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| 1 | In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells显示文摘Circulating tumor cells(CTCs)is an established biomarker of cancer metastasis.The circulation dynamics of CTCs are important for understanding the mechanisms underlying tumor cell dissemination.Although studies have revealed that the circadian rhythm may disrupt the growth of tumors,it is generally unclear whether the circadian rhythm controls the release of CTCs.In clinical examinations,the current in vitro methods for detecting CTCs in blood samples are based on a fundamental assumption that CTC counts in the peripheral blood do not change significantly over time,which is being challenged by recent studies.Since it is not practical to draw blood from patients repeatedly,a feasible strategy to investigate the circadian rhythm of CTCs is to monitor them by in vivo detection methods.Fluoresce nee in vivo flow cytometry(IVFC)is a powerful optical technique that is able to detect fluoresce nt circulating cells directly in living animals in a noninvasive manner over a long period of time.In this study,we applied fluorescence IVFC to monitor CTCs noninvasively in an orthotopic mouse model of human prostate cancer.We observed that CTCs exhibited stochastic bursts over cancer progression.The probability of the bursting activity was higher at early stages than at late stages.We longitudinally monitored CTCs over a 24-h period,and our results revealed striking daily oscillations in CTC counts that peaked at the onset of the night(active phase for rodents),suggesting that the release of CTCs might be regulated by the circadian rhythm. | Xi Zhu Yuanzhen Suo Yuting Fu Fuli Zhang Nan Ding Kai Pang Chengying Xie Xiaofu Weng Meilu Tian Hao He Xunbin Wei | 2021 | Light(Science & Applications)2021，10，6： | 6 |
| 2 | Investigation on fracture models and ground pressure distribution of thick hard rock strata including weak interlayer显示文摘Dynamic disasters,such as rock burst due to the breaking of large area stiff roof strata,are known to occur in the hard rock strata of coal mines.In this paper,mechanical models of the fracturing processes of thick hard rock strata were established based on the thick plate theory and numerical simulations.The results demonstrated that,based on the fracture characteristics of the thick hard rock strata,four fracture models could be analyzed in detail,and the corresponding theoretical failure criteria were determined in detail.In addition,the influence of weak interlayer position on the fracture models and ground pressure of rock strata is deeply analyzed,and six numerical simulation schemes have been implemented.The results showed that the working face pressure caused by the independent movement of the lower layer is relatively low.The different fracture type of the thick hard rock strata had different demands on the working resistance of the hydraulic powered supports.The working resistance of the hydraulic powered supports required by the stratified movements was lower than that of the non-stratified movements. | Meilu Yu Jianping Zuo Yunjiang Sun Changning Mi Zhengdai Li | 2022 | International Journal of Mining Science and Technology2022，32，1： | 5 |
| 3 | Reply to Comment on “In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells”显示文摘Dear Editor,We thank Niedre et al.for their correspondence regarding our recent paper1.They proposed a point that the temporal distribution of circulating tumor cells(CTCs)monitored by diffuse in vivo flow cytometry in a multiple myeloma mouse model in their previous work2 might be different from our results.Niedre et al.claimed that CTC detection statistics deviated from Poisson but did not found circadian variations in CTC numbers in a multiple myeloma mouse model.They also cite another literature by Juratli.et al.3,in which the authors reported that CTC numbers did not always correlate with tumor size during cancer progression.However,by establishing an orthotopic mouse model of prostate cancer and utilizing the technology in vivo flow cytometry(IVFC),we found CTCs exhibited bursting activity and daily oscillation in an orthotopic model of prostate cancer. | Xi Zhu Yuanzhen Suo Yuting Fu Fuli Zhang Nan Ding Kai Pang Chengying Xie Xiaofu Weng Meilu Tian Hao He Xunbin Wei | 2021 | Light(Science & Applications)2021，10，10： | 2 |
| 4 | Immunochemical analysis of human papillomavirus L1 capsid protein in liquid-based cytology samples from cervical lesions显示文摘 | Xiao Wei Bian Meilu Li ma | | 0，，： | 1 |
| 5 | Preparation and Characterization of Ag_2S/PMMA Nanocomposites by Microemulsion显示文摘Ag_2S nanoparticles in polymethyl methacrylate(PMMA) are prepared in n-heptane/sodium bis(2-ethylhexyl)sulfosuccinate/water microemulsions.The Ag_2S nanoparticles dispersed in the polymer are characterized by FT-IR spectrum,UV-Vis absorption spectroscopy,transmission electron microscopy(TEM),and X-ray powder diffraction(XRD).The FT-IR spectrum shows that the composite has the characteristic bands of nano-Ag_2S and pure PMMA.The TEM photograph of the sample shows that the Ag_2S nanoparticles are elliptical.The phase structure of the composite is characterized by XRD,which reveals that Ag_2S particles are formed.The UV-Vis absorption recorded at various times indicates an initial rapid formation of the nanoparticles and the quantum confinement effect of Ag_2S nanoparticles. | Yuzhen Li Lizhen Gao Wenjun Chen Weike Zhang Lili Gao Yanqing Yang Likun Shang Meilu Wang | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，1： | 1 |
| 6 | Active Coaxial and Active Inverted Coaxial Magnetron Electronic Guns显示文摘 | Meilus J O Petrauskas Z | 2004 | Elec- tronika ir Electroteehnika2004，56，7： | 1 |
| 7 | Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat显示文摘 | JieliChen YiLi MarkKatakowski XiaoguangChen LeiWang DunyueLu MeiLu Subhash C.Gautam MichaelChopp | 2003 | J Neurosci Res2003，，6： | 1 |
| 8 | Joint cooperative beamforming and artificial noise design for secrecy sum rate maximization in two-way AF relay networks显示文摘 | LIN Meilu GE Jianhua YANG Ye | 2014 | IEEE Communications Letters2014，18，2： | 1 |
| 9 | A micropro- cessor-based solar cell test system 显示文摘 | SCHULTZ R MEILUS A A HU S C | 1977 | Instrumentation and Measurement1977，26，4： | 1 |
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