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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin显示文摘LRP16 以前在乳癌房间作为导致雌激素的基因被识别。到在子宫内膜的癌症(EC ) 的雌激素和它的功能的效果的 LRP16 的应答的海角房间仍然是不清楚的。这里,我们证明 LRP16 基因的信使 rna 水平和倡导者活动被 17beta-estradiol (E2 ) 显著地在雌激素受体高山增加哈(嗯高山哈)-positiveIshikawa 人 EC 房间。尽管 Ishikawa 细胞的生长率没被 LRP16 的宫外的表示显然影响, Transwell 试金的结果显示出 LRP16-overexpressing 细胞的侵略能力的近似 one-thirdincrease。由于分子的屏蔽,我们观察到 E-cadherin 的表示,与肿瘤转移联系的一个必要粘附分子,被 LRP16 镇压。进一步的倡导者分析以一种剂量依赖者方式表明了那 LRP16 inhibitedE-cadherin transactivation。然而,抑制被雌激素剥夺废除,显示由 LRP16requires 的 E-cadherin 抄写的 down 规定嗯高山哈调停。染色质免疫降水分析表明到 E-cadherin 倡导者的 ERalpha 的绑定被 LRP16 反对,建议那 LRP16 能防碍嗯调停 alpha 的抄写。这些结果建议起来由雌激素的 LRP16 的规定能被在人的 EC 调整 E-cadherin 的 down 涉及侵略生长。 | Yuan Guang Meng Wei Dong Han Ya Li Zhao Ke Huang Yi Ling Si Zhi Qiang Wu Yi Ming Mu | 2007 | Cell Research2007，17，10： | 27 |
| 3 | Preventive and therapeutic effect of simvastatin on secondary inflammatory damage of rats with cerebral hemorrhage显示文摘Objective:To investigate the preventive and therapeutic effect and mechanism of simvastatin on secondary inflammatory damage of rats with cerebral hemorrhage.Methods:Sixty SD rat aged 9-12 weeks were chosen and divided into the control group,model group and simvastatintreated group randomly with 20 rats in each group.Rats in the model group and simvastatintreated group were infused with autologous fresh uncoagulated blood to the right brain tissue of the basal ganglia to build the cerebral hemorrhage model,while rats in the control group were treated with the same amount of normal saline.Then,rats in the simvastatin-treated group were given a gavage of 3 mg/kg of simvastatin once a day after modeling.Rats in the three groups were given nerve dysfunction score(NDS) and wet-dry weighting method was used to detect the brain water content(BWC) of brain tissues around the lesion of the rats.Then Nissl staining was conducted and the undamaged neurons were counted.Immunohistochemical SP method was applied to count the number of NF-d the immuno fluorκB,TLR4 and IL-1escence method wasβ positive cells in brain tissues around the lesions,an employed to determine the expression levels of NF-κB,TLR4 and IL-1me points were aβ proteins.Results:The NDS results of the simvastatin-treated group at all till significantly higher than those of the model group(P < 0.05);the BWC values of the simvastatin-treated group at all time points were all significantly lower than those of the model group at the same periods(P < 0.05);the number of the undamaged neurons around the lesions of the simvastatin-treated group at all time points were all significantly higher than those of the model group(P < 0.05);seven days after treatment,the number of the NF-κB,TLR4 and IL-1β positive cells in brain tissues around the lesions of the simvastatin-treated group were all significantly lower than those of the model group(P < 0.05),and its expression levels of NF-ower than those of the model group(κB,TLR4 and IL-1P < 0.05).Conclusioβ protein were also significantly lns:Simvastatin can inhibit the expressions of NF-κB,TLR4 and IL-1β proteins in rats with cerebral hemorrhage,and protect neurons and reduce secondary inflammatory damages by down-regulating the above protein-mediated inflammatory responses. | Hong-Xia Zhou Ling-Huan Gao Ling-Li Meng Yu-Xin Zhang Zi-Feng Wei Dao-Wen Si | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，2： | 17 |
| 4 | Safety of different acupuncture manipulations for posterior circulation ischemia with vertigo显示文摘Acupuncture at Fengchi(GB20) in the posterior neck improves vertigo.However,subarachnoid hemorrhage and spinal epidural hematoma have been reported to occur after acupuncture in the posterior neck.Therefore,in the present study,we assessed the safety of acupuncture at Fengchi.Laboratory tests and adverse event reports were used to evaluate the safety of different acupuncture manipulations for the treatment of posterior circulation ischemia with vertigo.A total of 136 patients were randomly assigned to four groups.Verum acupuncture was conducted with different needle insertion directions(contralateral paropia or prominentia laryngea) and different needle twisting frequencies(60 or 120 times/minute) at Fengchi and matching acupoints(for example,Zhongwan [CV12],Qihai [CV6],Zusanli [ST36],and Fenglong [ST40]).The patients received 14 treatments over 3–4 weeks.Routine blood analysis,hepatic and renal function tests,urine and feces tests and electrocardiography were performed before the first treatment session and after the final session.Adverse events were recorded after every session.Of the 136 patients,120 completed the study.There were no significant differences between pretreatment and posttreatment test results in any of the groups.Only five patients suffered from minor adverse events(needling pain,slight hematoma and transient chest tightness).No serious adverse events were found.Our results indicate that a 14-session course of needling at Fengchi is relatively safe for treating posterior circulation ischemia with vertigo. | Yan Wen Chao Zhang Xiao-feng Zhao Shi-zhe Deng Si He Ling-hui Huang Guang Tian Zhi-hong Meng | 2016 | Neural Regeneration Research2016，11，8： | 16 |
| 5 | Reversion effects of curcumin on multidrug resistance of MNNG/HOS human osteosarcoma cells in vitro and in vivo through regulation of P-glycoprotein显示文摘 | Si Meng Zhao Jie Li Xin Tian Ji-guang Li Yong-gang Li Jian-min | 2013 | Chinese Medical Journal2013，，21： | 14 |
| 6 | Green light-emitting diodes based on hybrid perovskite films with mixed cesium and methylammonium cations显示文摘我们报导高质量的 C 0.4 麻省 0.6 PbBr 3 有在进 perovskite 晶体的 C + 的介绍之上的将近完整的表面范围和好排放性质的薄电影。C 0.4 麻省 0.6 PbBr 3 薄电影在轻射出的二极管作为放射性的层被使用。~ 的最大的外部量效率 2.0% 为这些绿射出的设备被完成。 | Junjie Si Yang Liu Nana Wang Meng Xu Jing Li Haiping He Jianpu Wang Yizheng Jin | 2017 | Nano Research2017，10，4： | 9 |
| 7 | Review on the NO removal from flue gas by oxidation methods显示文摘Due to the increasingly strict emission standards of NOx on various industries,many traditional flue gas treatment methods have been gradually improved.Except for selective catalytic reduction(SCR)and selective non-catalytic reduction(SNCR)methods to remove NOx from flue gas,theoxidation method is paying more attention to NOx removal now because of the potential to simultaneously remove multiple pollutants from flue gas.This paper summarizes the efficiency,reaction conditions,effect factors,and reaction mechanism of NO oxidation from the aspects of liquid-phase oxidation,gas-phase oxidation,plasma technology,and catalytic oxidation.The effects of free radicals and active components of catalysts on NO oxidation and the combination of various oxidation methods are discussed in detail.The advantages and disadvantages of different oxidation methods are summarized,and the suggestions for future research on NO oxidation are put forward at the end.The review on the NO removal by oxidation methods can provide new ideas for future studies on the NO removal from flue gas. | Meng Si Boxiong Shen George Adwek Lifu Xiong Lijun Liu Peng Yuan Hongpei Gao Cai Liang Qihai Guo | 2021 | Journal of Environmental Sciences2021，33，3： | 8 |
| 8 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 9 | Increased Chondrocyte Apoptosis in Kashin-Beck Disease and Rats Induced by T-2 Toxin and Selenium Deficiency显示文摘Objective To investigate chondrocyte apoptosis and the expression of biochemical markers associated with apoptosis in Kashin-Beck disease(KBD) and in an established T-2 toxin-and selenium(Se) deficiency-induced rat model. Methods Cartilages were collected from the hand phalanges of five patients with KBD and five healthy children. Sprague-Dawley rats were administered a selenium-deficient diet for 4 weeks prior to T-2 toxin exposure. The apoptotic chondrocytes were observed by terminal deoxynucleotidyl transferase d UTP nick end labeling staining. Caspase-3, p53, Bcl-2, and Bax proteins in the cartilages were visualized by immunohistochemistry, their protein levels were determined by Western blotting, and m RNA levels were determined by real-time reverse transcription polymerase chain reaction. Results Increased chondrocyte apoptosis was observed in the cartilages of children with KBD. Increased apoptotic and caspase-3-stained cells were observed in the cartilages of rats fed with normal and Se-deficient diets plus T-2 toxin exposure compared to those in rats fed with normal and Se-deficient diets. Caspase-3, p53, and Bax proteins and m RNA levels were higher, whereas Bcl-2 levels were lower in rats fed with normal or Se-deficiency diets supplemented with T-2 toxin than the corresponding levels in rats fed with normal diet. Conclusion T-2 toxin under a selenium-deficient nutritional status induces chondrocyte death, which emphasizes the role of chondrocyte apoptosis in cartilage damage and progression of KBD. | YANG Hao Jie ZHANG Ying WANG Zhi Lun XUE Sen Hai LI Si Yuan ZHOU Xiao Rong ZHANG Meng FANG Qian WANG Wen Jun CHEN Chen DENG Xiang Hua CHEN Jing Hong | 2017 | Biomedical and Environmental Sciences2017，30，5： | 7 |
| 10 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 11 | Recent advances of phase engineering in group VI transition metal dichalcogenides显示文摘As the crystal quality and phase structure of two-dimensional(2D)transition metal dichalcogenides(TMDs)have significant impacts on their properties such as electroconductivity,superconductivity and chemical stability,the precise synthesis,which plays an important role in fundamental researches and industrial applications,is highly required.Group VI TMDs,such as MoS_(2),usually exhibit diverse polymorphs including semiconducting 1H and metallic 1T phases.Even great efforts are devoted to revealing the structure-dependent physicochemical nature of TMDs by modulating their phases from the stable to the metastable at the atomic scale,there are still challenges on the phase-controlled synthesis of Group VI TMDs with metallic or semimetal properties.In this review,methods such as ion intercalation,chemical doping,strain engineering,defect triggering,and electric-field treatment are examined in detail.Finally,challenges and opportunities in this research field are proposed. | Lingjia Meng Yang Ma Kunpeng Si Shiyu Xu Jinliang Wang Yongji Gong | 2019 | Tungsten2019，1，1： | 6 |
| 12 | Evolutionary ciphers against differential power analysis and differential fault analysis显示文摘Side channel analysis(SCA) focuses on attacking cryptographic algorithm implementations by collecting leaked information and analyzing the correlation between the leaked and key information in the cryptographic system.Currently,SCA is the main threat to cryptographic implementations,with DPA(differential power analysis) and DFA(differential fault analysis) being two of the most threatening types of SCA.However,the existing countermeasures against DPA and DFA have shortcomings and can hardly protect cipher designs perfectly.Based on a comprehensive analysis of DPA and DFA,this paper proposes a new idea of using an evolutionary cipher(EVOC) against DPAs based on the model proposed by Kocher,and several different new types of DFAs.In fact,an EVOC is a kind of dynamic cipher designing method.Moreover,combined with intelligent searching algorithms and cryptography design policies,EVOCs utilize the dynamic and unpredictable properties of TRNG(a truly random number generator) to ensure cipher design at a high level of security.Therefore,with an EVOC we could design cryptography algorithms with high security to resist mathematical analysis as well as DPAs and DFAs.This paper analyzes and proves the security,efficiency,cost,and original features of EVOCs against DPA and DFA both theoretically and experimentally.Compared with existing countermeasures against SCAs,EVOCs use dynamic non-linear operations to destroy the bases of DPA and DFA.At the algorithm level,EVOCs are more efficient than other resistance methods.Based on the theory and experiments,this paper proposes certain modifications to the EVOC in the AES(advanced encryption standard) algorithm,which can be referenced by other dynamic designs of cryptographic algorithms. | TANG Ming QIU ZhenLong YANG Min CHENG PingPan GAO Si LIU ShuBo MENG QinShu | 2012 | Science China(Information Sciences)2012，55，11： | 5 |
| 13 | Effect of TiO_2@SiO_2 nanoparticles on the mechanical and UV-resistance properties of polyphenylene sulfide fibers显示文摘In order to avoid the inherent photo-catalysis and aggregation of TiO2 in PPS, TiO2 nanoparticles were coated with SiO2 layers, which were chosen as the UV absorbent to improve the UV stability of polyphenylene sul fi de(PPS) fi ber. The PPS–TiO2@SiO2 nanocomposites fi bers were prepared via melt spinning, and the nanocomposites fi bers displayed different crystallization behaviors on variation of the diameters of TiO2@SiO2 nanoparticles, as con fi rmed by Differential Scanning Calorimetry(DSC). The spinnability, breaking strength and UV-resistance properties of PPS nanocomposites fi bers, as measured by homemade melt spinning machine, Xenon-lamp Weather Resistance Test Chamber and Yarn Tensile Tester, manifested the dependence on the diameters. The addition of nanoparticles with the diameter of 25 nm improved the spinnability and the mechanical performance of PPS most, which is attributed to the heterogeneous nucleation effect of nanoparticles. The UVresistance properties of the PPS nanocomposites were improved by the addition of TiO2@SiO2 nanoparticles. After aging for 180 h, PPS nanocomposites fi ber still maintained a high strength. | Zexu Hu Lili Li Bin Sun Si Meng Long Chen Meifang Zhu | 2015 | Progress in Natural Science:Materials International2015，25，4： | 5 |
| 14 | Structural control of silica aerogel fibers for methylene blue removal显示文摘The development of efficient adsorbents is significant for the miniaturization and cost reduction of water purifying facility. In our previous study, a new kind of silica aerogel fibers(SAFs) with hierarchical structure and hollow structure were developed, which shows outstanding mass transport property and adsorption performance. Herein, we further control and study the hierarchical structure and hollow structure of silica aerogel fibers by changing the sulfuric acid concentration of ageing bath and spinning speed. For removing methylene blue, A0 W120 SAFs sample, with DI water as ageing bath and a winding speed of 120 mm/s,presents the best mass transport property and adsorption performance, as they possess larger pore sizes in the outer layer, thinner fiber wall and higher degree of hollowness. The removal rates of methylene blue by A0 W120 SAFs sample is up to 91.6% and 98.2% in 2 and 5 min, respectively, which are at least 30% higher than other comparable commercial adsorbents, while the adsorption capacity of methylene blue reaches up to 139.1 mg/g. | MENG Si ZHANG JunYan XU Wen CHEN WenPing ZHU LiPing ZHOU Zhe ZHU MeiFang | 2019 | Science China(Technological Sciences)2019，62，6： | 5 |
| 15 | Signaling pathways in cancer-associated fibroblasts:recent advances and future perspectives显示文摘As a critical component of the tumor microenvironment(TME),cancerassociated fibroblasts(CAFs)play important roles in cancer initiation and progression.Well-known signaling pathways,including the transforming growth factor-β(TGF-β),Hedgehog(Hh),Notch,Wnt,Hippo,nuclear factor kappa-B(NF-κB),Janus kinase(JAK)/signal transducer and activator of transcription(STAT),mitogen-activated protein kinase(MAPK),and phosphoinositide 3-kinase(PI3K)/AKT pathways,as well as transcription factors,including hypoxia-inducible factor(HIF),heat shock transcription factor 1(HSF1),P53,Snail,and Twist,constitute complex regulatory networks in theTMEtomodulate the formation,activation,heterogeneity,metabolic characteristics and malignant phenotype of CAFs.Activated CAFs remodel the TME and influence the malignant biological processes of cancer cells by altering the transcriptional and secretory characteristics,and this modulation partially depends on the regulation of signaling cascades.The results of preclinical and clinical trials indicated that therapies targeting signaling pathways in CAFs demonstrated promising efficacy but were also accompanied by some failures(e.g.,NCT01130142 and NCT01064622).Hence,a comprehensive understanding of the signaling cascades in CAFs might help us better understand the roles of CAFs and the TME in cancer progression and may facilitate the development of more efficient and safer stroma-targeted cancer therapies.Here,we review recent advances in studies of signaling pathways in CAFs and briefly discuss some future perspectives on CAF research. | Zengli Fang Qingcai Meng Jin Xu Wei Wang Bo Zhang Jiang Liu Chen Liang Jie Hua Yingjun Zhao Xianjun Yu Si Shi | 2023 | Cancer Communications2023，43，1： | 5 |
| 16 | Application of next-generation sequencing to screen for pathogenic mutations in 123 unrelated Chinese patients with Marfan syndrome or a related disease显示文摘Marfan syndrome(MFS) is a systemic connective tissue disease principally affecting the ocular, skeletal and cardiovascular systems. This autosomal dominant disorder carries a prevalence of 1:3,000 to 1:5,000. This study aims to define the mutational spectrum of MFS related genes in Chinese patients and to establish genotype-phenotype correlations in MFS. Panel-based targeted next-generation sequencing was used to analyze the FBN1, TGFBR1 and TGFBR2 genes in 123 unrelated Chinese individuals with MFS or a related disease. Genotype-phenotype correlation analyses were performed in mutation-positive patients. The results showed that 97 cases/families(78.9%;97/123) harbor at least one(likely) pathogenic mutation, most of which were in FBN1;four patients had TGFBR1/2 mutations;and one patient harbored a SMAD3 mutation. Three patients had two FBN1 mutations, and all patients showed classical MFS phenotypes. Patients with a dominant negative-FBN1 mutation had a higher prevalence of ectopia lentis(EL). Patients carrying a haploinsufficiency-FBN1 mutation tended to have aortic dissection without EL. This study extends the spectrum of genetic backgrounds of MFS and enriches our knowledge of genotype-phenotype correlations. | Jiacheng Li Chaoxia Lu Wei Wu Yaping Liu Rongrong Wang Nuo Si Xiaolu Meng Shuyang Zhang Xue Zhang | 2019 | Science China(Life Sciences)2019，62，12： | 4 |
| 17 | Wearable wireless real-time cerebral oximeter for measuring regional cerebral oxygen saturation显示文摘Monitoring regional cerebral oxygen saturation throughout the perioperative clinical process is important for successful patient outcomes.Cerebral oximeters based on near-infrared spectroscopy(NIRS)have already been used for monitoring brain oxygenation and hemodynamics to avoid intraoperative ischemic stroke and reduce postoperative cognitive dysfunction.The current devices are all designed to be used as a bedside monitor,limiting their use to situations that center around a hospital bed.There is a current lack of wearable,miniaturized,wireless equipment that can extend brain oxygenation monitoring to motion tasks or tight spaces.We design a head-mounted wearable wireless oxygen saturation monitoring on head(WORTH)band based on NIRS for monitoring regional cerebral oxygen saturation.The band is embedded with a highly integrated central block,which comprises an optical module,a microprocessor unit,a wireless communication module,and a power management module.The performance of the WORTH band is evaluated by a controlled hypoxia experiment and a squat-to-stand experiment.The results confirm that the WORTH band can record cerebral oxygen saturation with an accuracy comparable to that of a clinical monitor and demonstrate that it is also effective during motion tasks. | Juanning SI Xin ZHANG Meng LI Jian YU Zhiyong ZHANG Qing HE Shaohua CHEN Lianqing ZHU Tianzi JIANG | 2021 | Science China(Information Sciences)2021，64，1： | 4 |
| 18 | Preparation of dye-sensitized solar cells with high photocurrent and photovoltage by using mesoporous titanium dioxide particles as photoanode material显示文摘几 mesoporous TiO 2(MT ) 材料在跟随 poly 使用的一个热水的过程(乙烯乙二醇) 的不同条件下面被综合 -block-poly(propylene-glycol)-block-poly(ethylene-glycol)(P123 ) 作为是的模板和钛 isopropoxide 钛来源。Ti/P123 的臼齿的比率,和在一个压热器的反应解决方案的 pH 值被调查。象 BrunauerEmmettTeller (赌注) 那样的各种各样的技术, X 光检查衍射(XRD ) , X 光检查光电子光谱学(XPS ) ,激光拉曼 spectrometry (LRS ) ,扫描电子显微镜学(SEM ) ,和高分辨率的传播电子显微镜学(HRTEM ) 被用来描绘产品。然后,这些材料被装配进敏化染料的太阳能电池(DSSC ) 。JV 曲线和电气化学的阻抗光谱学(EIS ) 的分析被使用描绘房间。结果显示特定的表面区域和这些材料的水晶的结构为房间提供高光电流的可能性,并且标本的结构的特征导致了,这增加了房间的电子转移抵抗,它为 DSSC 的 photovoltage 的改进是有益的。包含 MT 材料的房间的最高光电的变换效率到达了 8.33% ,与基于 P25 的太阳能电池(5.88%) 的相比,它增加了 41.7% 。 | Yi Zhang Bao Zhang Xiao Peng Lin Liu Shuo Dong Liping Lin Si Chen Shuxian Meng Yaqing Feng | 2015 | Nano Research2015，8，12： | 4 |
| 19 | Molecularly imprinted open porous membranes made from Pickering W/O HIPEs for selective adsorption and separation of methyl 4-hydroxybenzoate显示文摘In this study, novel molecularly imprinted open porous membranes(MIOPMs) were prepared using the Pickering HIPEs template method and molecular imprinting technology for selective adsorption and separation of methyl 4-hydroxybenzoate(M4HB). The template M4 HB, functional monomers,crosslinker and plastifier 2-ethylhexyl acrylate(2-EHA) were contained in the oil phase. Hydrophobic silica nanoparticles(HNP-Si O2) were employed as a stabilizer to establish stable W/O Pickering HIPEs with nonionic surfactant sorbitantrioleate(Span 85). The results of SEM and FTIR indicated that the optimal MIOPMs were prepared successfully and possessed open and interconnecting pores. Then, the MIOPMs were used as sorbents for M4 HB. The correlation coefficient(R2) values for the Langmuir–Freundlich isotherm model and pseudo-second-order kinetic model fitting to the adsorption equilibrium and kinetic data respectively were all higher than 0.95. The maximum adsorption capacity and the time of rapid adsorption for MIOPM4 were 4.146 mg g 1and 100 min, respectively. In addition, the permeability separation factor of MIOPMs for M4 HB compared to a structurally related analog methyl2-hydroxybenzoate(M2HB) could reach 3.122. | Hong-Yu Luo Min Zhang Nai-Chao Si Min-Jia Meng Li Yan Wen-Jing Zhu Chun-Xiang Li | 2015 | Chinese Chemical Letters2015，26，8： | 3 |
| 20 | Blockchain and MEC-Assisted Reliable Billing Data Transmission over Electric Vehicular Network:An Actor–Critic RL Approach显示文摘Recently,electric vehicles(EVs)have been widely used under the call of green travel and environmental protection,and diverse requirements for charging are also increasing gradually.In order to ensure the authenticity and privacy of charging information interaction,blockchain technology is proposed and applied in charging station billing systems.However,there are some issues in blockchain itself,including lower computing efficiency of the nodes and higher energy consumption in the consensus process.To handle the above issues,in this paper,combining blockchain and mobile edge computing(MEC),we develop a reliable billing data transmission scheme to improve the computing capacity of nodes and reduce the energy consumption of the consensus process.By jointly optimizing the primary and replica nodes offloading decisions,block size and block interval,the transaction throughput of the blockchain system is maximized,as well as the latency and energy consumption of the system are minimized.Moreover,we formulate the joint optimization problem as a Markov decision process(MDP).To tackle the dynamic and continuity of the system state,the reinforcement learning(RL)is introduced to solve the MDP problem.Finally,simulation results demonstrate that the performance improvement of the proposed scheme through comparison with other existing schemes. | Xinyu Ye Meng Li Pengbo Si Ruizhe Yang Enchang Sun Yanhua Zhang | 2021 | China Communications2021，18，8： | 3 |
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