cells were enhanced by pretreatment with autophagy activator Rapmycin and PI3K/AKT inhibitor LY294002 and reversed by autophagy inhibitor 3-methyladenine and PI3K/AKT activator IGF-1.Taken together,our results demonstrated that ISL could attenuate the fibrogenesis of TGF-β1-treated MRC-5 cells by activating autophagy via suppressing the PI3K/AKT/mTOR pathway.Therefore,ISL holds a great potential to be developed as a novel therapeutic agent for the treatment of pulmonary fibrosis. | Jinjuan He Hao Peng Meifang Wang Ying Liu Xingrong Guo Bin Wang Longjun Dai Xueqin Cheng Zhongji Meng Leyong Yuan Fenglin Cai Yijun Tang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 16 |
| 3 | Mechanism of floral scent production in Osmanthus fragrans and the production and regulation of its key floral constituents,β-ionone and linalool显示文摘Sweet osmanthus(Osmanthus fragrans Lour.)is among the top ten most well-known flowers in China and is recognized as both an aromatic plant and ornamental flower.Here,manual sectioning,scanning electron microscopy,and transmission electron microscopy of sweet osmanthus petals revealed that large amounts of lipids are present inside the petal cells and on the cell surfaces.However,no secretory structures were observed.Instead,the petal cells protrude slightly outward,and the surfaces of the cells are adorned with highly regular brush-shaped hairs.The surfaces of the‘Yingui’petals possessed mostly curled and more numerous hairs,whereas the‘Dangui’petals possessed fewer brush-shaped and more sparsely arranged hairs.In addition,many granular substances were attached to the brush-shaped hairs,and the granules were denser on the hairs of the‘Yingui’petals compared to the hairs on the‘Dangui’petals.Furthermore,35 aromatic components in the‘Yingui’petals and 30 aromatic components in the‘Dangui’petals were detected via GC-MS.The main aromatic component of the‘Yingui’petals wasβ-ionone,whereas that of the‘Dangui’petals was linalool and its oxides.Transcriptome sequencing and qRT-PCR indicated that the highβ-ionone content in the‘Yingui’petals was due to the overexpression of CCD1 and CCD4 and that the high linalool content in the‘Dangui’petals was due to the overexpression of MECS,HDR,IDI1,and LIS1,which function upstream of the linalool synthetic pathway.In particular,the expression levels of CCD4 and LIS1 were upregulated by 5.5-and 5.1-fold in the‘Yingui’and‘Dangui’petals,respectively.One transcription factor(ERF61)was cloned and named,and the expression pattern of ERF61 in sweet osmanthus petals was found to be generally consistent with that of CCD4.Tobacco transformation experiments,yeast one-hybrid experiments,and electrophoretic mobility shift assays indicated that ERF61 binds to the CCD4 promoter and stimulates CCD4 expression,thereby regulating the synthesis ofβ-ionone in sweet osmanthus petals. | Yuanji Han Hongyun Wang Xiaodan Wang Ke Li Meifang Dong Yong Li Qian Zhu Fude Shang | 2019 | Horticulture Research2019，6，1： | 13 |
| 4 | Short Panicle 3 controls panicle architecture by upregulating APO2/RFL and increasing cytokinin content in rice显示文摘Inflorescence architecture is a major determinant of spikelet numbers per panicle, a key component of grain yield in rice. In this study, Short Panicle 3(SP3) was identified from a short panicle 3(sp3) mutant in which T-DNA was inserted in the promoter of SP3, resulting in a knockdown mutation. SP3 encodes a DNA binding with one finger(Dof) transcriptional activator. Quantitative real time(q RT)-PCR and RNA in situ hybridization assays confirmed that SP3 is preferentially expressed in the young rice inflorescence, specifically in the branch primordial regions. SP3 acts as a negative regulator of inflorescence meristem abortion by upregulating APO2/RFL. SP3 both up-and downregulates expression of genes involved in cytokinin biosynthesis and catabolism, respectively. Consequently, cytokinin concentrations are decreased in young sp3 panicles, thereby leading to small panicles having fewer branches and spikelets. Our findings support a model in which SP3 regulates panicle architecture by modulating cytokinin homeostasis. Potential applications to rice breeding, through gene-editing of the SP3 promoter are assessed. | Yong Huang Xufeng Bai Meifang Luo Yongzhong Xing | 2019 | Journal of Integrative Plant Biology2019，61，9： | 10 |
| 5 | Application of artificial neural networks in global climate change and ecological research:An overview显示文摘Fields that employ artificial neural networks(ANNs)have developed and expanded continuously in recent years with the ongoing development of computer technology and artificial intelligence.ANN has been adopted widely and put into practice by research-ers in light of increasing concerns over ecological issues such as global warming,frequent El Nio-Southern Oscillation(ENSO)events,and atmospheric circulation anomalies.Limitations exist and there is a potential risk for misuse in that ANN model pa-rameters require typically higher overall sensitivity,and the chosen network structure is generally more dependent upon individ-ual experience.ANNs,however,are relatively accurate when used for short-term predictions;despite global climate change re-search favoring the effects of interactions as the basis of study and the preference for long-term experimental research.ANNs remain a better choice than many traditional methods when dealing with nonlinear problems,and possesses great potential for the study of global climate change and ecological issues.ANNs can resolve problems that other methods cannot.This is especially true for situations in which measurements are difficult to conduct or when only incomplete data are available.It is anticipated that ANNs will be widely adopted and then further developed for global climate change and ecological research. | LIU ZeLin PENG ChangHui XIANG WenHua TIAN DaLun DENG XiangWen ZHAO MeiFang | 2010 | Chinese Science Bulletin2010，55，34： | 9 |
| 6 | Induction of apoptosis by casticin in cervical cancer cells: reactive oxygen species-dependent sustained activation of Jun N-terminal kinase显示文摘Casticin,从 Fructus viticis 的 polymethoxyflavone 在中国传统的药用作一个反煽动性的代理人,被报导了有反癌症活动。这研究的目的是在人的颈的癌症房间和它的分子的机制上检验 casticin 的 apoptotic 活动。我们揭示了导致 casticin 的 apoptosis 由发生的新奇机制并且第一次证明 casticin 导致的 apoptosis 通过反应的氧种类(ROS ) 的产生被调停并且在 HeLa 细胞支撑了 c6 月 N 终端 kinase (JNK ) 的激活。Casticin 显著地增加了细胞内部的 ROS 的层次并且导致了 phosphorylated JNK 和 c6 月蛋白质的表示。有 N-acetylcysteine 和 SP600125 的预告的处理有效地在 HeLa 房间由 casticin 稀释了 apoptosis 的正式就职。而且, casticin 在另外的颈的癌症房间线导致了 ROS 生产和 apoptotic 房间死亡,例如 CasKi 和 SiHa。重要地, casticin 没在正常的人的外部血 mononuclear 房间和胚胎的肾上皮引起 ROS 的产生或 apoptosis 的正式就职 293 个房间。这些结果建议由 casticin 的 ROS 产生和持续 JNK 激活在导致 casticin 的 apoptosis 起一个作用并且提起有 casticin 的治疗可能作为对人的颈的癌症的新治疗有希望的可能性。 | Fanxiang Zeng Li Tian Fei Liu Jianguo Cao Meifang Quan Xifeng Sheng | 2012 | Acta Biochimica et Biophysica Sinica2012，44，5： | 9 |
| 7 | Enhanced flame-retardant performance of poly(lactic acid)(PLA) composite by using intrinsically phosphorus-containing PLA显示文摘The intrinsically phosphorous-containing flame-retardant poly(lactic acid)(P-PLA) was synthesized through the chain extension of L-lactide and 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide(DOPO) derivative, then P-PLA was melt blended with neat PLA to produce flame-retardant PLA composite(FR-PLA). The flame-retardant properties of FR-PLAs were investigated by Limiting Oxygen Index(LOI), UL-94, and Cone Calorimeter Tests, the results indicated that the flame-retardant properties of PLA composites were significantly improved with the addition of P-PLA due to its excellent ability to carbonize and dilute combustible gases. The LOI value of FRPLA10 composite(consisting of 90 wt% neat PLA and 10 wt% P-PLA) increased from 20.5 to 27.8 and UL-94 rating reached up to V-1, the peak heat release rate and total heat release of FR-PLA composite were lower than those of neat PLA. The flame-retardant mechanism of FR-PLA depended on both condensed and gaseous phases,which was confirmed by the FTIR, Raman and TG-FTIR. Besides, the tensile strength of FR-PLA10 slightly decreased from 72.4 to 61.8 MPa, which met the requirements of most practical applications. Therefore, the modification method used in this work presented a feasible approach to prepare FR-PLA composite with satisfactory mechanical property. | Senlong Yu Hengxue Xiang Jialiang Zhou Meifang Zhu | 2018 | Progress in Natural Science:Materials International2018，28，5： | 8 |
| 8 | Intriguing anti-superbug Cu2O@ZrP hybrid nanosheet with enhanced antibacterial performance and weak cytotoxicity显示文摘In view of it's strong antibacterial function and minor toxicity,cuprous oxide (Cu2O) is frequently used in various broad-spectrum antibacterial reagents.Nonetheless the undesirable effects of superbugs still remain challenging.In this research,a chemical deposition approach is used to prepare a Cu2O@ZrP composite with nanosheet configuration demonstrating excellent dispersibility and antibacterial traits.From systematic analysis,it was inffered that the content of copper in the nanosheet was about 57-188 mg/g while the average thickness of the nanosheets Cu2O formed on ZrP is approximately 0.8 nm.The results of the minimal inhibitory concentration (MIC) revealed that an extremely low loading of Cu2O in Cu2O@ZrP nanosheet can lead to exceptional antibacterial activity.Examined on two various superbugs;i.e.methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE),the composite nanosheet reagent performed over 99% microbial reduction.More intesetingly,the cell growth rate of the Cu2O@ZrP nanosheet was determined to be 20% lower than that of the neat Cu2O,manifesting a weaker cytotoxicity.This unique hybrid nanosheet with intriguing anti-superbug performance promises highly efficient protection for the fabrics,battledress,and medical textiles. | Jialiang Zhou Hengxue Xiang Fatemeh Zabihi Senlong Yu Bin Sun Meifang Zhu | 2019 | Nano Research2019，12，6： | 7 |
| 9 | Flame retardancy of polyamide 6 hybrid fibers:Combined effects of α-zirconium phosphate and ammonium sulfamate显示文摘Synergistic effect between α-zirconium phosphate(α-ZrP) and ammonium sulfamate(AS) for enhanced flame retardant properties of Polyamide 6(PA6) was investigated by using oxygen index instrument,cone calorimeter,thermogravimetric analyzer(TGA),Instron universal test machine and scanning electron microscopy(SEM).PA6/AS/α-ZrP ternary hybrid materials with various contents of α-ZrP and AS were fabricated by melt-mixing method.The result from flammabihty indicated that the Limiting oxygen index(LOI) and Underwriters Laboratories-94(UL-94) rating of PA6/AS/α-ZrP were significantly accelerated under the coordinating function of α-ZrP and AS.Moreover,the thermal stability for PA6/AS/α-ZrP studied by TGA also demonstrated this synergistic effect between α-ZrP and AS on the heat resistance.The effects of the usage amount of α-ZrP and AS on mechanical properties were analyzed by using uniaxial tensile test.It was found that the addition of AS provided negative effects on the tensile strength of PA6/AS/α-ZrP,however,the adverse trends that mentioned above could be overcome by using the well dispersed α-ZrP. | Hengxue Xiang Lili Li Wei Chen Senlong Yu Bin Sun Meifang Zhu | 2017 | Progress in Natural Science:Materials International2017，27，3： | 7 |
| 10 | Adsorption of 2-mercaptobenzothiazole from aqueous solution by organo-bentonite显示文摘The adsorption behavior of 2-mercaptobenzothiazole onto organo-bentonite was investigated.Natural bentonite from Gaozhou in Guangdong Province,China was collected.Organo-bentonite was prepared by intercalation of cetyltrimethyl ammonium bromide into the natural bentonite.The physicochemical properties of the prepared organo-bentonite were characterized by X-ray diffraction,N2 adsorption-desorption isotherm and Fourier transform infrared spectroscopy.The results showed that montmorillonite is the main component of the natural bentonite.The basal spacing of the natural bentonite is 1.47 nm,which increased to 1.98 nm on intercalation with cetyltrimethyl ammonium bromide.Moreover,both the surface area and pore volume increased with intercalation.Clear CH2 stretching(3000-2800 cm-1) and scissoring(1480-1450 cm-1) modes of the intercalated surfactants were observed for organobentonite.Compared with the pseudo first-order kinetic model,the pseudo second-order kinetic model is more suitable to describe the adsorption kinetics of 2-mercaptobenzothiazole onto organo-bentonite.The adsorption capacity of 2-mercaptobenzothiazole onto organo-bentonite increased with increasing initial concentration of 2-mercaptobenzothiazole,but decreased with increasing adsorbent dosage.The adsorption isotherm of 2-mercaptobenzothiazole onto organo-bentonite fits well with the Langmuir model.The maximum adsorption capacity of organo-bentonite for 2-mercaptobenzothiazole was 33.61 mg/g,indicating that organo-bentonite is a promising adsorbent for 2-mercaptobenzothiazole. | Ping Jing Meifang Hou Ping Zhao Xiaoyan Tang Hongfu Wan | 2013 | Journal of Environmental Sciences2013，25，6： | 6 |
| 11 | Magnetic resonance study of the structure and function of the hippocampus and amygdala in patients with depression显示文摘 | Li Yuefeng Yan Jinchuan Wang Dongqing Sun Meifang Zhu Yan Zhu Xiaolan Jiang Ping Yin Ruigen Zhao Liang | 2014 | Chinese Medical Journal2014，，20： | 6 |
| 12 | Effect of TiO_2@SiO_2 nanoparticles on the mechanical and UV-resistance properties of polyphenylene sulfide fibers显示文摘In order to avoid the inherent photo-catalysis and aggregation of TiO2 in PPS, TiO2 nanoparticles were coated with SiO2 layers, which were chosen as the UV absorbent to improve the UV stability of polyphenylene sul fi de(PPS) fi ber. The PPS–TiO2@SiO2 nanocomposites fi bers were prepared via melt spinning, and the nanocomposites fi bers displayed different crystallization behaviors on variation of the diameters of TiO2@SiO2 nanoparticles, as con fi rmed by Differential Scanning Calorimetry(DSC). The spinnability, breaking strength and UV-resistance properties of PPS nanocomposites fi bers, as measured by homemade melt spinning machine, Xenon-lamp Weather Resistance Test Chamber and Yarn Tensile Tester, manifested the dependence on the diameters. The addition of nanoparticles with the diameter of 25 nm improved the spinnability and the mechanical performance of PPS most, which is attributed to the heterogeneous nucleation effect of nanoparticles. The UVresistance properties of the PPS nanocomposites were improved by the addition of TiO2@SiO2 nanoparticles. After aging for 180 h, PPS nanocomposites fi ber still maintained a high strength. | Zexu Hu Lili Li Bin Sun Si Meng Long Chen Meifang Zhu | 2015 | Progress in Natural Science:Materials International2015，25，4： | 5 |
| 13 | Novel Ag nanocrystals based dental resin composites with enhanced mechanical and antibacterial properties显示文摘The aim of this work was to investigate the effect of trace addition of oleic acid coated Ag nanocrystals(Ag NCs) on mechanical and antibacterial properties of dental resin composites.Composites(70 wt%of silica loading) with 25 ppm,50 ppm,75 ppm and 100 ppm(wt) Ag NCs were prepared and the composite without Ag NCs served as a control.The experimental results showed that the addition of Ag NCs significantly improved the strength and modulus of the resin composite without compromising the shade.For the composite with 50 ppm Ag NCs,fiexural strength(140.3 MPa),modulus(13.2 GPa)and compressive strength(347.2 MPa) were increased by 4.1%,22.2%,13.3%,respectively,compared with the control.The antibacterial test demonstrated that trace Ag NCs provided the resin composites with an antibacterial effect.Such strong and antibacterial dental resin composites might be advantageous to prevent secondary caries and be potential for future clinical applications. | Fengwei Liu Ruili Wang Yuyuan Shi Xiaoze Jiang Bin Sun Meifang Zhu | 2013 | Progress in Natural Science:Materials International2013，23，6： | 5 |
| 14 | Casticin suppresses self-renewal and invasion of lung cancer stem-like cells from A549 cells through down-regulation of pAkt显示文摘癌症干细胞的 subpopulation 作为 tumorigenesis 的原因被认出并且传播。调查 casticin ( 5,3-dihydroxy-3,6,7,4-tetramethoxyflavone )的效果,源于 Fructus Viticis Simplicifoliae 在肺癌症干细胞上,我们孤立并且识别肺癌症的 subpopulation 从有包括在 vitro 的自强能力和高侵略的特征的 non-small-cell 肺癌 A549 房间的像茎的房间( LCSLC ),在 vivo 的提高的 tumorigenic 活动,和 stemness 标记 CD133 , CD44 ,和醛脱氢酶的高表示 1 ( ALDH1 ),用 serum-f 我们然后发现 casticin 能与 0.4 mol/L 的 IC50 价值以一种集中依赖者方式压制 LCSLC 的增长,在父母 A549 房间是比那强壮得多的。另外, casticin 能与减少的 CD133, CD44,和 ALDH1 蛋白质压制 LCSLC 伴随物的自强和侵略表示和减少的 MMP-9 活动。进一步的实验证明 casticin 通过 Akt phosphorylation 的下面规定部分至少压制了自强和侵略。在结论, casticin 压制了 LCSLC 的特征,建议 casticin 可以是为治好经由消除癌症干细胞的肺癌症的候选人混合物。 | Fei Liu Xiaozheng Cao Zhihong Liu Hui Guo Kaiqun Ren Meifang Quan Yuan Zhou Honglin Xiang Jianguo Cao | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 5 |
| 15 | Lignin-based carbon fibers: Formation, modification and potential applications显示文摘As an aromatic polymer in nature, lignin has recently attracted gross attention because of its advantages of high carbon content, low cost and bio-renewability. However, most lignin is directly burnt for power generation to satisfy the energy demand of the pulp mills. As a result, only a handful of isolated lignin is used as a raw material. Thus, increasing value addition on lignin to expand its scope of applications is currently a challenge demanding immediate attention. Many efforts have been made in the valorization of lignin, including the preparation of precursors for carbon fibers. However, its complex structure and diversity significantly restrict the spinnability of lignin. In this review, we provide elaborate knowledge on the preparation of lignin-based carbon fibers ranging from the relationships among chemical structures, formation conditions and properties of fibers, to their potential applications. Specifically, control procedures for different spinning methods of lignin, including melt spinning, solution spinning and electrospinning, together with stabilization and carbonization are deeply discussed to provide an overall understanding towards the formation of lignin-based carbon fibers. We also offer perspectives on the challenges and new directions for future development of lignin-based carbon fibers. | Shichao Wang Jixing Bai Mugaanire Tendo Innocent Qianqian Wang Hengxue Xiang Jianguo Tang Meifang Zhu | 2022 | Green Energy & Environment2022，7，4： | 5 |
| 16 | Structural control of silica aerogel fibers for methylene blue removal显示文摘The development of efficient adsorbents is significant for the miniaturization and cost reduction of water purifying facility. In our previous study, a new kind of silica aerogel fibers(SAFs) with hierarchical structure and hollow structure were developed, which shows outstanding mass transport property and adsorption performance. Herein, we further control and study the hierarchical structure and hollow structure of silica aerogel fibers by changing the sulfuric acid concentration of ageing bath and spinning speed. For removing methylene blue, A0 W120 SAFs sample, with DI water as ageing bath and a winding speed of 120 mm/s,presents the best mass transport property and adsorption performance, as they possess larger pore sizes in the outer layer, thinner fiber wall and higher degree of hollowness. The removal rates of methylene blue by A0 W120 SAFs sample is up to 91.6% and 98.2% in 2 and 5 min, respectively, which are at least 30% higher than other comparable commercial adsorbents, while the adsorption capacity of methylene blue reaches up to 139.1 mg/g. | MENG Si ZHANG JunYan XU Wen CHEN WenPing ZHU LiPing ZHOU Zhe ZHU MeiFang | 2019 | Science China(Technological Sciences)2019，62，6： | 5 |
| 17 | Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers显示文摘It is an urgent need to tackle drug-resistance microbial infections that are associated with implantable biomedical devices.Host defense peptide-mimicking polymers have been actively explored in recent years to fight against drug-resistant microbes.Our recent report on lithium hexamethyldisilazide-initiated superfast polymerization on amino acid N-carboxyanhydrides enables the quick synthesis of host defense peptide-mimicking peptide polymers.Here we reported a facile and cost-effective thermoplastic polyurethane(TPU)surface modification of peptide polymer(DLL:BLG=90:10)using plasma surface activation and substitution reaction between thiol and bromide groups.The peptide polymer-modified TPU surfaces exhibited board-spectrum antibacterial property as well as effective contact-killing ability in vitro.Furthermore,the peptide polymer-modified TPU surfaces showed excellent biocompatibility,displaying no hemolysis and cytotoxicity.In vivo study using methicillin-resistant Staphylococcus aureus(MRSA)for subcutaneous implantation infectious model showed that peptide polymer-modified TPU surfaces revealed obvious suppression of infection and great histocompatibility,compared to bare TPU surfaces.We further explored the antimicrobial mechanism of the peptide polymer-modified TPU surfaces,which revealed a surface contact-killing mechanism by disrupting the bacterial membrane.These results demonstrated great potential of the peptide-modified TPU surfaces for practical application to combat bacterial infections that are associated with implantable materials and devices. | Ziyi Lu Yueming Wu Zihao Cong Yuxin Qian Xue Wu Ning Shao Zhongqian Qiao Haodong Zhang Yunrui She Kang Chen Hengxue Xiang Bin Sun Qian Yu Yuan Yuan Haodong Lin Meifang Zhu Runhui Liu | 2021 | Bioactive Materials2021，6，12： | 5 |
| 18 | Flight dynamics modeling of a small ducted fan aerial vehicle based on parameter identifcation显示文摘This paper presents a simple and useful modeling method to acquire a dynamics model of an aerial vehicle containing unknown parameters using mechanism modeling,and then to design different identifcation experiments to identify the parameters based on the sources and features of its unknown parameters.Based on the mathematical model of the aerial vehicle acquired by modeling and identifcation,a design for the structural parameters of the attitude control system is carried out,and the results of the attitude control flaps are verifed by simulation experiments and flight tests of the aerial vehicle.Results of the mathematical simulation and flight tests show that the mathematical model acquired using parameter identifcation is comparatively accurate and of clear mechanics,and can be used as the reference and basis for the structural design. | Wang Zhengjie Liu Zhijun Fan Ningjun Guo Meifang | 2013 | Chinese Journal of Aeronautics2013，26，6： | 5 |
| 19 | Self-reinforcement of Light, Temperature-Resistant Silica Nanofibrous Aerogels with Tunable Mechanical Properties显示文摘Silica aerogels have attracted significant interest in thermal insulation applications because of their low thermal conductivity and great thermal stability,however,their fragility has limited their application in every-day products.Herein,a self-reinforcing strategy to design silica nanofibrous aerogels(SNFAs)is proposed using electrospun SiO2 nanofibers as the matrix and a silica sol as a high-temperature nanoglue.Adopting this approach results in a strong and compatible interfacial interaction between the SiO_(2) fibers and the silica sol,which results in the SNFAs exhibiting high-temperature-resistant and tunable mechanical properties from elastic to rigid.Furthermore,additional properties such as low density,high thermal insulation performance,and fire-resistance are still retained.The self-reinforcing method described herein may be extended to numerous other new ceramic aerogels that require robust mechanical properties and high-temperature resistance. | Tao Huang Yue Zhu Jie Zhu Hao Yu Qinghua Zhang Meifang Zhu | 2020 | Advanced Fiber Materials2020，2，6： | 4 |
| 20 | The role of β18-β19 loop structure in insecticidal activity of Cry1Ac toxin from Bacillus thuringiensis显示文摘The β18-β19 loop in domain III of Cry1Ac toxin is unique among Bacillus thuringiensis Cry proteins. In this study, the role of the loop structure in insecticidal activity of Cry1Ac toxin was investigated. Alanine scanning mutations within the loop were initially generated and most mutants were over-expressed and reduced toxicity at different degrees, except mutant N546A that showed almost 2 times enhanced toxicity against Helicoverpa armigera larvae. Further mutagenic analysis of N546 revealed that a charged amino acid in this position would cause very unfavorable influence on insecticidal activity. In addition, the deletion of N546 led to protein instability because of destruction of the loop integrity. Besides, mutant W544F was much more toxic than W544Y, indicating that hydrophobic nature of the position was important for maintaining the stability and activity of Cry1Ac protein. These findings are the first biological evidence for a structural function of β18-β19 loop in insecticidal activity of the Cry1Ac toxin. | XIA LiQiu WANG FaXiang DING XueZhi ZHAO XinMin FU ZuJiao QUAN MeiFang YU ZiNiu | 2008 | Chinese Science Bulletin2008，53，20： | 4 |
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