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| 1 | DNA methylation in human diseases显示文摘Even though the importance of epigenetics was first recognized in light of its role in tissue development,an increasing amount of evidence has shown that it also plays an important role in the development and progression of many common diseases.We discuss some recent findings on one representative epigenetic modification,DNA methylation,in some common diseases.While many new risk factors have been identified through the population-based epigenetic epidemiologic studies on the role of epigenetics in common diseases,this relatively new field still faces many unique challenges.Here,we describe those promises and unique challenges of epigenetic epidemiological studies and propose some potential solutions. | Zelin Jin Yun Liu | 2018 | Genes & Diseases2018，5，1： | 12 |
| 2 | Application of artificial neural networks in global climate change and ecological research:An overview显示文摘Fields that employ artificial neural networks(ANNs)have developed and expanded continuously in recent years with the ongoing development of computer technology and artificial intelligence.ANN has been adopted widely and put into practice by research-ers in light of increasing concerns over ecological issues such as global warming,frequent El Nio-Southern Oscillation(ENSO)events,and atmospheric circulation anomalies.Limitations exist and there is a potential risk for misuse in that ANN model pa-rameters require typically higher overall sensitivity,and the chosen network structure is generally more dependent upon individ-ual experience.ANNs,however,are relatively accurate when used for short-term predictions;despite global climate change re-search favoring the effects of interactions as the basis of study and the preference for long-term experimental research.ANNs remain a better choice than many traditional methods when dealing with nonlinear problems,and possesses great potential for the study of global climate change and ecological issues.ANNs can resolve problems that other methods cannot.This is especially true for situations in which measurements are difficult to conduct or when only incomplete data are available.It is anticipated that ANNs will be widely adopted and then further developed for global climate change and ecological research. | LIU ZeLin PENG ChangHui XIANG WenHua TIAN DaLun DENG XiangWen ZHAO MeiFang | 2010 | Chinese Science Bulletin2010，55，34： | 9 |
| 3 | Top-emitting thermally activated delayed fluorescence organic light-emitting devices with weak light-matter coupling显示文摘Resonance interaction between a molecular transition and a confined electromagnetic field can lead to weak or strong light-matter coupling.Considering the substantial exciton–phonon coupling in thermally activated delayed fluorescence(TADF)materials,it is thus interesting to explore whether weak light-matter coupling can be used to redistribute optical density of states and to change the rate of radiative decay.Here,we demonstrate that the emission distribution of TADF emitters can be reshaped and narrowed in a top-emitting organic light-emitting device(OLED)with a weakly coupled microcavity.The Purcell effect of weak microcavity is found to be different for TADF emitters with different molecular orientations.We demonstrate that radiative rates of the TADF emitters with vertical orientation can be substantial increased in weakly coupled organic microcavity.These observations can enhance external quantum efficiencies,reduce efficiency roll-off,and improve color-purities of TADF OLEDs,especially for emitters without highly horizontal orientation. | Chunxiu Zang Shihao Liu Mengxin Xu Ruifang Wang Chen Cao Zelin Zhu Jiaming Zhang Hui Wang Letian Zhang Wenfa Xie Chun-Sing Lee | 2021 | Light(Science & Applications)2021，10，7： | 7 |
| 4 | Deformation geometry and timing of the Wupoer thrust belt in the NE Pamir and its tectonic implications显示文摘 | Xiaogan CHENG Hanlin CHEN Xiubin LIN Shufeng YANG Shenqiang CHEN Fenfen ZHANG Kang LI Zelin LIU | 2016 | Frontiers of Earth Science2016，10，4： | 6 |
| 5 | Advances in environmental behaviors and effects of dissolved organic matter in aquatic ecosystems显示文摘Dissolved organic matter(DOM) is a group of compounds that have complex chemical structures and multiple interactions with their surrounding materials. More than one trillion tons of DOM are stocked in the world's aquatic ecosystems. DOM is a very important part of aquatic ecosystem productivity and plays a crucial role in global carbon cycling. DOM has rich environmental behaviors and effects such as influencing the bioavailability of contaminants, serving as an important inducer of reactive oxygen species(ROS), and protecting aquatic organisms from the harm of dangerous ultraviolet radiation. There have been many systematic studies on the composition, structure, and sources of DOM because such studies are much easier to conduct than studies on the environmental behaviors and effects of DOM. Due to many factors, the research systems of DOM's environmental behaviors and effects are still being developed and have become a hotspot of environmental science. This review paper focuses on some critical progress, problems, and trends of DOM's environmental behaviors and effects in aquatic ecosystems, including mutual exchange mechanisms between DOM and particulate organic matter(POM) with influencing factors, photochemical behaviors of DOM especially inducing ROS, binding interactions between DOM and anthropogenic organic contaminants(AOC), interactions between DOM and microorganisms, effects of DOM on pollutants' bioavailability, ecotoxicity, and ecological risks. Hopefully, this paper will contribute to a more systematic understanding of the DOM environmental behaviors and effects and to promoting further relevant studies. | HE Wei BAI ZeLin LI YiLong KONG XiangZhen LIU WenXiu YANG Chen YANG Bin XU FuLiu | 2016 | Science China Earth Sciences2016，59，4： | 6 |
| 6 | A motion compensation method for wide-swath synthetic aperture sonar显示文摘When the swath of Synthetic Aperture Sonar(SAS) is considerably wide, the spacevariant effect of motion errors becomes remarkable. This space-variant effect makes Displace Phase Center Algorithm(DPCA) invalid. To solve the problem, a motion compensation method for wide-swath SAS is proposed. This method uses mixed modulated Lagrange explicit time delay estimation(MMLETDE) to estimate the time delay between two successive pings of the raw echo data, and then motion errors are fitted by linear regression. After that, the raw echo data can be precisely compensated point by point with the estimations of motion errors.Simulation results show that the proposed method can obtain better motion estimation results than DPCA. The resolution measured on the reconstructed image processed by the proposed method is very close to the theoretical resolution. The lake trail results of high frequency and low frequency SAS data show that the quality of the images of the terrain area and small targets is significantly improved. | ZHANG Pengfei JIANG Zelin LIU Wei LIU jiyuan ZHANG Chunhua | 2016 | Chinese Journal of Acoustics2016，35，3： | 4 |
| 7 | Changes in dendritic cells and dendritic cell subpopulations in peripheral blood of recipients during acute rejection after kidney transplantation显示文摘 | Ma Linlin Liu Yong Wu Junjie Xu Xiuhong Liu Fen Feng Lang Xie Zelin Tang Yawang Sun Wen Guo Hongbo Zhang Lei Lin Jun Tian Ye | 2014 | Chinese Medical Journal2014，，8： | 3 |
| 8 | A hazard analysis via an improved timed colored petri net with time–space coupling safety constraint显示文摘Petri nets are graphical and mathematical tools that are applicable to many systems for modeling, simulation, and analysis. With the emergence of the concept of partitioning in time and space domains proposed in avionics application standard software interface(ARINC 653), it has become difficult to analyze time–space coupling hazards resulting from resource partitioning using classical or advanced Petri nets. In this paper, we propose a time–space coupling safety constraint and an improved timed colored Petri net with imposed time–space coupling safety constraints(TCCP-NET) to fill this requirement gap. Time–space coupling hazard analysis is conducted in three steps: specification modeling, simulation execution, and results analysis. A TCCP-NET is employed to model and analyze integrated modular avionics(IMA), a real-time, safety-critical system. The analysis results are used to verify whether there exist time–space coupling hazards at runtime. The method we propose demonstrates superior modeling of safety-critical real-time systems as it can specify resource allocations in both time and space domains. TCCP-NETs can effectively detect underlying time–space coupling hazards. | Li Zelin Wang Shihai Zhao Tingdi Liu Bin | 2016 | Chinese Journal of Aeronautics2016，29，4： | 2 |
| 9 | Strong controls of daily minimum temperature on the autumn photosynthetic phenology of subtropical vegetation in China显示文摘Background:Vegetation phenology research has largely focused on temperate deciduous forests,thus limiting our understanding of the response of evergreen vegetation to climate change in tropical and subtropical regions.Results:Using satellite solar-induced chlorophyll fluorescence(SIF)and MODIS enhanced vegetation index(EVI)data,we applied two methods to evaluate temporal and spatial patterns of the end of the growing season(EGS)in subtropical vegetation in China,and analyze the dependence of EGS on preseason maximum and minimum temperatures as well as cumulative precipitation.Our results indicated that the averaged EGS derived from the SIF and EVI based on the two methods(dynamic threshold method and derivative method)was later than that derived from gross primary productivity(GPP)based on the eddy covariance technique,and the time-lag for EGSsif and EGSevi was approximately 2 weeks and 4 weeks,respectively.We found that EGS was positively correlated with preseason minimum temperature and cumulative precipitation(accounting for more than 73%and 62%of the study areas,respectively),but negatively correlated with preseason maximum temperature(accounting for more than 59%of the study areas).In addition,EGS was more sensitive to the changes in the preseason minimum temperature than to other climatic factors,and an increase in the preseason minimum temperature significantly delayed the EGS in evergreen forests,shrub and grassland.Conclusions:Our results indicated that the SIF outperformed traditional vegetation indices in capturing the autumn photosynthetic phenology of evergreen forest in the subtropical region of China.We found that minimum temperature plays a significant role in determining autumn photosynthetic phenology in the study region.These findings contribute to improving our understanding of the response of the EGS to climate change in subtropical vegetation of China,and provide a new perspective for accurately evaluating the role played by evergreen vegetation in the regional carbon budget. | Peixin Ren Zelin Liu Xiaolu Zhou Changhui Peng Jingfeng Xiao Songhan Wang Xing Li Peng Li | 2021 | Forest Ecosystems2021，8，3： | 2 |
| 10 | The Present Situation on Disseminated Intravascular. Coagulation Studies显示文摘DIC is not a clinical entity in itself. Instead, it always occurs secondary to a broad spectrum of various diseases. DIC may be defined as an acquired syndrome characterized by the activation of intravascular coagulation up to intravascular fibrin formation. Although the trigger for the activation of the coagulation system may vary depending on the underlying condition, it is usually mediated by several cytokines. Thrombin generation proceeds via the (extrinsic) tissue factor/factor Ⅶ a route and simultaneous depression of inhibitory mechanisms, such as the protein C and protein S system. In addition, impaired fibrin degradation, dur to high circulating levels of PAI-1, contributes to enhanced introvascular fibrin deposition. | LIU Zelin 刘泽霖 | 2001 | 血栓与止血学2001，7，3： | 2 |
| 11 | PC4 serves as a negative regulator of skin wound healing in mice显示文摘Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role of PC4 in skin wound healing through PC4 knock-in mouse model.Methods:A PC4 knock-in mouse model(PC4^(+/+))with a dorsal full-thickness wound was used to investigate the biological functions of PC4 in skin wound healing.Quantitative PCR,Western blot analysis and immunohistochemistry were performed to evaluate the expression of PC4;Sirius red staining and immunofluorescence were performed to explore the change of collagen deposition and angiogenesis.Proliferation and apoptosis were detected using Ki67 staining and TUNEL assay.Primary dermal fibroblasts were isolated from mouse skin to perform cell scratch experiments,cck-8 assay and colony formation assay.Results:The PC4^(+/+)mice were fertile and did not display overt abnormalities but showed an obvious delay in cutaneous healing of dorsal skin.Histological staining showed insufficient re-epithelialization,decreased angiogenesis and collagen deposition,increased apoptosis and decreased cell proliferation in PC4^(+/+)skin.Our data also showed decreased migration rate and proliferation ability in cultured primary fibroblasts from PC4^(+/+)mice in vitro.Conclusions:This study suggests that PC4 might serve as a negative regulator of skin wound healing in mice. | Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 1 |
| 12 | Study of propagation characteristics of plasma surface wave in the medium tube显示文摘 | WANG Shiqing YAN Zelin LI Wenzhong LIU Jian XU Linfei | 2008 | Plasma Science and Tecnology2008，10，6： | 1 |
| 13 | Naturally teaching a humanoid Tri-Co robot in a real-time scenario using first person view显示文摘Dear editor,As a direct method of endowing robots with human knowledge, teaching renders the development of robot intelligence to an extraordinary extent.However, as we inevitably encounter complicated motions with multiple degrees of freedom (DOFs),traditional teaching methods continue to face a number of challenges. | Liang GONG Xudong LI Wenbin XU Binhao CHEN Zelin ZHAO Yixiang HUANG Chengliang LIU | 2019 | Science China(Information Sciences)2019，62，5： | 1 |
| 14 | In-situ observation and modeling approach to evolution of pore-fracture structure in coal显示文摘The characterisation of the pore-fracture structure(PFS)and its evolution in coal during mining are essential for preventing gas outbursts and improving gas extraction efficiency.In this study,the evolution of the PFS in coal samples under the condition of mining stress was directly captured in situ by combination of the mechanical testing system with high-precision visualisation nuclear magnetic resonance equipment.A fractional derivative model was established to describe the relationship between stress and porosity based on experimental results of the PFS under different stress states.The results showed that with an increase in the deviatoric stress,the adsorption pore content increases rapidly initially and then increases slowly or remains unchanged;the seepage pore and fracture(SPF)content decreases initially and then increases.The SPF compressibility coefficient decreases with an increase in the deviatoric stress.The fractional derivative model can accurately describe the stress sensitivity of the SPFs at the pre-peak stage,thus providing a new approach for accurately characterising the seepage characteristics of coal reservoirs. | Hongwei Zhou Zelin Liu Jiawei Zhao Bocen Chen Xiangnan Li Jiangcheng Zhong | 2023 | International Journal of Mining Science and Technology2023，33，3： | 1 |
| 15 | Knowledge flow in engineering design:an ontological framework显示文摘 | ZHANG Zhinan LIU Zelin CHEN Yong | 2013 | Jour- nal of Mechanical Engineering Science2013，227，4： | 1 |
| 16 | Genomic basis of evolutionary adaptation in a warm-blooded fish显示文摘Few fishes have evolved elevated body temperatures compared with ambient temperatures,and only in opah(Lampris spp)is the entire body affected.To understand the molecular basis of endothermy,we analyzed the opah genome and identified 23 genes with convergent amino acid substitutions across fish,birds,and mammals,including slc8b1,which encodes the mitochondrial Na+/Ca2+exchanger and is essential for heart function andmetabolic heat production.Among endothermic fishes,44 convergent genes with suggestive metabolic functions were identified,such as glrx3,encoding a crucial protein for hemoglobin maturation.Numerous genes involved in the production and retention of metabolic heat were also found to be under positive selection.Analyses of opah’s unique inner-heat-producing pectoral muscle layer(PMI),an evolutionary key innovation,revealed that many proteins were co-opted from dorsal swimming muscles for thermogenesis and oxidative phosphorylation.Thus,the opah genome provides valuable resources and opportunities to uncover the genetic basis of thermal adaptations in fish. | Xin Wang Meng Qu Yali Liu Ralf F.Schneider Yue Song Zelin Chen Hao Zhang Yanhong Zhang Haiyan Yu Suyu Zhang Dongxu Li Geng Qin Shaobo Ma Jia Zhong Jianping Yin Shuaishuai Liu Guangyi Fan Axel Meyer Dazhi Wang Qiang Lin | 2022 | The Innovation2022，3，1： | 1 |
| 17 | A knowledge-based framework for creative conceptual design of mulit-disciplinary systems 显示文摘 | Chen Yong Liu Zelin Xie Youbai | 2012 | Computer Aided Design2012，44，2： | 1 |
| 18 | Synthesis and crystal structure of β-hexanitrohexaazaisowurtzitane显示文摘 | Yuxiang Ou Huiping Jia Yongjiang Xu Boren Chen Guangyu Fan Lihua Liu Fuping Zheng Zelin Pan Cai Wang | 1999 | Science in China Series B: Chemistry1999，，2： | 1 |
| 19 | Mutation analysis of the HCP gene in acute leukemia显示文摘 | Luo Jianmin Liu Zelin Hao Hongling | 2004 | J Experi mental Hematology2004，12，2： | 1 |
| 20 | Effects of Different Row Ratios of Male and Female Parents and Application Amount of Nitrogen Fertilizer on Hybrid Wheat Seed Production and Its Component Factors显示文摘In order to screen suitable high hybrid wheat seed production technology,the split-plot experiment design was adopted and study was carried out about the effects of the different row ratios of male and female parents and application amount of nitrogen fertilizer on hybrid wheat seed production and its component factors. The results showed that the seed production increased with the increase in the number of female parent row. When the row ratio of male and female parents was 2 ∶ 6,the seed production was 3 683. 8 kg/ha; when the application amount of nitrogen fertilization was 50 kg/ha,the seed production was 3 649. 4 kg/ha; the interaction between the row ratio of male and female parents and the application amount of nitrogen fertilizer indicated that when the row ratio of male and female parents was 2∶ 6 and the application amount of nitrogen fertilizer was 300 kg/ha,the seed production reached the highest( 4160. 6 kg/ha). The row ratio of male and female parents and application amount of nitrogen fertilizer had significant effect on the component factors of seed production,including the number of grains per spike,spike weight and setting percentage. When the row ratio of male and female parents was 2∶ 5,the number of grains per spike,spike weight and setting percentage were the highest at 26. 7 grains,1. 12 g,and 62. 6% respectively; when application amount of nitrogen fertilizer was 450 kg/ha,the number of grains per spike,spike weight and setting percentage were the highest at 26. 0 grains,1. 08 g,and59. 2% respectively; the interaction of row ratio of male and female parents and application amount of nitrogen fertilizer had significant effect on the number of grains per spike,spike weight and setting percentage; when the row ratio of male and female parents was 2∶ 5 and the application amount of nitrogen fertilizer was 300 kg/ha,the number of grains per spike,spike weight and setting percentage were the highest at 29. 6grains,1. 24 g,and 71. 6% respectively. The number of grains per spike is the largest component factor for seed production. Increasing the number of grains per spike can increase the seed production. According to the effects of row ratio of male and female parents and application amount of nitrogen fertilizer on the component factors of seed production,the optimal condition was 2∶ 5-2∶ 6 for row ratio of male and female parents and 300-450 kg/ha for application amount of nitrogen fertilizer. | Can SUN Renwu RUAN Lili YAN Dan HU Xingbei LIU Hengzhi SHE Manman XU Zhongan LI Zelin YI Yuheng YANG | 2017 | Asian Agricultural Research2017，9，3： | 1 |
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